消息面上，11月21日，恒生指数系列季度检讨结果出炉，所有变动将于2025年12月8日起生效。其中， 信达生物将被纳入恒生指数成份股，成份股数目将由88只增加至89只。 信达生物(01801)一度涨近5%，截至发稿，涨3.9%，报90.65港元，成交额1.77亿港元。 值得一提的是，11月20日，信达生物宣布，玛仕度肽注射液(胰高血糖素[GCG]/胰高血糖素样肽-1[GLP- 1]双受体激动剂，研发代号：IBI362)在中国中重度肥胖人群中开展的III期临床研究(GLORY-2)达成主要 终点和所有关键次要终点，信达生物将于近期向监管机构递交玛仕度肽9mg用于成人体重控制的新药上 市申请。 ...

Summary of Key Points from Conference Call Records Industry Overview - The conference call discusses the **innovative drug industry** in China, focusing on the **2026 outlook** and the ongoing **internationalization** of Chinese pharmaceutical companies [1][3][5][8]. Core Insights and Arguments - **Healthcare Negotiations**: Ongoing negotiations in healthcare are emphasizing tumor drugs, with innovative drugs receiving support but at potentially lower price reductions. The average price reduction for drugs is stabilizing around **60%** [2][4]. - **Commercial Insurance Directory**: The establishment of a commercial insurance directory for innovative drugs provides a second payment pathway for high-value drugs, benefiting CAR-T and ADC therapies [1][2]. - **Internationalization Phase 2.0**: Chinese pharmaceutical companies are entering the **2.0 phase** of internationalization, with a **60%** year-on-year increase in business development transactions, totaling **$88.26 billion** [3][5]. - **Focus on Innovative Technologies**: Key areas of focus include **ADC**, **I/O (immunotherapy)**, and **small nucleic acids**. Notable products and data releases are anticipated in these fields [1][6][7]. - **GLP-1 Market Potential**: The GLP-1 market is expected to grow significantly, with major companies like Eli Lilly, Roche, and AstraZeneca set to release critical clinical data in cardiovascular, diabetes, and obesity sectors [1][7]. Additional Important Content - **Collective Procurement Policies**: The latest round of collective procurement has introduced new focus areas such as maintaining clinical stability and ensuring quality, with price reductions stabilizing [4]. - **CRO Industry Recovery**: The CRO industry is experiencing a recovery, with significant growth in biopharmaceutical investments, particularly in the CDMO sector, which is benefiting from strong commercial demand [9][10]. - **Upstream Supply Chain and Equipment**: The domestic upstream supply chain and pharmaceutical equipment sectors are seeing improvements in profitability due to increased localization and technological upgrades [13]. - **Research Reagents Market**: The demand for research reagents is strong, driven by increased funding for research, with domestic brands improving in quality and responsiveness [14]. - **Impact of Global Expansion**: Local companies are leveraging global expansion strategies to alleviate domestic price pressures and enhance their competitive positioning in the international market [15]. This summary encapsulates the key points discussed in the conference call, providing insights into the current state and future outlook of the innovative drug industry in China.

智通财经APP获悉，信达生物(01801)一度涨近5%，截至发稿，涨3.9%，报90.65港元，成交额1.77亿港 元。 消息面上，11月21日，恒生指数系列季度检讨结果出炉，所有变动将于2025年12月8日起生效。其中， 信达生物将被纳入恒生指数成份股，成份股数目将由 88 只增加至 89 只。 值得一提的是，11月20日，信达生物宣布，玛仕度肽注射液（胰高血糖素[GCG] /胰高血糖素样 肽-1[GLP-1] 双受体激动剂，研发代号：IBI362）在中国中重度肥胖人群中开展的III期临床研究 （GLORY-2）达成主要终点和所有关键次要终点，信达生物将于近期向监管机构递交玛仕度肽9mg用于 成人体重控制的新药上市申请。 ...

Group 1: Market Overview - Global stock markets experienced a downward trend last week, with the Hang Seng Index falling below its six-month support level [1] - The relationship between China and Japan is a significant variable for the market, with potential economic uncertainties arising from diplomatic tensions [1] - Positive developments include a dovish speech from a key Federal Reserve official, raising expectations for a rate cut in December [1] Group 2: AI and Technology Developments - Ant Group's AI assistant "Lingguang" quickly rose to the top of the iOS free tools chart, indicating strong market interest in AI applications [2] - NVIDIA is considering exporting advanced H200 chips to China, which could benefit related computing stocks [1] Group 3: Company Performance - Innovent Biologics reported a total revenue of 5.953 billion yuan for the first half of 2025, a year-on-year increase of over 50%, and achieved a net profit of 1.213 billion yuan [3] - Innovent's core product, Tyvyt (sintilimab), showed steady growth, while its dual-target weight loss drug, Ma Shidu, is a key driver of revenue growth [3][4] Group 4: Industry Insights - The number of breeding sows in China has fallen below 40 million, with a 1% month-on-month decrease in October, indicating ongoing challenges in the livestock sector [5] - The current cycle of pig prices has reached a new low, with some regions seeing prices drop below 10 yuan per kilogram, leading to deepening industry losses [6] - The market anticipates a prolonged period of industry losses, with expectations of 16 months of low profitability in the pig farming sector [6] Group 5: Stock Market Data - The Hang Seng Index is positioned at 25,220 points, with a potential for rebound as the market shows bullish sentiment [7] - The total number of open contracts for the Hang Seng Index futures is 117,319, with a net open interest of 46,187 contracts [7]

