[Table_Main] 证券研究报告 | 公司点评 再鼎医药(09688.HK) 2025 年 04 月 14 日 买入（维持） 所属行业：医疗保健业/药品及生物科技 当前价格(港币)：22.20 元 证券分析师 周新明 资格编号：S0120524060001 邮箱：zhouxm＠tebon.com.cn 李霁阳 资格编号：S0120523080003 邮箱：lijy7＠tebon.com.cn 市场表现 -31% 0% 31% 63% 94% 126% 157% 188% 2024-04 2024-08 2024-12 再鼎医药 恒生指数 | 恒 生 指 数 对 | 1M | 2M | 3M | | --- | --- | --- | --- | | 比 | | | | | 绝对涨幅(%) | -18.83 | 5.21 | 17.34 | | 相对涨幅(%) | -7.45 | 9.53 | 7.63 | | 资料来源：德邦研究所，聚源数据 | | | | 重症肌无力领域近期新药进展众多，我们认为艾加莫德作为 BIC，在 MG 治疗领 域地位难以被撼动。 1）快速起效，快速达标：越来越多的临床试验使用基 ...

相关ETF方面，截至发稿，港股创新药ETF（159567）高开高走，现涨5%。成分股中，再鼎医药涨超 14%，药明合联、科伦博泰生物-B、东阳光长江药业、荣昌生物等涨幅居前。 4月14日，港股集体高开，创新药板块涨幅居前。 消息面上，Wind金融终端数据显示，截至4月13日，已有超过230家生物医药行业上市公司披露了2024 年度经营数据（含年报、业绩快报）。其中，25家公司营收突破百亿元大关，上海医药以2752.51亿元 的营收一骑绝尘；有近半数企业盈利能力持续上升，26家公司归母净利润超过10亿元，药明康德以94.5 亿元的归母净利润领跑行业；超过半数的企业研发投入持续增长，其中百济神州全年研发费用高达 19.53亿美元（约合人民币142.79亿元），同比增长9.8%，占营收比例约为52%。 广发证券表示，建议重视港股创新药的配置价值，原因在于：首先，中国创新药出海的全球竞争优势正 在凸显。近年来，中国药企在海外市场的License-out交易实现了跨越式发展，展现出中国创新药研发的 全球竞争力。NewCo模式的兴起，进一步为原药企解决了融资难、变现难、研发风险大等问题。其 次，当前关税政策对创新药影响远 ...

Group 1 - The Hang Seng Healthcare Index (HSHCI) has seen a strong increase of 2.95%, with notable gains from companies such as Zai Lab (09688) up 12.39% and Dongyangguang Changjiang Pharmaceutical (01558) up 9.04% [3] - The Hang Seng Healthcare ETF (513060) has risen by 3.15%, marking its fourth consecutive increase, with a recent price of 0.46 yuan [3] - Over the past three months, the Hang Seng Healthcare ETF has accumulated a total increase of 21.98% [3] Group 2 - The Hang Seng Healthcare ETF has experienced a net value increase of 26.66% over the past year, with the highest single-month return reaching 28.34% since its inception [4] - The ETF's Sharpe ratio stands at 1.27, indicating strong risk-adjusted returns [4] - The ETF's management fee is 0.50%, and the custody fee is 0.15% [4] Group 3 - The top ten weighted stocks in the Hang Seng Healthcare Index account for 56.37% of the index, with companies like BeiGene (06160) and WuXi Biologics (02269) leading the list [5] - The performance of these stocks varies, with BeiGene showing a gain of 5.34% and WuXi Biologics up by 2.81% [7] Group 4 - The current market environment emphasizes the importance of domestic consumption growth due to pressures from U.S.-China tariffs, highlighting healthcare consumption as a key investment area [8] - The market sentiment is recovering, with a focus on undervalued blue-chip stocks and companies with solid fundamentals, particularly in the healthcare sector [8]

港股生物医药板块盘初走强，再鼎医药(09688.HK)涨超12%，君实生物(01877.HK)涨超5%，百济神州 (06160.HK)、药明康德(02359.HK)等跟涨。 ...

Group 1 - The Hong Kong pharmaceutical stocks showed a strong performance, with notable gains in several companies [1] - Zai Lab (09688.HK) experienced a significant increase of 13.51% [1] - Other companies such as LianKe Pharma-B (02105.HK) and Kintor Pharmaceutical (02137.HK) also saw substantial rises of 10.34% and 6.17% respectively [1][1]

