Group 1 - Kingsray Biotechnology (01548.HK) announced a revised licensing agreement with Nanjing Pengbo, granting a global transferable license for anti-PD-1 domain antibodies and related proprietary technologies to Lixin, enabling development, production, and commercialization of licensed products for all global uses [1] - By June 27, 2025, Nanjing Pengbo and its subsidiary, Zhenjiang Pengbo Biotechnology Co., Ltd., are expected to receive approximately $213.8 million (after tax deductions) under the revised licensing agreement, which includes an upfront payment, milestone payments, and sublicensing revenue related to the licensed anti-PD-1 domain antibodies [1] - The licensed anti-PD-1 domain antibodies are being utilized in the development of Lixin's investigational PD1/VEGF bispecific antibody LM-299, which has received approval for new drug clinical research [1] Group 2 - The licensed anti-PD-1 domain antibodies demonstrate high efficiency and specificity in binding to human and cynomolgus monkey PD1, effectively blocking PD1/PD-L1 integration and inhibiting tumor growth in rodent efficacy models, showing comparable efficacy to Merck's Keytruda [2] - The anti-PD-1 domain antibodies also exhibit ideal CMC (Chemistry, Manufacturing, and Controls) drug-like properties [2]

Investment Rating - The investment rating for Genscript Biotech Corp. is "Buy" with a 12-month price target of HK$27.34, indicating an upside potential of 84.5% from the current price of HK$14.82 [8]. Core Insights - Management highlighted that ProBio revenues are expected to bottom out, driven by the LaNova deal, with a projected revenue of US$95 million in FY24, reflecting a 13% year-over-year decline [5]. - The protein segment is anticipated to become the second growth engine for the life science group, with a significant increase in revenue contribution from 23% in 2023 to nearly 30% [6]. - The company expects a steadily improving bottom line, with share buybacks and dividends under consideration as profitability improves starting from 2025 [6]. Summary by Sections ProBio Performance - ProBio revenues are projected to recover, with management confident that the revenue is bottoming out due to factors such as improved funding for biotech clients and stabilizing pricing in China [5]. - The LaNova/Merck deal is expected to contribute significantly, with US$235 million booked in the first half and an additional US$75 million milestone expected in 2H25 [5]. Life Science Group Growth - The life science group has shown steady growth of 10-20% over the years, with gene synthesis having a total addressable market (TAM) of US$1-2 billion, while customized protein synthesis is expected to have a TAM 10 times larger [6]. - The company is reallocating resources to enhance growth in the protein synthesis sector, which is expected to be a major growth driver in the coming years [6]. Financial Outlook - Excluding the impact from Legend deconsolidation, the adjusted net profit for the ex-Legend businesses is expected to reach US$60 million in FY24, with consistent profitability anticipated starting in 2025 [6]. - Management expects the EBITDA break-even point for ProBio to be achieved when revenues reach US$150-200 million, with Bestzyme remaining at break-even until 2027 [6].

Core Points - The Hong Kong Biotechnology Index (CESHKB) experienced a decline of 3.05%, closing at 7087.18 points with a trading volume of 11.816 billion [1] - Over the past month, the index has increased by 26.57%, by 25.92% over the last three months, and has risen 63.14% year-to-date [1] - The index is compiled by China Securities Index Co., Ltd. under the commission of China Securities Trading Service Co., Ltd. and aims to reflect the overall performance of biotechnology companies listed in Hong Kong [1] Index Composition - The top ten weighted stocks in the index include: - CanSino Biologics (10.86%) - Innovent Biologics (10.22%) - WuXi Biologics (9.54%) - BeiGene (9.36%) - 3SBio (7.95%) - Zai Lab (6.01%) - WuXi AppTec (5.63%) - Kelun-Biotech (5.20%) - Genscript Biotech (4.44%) - Ascentage Pharma-B (3.91%) [1] Market and Industry Overview - The index's holdings are entirely composed of stocks listed on the Hong Kong Stock Exchange, with a 100% representation in the pharmaceutical and healthcare sector [2]

