(一) 提前离任的基本情况 证券代码：600867 证券简称：通化东宝 公告编号：2025-051 通化东宝药业股份有限公司 关于总经理辞职暨新任公司总经理的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示： 通化东宝药业股份有限公司（以下简称"公司"或"通化东宝"）董事会近 日收到总经理冷春生先生递交的书面辞职报告，冷春生先生因工作安排调整，基 于参股公司君合盟生物制药（杭州）有限公司的发展需要，申请辞去公司总经理 的职务。辞职后，冷春生先生继续担任公司副董事长职务并担任董事会战略委员 会、薪酬与考核委员会、提名委员会委员和审计委员会委员职务。同时公司决定， 聘任冷春生先生为公司首席科学顾问。 一、总经理离任情况 | 姓名 | 离任职务 | 离任时间 | 原定任期 | | 是否继 续在上 | | 是否存 在未履 行完毕 | | --- | --- | --- | --- | --- | --- | --- | --- | | | | | 到期日 | 离任原因 | 市公司 及其控 | 具体职务（如适 用） | ...

证券代码：600867 证券简称：通化东宝 公告编号：2025-050 通化东宝药业股份有限公司 第十一届董事会第十六次会议决议公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 一、董事会会议召开情况 通化东宝药业股份有限公司（以下简称"公司"或"通化东宝"）第十一届 董事会第十六次会议，于 2025 年 8 月 25 日在公司会议室以现场结合通讯方式召 开，会议通知于 2025 年 8 月 15 日，以书面、电子邮件等形式发出。本次会议应 参加会议董事 9 人，实际出席会议董事 9 人，会议由董事长李佳鸿先生主持，监 事及高级管理人员列席了会议。会议符合《公司法》和《公司章程》的有关规定， 所作决议合法有效。会议审议并通过了如下决议： 二、董事会会议审议情况 （一）审议通过了《关于聘任公司总经理的议案》； 冷春生先生因工作安排调整，辞去公司总经理职务，聘任李佳鸿先生为公司 总经理。 任期自本次董事会审议通过之日起至第十一届董事会任期届满时止。 具体内容详见公司 2025 年 8 月 26 日在中国证券报、上海证券报及上海 ...

公司代码：600867 公司简称：通化东宝 通化东宝药业股份有限公司 2025 年半年度报告 通化东宝药业股份有限公司2025 年半年度报告 四、 公司负责人李佳鸿、主管会计工作负责人迟军玉及会计机构负责人（会计主管人员）王熠 声明：保证半年度报告中财务报告的真实、准确、完整。 五、 董事会决议通过的本报告期利润分配预案或公积金转增股本预案 无 1 / 183 通化东宝药业股份有限公司2025 年半年度报告 重要提示 一、 本公司董事会、监事会及董事、监事、高级管理人员保证半年度报告内容的真实性、准确 性、完整性，不存在虚假记载、误导性陈述或重大遗漏，并承担个别和连带的法律责任。 二、 公司全体董事出席董事会会议。 三、 本半年度报告未经审计。 六、 前瞻性陈述的风险声明 √适用 □不适用 本报告中所涉及的未来计划、发展战略等前瞻性描述不构成公司对投资者的实质承诺，敬请 投资者注意投资风险。 七、 是否存在被控股股东及其他关联方非经营性占用资金情况 否 八、 是否存在违反规定决策程序对外提供担保的情况 否 九、 是否存在半数以上董事无法保证公司所披露半年度报告的真实性、准确性和完整性 否 十、 重大风险提示 ...

Core Viewpoint - The company announced the resignation of its general manager, Leng Chunsheng, due to work arrangement adjustments and the needs of its affiliated company, Junhe Alliance Biopharmaceuticals [1] Group 1 - Leng Chunsheng will continue to serve as the vice chairman of the company and has been appointed as the chief scientific advisor after his resignation [1] - The board of directors has approved the appointment of Li Jiahong as the new general manager, with a term lasting until the end of the current board's tenure [1]

通化东宝公告，2025年上半年营业收入13.73亿元，同比增长85.60%。净利润2.18亿元，上年同期为净 亏损2.3亿元。 ...