Core Viewpoint - The Hang Seng Healthcare Index (HSHCI) has shown strong performance, with significant increases in constituent stocks and the Hang Seng Healthcare ETF, indicating positive market sentiment in the healthcare sector [1][4]. Group 1: Market Performance - As of April 1, 2025, the HSHCI rose by 2.09%, with notable gains in stocks such as Genscript Biotech (8.36%) and Haijia Medical (7.74%) [1]. - The Hang Seng Healthcare ETF (513060) opened high and increased by 2.53%, with a latest price of 0.49 HKD and a trading volume of 1.28 billion HKD, achieving a turnover rate of 0.97% [1]. Group 2: ETF Growth and Performance Metrics - The Hang Seng Healthcare ETF has seen a significant growth of 2.648 billion HKD in size over the past year, ranking in the top third among comparable funds [4]. - The ETF's financing buy-in amount reached 322 million HKD, with a financing balance of 545 million HKD [4]. - Since its inception, the ETF recorded a highest monthly return of 28.34% and an average monthly return of 7.01% [4]. - The ETF's Sharpe ratio for the past year is 1.40, indicating strong risk-adjusted returns [4]. Group 3: Valuation and Industry Outlook - The latest price-to-earnings ratio (PE-TTM) for the HSHCI is 25.11, placing it in the 2.17% percentile over the past year, suggesting it is undervalued compared to historical levels [5]. - The National Medical Products Administration reported that 48 innovative drugs were approved in 2024, covering various therapeutic areas, indicating a robust pipeline for the pharmaceutical industry [5]. - Recent policies are shifting from cost control to encouraging innovation, with a focus on leading companies with strong international capabilities [5]. Group 4: Index Composition - As of March 31, 2025, the top ten weighted stocks in the HSHCI include WuXi Biologics, BeiGene, and Innovent Biologics, collectively accounting for 56.21% of the index [6].

今日港股回调，创新药再度逆市上涨！港股通创新药ETF（159570）强势大涨近3%，成交额继续爆量，盘中成交近5亿元！上周五成交额再度刷新历史，天 量成交16.49亿元！资金持续乐观，上周累计获资金净流入近2亿元，今日盘中再获净申购4300万份！ 港股通创新药ETF（159570）成分股多数飘红：乐普生物涨超12%，百济神州涨超5%，信达生物涨超3%，晶泰控股涨超2%，康方生物、药明生物、科伦博 泰生物涨超1%。 资金狂涌创新药，港股通创新药ETF（159570）近60日"吸金"近10亿元，融资余额保持历史高位，反映杠杆资金布局意愿！最新规模19.27亿元创上市新 高，1个月实现规模翻倍！ 【机构：医药见底回暖，创新药主线强化】 光大证券认为，医药行情见底回暖，优化集采政策有望稳定资产盈利能力。近期，医药行情整体已显现见底回暖迹象，从2025.1.2~2025.3.27期间，港股创 新药指数上涨26.28%，跑赢恒生科技1.20pp。2025年工作报告提出"优化药品集采政策"，有望优化产业竞争环境，仿制药利润压缩接近尾声，竞争格局趋于 稳定，龙头白马企业凭借技术壁垒与产能优势，盈利能力有望企稳。后集采时代，行 ...

Group 1 - The Hang Seng Healthcare Index (HSHCI) has seen a strong increase of 1.80%, with notable gains from companies such as Lepu Biopharma-B (up 16.56%) and Zai Lab (up 10.27%) [1] - The Hang Seng Medical ETF (513060) has risen by 2.11%, marking its third consecutive increase, with a trading volume of 4.69 billion yuan [1][2] - The second Boao Lecheng Stem Cell Conference has opened, marking a new phase of standardized and high-quality development in China's stem cell industry [2] Group 2 - Financial analysts predict that the approval and implementation of more projects in the stem cell sector will lead to advanced treatment methods benefiting the public [2] - The domestic medical innovation industry is expected to experience multiple growth opportunities, particularly for companies with true innovation capabilities in new drug development [2] - The Hang Seng Medical ETF has seen a significant growth in scale, increasing by 34.09 billion yuan over the past year, ranking in the top third among comparable funds [2] Group 3 - Since its inception, the Hang Seng Medical ETF has achieved a maximum monthly return of 28.34% and an average monthly return of 7.00% [3] - The ETF has outperformed its benchmark with an annualized excess return of 2.02% over the past year [3] - The ETF's management fee is 0.50%, and the custody fee is 0.15% [3] Group 4 - The tracking error of the Hang Seng Medical ETF is 0.033%, the highest tracking precision among comparable funds [4] - The latest price-to-earnings ratio (PE-TTM) of the Hang Seng Medical Healthcare Index is 24.97, indicating it is at a historical low compared to the past year [4] - The top ten weighted stocks in the Hang Seng Medical Healthcare Index account for 55.64% of the index, with companies like WuXi Biologics and BeiGene among the leaders [4][6]

Group 1 - The company reported total revenue of $399 million for the year ending December 31, 2024, representing a year-on-year increase of 49.59% [1] - Revenue growth was primarily driven by the strong commercialization of Weiwei Jia since its launch in September 2023 and its inclusion in the national medical insurance catalog in January 2024 [1] - The company continues to maintain its leading position in the ovarian cancer PARP inhibitor market and has seen steady sales growth from its products included in the national medical insurance catalog [1] Group 2 - The company achieved positive results in the global Phase I study of ZL-1310, a targeted DLL3 ADC for the treatment of extensive small cell lung cancer [2] - Encouraging preclinical data was obtained for ZL-1503, a dual-specific antibody targeting IL-13/IL-31R for the treatment of atopic dermatitis [2] - The company expanded its product pipeline through strategic collaborations, including a partnership with Yilian Bio to develop ZL-6201, a novel targeted LRRC15 ADC for specific solid tumors [2]