Group 1 - The core stock price of Kingsray Biotechnology (01548.HK) closed at HKD 16.800 on June 10, down 1.06% from the previous trading day, with an intraday high of HKD 17.280, marking a nearly one-year high [1] - On the same day, the net capital flow showed an inflow of HKD 306.183 million and an outflow of HKD 356.299 million, resulting in a net outflow of HKD 50.115 million [1] - Kingsray Biotechnology is a significant global provider of life science research and production services, established in 2002 and listed on the Hong Kong Stock Exchange in 2015, with operations in over 100 countries and regions [1] Group 2 - The company has over 6,900 employees globally and has been cited in more than 103,600 academic journal articles reviewed by international peers [1] - Kingsray holds over 300 authorized patents and more than 900 patent applications, along with numerous trade secrets [1] - The company's mission is to use biotechnology to enhance the health of people and nature, aiming to become the most trusted biotechnology company globally [2]

Core Viewpoint - The current "medication" market rally is distinct from previous ones, with leading gains concentrated in innovative pharmaceutical companies, particularly strong performance in the Hong Kong stock market [1][2] Group 1: Market Performance - On June 9, both Hong Kong and A-share innovative pharmaceutical sectors saw significant gains, with the Hang Seng Innovative Drug ETF rising by 4.08% and the Hong Kong Stock Connect Medical ETF increasing by 4.25% [3] - Notable individual stock performances included 3SBio (01530.HK) reaching a peak of 22.5 HKD, just shy of its historical high, and a 260% increase in its stock price since February [3] - The A-share innovative drug index rose by 31.5% and the Hong Kong innovative drug index surged by 61.54% since April 9, with several stocks doubling in value [4] Group 2: Catalysts for Growth - The surge in innovative drug stocks is attributed to multiple factors, including recent approvals for 11 innovative drugs from eight companies and promising clinical data for major diseases [5] - The upcoming 2025 ASCO annual meeting will feature 73 research studies from China, a 30% increase from the previous year [5] Group 3: Long-term Positive Factors - Many leading companies are approaching breakeven points, with significant revenue growth reported, particularly for Ascentage Pharma (332.31% growth) [7][8] - The overseas licensing deals have seen substantial increases, with a record-breaking deal of 6.05 billion USD for 3SBio's drug rights to Pfizer [9] - The overall licensing-out transactions in the innovative drug sector have surged, with 41 transactions in Q1 2024 alone, totaling 36.93 billion USD [9] Group 4: Policy Support - Recent policy changes are favorable for innovative drug companies, including optimized centralized procurement policies and increased support for innovative drugs in government reports [10] - The 2024 government work report includes 38 new innovative drugs in the medical insurance catalog, the highest ever, with plans for further optimization in 2025 [10] Group 5: Market Outlook - The valuation of the pharmaceutical sector remains relatively safe compared to other growth industries, with a current TTM P/E ratio of 27.1 times [11] - Some analysts suggest that the innovative drug sector is transitioning from following to leading in the global market, indicating a new era for domestic innovation [11] - However, there are concerns about potential short-term volatility due to rapid price increases and profit-taking by investors [11]

Group 1 - The core viewpoint of the articles highlights the strong performance of innovative drug stocks, particularly in the Hong Kong market, with significant gains in related ETFs and a notable increase in capital inflow [1][2] - The Hong Kong Innovative Drug 50 ETF (513780) saw a 5.14% increase in early trading on June 9, with a transaction volume exceeding 336 million yuan, and several component stocks, including King’s Ray Biotechnology, rising over 15% [1] - The innovative drug sector has shown remarkable performance this year, with many related ETFs increasing by over 50%, indicating a robust independent market trend despite broader market fluctuations [1] Group 2 - According to Huafu Securities, the total transaction amount for innovative drug BD is projected to rise from 9.2 billion USD in 2020 to 52.3 billion USD by 2024, with upfront payments increasing from 600 million USD to 4.1 billion USD [1] - The China Securities Index indicates that the top ten component stocks of the Hong Kong Innovative Drug Index account for 71.5% of the total weight, including high-quality A-share companies like Innovent Biologics and BeiGene [2] - The ETF supports T+0 trading, allowing investors to conduct multiple transactions within a trading day, enhancing capital efficiency and liquidity [2]

