康哲药业新交所IPO获中国证监会备案 智通财经6月26日电，中国证监会国际合作司发布关于China Medical System Holdings Limited（康哲药业 控股有限公司）境外发行上市备案通知书，公司拟通过介绍方式在新加坡证券交易所上市。 ...

Group 1: Brain-Computer Interface Standards - The National Standard for Non-Invasive Medical Devices Using Brain-Computer Interface Technology is open for public consultation, aiming to establish performance indicators and testing methods for such devices [1] - The standardization is expected to enhance international cooperation and improve regulatory efficiency, addressing the rapid development in the non-invasive neural modulation sector [1] Group 2: Pharmaceutical Industry Innovation - The head of the National Medical Products Administration emphasized the importance of supporting drug and medical device R&D innovation to strengthen China's pharmaceutical industry [2] - Key strategies include early intervention, tailored guidance for enterprises, and promoting international multi-center clinical trials to synchronize the development and approval of innovative drugs and devices [2][3] Group 3: Clinical Trials and Approvals - Shenzhou Cell announced that its product SCTB39G received approval for clinical trials in advanced solid tumors [4] - Hanyu Pharmaceutical's subsidiary received approval for the listing of the raw material drug Acetate Degarelix, which is used for treating advanced prostate cancer [6] Group 4: Market Expansion and IPOs - Kangzhe Pharmaceutical plans a secondary listing in Singapore, reflecting a trend of pharmaceutical companies expanding into Southeast Asian markets [7] - Lianya Pharmaceutical's IPO application has been accepted, focusing on complex drug formulations and high-end generic drugs [9] Group 5: Strategic Collaborations - Bayer and Tsinghua University signed a strategic cooperation agreement to enhance research in various medical fields, aiming to accelerate drug innovation [11][12] Group 6: Clinical Trial Developments - Fuhong Hanlin announced the first patient enrollment in a bridging clinical trial for its drug H, which is approved for first-line treatment of small cell lung cancer in multiple countries [13] Group 7: Corporate Leadership Changes - Fosun Pharma held a shareholder meeting to elect new board members, appointing Chen Yuqing as chairman and Liu Yi as CEO [14]

24 June 2025 | 10:37PM HKT China Medical System Holdings (0867.HK): China Healthcare Corporate Day 2025 — Key Takeaways: Highlighted drivers beyond Key Takeaways Highlighted topline growth albeit divestiture of Dermavon: the company emphasized that positive sales growth in 2026 could be achieved after the spin-off of Dermavon, a subsidiary focusing on dermatology diseases. The previous guidance of double-digit sales growth for 2025 remain unchanged as the spin-off is expected to complete by YE25, driven by: ...

Company News - JD Logistics (02618.HK) has begun recruiting full-time delivery riders for its food delivery service [1] - Cao Cao Travel (02643.HK) announced the results of its share distribution, with a global offering of 44.1786 million H-shares, and a 21.14 times subscription for the Hong Kong public offering, raising approximately HKD 1.718 billion, with a share price of HKD 41.94 [2][3] - Kangji Medical (00867.HK) proposed to list its ordinary shares on the Singapore Exchange as a secondary listing [4][8] - China Electric Power Technology (00085.HK) expects a mid-term net profit of approximately HKD 135 million to HKD 150 million, compared to HKD 309.5 million in the same period last year [5][6] - Chang Gao Mei Group (08371.HK) reported a net profit attributable to shareholders of HKD 95.533 million for the year ending March 31, 2025, representing a year-on-year increase of 5.61% [7] - Li Ning (02331.HK) saw an increase of 6.4 million shares purchased by Li Jin at a price of approximately HKD 14.96 per share [8] - BOSS Zhipin (02076.HK) plans to issue 30 million new shares, aiming to raise a maximum of approximately HKD 2.2613 billion [9]

