每经记者｜许立波 每经编辑｜陈俊杰 9月16日，港股上市创新药企业药捷安康（HK02617）股价出现大幅波动。盘中，药捷安康曾大涨 63%，最高每股报679.5港元，市值逼近2700亿港元，在国内创新药企业中市值仅次于恒瑞医药、百济 神州两家龙头。但到下午两点，药捷安康股价遭遇大幅跳水，由大涨转大跌，截至当日收盘，报192.00 港元/股，下跌53.73%，市值缩水至762亿港元。 对于股价异动，药捷安康曾在当日午间披露公告称："概不知悉股价异动原因，业务营运及财务状况无 重大变动。" 公司目前没有商业化产品 药捷安康是一家以临床需求为导向、处于注册临床阶段的生物制药公司，专注于发现及开发肿瘤、炎症 及心脏代谢疾病小分子创新疗法。药捷安康目前还没有商业化产品，今年上半年，公司营业收入为0， 亏损1.23亿元。 药捷安康是一只典型的港股"小盘股"。资料显示，公司于今年6月23日正式登陆港交所。此次IPO（首次 公开募股），药捷安康发行价13.15港元，总股本约3.97亿股，IPO公开发行1528.1万股，除去基石投资 者认购的约979万股，实际流通股仅约549万股。市场流通盘小意味着药捷安康在二级市场上的可交易 ...

Core Viewpoint - The extreme volatility of the stock price of药捷安康 (02617.HK) has raised concerns in the market, with a significant drop following a sharp rise, indicating potential instability and investor caution [1][5]. Group 1: Stock Price Movement -药捷安康's stock price surged by 63% to 679.5 HKD per share in the morning, before plummeting to 192 HKD per share by the end of the day, resulting in a decline of 53.73% [1]. - The stock's market capitalization fluctuated dramatically, reaching nearly 270 billion HKD at its peak and then shrinking to 76.2 billion HKD, leading to a loss of over 190 billion HKD in a single day [5]. - The stock's trading volume was notably high, with a turnover rate of 4.13%, significantly exceeding the previous day's rate of 1.34% [5]. Group 2: Market Impact - The volatility of药捷安康's stock affected several pharmaceutical ETFs, including the 恒生创新药ETF (159316) and 港股通创新药ETF (520880), which fell by 1.18% and 1.11% respectively [3]. - Following the inclusion of药捷安康 in the Hong Kong Stock Connect and major innovation drug indices on September 8, there was a notable increase in southbound capital, which bought 3.0625 million shares by September 15, accounting for 56% of the company's actual circulating shares [4]. Group 3: Company Fundamentals -药捷安康's core product,替恩戈替尼, is currently in clinical trials, with no drugs yet on the market as of June 30, 2025, and the company reported a net loss of 123 million HKD in the first half of the year [6]. - The company relies heavily on previous financing to support its research and development, with R&D expenses amounting to 98.43 million HKD and management expenses of 27.47 million HKD during the same period [6]. Group 4: Index Adjustments - The recent adjustments to the calculation methods of the 恒生创新药指数 and related indices aim to better reflect companies involved in innovative drug research and development, excluding service providers in the CXO sector [8][9]. - Following these adjustments,药捷安康 was included in multiple key indices, which contributed to its recent stock price movements and the overall performance of related ETFs [9].

本文字数：756，阅读时长大约2分钟 作者 |第一财经 林志吟 在经历了四个交易日连续暴涨后，今日，药捷安康（02617.HK）股价上演了一场"高台跳水"行情。 今日早盘，该公司股价最大涨幅超过60%，冲到670港元/股以上；午后开盘后，股价又一路滑落，最后 以暴跌53.73%收盘，股价仅剩下192港元/股，市值跌回千亿港元以下，为762.04亿港元。 药捷安康于2025年6月23日才在港股市场挂牌交易，彼时公司IPO首发价只有13.15港元/股，公司当前股 价较首发价涨幅仍高达13.6倍。上一交易日，即9月15日，公司收盘价曾高达415港元/股，股价较IPO首 发价涨幅约30.6倍，总市值达到1647.13亿港元。 药捷安康是一家处于注册临床阶段的创新药公司，专注于发现及开发肿瘤、炎症及心脏代谢疾病小分子 创新疗法。截至2025年6月30日，公司主要管线包括六款临床阶段候选产品及多款临床前阶段候选产 品。替恩戈替尼是药捷安康研发进度最快的产品，同时也是公司的核心产品，这是一款选择性聚焦多激 酶抑制剂，主要靶向三个关键通路——FGFR/VEGFR、JAK和Aurora激酶，但进度最快的适应症为胆管 癌，为小癌 ...