Revenue Growth - Product revenue increased by $130.9 million (or 49%) to $397.6 million, driven by the sales growth of Weiwei Jia® since its launch in September 2023 and its inclusion in the national medical insurance catalog in January 2024 [4] - Total revenue for the year ended December 31, 2024, was $398.988 million, a significant increase of 49.5% compared to $266.719 million in 2023 [20] - Product revenue, net, reached $397.614 million, up from $266.719 million in the previous year, indicating strong growth in product sales [20] - Total product revenue for 2024 reached $423.855 million, a 42% increase from $298.911 million in 2023 [81] - The net revenue from the product "卫偉迦╱衛力迦" surged by 835% to $93.6 million in 2024 from $10.0 million in 2023 [180] Expenses and Losses - R&D expenses decreased by $31.4 million (or 12%) to $234.5 million, primarily due to the progress of existing research projects, partially offset by increased licensing fees [4] - Selling, general and administrative expenses increased by $17.1 million (or 6%) to $298.7 million, mainly due to increased general sales expenses from the launch of Weiwei Jia® and the sales growth of Nuo Zai Le® [4] - Net loss decreased by $77.5 million (or 23%) to $257.1 million, primarily due to product revenue growth outpacing net operating expenses, offset by decreased interest income and increased foreign exchange losses [4] - The net loss for 2024 was $257,103,000, a decrease from the net loss of $334,620,000 in 2023, representing a 23.2% improvement [21] - The comprehensive loss for 2024 was $244,214,000, compared to $322,679,000 in 2023, indicating a 24.4% reduction [21] Cash and Liquidity - Cash and cash equivalents as of December 31, 2024, were $449.667 million, down from $790.151 million in 2023, indicating a reduction in liquidity [19] - The company reported a total cash and cash equivalents of $550,781,000 at the end of 2024, down from $791,264,000 at the end of 2023 [23] - Cash flow from operating activities showed a net cash outflow of $214,869,000 in 2024, compared to $198,178,000 in 2023, reflecting a 8.4% increase in cash outflow [23] - Cash, cash equivalents, and restricted cash amounted to $550.8 million as of December 31, 2024, including $531.0 million in USD [194] Assets and Liabilities - Total assets increased to $1.185753 billion in 2024 from $1.036295 billion in 2023, showing overall growth in the company's asset base [19] - Total liabilities rose to $344.855 million in 2024, compared to $240.177 million in 2023, indicating increased financial obligations [19] - Shareholders' equity increased to $840.898 million in 2024 from $796.118 million in 2023, reflecting a positive trend in equity position [19] - The company reported a decrease in accumulated deficit to $2,453,083,000 in 2024 from $2,195,980,000 in 2023, reflecting ongoing financial challenges [22] Research and Development - Research and development expenses totaled $234.504 million, a decrease from $265.868 million in the prior year, suggesting a focus on efficiency [20] - Clinical project expenses were $86,126, down from $112,158, indicating a reduction of approximately 23.2% year-over-year [138] - The investment in R&D and operational expenses continues to drive significant losses, with a focus on long-term development of quality candidates [165] - The company has multiple candidates in late-stage clinical development, with the ability to generate revenue dependent on obtaining regulatory approvals [174] Stock and Equity - Basic and diluted loss per share was $0.26, a decrease of 25% from $0.35 [4] - The weighted average number of shares outstanding increased to 989,477,730 in 2024 from 966,394,130 in 2023, reflecting potential dilution effects [20] - The company granted 20,947,480 stock options in 2024, with an average exercise price of $1.69 [108] - The total intrinsic value of stock options exercised in 2024 was approximately $9.4 million, compared to $20.3 million in 2023 [108] Collaborations and Agreements - The company has entered into a licensing agreement with Seagen for the development and commercialization of Tisotumab Vedotin (TIVDAK) in Greater China, with potential milestone payments up to $258 million [122] - A collaboration and licensing agreement with Yilian Biopharmaceuticals was established for the global exclusive rights to develop and commercialize DLL3-targeted ADC compounds, with potential milestone payments up to $592 million [124] - The company recorded a milestone expense of $12.0 million related to sales for the collaboration agreement with GSK for Niraparib in 2023 [113] Financial Instruments and Accounting - The company operates under US GAAP for its consolidated financial statements, ensuring compliance with important accounting policies [27] - The company applies ASC 606 for revenue recognition, confirming revenue when control of goods or services is transferred to customers [49] - The company recognizes lease liabilities and right-of-use assets at the commencement date of the lease, measuring lease liabilities at the present value of future fixed lease payments [39] Market and Future Outlook - The company expects revenue growth from existing and recently launched commercialized products to continue into 2025 [167] - The company plans to continue its market expansion efforts and explore new product development opportunities [139] - Strategic collaborations have been established with Yilian Bio and Vertex to enhance the product pipeline and leverage new therapeutic developments [168]