Core Viewpoint - The botulinum toxin industry in China is experiencing rapid growth, with the market size projected to increase from 1.9 billion yuan in 2017 to 9.9 billion yuan by 2024, reflecting a compound annual growth rate (CAGR) of 26.6% [1][13]. Industry Overview - Botulinum toxin, originally used for treating muscle spasms, has become a popular choice in medical aesthetics due to its minimal invasiveness and quick recovery time [3][13]. - The application range of botulinum toxin is expanding beyond traditional uses like wrinkle reduction and facial slimming to include treatments for conditions such as migraines and muscle tension disorders [1][13]. Market Dynamics - The medical aesthetics market in China is projected to reach 288 billion yuan by 2024, with a year-on-year increase of 8.03%, indicating a growing consumer demand for beauty enhancement services [11][13]. - The market is characterized by a "six-way split" among leading products, with brands like Botox, Hengli, and Letyb gaining significant market shares [15][17]. Competitive Landscape - The botulinum toxin market is competitive, with established companies like Fosun Pharma, Haohai Biological Technology, and Lanzhou Biological Products Research Institute leading the industry [17][18]. - New entrants are emerging, leveraging innovative technologies and marketing strategies to capture market share [17]. Development Trends 1. **Increasing Industry Penetration** - As living standards rise, the penetration rate of medical aesthetics is expected to increase, particularly in lower-tier cities and rural areas, driven by a younger consumer base [23]. 2. **Enhanced Regulatory Oversight** - The government is intensifying regulations on botulinum toxin production and distribution to ensure safety and quality, which will promote the healthy development of the market [24]. 3. **Rise of Recombinant Botulinum Toxin** - Recombinant botulinum toxin is anticipated to become a future trend due to its lower biological risks, higher purity, and production efficiency, addressing limitations of traditional products [25].

Core Viewpoint - Kangzheng Pharmaceutical (00867.HK) plans to spin off its skin health business, Demy Pharmaceutical, for a "listing by introduction" on the Hong Kong Stock Exchange, marking it as the first "zero fundraising" IPO case in 2025 [2][5][18] Company Overview - Kangzheng Pharmaceutical has faced declining performance, with revenue dropping from 91.5 billion RMB in 2022 to 80.13 billion RMB in 2023, and further down to 74.69 billion RMB in 2024, representing a year-on-year decline of 12.4% and 6.7% respectively [6][7] - The company experienced a significant drop in net profit, from 23.84 billion RMB in 2023 to 16.13 billion RMB in 2024, a decrease of 27.2% [7] - The decline in performance is attributed to the failure of key products to win bids in national procurement, leading to a loss of market share and revenue [7][8] Demy Pharmaceutical Financials - Demy Pharmaceutical's revenue grew from 384 million RMB in 2022 to 618 million RMB in 2024, but it also reported increasing losses, from 55.17 million RMB in 2022 to 105.63 million RMB in 2024 [8][9] - The company's cost structure is heavily skewed towards sales expenses, which consumed 99% of its gross profit in 2024, leading to a net loss of 106 million RMB [10][12] - Demy Pharmaceutical's research and development expenditure remains low compared to its sales expenses, with a research expenditure rate of only 4% [10][12] Strategic Implications - The spin-off is seen as a strategic move to alleviate financial pressure on Kangzheng Pharmaceutical while allowing Demy Pharmaceutical to seek independent funding and partnerships [18] - The choice of "listing by introduction" allows for a quicker and less costly process, avoiding the dilution of shares and the complexities of traditional IPOs [17][18] - However, Demy Pharmaceutical will still face scrutiny regarding its ongoing losses and the sustainability of its business model post-spin-off [13][15] Market Context - The move reflects a broader trend among Chinese pharmaceutical companies seeking to adapt to the pressures of national procurement policies and increasing competition in the industry [17] - Since 2020, over 20 pharmaceutical companies have pursued similar spin-offs to focus on high-growth areas like medical aesthetics and consumer healthcare [17]

Group 1 - The core viewpoint of the news is that Kangzheng Pharmaceutical plans to spin off its subsidiary, Demai Pharmaceutical, which focuses on skin health, for independent listing on the Hong Kong Stock Exchange, allowing shareholders to directly hold shares in Demai and benefit from its independent valuation and business growth [1][3] Group 2 - Demai Pharmaceutical operates primarily in the skin health sector in mainland China, with a product portfolio covering major skin diseases such as psoriasis, vitiligo, and atopic dermatitis. The market for skin disease treatment and care in China is projected to reach RMB 169.4 billion by 2030, indicating significant market potential [2] - Demai's product strategy combines prescription drugs and skincare products, creating a comprehensive solution that spans various skin diseases and the entire disease management cycle, positioning the company favorably to seize growth opportunities [2] - The company has a differentiated product mix, a professional marketing team, and extensive academic resources, which may enhance its valuation growth. Demai is expected to lead the industry in prescription drug revenue in 2024, supported by a strong sales network covering over 10,000 hospitals and 100,000 retail pharmacies [2] Group 3 - The spin-off is expected to benefit both shareholders and the company, as it will not involve new share issuance, thus preventing dilution of shareholder equity. This will clarify the business positioning of both Kangzheng and Demai, potentially attracting niche investors and driving value re-evaluation [3] - After the listing, Demai will be able to raise funds directly from the capital market, supporting its business and future expansion. The requirement for regular disclosure of operational and financial status will enhance transparency, allowing investors to make informed decisions [3] - The spin-off is anticipated to create structural benefits for shareholders and open specialized development paths for both companies, serving as a potential benchmark for value re-evaluation in the pharmaceutical industry [3]