Group 1 - The stock price of Tonghua Dongbao is reported at 8.46 yuan as of August 22, 2025, with a decrease of 0.03 yuan, representing a decline of 0.35% from the previous trading day [1] - The trading volume on the same day reached 1.56 billion yuan, with a turnover rate of 0.94%, and the total market capitalization stands at 16.569 billion yuan [1] - Tonghua Dongbao's main business includes the biopharmaceutical sector, focusing on innovative drugs and weight loss medications [1] Group 2 - The company's mid-year report for 2025 indicates a turnaround in performance, leading to increased market attention [1] - On August 22, there was a net outflow of 11.1417 million yuan from major funds, with a cumulative net outflow of 155 million yuan over the past five trading days [1]

Core Viewpoint - The leading companies in the insulin market, namely Ganli Pharmaceutical and Tonghua Dongbao, have shown signs of recovery in their financial performance, indicating a positive trend following two rounds of centralized procurement [1][2]. Group 1: Financial Performance - Tonghua Dongbao expects a net profit of approximately 217 million yuan for the first half of 2025, marking a turnaround from losses in the previous year [1]. - Ganli Pharmaceutical reported a revenue of 2.067 billion yuan and a net profit of 604 million yuan for the first half of 2025, representing year-on-year increases of 57.18% and 101.96%, respectively [3]. Group 2: Revenue Growth Drivers - Tonghua Dongbao attributes its turnaround to significant sales growth of insulin analog products and successful international expansion, leading to a notable increase in export revenue [2]. - Ganli Pharmaceutical's domestic revenue reached 1.845 billion yuan, a year-on-year increase of 55.28%, with its formulation sales growing by 57.09% [2]. Group 3: International Expansion - Ganli Pharmaceutical has received approvals for its products in countries such as Malaysia, Pakistan, and Argentina, and has successfully introduced insulin production technology in Brazil [4]. - Tonghua Dongbao has also expanded its international presence, with its insulin products approved for sale in Uzbekistan and Nicaragua [4]. Group 4: R&D Focus - The companies are shifting their focus towards developing new products, including fourth-generation insulin and GLP-1 class hypoglycemic drugs, as traditional insulin products face profit pressures from centralized procurement [5]. - Ganli Pharmaceutical is advancing several clinical projects, including GZR4 and GZR101, which are in different phases of clinical trials, and its GLP-1RA dual-week formulation, Bofanglure, is in phase III clinical research [5][6].

关于控股股东股份解押及再质押公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示: 通化东宝药业股份有限公司（以下简称"公司"或"本公司"）控股股东东 宝实业集团股份有限公司（以下简称"东宝集团"）及其一致行动人合计持有公 司股份 631,511,775 股，占公司目前股份总额的 32.24%；东宝集团及其一致行 动人持有公司股份累计质押数量（本次解押及再质押后）为 565,939,472 股，占 其及一致行动人所持有公司股份总额的 89.62%，占公司目前股份总额的 28.90%。 其中：东宝集团持有公司股份 609,649,596 股，占公司目前股份总额的 31.13%， 东宝集团持有公司股份累计质押数量（本次解押及再质押后）为 565,939,472 股， 占其所持有公司股份总额的 92.83%，占公司目前股份总额的 28.90%。 2025 年 7 月 25 日,本公司接到东宝集团关于股份解押及再质押相关情况的 告知函,具体情况如下: 一、公司控股股东本次股份质押解除的具体情况 证券代码：600867 证 ...