Core Viewpoint - The Hong Kong stock market opened higher, driven by gains in large technology and pharmaceutical stocks, with significant increases in various individual stocks and a notable rise in the Hong Kong Technology ETF [1] Group 1: Market Performance - The Hong Kong Technology ETF (159747) rose by 2.70%, with a year-to-date increase of over 26% [1] - Notable individual stock performances include King’s Ray Biotechnology up over 15%, MicroPort Medical up over 8%, and Kintor Pharmaceutical, among others, also showing strong gains [1] Group 2: Pharmaceutical Sector Insights - The U.S. is reportedly "buying" Chinese innovative drugs amid tariff concerns, with a significant increase in licensing agreements from multinational pharmaceutical companies recognizing Chinese biotech [1] - According to Stifel's report, approximately 30% of drugs licensed by large pharmaceutical companies in 2023 and 2024 will come from Chinese biotech firms, up from 12% in the previous two years [1] Group 3: Financial Trends in Innovative Drugs - The total value of innovative drug business development (BD) transactions is projected to rise from $9.2 billion in 2020 to $52.3 billion in 2024, with upfront payments increasing from $600 million to $4.1 billion [1] - From early 2025 to the present, the total value of innovative drug overseas transactions has reached $45.5 billion, with upfront payments hitting $2.2 billion, indicating a potential record year [1] Group 4: Technology Sector Outlook - Hong Kong stocks are expected to benefit from the scarcity of leading technology stocks amid the AI industry transformation, with strong growth in capital expenditure and cloud business revenue among leading internet companies [1] - The current valuation levels of Hong Kong technology stocks are considered not high, with strong earnings growth expected in the sector by 2025, suggesting potential improvements in return on equity (ROE) and subsequent valuation increases [1]

截至2025年6月9日 10:02，恒生医疗保健指数(HSHCI)强势上涨2.78%，成分股金斯瑞生物科技(01548)上 涨11.76%，欧康维视生物-B(01477)上涨11.62%，诺诚健华(09969)上涨8.83%，云顶新耀(01952)，东阳 光长江药业(01558)等个股跟涨。恒生医疗ETF(513060)上涨2.59%，最新价报0.55元。流动性方面，恒生 医疗ETF盘中换手8.57%，成交7.34亿元。拉长时间看，截至6月6日，恒生医疗ETF近1周日均成交15.55 亿元，排名可比基金第一。 数据显示，杠杆资金持续布局中。恒生医疗ETF前一交易日融资净买额达3934.36万元，最新融资余额 达3.26亿元。 消息面上，2025年6月20日-23日，第85届美国糖尿病协会科学会议（ADA）将在美国芝加哥召开， ADA会议是全球规模最大的糖尿病会议，根据我们不完全统计，本次大会有众生药业、博瑞医药、甘 李药业、来凯医药等众多中国创新药企业受邀出席，主要涉及GLP-1相关创新药项目的临床数据解读。 截至6月6日，恒生医疗ETF近1年净值上涨49.67%，QDII股票型基金排名15/119，居于前1 ...

港股生物医药股盘中震荡上升，金斯瑞生物(01548.HK)涨超10.5%，诺诚健华(09969.HK)涨超9.5%，泰 格医药(03347.HK)涨超6.5%，君实生物(01877.HK)涨超5.5%，药明生物(02269.HK)涨超4%。 ...

6月9日，港股高开，恒生指数开盘涨0.78%。恒生科技指数涨0.97%，国证港股通创新药指数高开 0.75%。 相关ETF方面，截至发稿，港股创新药ETF（159567）涨1.05%，成交额超2.1亿元，换手率超13%，盘 中交投持续活跃。成分股中，金斯瑞生物科技涨超7%，东阳光长江药业、药明生物、凯莱英、晶泰控 股、诺诚健华等股跟涨。 港股创新药ETF（159567）紧密跟踪港股通创新药指数（987018），该指数反映港股通生物科技产业上 市公司的运行特征。 消息面来看，据中证报，今年以来，创新药板块表现十分亮眼，尤其是港股创新药，在近期市场震荡中 走出了独立行情。在此背景下，港股创新药主题ETF"霸榜"ETF涨幅榜，多只相关ETF今年以来涨幅超 过50%。机构认为，国产创新药在全球市场的竞争力不断提升，国际投资者对我国创新药企业的投资信 心不断增强，国产创新药正实现从"跟跑"到"领跑"的跨越式发展，投资机会值得重视。而港股作为布局 创新药的核心市场，可优先关注具备全球竞争力的前沿领域稀缺标的。 中信建投指出，美国临床肿瘤学会（ASCO）年会是世界上规模最大、学术水平最高、最具权威的临床 肿瘤学会议。近年来 ...