Core Viewpoint - 康哲药业 plans to spin off its skin health subsidiary, 德镁医药, and list it on the Hong Kong main board through a distribution of shares to existing shareholders, without diluting their equity [1] Group 1: Company Overview - 德镁医药 focuses on skin health and is responsible for 康哲药业's domestic skin health business, providing comprehensive solutions from prevention to long-term care [1] - The company has incurred losses during the performance record period due to ongoing investments in business development, which aligns with the growth logic of a developing enterprise [1] Group 2: Product Pipeline and Market Position - 德镁医药's product pipeline includes three marketed products, four candidates in clinical or late-stage trials, and two preclinical candidates, covering major skin diseases such as psoriasis, vitiligo, and atopic dermatitis [2] - The company ranks first among Chinese innovative pharmaceutical companies in terms of the number of skin disease indications covered by products in late-stage clinical trials or commercialization [2] - Notable products include the innovative drug, 芦可替尼乳膏, which targets the unapproved treatment area of vitiligo, and the commercialized drug IL-23益路取, which is penetrating the psoriasis market [1][2]

文｜胡香赟 36氪获悉，再生医学领域企业「白衣缘生物」近期获得一笔数千万元人民币融资。本轮融资由上市公司康哲药业独家投资，募集资金将主要用于新品研发、 市场开拓及产线升级。穆棉资本担任长期战略首席财务顾问，协助白衣缘与康哲药业达成股权及产品战略全面合作。 前者主要应用于口腔种植牙治疗的引导骨再生术（GBR）中，其相对持久的屏障作用和诱导再生功能可以为骨再生提供理想的微环境，从而减少术后并发 症的发生；后者则针对神经外科领域，适用于硬脑膜修复和重建，降低术后感染风险。白衣缘生物方面提供的临床数据显示，对比同类进口产品，在相同周 期内，百建固®可吸收生物膜在GBR手术完成后骨增量流失率约为3-5%，而进口产品约为10%左右。 据悉，两款产品均已进入商业化阶段，并在全国24省完成挂网。在2024年首个完整销售年份，实现超千万元级收入。 白衣缘生物成立于2011年，专注于研发和生产以细胞外基质（ECM）为代表的组织修复、创面愈合及再生医疗美容等新型生物医用材料产品。公司现已在 上海建设研发中心及GMP产业化基地，并于2019年取得高新技术企业认证。 当前，公司主要以猪小肠粘膜下层细胞外基质（SIS-ECM）动物源性的 ...

文｜胡香赟 编辑｜海若镜 40多年前，当传奇巨星迈克尔·杰克逊踩着太空步在舞台上"封神"时，其肤色由黑到白的奇异转变，也让彼时尚不为大众熟知的皮肤病——白癜风，成为社 会关注的焦点。 在中国，白癜风患者数量超1000万人。但由于致病机理复杂，市面上能有效治疗白癜风的药物寥寥无几。直到去年9月，一款专门针对该疾病而开发的药 物"芦可替尼乳膏"，正式在国内递交上市申请。 市场仿佛已经提前嗅到了一个百亿市场的爆发。尽管芦可替尼乳膏尚未获批，但其背后的销售"操盘手"康哲药业（00867.HK），已经决定将持有该药物国 内权益的子公司德镁医药拆分，并在香港独立上市。 4月底，德镁医药递交招股书，市场得以窥见其真容：产品管线几乎囊括了康哲药业这家老牌CSO公司决心发力皮肤健康赛道后，从世界各地搜罗到的优质 品种，其中不乏多款已上市的成熟药物。 凭借这些，过去3年间，德镁医药虽还未实现盈利，但每年都有可观的现金流进账。2024年，公司收入突破6亿元。 脱离母公司支持后，背靠有着"刚性治疗需求"的皮肤病市场，德镁医药能否在港股生物科技版块杀出重围？高度依赖引进的策略，又能否为这个想打造皮肤 药帝国的公司，构建起足够高的产品壁 ...