Market Overview - On September 12, the Hang Seng Index rose by 1.16%, closing at 26,388.16 points, with a net inflow of HKD 7.331 billion through the southbound trading channel [2] - The total trading volume for the southbound trading on that day was HKD 157.992 billion, with a net buying amount of HKD 7.331 billion [2] Southbound Trading Details - The Shanghai Stock Exchange's southbound trading had a total transaction amount of HKD 97.259 billion, with a net selling of HKD 1.487 billion; while the Shenzhen Stock Exchange's southbound trading had a transaction amount of HKD 60.733 billion, with a net buying of HKD 8.818 billion [2] - The most actively traded stock in the Shanghai southbound trading was Alibaba-W, with a transaction amount of HKD 87.744 billion and a net buying of HKD 2.076 billion, closing with a price increase of 5.44% [2] - In the Shenzhen southbound trading, Alibaba-W also led with a transaction amount of HKD 63.889 billion and a net buying of HKD 2.304 billion, maintaining the same closing price increase of 5.44% [3] Active Stocks Summary - The top ten actively traded stocks in the southbound trading included Alibaba-W, Meituan-W, and SMIC, with transaction amounts of HKD 87.744 billion, HKD 50.99 billion, and HKD 37.02 billion respectively [2] - Meituan-W had the highest net selling amount of HKD 1.635 billion, closing flat [2] - Other notable stocks included Tencent Holdings and Xiaomi Group, with transaction amounts of HKD 32.17 billion and HKD 23.17 billion respectively, and Tencent saw a net buying of HKD 0.744 billion [3] Additional Stock Performance - The stock performance of various companies showed that 8 out of the top ten stocks had net buying, with Alibaba-W leading at HKD 2.304 billion [3] - The stock of Sanofi had the highest net selling amount of HKD 0.295 billion, while its closing price increased by 1.81% [4]

9月12日，药捷安康-B（02617.HK）股价盘中一度大涨131.26%，尽管尾盘有所回落，但截至收盘仍报 192.5港元/股，日内涨幅达77.09%，推动市值突破700亿港元，这家6月23日刚登陆港交所的生物制药企 业，发行价仅13.15港元，若以今日最高价251.4港元/股计算，药捷安康上市两个多月股价最高涨超18 倍。 药捷安康的市值飙升或与其核心产品替恩戈替尼（Tinengotinib，TT-00420）密切相关。9月10日，药捷 安康发布公告称，公司核心产品替恩戈替尼联合氟维司群治疗经治失败的激素受体阳性（HR+）且人表 皮生长因子受体2阴性或低表达（HER2-）的复发或转移性乳腺癌II期临床试验，已获了中国国家药品监 督管理局的临床默示许可。 财务数据显示，药捷安康在2022年、2023年、2024年分别亏损2.52亿元、3.43亿元、2.75亿元，三年累 计亏损达8.7亿元。2025年上半年仍延续亏损态势，营收仅为98.6万元，同比大跌90.4%，税前亏损1.23 亿元。 截至2025年6月30日，公司的现金及现金等价物仅有4.49亿元。而上半年的研发成本为0.98亿元，管理成 本为2747万 ...

Group 1 - On September 12, 2025, Alibaba-W (09988), Meituan-W (03690), and SMIC (00981) were the top three companies by trading volume in the Southbound Stock Connect, with transaction amounts of 87.74 billion, 50.99 billion, and 37.02 billion respectively [1] - In the Southbound Stock Connect for Shenzhen-Hong Kong, Alibaba-W (09988), Tencent Holdings (00700), and Xiaomi Group-W (01810) led the trading volume, with transaction amounts of 63.89 billion, 32.17 billion, and 23.17 billion respectively [1] Group 2 - In the Southbound Stock Connect (Hong Kong), the top active trading companies included: - Alibaba-W (09988) with a net buy of +20.76 billion - Tencent Holdings (00700) with a net buy of +1.85 billion - Meituan-W (03690) with a net sell of -16.35 billion [2] - In the Southbound Stock Connect (Shenzhen), the top active trading companies included: - Alibaba-W (09988) with a net buy of +23.04 billion - Tencent Holdings (00700) with a net buy of +7.44 billion - Meituan-W (03690) with a net sell of -46.59 million [2]