Core Viewpoint - The extreme volatility of the stock of Yaojie Ankang-B (02617) on September 16 highlights the influence of quantitative trading in a shallow market, resulting in a dramatic price fluctuation and revealing liquidity traps [1][12]. Group 1: Stock Performance - Yaojie Ankang-B experienced a rollercoaster ride, opening at 477.2 HKD, peaking at 679.5 HKD (up nearly 60%), and closing at 192 HKD, marking a total intraday fluctuation of approximately 124% [1][6]. - The stock's total market capitalization fell to 76.204 billion HKD, with a trading volume exceeding 4.5 billion HKD and a turnover rate of only 4.13% [1][6]. Group 2: Trading Characteristics - The stock's trading exhibited abnormal characteristics, with a significant disparity between buy and sell orders, where buy orders accounted for 90.91% and sell orders only 9.09%, indicating a lack of active market participation [6][12]. - The low turnover rate amidst high volatility suggests that most shares were locked up, with only a few experiencing panic selling and buying [6][12]. Group 3: Investor Behavior - The investor base for Yaojie Ankang-B is polarized, consisting of long-term strategic investors who hold their positions and short-term quantitative traders who engage in high-frequency trading [7][12]. - The selling pressure from quantitative traders, combined with the stability of long-term holders, led to significant price drops when sell orders were executed [7][12]. Group 4: Algorithmic Trading Mechanism - The extreme market behavior can be broken down into four phases: liquidity attraction and short squeeze, liquidity withdrawal and flash crash, cascading stop-loss triggers, and low-price turnover and position adjustment [9][10]. - The trading dynamics revealed a stark contrast in actions between different investor groups, with mainland funds showing significant divergence in their valuation judgments of the stock [10][12].

Core Viewpoint - The extreme volatility of the stock of Yaojie Ankang-B (02617) on September 16 highlights the influence of quantitative trading in a shallow market, showcasing a series of algorithm-driven operations that led to significant price fluctuations and trading anomalies [1][12]. Group 1: Stock Performance - Yaojie Ankang-B experienced a dramatic price movement, soaring nearly 60% in the morning to a peak of 679.5 HKD before plummeting to 192 HKD by the end of the day, resulting in a total intraday fluctuation of approximately 124% [1][6]. - The stock opened at 477.2 HKD, representing a 15% jump from the previous closing price of 415 HKD, indicating strong bullish sentiment [3][6]. - The total trading volume reached 45.43 billion HKD, but the turnover rate was only 4.13%, suggesting a lack of active trading participation despite high volatility [6][12]. Group 2: Market Dynamics - The trading behavior exhibited by Yaojie Ankang-B revealed a significant liquidity trap, with a buy-sell ratio of 90.91% to 9.09%, indicating that most buy orders were placed at much lower prices, waiting for bargains, while active buying at current prices was minimal [6][12]. - The stock's extreme volatility is rare in mature capital markets, suggesting a failure of the price discovery mechanism within a short timeframe [6][12]. Group 3: Investor Behavior - The investor base for Yaojie Ankang-B is polarized, consisting of long-term strategic investors who hold their positions and short-term quantitative traders who engage in high-frequency trading [7][12]. - The selling pressure from quantitative traders, combined with the lack of sufficient buying support from long-term holders, led to a rapid decline in stock price when sell orders were triggered [7][12]. Group 4: Algorithmic Trading Mechanism - The extreme market behavior can be broken down into four phases: liquidity attraction and short squeeze, liquidity withdrawal and flash crash, cascading stop-loss triggers, and low-price turnover and position adjustment [9][10]. - The initial price surge likely attracted trend-following traders, while the subsequent withdrawal of liquidity by quantitative funds triggered a rapid price decline, exacerbated by stop-loss orders [9][10]. - The final phase saw short positions being covered and bottom-fishing activities as the stock price reached a sufficiently low level, completing a cycle of "high sell, low buy" [10][12].