Summary of Key Points from the Conference Call Industry Overview - **Industry Focus**: The conference call primarily discusses the healthcare sector in China, particularly the medical technology (Medtech), in vitro diagnostics (IVD), retail pharmacies, hospitals, vaccines, and insulin markets [1][2]. Core Insights and Arguments Medtech - **Key Areas of Focus**: 1. Progress of capital equipment value-based procurement (VBP) and the trade-in policy [1] 2. Channel destocking trends [1] 3. Import substitution trends post-VBP, including intraocular lenses (IOLs) and IVD [1] - **VBP Impact**: The June bidding value data showed a year-on-year growth rate of 49%, but a month-on-month decline of 3%, indicating lower unit prices due to VBP [10]. IVD Market - **Weak Demand**: The IVD sector continues to face challenges, with a projected 20% year-on-year decline in the CLIA reagent market size for 2025 [19]. - **AmoyDx Performance**: AmoyDx is expected to grow against the trend due to its strong presence in compliant in-hospital sales channels, benefiting from the anti-corruption campaign [21]. Insulin Market - **Domestic Substitution**: The insulin industry has seen significant growth, particularly for insulin analogs from companies like Gan & Lee and THDB, which reported rapid revenue growth in 1Q25 [22]. Retail Pharmacies - **Market Pressure**: Retail pharmacies are under pressure due to strict reimbursement policies and weak consumer spending. However, there is a potential market-clearing trend expected by year-end [31]. Hospitals - **New Product Feedback**: Hospitals are seeing new product introductions, such as the new version of SMILE surgery and new PIOL products, which are expected to drive consumption recovery [1]. Vaccine Market - **Anti-Corruption Campaign**: The ongoing anti-corruption campaign within the CDC system is impacting vaccine demand and distribution channels [1]. Financial Performance and Estimates Earnings Revisions - **Mindray**: Annual earnings estimates revised down by 2.1% to 5.0% for 2025E-27E due to industry headwinds in medical equipment and IVD [2][37]. - **United Imaging**: Revenue and earnings forecasts adjusted down to reflect lower-than-expected bidding data [39]. - **SNIBE**: Earnings estimates revised down by 1.4% to 7.1% for 2025E-27E due to policy headwinds in the IVD sector [40]. Revenue Growth Expectations - **High Growth Companies**: THDB and Gan & Lee are expected to achieve the highest revenue growth due to a low base from VBP renewal in 2Q24 [6]. - **Mindray's Decline**: Mindray's China business is expected to decline by 26% year-on-year in 2Q25 due to IVD weakness [9]. Other Important Insights - **Trade-in Policy Concerns**: The trade-in stimulus fund is expected to run out, leading to a decline in applications and a reduced stimulus effect in the second half of 2025 [10]. - **Market Dynamics**: The healthcare market is experiencing a shift with increasing government support for procurement and a focus on innovative products [47][48]. Conclusion - The healthcare sector in China is facing various challenges, including policy headwinds, weak demand in certain segments, and the impact of ongoing reforms. However, there are also opportunities for growth, particularly in innovative products and domestic substitution trends. Companies like AmoyDx, Gan & Lee, and THDB are positioned to benefit from these trends, while others like Mindray and SNIBE are facing headwinds that may impact their performance in the near term.

Core Viewpoint - The Chinese innovative drug industry is experiencing a significant moment in the first half of 2025, driven by policy benefits and international breakthroughs, with three companies expected to turn losses into profits [1]. Group 1: Company Performance - Tonghua Dongbao expects to achieve a net profit of approximately 217 million yuan for the first half of 2025, marking a turnaround from losses in the previous year [2]. - The main reason for Tonghua Dongbao's performance improvement is the significant growth in sales of insulin analog products, leading to a substantial increase in domestic sales revenue [4]. - The internationalization strategy has also shown significant results, with noticeable growth in export revenue [5]. Group 2: Other Companies' Performance - Zhaoyan New Drug anticipates a net profit of between 50.32 million and 75.49 million yuan for the first half of 2025, recovering from a loss of 169 million yuan in the same period last year [6]. - The decline in Zhaoyan New Drug's operating income is attributed to intensified competition, which has compressed order profits and exacerbated losses in laboratory services [8]. - The fair value changes of biological assets have offset some business losses, contributing to the overall turnaround [9]. Group 3: BoTeng Co. Performance - BoTeng Co. expects a net profit ranging from 0 to 30 million yuan for the first half of 2025, recovering from a loss of 170 million yuan in the previous year [10]. - The company anticipates achieving revenue of 1.55 billion yuan, representing a year-on-year growth of 15% to 20% [12]. - The improvement in BoTeng Co.'s performance is driven by robust revenue growth, enhanced gross margins, effective cost control, and a reduction in losses from new businesses, along with non-recurring investment income of approximately 18.21 million yuan [13][14]. Group 4: Overall Industry Insights - The performance turnaround of Tonghua Dongbao, Zhaoyan New Drug, and BoTeng Co. reflects the positive progress of different segments within the biopharmaceutical industry in overcoming challenges and seeking growth and profitability restoration [15]. - However, the specific paths and sustainability of these improvements depend on each company's business model and future operating environment [15].