Core Insights - The Chinese innovative pharmaceutical industry is experiencing significant transformation, marked by substantial licensing deals and a shift towards global leadership in quality over quantity [2][3][6] - The total amount of License-out upfront payments has surpassed that of the primary market for the first time, indicating a shift in funding dynamics within the industry [13][31] - Despite the growth, there are underlying challenges such as a lack of clinical development capabilities and the undervaluation of early-stage pipelines, leading to a phenomenon of "selling seedlings at a discount" [16][20][24] Group 1: Industry Growth and Transactions - In 2025, the total amount of License-out transactions in China is expected to exceed that of the U.S. by 3.2 times, reflecting a rapid acceleration in drug approvals and a surge in innovative drug development [3][6] - The total amount of BD transactions in the Chinese pharmaceutical sector has surpassed $100 billion, with a significant increase in both the number of deals and transaction values [8][11] - Major transactions include a $125 billion collaboration between Hengrui Medicine and GSK, a $114 billion partnership between Innovent Biologics and Takeda, and a $61.5 billion deal between 3SBio and Pfizer, positioning these deals among the largest in global innovative drug licensing [9][10] Group 2: Challenges and Market Dynamics - The industry faces a stark divide, with leading companies achieving profitability while smaller biotech firms struggle with funding and development risks, leading to a survival of the fittest scenario [28][31] - The proportion of License-out transactions for late-stage clinical projects has only slightly increased, indicating ongoing challenges in clinical development capabilities [16][20] - The gap in clinical trial design and execution between Chinese companies and multinational corporations (MNCs) remains significant, impacting the ability of domestic firms to retain control over late-stage assets [19][21][24] Group 3: Financial Performance and Market Reactions - Innovative drug companies in China reported a revenue increase of 22.1% year-on-year in the first three quarters of 2025, with a notable reduction in net losses [28][31] - The market is becoming more discerning, focusing on clinical value and commercialization potential rather than short-term trading excitement, leading to a more cautious approach to BD transactions [32][33] - The capital market's response to BD transactions has been mixed, with significant deals not necessarily translating into sustained stock price increases, highlighting the need for long-term value realization [32][33]

Core Viewpoint - Innovent Biologics has been successfully included as a constituent stock of the Hang Seng Index (HSI), marking a significant milestone in its development and recognition in the international capital market [1][4][5]. Company Overview - Innovent Biologics is a leading biopharmaceutical company founded in 2011, focusing on developing high-quality medicines for major diseases such as cancer, cardiovascular and metabolic disorders, autoimmune diseases, and ophthalmology [3][6]. - The company has launched 16 products and has a diversified drug pipeline that includes monoclonal antibodies, bispecific antibodies, antibody-drug conjugates (ADCs), and small-molecule drugs [3][6]. Market Recognition - The inclusion in the HSI and other indices like the Hang Seng China Enterprises Index (HSCEI) and the Hang Seng ESG Enhanced Index highlights the strong recognition of Innovent's value as an innovative biopharmaceutical company [1][4]. - This milestone reflects the Hong Kong stock market's preference for high-quality Chinese innovative biopharmaceutical enterprises [4]. Strategic Implications - Innovent's inclusion in the HSI is expected to broaden its investor base, enhance international visibility, and provide solid capital support for ongoing investments in innovative R&D and global business expansion [5]. - The company aims to continue its mission of developing affordable, high-quality biopharmaceuticals for patients worldwide, thereby creating long-term value for investors [5][6].