Core Insights - The Hong Kong stock market saw a net inflow of 73.31 billion HKD from northbound trading on September 12, with the Shanghai Stock Connect recording a net outflow of 14.87 billion HKD and the Shenzhen Stock Connect a net inflow of 88.18 billion HKD [1] Group 1: Stock Performance - Alibaba (09988) had a net inflow of 54.25 billion HKD, with total trading volume of 87.74 billion HKD, resulting in a net inflow of 20.76 billion HKD [2] - Tencent (00700) recorded a net inflow of 16.78 billion HKD, with a total trading volume of 31.72 billion HKD, leading to a net inflow of 1.85 billion HKD [2] - Pop Mart (09992) saw a net inflow of 8.70 billion HKD, with a total trading volume of 15.81 billion HKD, resulting in a net inflow of 1.60 billion HKD [2] Group 2: Notable Stocks - Alibaba (09988) received a net inflow of 43.8 billion HKD this week, totaling approximately 220 billion HKD in net inflows, driven by news of its internal chip development for AI models [4] - Tencent (00700) gained a net inflow of 9.29 billion HKD, with market analysts noting that its gaming and advertising businesses are entering a mature phase, making future growth challenging [5] - Pop Mart (09992) attracted a net inflow of 6.42 billion HKD, with positive outlooks from analysts regarding upcoming product launches and seasonal sales [5] Group 3: Other Stocks - Semiconductor stocks like Hua Hong Semiconductor (01347) and SMIC (00981) received net inflows of 4.01 billion HKD and 830.3 million HKD respectively, amid reports of domestic chip development [6] - Kangfang Biologics (09926) had a net inflow of 2.25 billion HKD, supported by positive clinical data announcements [7] - Yaojie Ankang-B (02617) saw a net inflow of 1.8 billion HKD after being added to the Hong Kong Stock Connect list [7]

Market Overview - The Hong Kong stock market opened higher and slightly retreated, with the Hang Seng Index closing at 26,388.16 points, up 301.84 points, a rise of 1.16% [1] - The Hang Seng Tech Index closed at 5,989.27 points, increasing by 100.50 points, a rise of 1.71% [1] Focus Companies - Drug developer Jiajie Ankang-B (02617.HK) saw its stock price rise over 130% during the day, ultimately closing with a gain of 77% [3] - Jiajie Ankang is a clinical-stage biopharmaceutical company focused on developing small molecule therapies for cancer, inflammation, and cardiovascular metabolic diseases [5] - The company was recently added to the Hong Kong Stock Connect list, allowing southbound funds to purchase its shares [5] - Other newly added stocks to the Hong Kong Stock Connect include Brainhole Aurora-B (06681.HK), which closed up 32%, and Boleton (01333.HK), which rose over 21% [5] Capital Flow - Southbound funds continued to show strong buying momentum, with a net purchase amount exceeding 7.3 billion HKD by the end of the trading day [9] Analyst Insights - Analysts noted that the recent influx of southbound funds has driven up the prices of newly added stocks in the Hong Kong Stock Connect [7] - The Hong Kong market is characterized by T+0 trading, which can lead to significant price volatility [7] - Major tech stocks maintained strong performance, with Baidu Group-SW (09888.HK) rising over 8%, Alibaba-W (09988.HK) up over 5%, and Tencent Holdings (00700.HK) closing at 643.5 HKD, just 10% away from its historical high [7] Future Market Outlook - CICC highlighted that the Hong Kong market's structure is more significant than the index itself, with a focus on sector rotation [11] - Citigroup raised its year-end target for the Hang Seng Index by 7% to 26,800 points, with further increases expected in 2024 [11] - GF Securities noted that the Hong Kong market tends to perform well in the 12 months following the Federal Reserve's first rate cut, suggesting a favorable environment for A/H assets [11]

Market Overview - The Hong Kong stock market opened higher and slightly retreated, with the Hang Seng Index closing at 26,388.16 points, up 301.84 points, a rise of 1.16% [1] - The Hang Seng Tech Index closed at 5,989.27 points, increasing by 100.50 points, a rise of 1.71% [1] Company Highlights - A notable company,药捷安康 (Jiangsu Hengrui Medicine Co., Ltd.), is focused on discovering and developing innovative small molecule therapies for tumors, inflammation, and cardiovascular metabolic diseases. It was recently added to the Hong Kong Stock Connect list, allowing southbound funds to purchase its shares [3] -药捷安康-B (02617.HK) saw its stock price rise over 130% during the day, ultimately closing with a gain of 77% [4] - Other newly added stocks in the Hong Kong Stock Connect include 博雷顿 (Boreton, 01333.HK), which closed up over 21%, and 曹操出行 (Caocao Chuxing, 02643.HK), which peaked at a 14% increase during the day [5] Market Trends - Analysts noted a strong influx of southbound funds into the Hong Kong stock market, leading to significant price increases for newly added stocks. However, the T+0 trading system in Hong Kong presents risks of high volatility [7] - The technology sector in Hong Kong maintained a strong performance, with notable increases in stock prices for major companies such as 百度集团 (Baidu, 09888.HK) up over 8%, 阿里巴巴 (Alibaba, 09988.HK) up over 5%, and 腾讯控股 (Tencent, 00700.HK) up over 2%, closing at 643.5 HKD, nearing its historical high [7] Future Outlook - 中金公司 (CICC) highlighted that the Hong Kong market's key characteristic this year is structural performance over index performance, with a focus on sectors driven by profit trends [10] - 花旗 (Citi) raised its year-end target for the Hang Seng Index by 7% to 26,800 points, with expectations for further increases to 27,500 points and 28,800 points in the first half and by year-end next year, respectively [10] - 广发证券 (Guotai Junan) analyzed past performance during the Federal Reserve's rate-cutting cycles, indicating that the Hong Kong market tends to rise in the 12 months following the first rate cut, suggesting a favorable environment for A/H assets [10]

