股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年7月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 微創腦科學有限公司 呈交日期: 2025年8月5日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 02172 | 說明 | | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 2,500,000,000 | USD | | 0.00002 | USD | | 50,000 | | 增加 / 減少 (-) | | | | | | | USD | | | | 本月底結存 | | | 2,500,000,000 | USD | | 0.00002 | USD | | 50,000 | 本月底法定/註冊股本總額： ...

消息面上，据报道，苹果公司正在与脑机接口公司合作开发"使用大脑信号操纵苹果设备"的技术标准。 周一公布的一段展示视频，首次演示了这项技术的进展。演示视频显示，一位渐冻症患者通过脑机设备 成功实现用意念控制iPad操作，并展现应用脑机接口使用"快捷指令"等操作。 另据央视新闻报道，为支持药品和医疗器械创新发展，国家医保局制定新上市药品首发价格机制，新增 了100多项与医疗新技术相关的价格项目。其中，神经系统类立项指南统一设立"脑机接口置入费""脑机 接口适配费"等价格项目，脑机接口技术成熟获批进入临床后，可快速进入临床应用并收费。湘财证券 认为，作为医疗领域前沿技术，脑机接口的应用将在患者检测、疾病康复、技能替代等方向逐步落地。 智通财经APP获悉，脑机概念股走高，截至发稿，南京熊猫电子股份(00553)涨4.93%，报5.11港元；微 创脑科学(02172)涨3.72%，报14.22港元。 ...

脑机概念股走高，截至发稿，南京熊猫（600775）电子股份(00553)涨4.93%，报5.11港元；微创脑科学 (02172)涨3.72%，报14.22港元。 另据央视新闻报道，为支持药品和医疗器械创新发展，国家医保局制定新上市药品首发价格机制，新增 了100多项与医疗新技术相关的价格项目。其中，神经系统类立项指南统一设立"脑机接口置入费""脑机 接口适配费"等价格项目，脑机接口技术成熟获批进入临床后，可快速进入临床应用并收费。湘财证券 认为，作为医疗领域前沿技术，脑机接口的应用将在患者检测、疾病康复、技能替代等方向逐步落地。 消息面上，据报道，苹果公司正在与脑机接口公司合作开发"使用大脑信号操纵苹果设备"的技术标准。 周一公布的一段展示视频，首次演示了这项技术的进展。演示视频显示，一位渐冻症患者通过脑机设备 成功实现用意念控制iPad操作，并展现应用脑机接口使用"快捷指令"等操作。 ...

Core Insights - The National Healthcare Security Administration (NHSA) has established a pricing mechanism for newly launched drugs and medical devices, specifically supporting the clinical application and pricing of brain-computer interface (BCI) technologies [1][2] - The introduction of standardized pricing for BCI services is expected to facilitate the adoption of these technologies in clinical settings, indicating that BCI technology is nearing clinical usability [3] Industry Developments - Over 100 new pricing items related to medical technologies have been added, including specific fees for invasive and non-invasive BCI procedures [1] - Provinces such as Jiangsu, Zhejiang, and Hubei have published their BCI service pricing, with fees for non-invasive BCI adaptation set at approximately 966 RMB per session, invasive BCI implantation at around 6,600 RMB, and extraction fees ranging from 3,139 to 3,200 RMB [2] - The NHSA's guidelines emphasize the integration of artificial intelligence in rehabilitation, setting a target for AI-assisted rehabilitation services to be implemented nationwide by 2025, which aligns with the development of BCI technologies [2] Market Potential - Analysts predict significant growth in the global BCI medical application market, estimating it could reach $40 billion by 2030 and $145 billion by 2040 [3] - The BCI industry in China is transitioning from laboratory research to commercial application, indicating a high growth potential and the need for long-term investment strategies focused on technology stability and production capabilities [3] Related Companies - MicroPort NeuroScience (02172) has achieved a significant market share in China's neuro-interventional medical device sector, ranking fourth based on 2023 sales revenue [4] - HeartVue Medical-B (06609) successfully completed animal trials for China's first interventional BCI, with expectations of turning a profit by mid-2025 [4] - Nanjing Panda Electronics (00553) is actively developing a multimodal human-computer interaction system based on BCI technology as part of a key provincial research project [4]

New Stock Listings - Dingjia Precision listed on July 31, 2025, with an issue price of 11.16[1] - Shenkai Co., Ltd. has a tender offer period from July 29 to August 27, 2025[1] - ST Kelly's tender offer period is from July 17 to August 15, 2025[1] Market Alerts - Xizang Tourism reported severe abnormal fluctuations on July 31, 2025[1] - A total of 30 companies have announced abnormal fluctuations in their stock prices recently[2] Financial Data - The report includes links to detailed announcements for each stock, providing transparency and access to further information[1] - The document lists various companies with their respective stock codes and announcement dates, indicating active market engagement[1]