Investment Rating - The report maintains an investment rating of "Outperform" with a rating of A [7] Core Insights - The report highlights significant advancements in small nucleic acid drugs for the treatment of hepatitis B, particularly the promising data from the drug AHB-137 presented at the AASLD 2025 conference, indicating its potential as the best small nucleic acid drug for hepatitis B [3][22] Summary by Sections Weekly New Drug Market Review - From November 17 to November 23, 2025, the top five gainers in the new drug sector were: - LaiKai Pharmaceutical (+13.34%) - Beihai Kangcheng (+2.67%) - Jiahe Biotech (+2.19%) - Yongtai Biotech (+1.94%) - Youzhi You (+1.14%) - The top five losers were: - WuXi AppTec (-15.75%) - Adi Pharma (-14.56%) - Mengke Pharma (-14.34%) - Yiming Oncology (-13.40%) - Kain Technology (-13.04%) [1][16] Weekly Focused Investment Targets - The report suggests focusing on several promising targets due to upcoming catalysts, including: 1. Products with high certainty for overseas expansion certified by MNCs: Sanofi, Federated Pharmaceuticals, and Kelun-Botai 2. Products with overseas data catalysts: Betta Pharmaceuticals, Hutchison China MediTech, and Yiming Biotech 3. Potential blockbuster products for overseas licensing by MNCs: Fuhong Hanlin, CSPC Pharmaceutical Group, and Yifang Biotech 4. New innovative drug technology breakthroughs: small nucleic acids, in vivo CAR-T, fat reduction and muscle gain, autoimmune CAR-T/bispecific antibodies, and gene therapy [2][20] Weekly New Drug Industry Analysis - The report emphasizes the breakthrough data for small nucleic acid drugs in treating hepatitis B, particularly the two-phase follow-up data for AHB-137, which shows a high potential for becoming the leading small nucleic acid drug in this field [3][22] Weekly New Drug Approval & Acceptance Status - No new drug or new indication approvals were reported this week, but six new drug or new indication applications were accepted [4][24] Weekly New Drug Clinical Application Approval & Acceptance Status - This week, 42 new drug clinical applications were approved, and 44 new drug clinical applications were accepted [5][26] Domestic Market Key Events TOP3 - Key events included: 1. Zean Biopharma's strategic collaboration with GSK to develop up to four "first-in-class" candidates in oncology [11] 2. Innovent Biologics announcing successful Phase III clinical study results for a drug in moderate to severe obesity [11] 3. Fuhong Hanlin's FDA approval for a biosimilar product [11] Overseas Market Key Events TOP3 - Key events included: 1. Merck's presentation of key Phase III trial results at the AHA Scientific Sessions [12] 2. Johnson & Johnson's acquisition of Halda Therapeutics for $3.05 billion [12] 3. The EMA's recommendation for the approval of a gene therapy product [12]

Group 1 - The Hang Seng Index Company announced the quarterly index review results for the Hang Seng ESG Enhanced Index, Hang Seng ESG Enhanced Select Index, and Hang Seng National Index ESG Enhanced Index, effective from December 8, 2025 [1] - The number of constituents in the Hang Seng ESG Enhanced Index will increase from 76 to 77, with the inclusion of Innovent Biologics (01801) and Zijin Mining (02899), while Cheung Kong (00001) will be removed [1][3] - The Hang Seng ESG Enhanced Select Index will also see the addition of Innovent Biologics (01801) and Zijin Mining (02899), increasing its constituents from 74 to 75, with Cheung Kong (00001) being excluded [3][4] Group 2 - The Hang Seng National Index ESG Enhanced Index will include China National Offshore Oil Corporation (00883), Innovent Biologics (01801), and Yum China (09987), maintaining a total of 45 constituents [5] - The inclusion of these companies reflects a focus on ESG criteria within the indices [1][5]

Group 1 - The Hang Seng Index Company and Hong Kong Exchanges and Clearing Limited announced the quarterly index review results for the Hang Seng Stock Connect China Enterprises Index as of September 30, 2025 [1] - The number of constituent stocks remains at 80, with four new additions: China Hongqiao Group (01378), Innovent Biologics (01801), Yum China (09987), and North Huachuang (002371) [1] - Four stocks were removed from the index: New Energy (02688), Huaneng Lancang River Hydropower (600025), and Inner Mongolia Yili Industrial Group (600887) [1] Group 2 - The changes will take effect on December 8, 2025 [1]

Group 1 - The Hang Seng Index Company announced the quarterly index review results for the Hang Seng ESG Enhanced Index, Hang Seng ESG Enhanced Select Index, and Hang Seng China Enterprises ESG Enhanced Index, effective from December 8, 2025 [1] - The number of constituents in the Hang Seng ESG Enhanced Index will increase from 76 to 77, with the inclusion of Innovent Biologics (01801) and Zijin Mining Group (02899), while Cheung Kong (00001) will be removed [1][3] - The Hang Seng ESG Enhanced Select Index will also see the addition of Innovent Biologics (01801) and Zijin Mining Group (02899), increasing its constituents from 74 to 75, with Cheung Kong (00001) being removed [1][3] Group 2 - The Hang Seng China Enterprises ESG Enhanced Index will include China National Offshore Oil Corporation (00883), Innovent Biologics (01801), and Yum China Holdings (09987), maintaining a total of 45 constituents [1][5] - The inclusion of these companies reflects a focus on enhancing the ESG profile of the indices [1]