Summary of Key Points Core Viewpoint - As of September 12, 197 stocks reached their 52-week highs, indicating a strong performance in the market, with notable leaders in various sectors [1]. Group 1: Top Performers - The top three stocks that achieved the highest increase in their 52-week high rates are: - Yaojie Ankang-B (02617) with a high rate of 114.69%, closing at 192.500 and reaching a peak of 251.400 [1] - Jinxing Group (00794) with a high rate of 50.00%, closing at 0.210 and peaking at 0.300 [1] - Kaizhile International (02122) with a high rate of 29.51%, closing at 0.360 and peaking at 0.395 [1] Group 2: Additional Notable Stocks - Other notable stocks that reached significant highs include: - Maple Leaf Education (01317) with a 25.00% increase, closing at 0.495 and peaking at 0.550 [1] - Brainstorm Aurora-B (06681) with a 21.25% increase, closing at 7.500 and peaking at 9.470 [1] - Yuhua Education (06169) with a 20.97% increase, closing at 0.730 and peaking at 0.750 [1] Group 3: Market Trends - The overall trend shows a robust market performance with a significant number of stocks hitting new highs, reflecting positive investor sentiment and potential growth opportunities across various sectors [1].

Core Viewpoint - The stock of药捷安康-B (02617) experienced significant market interest, surging nearly 130% at one point during the day, ultimately closing up 77.09% at 192.5 HKD, with a total trading volume of 2.613 billion HKD and a turnover rate of approximately 4.74% [1] Company Overview -药捷安康 is a clinical-stage biopharmaceutical company focused on discovering and developing small molecule innovative therapies for oncology, inflammation, and cardiovascular metabolic diseases [1] - As of June 30, 2025, the company has six clinical-stage candidate products and several preclinical candidates in its pipeline [1] Key Product Highlights - The core product,替恩戈替尼 (TT-00420), has garnered significant market attention due to multiple recent positive developments [1] - On September 10,替恩戈替尼 received clinical implied approval from the National Medical Products Administration of China for a Phase II clinical trial in treating hormone receptor-positive (HR+) and HER2-negative or low-expressing recurrent or metastatic breast cancer [1] - The product is also involved in an open-label, multicenter Phase II clinical study for advanced hepatocellular carcinoma (HCC) in combination with 康方生物's 开坦尼/依达方, with the first patient recently dosed [1] - Additionally,替恩戈替尼 has been granted Fast Track designation by the U.S. Food and Drug Administration (FDA) for the treatment of metastatic castration-resistant prostate cancer [1]

值得注意的是，替恩戈替尼近期迎多重利好。替恩戈替尼联合氟维司群治疗经治失败的激素受体阳性 （HR+）且人表皮生长因子受体2阴性或低表达（HER2-）的复发或转移性乳腺癌II期临床试验，已于9 月10日获得了中国国家药品监督管理局的临床默示许可；替恩戈替尼分别联用康方生物的开坦尼/依达 方的治疗晚期肝细胞癌(HCC)的开放性、多中心II期临床研究，于近日完成首例患者给药；替恩戈替尼 获得美国食品药物管理局(FDA)授予治疗转移性去势抵抗性前列腺癌的快速通道认证。 智通财经APP获悉，药捷安康-B(02617)今日获市场资金热捧，午后一度涨近130%，尾盘涨幅有所回 落。截至收盘，涨77.09%，报192.5港元，全天成交额26.13亿港元，换手率约4.74%。 消息面上，上交所、深交所近日发布公告，药捷安康被调入港股通标的名单，自9月8日起生效。公开资 料显示，药捷安康是一家以临床需求为导向、处于注册临床阶段的生物制药公司，专注于发现及开发肿 瘤、炎症及心脏代谢疾病小分子创新疗法。截至2025年6月30日，该公司主要管线包括六款临床阶段候 选产品及多款临床前阶段候选产品。其中，替恩戈替尼（TT-00420）这款 ...

Core Viewpoint - The stock of ZhiJie AnKang-B (02617) has surged nearly 88%, reaching a high of 204.6 HKD, representing an increase of over 1455% from its IPO price of 13.15 HKD, driven by its inclusion in the Hong Kong Stock Connect list and positive developments regarding its core product, Tiengertinib [1][1][1] Company Developments - ZhiJie AnKang's Tiengertinib is the world's first and only FGFR inhibitor to enter the registration clinical stage for treating patients with recurrent or refractory cholangiocarcinoma [1][1] - The company has received multiple positive updates for Tiengertinib, including the approval for a Phase II clinical trial in China for treating HR+ and HER2- recurrent or metastatic breast cancer, which was granted clinical implied permission on September 10 [1][1] - Tiengertinib is also involved in an open-label, multicenter Phase II clinical study for advanced hepatocellular carcinoma (HCC) in combination with other therapies, with the first patient recently dosed [1][1] - The drug has received Fast Track designation from the FDA for the treatment of metastatic castration-resistant prostate cancer [1][1]