Core Viewpoint - The stock of the biopharmaceutical company Yaojie Ankang-B (02617.HK) experienced extreme volatility, soaring by 63.73% to a peak of 679.5 HKD per share before plummeting by over 75% within the same trading day, highlighting the disconnect between stock performance and the company's fundamental financial health [1][3][5]. Company Summary - Yaojie Ankang, founded in 2014, focuses on developing innovative therapies for cancer, inflammation, and cardiovascular diseases, and went public on June 23, 2023, with an IPO price of 13.15 HKD per share [5]. - The company's stock price surged dramatically after announcing clinical trial progress for its core product, Tinengotinib, which is the first FGFR inhibitor in clinical registration for treating cholangiocarcinoma [5][6]. - Despite the stock's meteoric rise, Yaojie Ankang has not achieved commercial profitability, reporting losses of 252 million CNY, 343 million CNY, and 275 million CNY for 2022, 2023, and 2024 respectively, totaling 870 million CNY in losses over three years [7]. Industry Summary - The innovative drug sector in China has seen significant activity, with the sector's index rising over 50% year-to-date as of September 16, 2023, indicating a heightened interest and investment sentiment in the market [8]. - Analysts suggest that the current market enthusiasm for innovative drug companies should be tempered with a rational analysis of their R&D progress, commercialization potential, and cash flow status [8]. - The future of China's innovative drug industry is viewed positively, with expectations for increased capital market support to enhance R&D and international expansion, aiming to elevate China's position from a "pharmaceutical giant" to a "pharmaceutical powerhouse" [9].

Core Viewpoint - The stock price of药捷安康-B (02617.HK) experienced extreme volatility today, with a peak increase of over 60% in the morning, followed by a sharp decline of more than 60% in the afternoon, leading to significant market capitalization loss. Group 1: Stock Performance - In the morning, the stock price reached a high of 679.5 HKD per share, with market capitalization nearing 270 billion HKD [1][2] - By the afternoon, the stock price plummeted to a low of 165 HKD per share, resulting in a drop of 60.24% [2] - The closing price was reported at 192 HKD per share, reflecting a decrease of 53.73% and a market capitalization of 76.2 billion HKD [2] Group 2: Company Announcements - The company issued a statement acknowledging the unusual stock price and trading volume fluctuations, stating that it was unaware of any reasons for these changes [4] - The board confirmed that there were no significant changes in the company's business operations or financial status [4] Group 3: Historical Context -药捷安康 was listed on the Hong Kong Stock Exchange on June 23, with an initial price of 13.15 HKD per share, and has seen its stock price increase significantly since then [5] - The stock price surged nearly 500% from September 10 to September 15, with a peak price of 679.5 HKD representing a 5067% increase from the initial listing price [6] Group 4: Financial Performance - The company remains in a loss position, with a pre-tax loss of 123 million HKD for the first half of the year, an improvement from a loss of 160 million HKD in the same period last year [6] - Other income and revenue decreased by 65.1%, from 10.4 million HKD to 3.6 million HKD, primarily due to reduced bank interest and government subsidies [6] - Research and development costs decreased by 30.9% to 98.43 million HKD, attributed to lower clinical trial expenses for the TT-00420 project [6]