Group 1 - The Hang Seng Biotechnology Index (HSHKBIO) has seen a strong increase of 1.88%, with notable gains from constituent stocks such as MicroPort Medical (00853) up 8.63%, and Stone Pharmaceutical Group (01093) up 7.40% [1] - The Hang Seng Biotechnology ETF (513280) has risen by 3.00%, marking its third consecutive increase, with a latest price of 1.34 HKD and a weekly cumulative increase of 8.89% [1] - The trading volume for the Hang Seng Biotechnology ETF was active, with a turnover of 34.45% and a transaction value of 161 million HKD, indicating strong market participation [1] Group 2 - The Hang Seng Biotechnology ETF has experienced a significant increase in shares, growing by 2 million shares over the past week, ranking in the top third among comparable funds [2] - The ETF has seen continuous net inflows over the last three days, with a peak single-day net inflow of 3.83 million HKD, totaling 8.73 million HKD in net inflows [2] Group 3 - Over the past year, the net value of the Hang Seng Biotechnology ETF has increased by 130.59%, ranking 3rd out of 122 QDII equity funds, placing it in the top 2.46% [3] - WuXi Biologics announced the construction of a modular biomanufacturing facility in Singapore, which is part of a strategic collaboration with Pharmadule Morimatsu [3] - The latest report from Zhongyin Securities suggests focusing on three main lines: 1) sectors with stable growth such as medical devices and pharmaceuticals, 2) the CXO sector and medical equipment expected to see a turnaround, and 3) innovative fields related to national medical insurance negotiations [3] Group 4 - The Hang Seng Biotechnology ETF (513280) is highlighted as the only ETF tracking the Hang Seng Biotechnology Index to have received net inflows this year, with the lowest management fee of 0.15% per year among Hong Kong pharmaceutical ETFs [4]

Group 1 - The Hang Seng Index fell by 0.43%, down 109 points, while the Hang Seng Tech Index dropped by 1.57%. The morning trading volume in Hong Kong stocks was HKD 148.2 billion [1] - The Hang Seng Biotechnology Index rose by 1.77%, with notable gains from MicroPort Medical (00853) up 9.7%, MicroPort NeuroScience (02172) up over 8%, and Innovent Biologics (01801) up 4.85% [1] - WuXi AppTec (02359) increased by 2.24%, WuXi Biologics (02126) rose by 6.5%, and WuXi Biologics (02269) saw an increase of over 3% after announcing the construction of a modular biomanufacturing facility in Singapore [1] Group 2 - Mindray Medical-B (02160) surged by 8.8% as the company is expected to acquire and restructure the MicroPort cardiac rhythm management business, enhancing its product pipeline [2] - Insurance stocks continued to rise, with New China Life Insurance (01336) up 4.47% and China Life Insurance (02628) increasing by 1.5% [3] Group 3 - 361 Degrees (01361) rose by 6.5%, with the company showing steady revenue growth, and institutions expect strong revenue growth for the full year [4] - Dreamscape (01119) increased by 3.5% after signing a capitalization agreement with Playrix, bringing in a long-term strategic partner [5] Group 4 - GAC Group-B (01167) surged over 20% as a concerted action party increased its holdings by over 60,000 shares, raising its stake to 25.36% [6] - Semiconductor stocks collectively declined, with Hua Hong Semiconductor (01347) down 5.3%, SMIC (00981) down 3.9%, and ASMPT (00522) down 2.74% [6]

Market Overview - The Hang Seng Index fell by 0.43%, down 109 points, while the Hang Seng Tech Index decreased by 1.57%. The early trading volume in Hong Kong stocks was HKD 148.2 billion [1]. Biotechnology Sector - The Hang Seng Biotechnology Index rose by 1.77%. Notable gainers included MicroPort Medical (00853) up 9.7%, MicroPort NeuroTech (02172) up over 8%, and Innovent Biologics (01801) up 4.85% [1]. - WuXi AppTec (02359) increased by 2.24%, WuXi Biologics (02126) rose by 6.5%, and WuXi Biologics (02269) saw an increase of over 3% following the announcement of the construction of a modular biologics manufacturing facility in Singapore [1]. - Fosun Pharma (02196) gained over 5% after acquiring exclusive rights for the innovative Alzheimer's drug AR1001 [1]. - HeartCare Medical-B (02160) surged by 8.8% as the company is expected to acquire and restructure MicroPort's cardiac management business, enhancing its product pipeline [1]. Insurance Sector - Insurance stocks continued their upward trend, with New China Life Insurance (01336) rising by 4.47% to reach a new high, and China Life Insurance (02628) increasing by 1.5% [2]. Consumer Sector - 361 Degrees (01361) rose by 6.5%, with institutions expecting strong revenue growth for the full year [3]. - Dreamland (01119) increased by 3.5% after signing a capitalization agreement with Playrix, bringing in a strategic shareholder from the upstream development sector [4]. Semiconductor Sector - Gako Technology-B (01167) surged over 20% as a concerted action party increased its stake by over 60,000 shares, raising its total holding to 25.36% [5]. - Semiconductor stocks collectively declined, with Huahong Semiconductor (01347) down 5.3%, SMIC (00981) down 3.9%, and ASMPT (00522) down 2.74%. Nvidia's order for 300,000 H20 chips and Morgan Stanley's comments on the potential impact of the 520 unlock on local industry sentiment contributed to this decline [5].

New Stock Issuance - The new stock issuance for 酉立智能 (stock code: 920007) is priced at 23.99[1] - The offer period for 申科股份 (stock code: 002633) is from July 29, 2025, to August 27, 2025[1] - The offer period for ST凯利 (stock code: 300326) is from July 17, 2025, to August 15, 2025[1] Abnormal Fluctuations - The report highlights severe abnormal fluctuations for multiple stocks, including 广生堂 (stock code: 300436) and 华银电力 (stock code: 600744)[1] - The announcement links for stocks experiencing abnormal fluctuations are provided for further details[1] - The report includes a list of stocks with significant trading activity and their respective announcement dates[1] General Market Insights - The report provides a comprehensive overview of new stock offerings and market activities on July 29, 2025[1] - It emphasizes the importance of monitoring stock performance and market trends for informed investment decisions[1]

Market Overview - The US stock market was closed on July 4th for Independence Day [1] Hong Kong Stock Market Highlights - Yum China (09987) rose over 3% after announcing the establishment of an innovation fund to convert operational needs into practical applications [2] - H&H International Holdings (01112) fell over 7%, expecting a 45% to 65% decline in net profit for the first half of the year [2] - China Rare Earth Holdings (03788) surged nearly 9% as it plans to spin off its gold business for independent listing on the Hong Kong Stock Exchange, potentially seeking financing before the spin-off [2] - Health Road (02587) jumped over 18% as its controlling shareholder voluntarily extended the lock-up period, focusing on digital health services [2] - Smoore International (06969) increased over 5% with the launch of Glo Hilo in Japan, maintaining high profit margins [2] - Tencent Music (01698) rose nearly 3% as institutions noted that recent acquisition plans would enhance overall content supply [2] - Jihong Co., Ltd. (02603) surged over 7%, with a projected net profit increase of over 55% year-on-year for the first half [2] - Solar stocks collectively declined, with Xinyi Solar (00968) down 4.86%, Fuyao Glass (06865) down 3.88%, New Energy (01799) down 3.19%, and Xinyi Glass (00868) down 2.64% [2] Other Notable Movements - Kuaishou-W (01024) rose over 3% as it plans to launch a live streaming initiative across multiple cities to create a collaborative ecosystem [3] - Gold stocks faced pressure, with Shandong Gold (01787) down 5.09%, China Gold International (02099) down 3.44%, Lingbao Gold (03330) down 2.68%, and Chifeng Jilong Gold (06693) down 2.33% [3] - China Shipbuilding Defense (00317) increased over 3% after the approval of a merger and acquisition restructuring plan, optimizing resources in the shipbuilding industry [3] - Medical device stocks saw a broad increase, with Spring Medical (01858) up 6.36%, Yongsheng Medical (01612) up 7.27%, Xinwei Medical-B (06609) up 3.55%, and Microneuroscience (02172) up 1.12% [3] - Some stablecoin concept stocks rose, with Victory Securities (08540) up 6.9%, Guotai Junan International (01788) up 5.15%, Yika (09923) up 2.59%, and China Everbright Holdings (00165) up 1.96% [3] - SF Express City (09699) rose nearly 7% amid intensified competition in the food delivery sector, with expectations of increased order volume [3] - HSSP International (03626) fell over 20% after being named by the Hong Kong Securities and Futures Commission for high stock concentration [3] Strategic Partnerships and New Listings - Shengye (06069) opened nearly 15% higher after forming a strategic partnership with Stand Robot to enhance its robotics industry chain [4] - Beverage stocks opened high, with Cha Bai Dao (02555) up 15%, Nayuki's Tea (02150) up 9.87%, Gu Ming (01364) up 5.77%, Hu Shang Ayi (02589) up 2.99%, and Mixue Group (02097) up 2.92% [4] - FWD Group (01828) had a flat opening on its first day of listing, being a life insurance company under Li Zeqiang's control [4]