Core Viewpoint - The article discusses the dramatic fluctuations in the stock price of the biopharmaceutical company Yaojie Ankang-B, highlighting the volatility and the disconnect between its stock performance and fundamental business metrics [1][6][8]. Stock Performance Summary - On September 16, Yaojie Ankang-B's stock price surged to a peak of 679.5 HKD per share, representing a 63.73% increase, with a market capitalization nearing 270 billion HKD [1]. - However, the stock experienced a sharp decline, dropping to a low of 165 HKD per share, resulting in a maximum intraday loss of over 75%, and closing at 192 HKD, down 53.73% from the previous day [1][3]. - The stock's price had increased over 50 times since its IPO at 13.15 HKD per share just three months prior [6][8]. Company Background and Financials - Yaojie Ankang, established in 2014, focuses on developing innovative therapies for cancer, inflammation, and cardiovascular diseases, currently in the registration phase [6][8]. - The company has not achieved commercial profitability, reporting losses of 252 million CNY, 343 million CNY, and 275 million CNY for the years 2022, 2023, and 2024 respectively, totaling 870 million CNY in losses over three years [8]. - As of mid-2025, the company had cash and cash equivalents of only 449 million CNY, with a significant drop in revenue of 90.4% year-on-year [8]. Market Dynamics and Investor Sentiment - The stock's volatility is attributed to speculative trading, particularly following the announcement of a clinical trial for its core product, Tinengotinib, which is the first FGFR inhibitor for certain cancer patients [7][8]. - The inclusion of Yaojie Ankang in the Hong Kong Stock Connect program has also contributed to increased trading volume and market activity [7]. - Analysts suggest that the current market sentiment towards innovative drugs is high, but caution against making investment decisions based solely on market emotions without considering the company's fundamentals [10][11]. Industry Outlook - The innovative drug sector in China has seen significant activity, with many collaborations and milestones achieved, leading to a 50% increase in the sector's stock performance this year [10]. - The future of China's innovative drug industry is viewed positively, with expectations for enhanced support from capital markets to foster research and international expansion [11].

2025.09. 16 本文字数：756，阅读时长大约2分钟 作者 | 第一财经 林志吟 在经历了四个交易日连续暴涨后，今日，药捷安康（02617.HK）股价上演了一场"高台跳水"行情。 今日早盘，该公司股价最大涨幅超过60%，冲到670港元/股以上；午后开盘后，股价又一路滑落， 最后以暴跌53.73%收盘，股价仅剩下192港元/股，市值跌回千亿港元以下，为762.04亿港元。 药捷安康于2025年6月23日才在港股市场挂牌交易，彼时公司IPO首发价只有13.15港元/股，公司当 前股价较首发价涨幅仍高达13.6倍。上一交易日，即9月15日，公司收盘价曾高达415港元/股，股价 较IPO首发价涨幅约30.6倍，总市值达到1647.13亿港元。 药捷安康是一家处于注册临床阶段的创新药公司，专注于发现及开发肿瘤、炎症及心脏代谢疾病小分 子创新疗法。截至2025年6月30日，公司主要管线包括六款临床阶段候选产品及多款临床前阶段候 选产品。替恩戈替尼是药捷安康研发进度最快的产品，同时也是公司的核心产品，这是一款选择性聚 焦多激酶抑制剂，主要靶向三个关键通路——FGFR/VEGFR、JAK和Aurora激酶，但进度最快 ...

Core Insights - On September 16, 2025, Alibaba-W (09988), Brainstorm Aurora-B (06681), and Baize Medical (02609) were the top three stocks by trading volume in the Southbound Stock Connect, with trading amounts of 57.96 billion, 55.71 billion, and 48.83 billion respectively [1] - In the Shenzhen-Hong Kong Stock Connect, Alibaba-W (09988), Xiaomi Group-W (01810), and PharmaJet-B (02617) led the trading volume, with amounts of 31.74 billion, 18.85 billion, and 18.82 billion respectively [1] Southbound Stock Connect - Top Active Companies - Alibaba-W (09988) had a trading amount of 57.96 billion with a net buying amount of +18.98 billion [2] - Brainstorm Aurora-B (06681) recorded a trading amount of 55.71 billion with a net buying amount of +98.28 million [2] - Baize Medical (02609) achieved a trading amount of 48.83 billion with a net buying amount of +2.17 billion [2] - Meituan-W (03690) had a trading amount of 32.61 billion with a net buying amount of +2.65 billion [2] - The Yingfu Fund (02800) had a trading amount of 31.85 billion with a net selling amount of -31.70 billion [2] Shenzhen-Hong Kong Stock Connect - Top Active Companies - Alibaba-W (09988) had a trading amount of 31.74 billion with a net buying amount of +11.33 billion [2] - Xiaomi Group-W (01810) recorded a trading amount of 18.85 billion with a net selling amount of -3.48 billion [2] - PharmaJet-B (02617) achieved a trading amount of 18.82 billion with a net selling amount of -4.50 billion [2] - Brainstorm Aurora-B (06681) had a trading amount of 18.22 billion with a net buying amount of +26.73 million [2] - Meituan-W (03690) had a trading amount of 18.15 billion with a net buying amount of +4.51 billion [2]