Core Viewpoint - Haoyuan Pharmaceutical disclosed that it will report the number of shareholders as of the end of the reporting period in accordance with the principle of information disclosure fairness [1] Summary by Category - **Shareholder Information** - As of September 30, 2025, the total number of shareholders for Haoyuan Pharmaceutical is 12,019 [1]

Market Overview - The medical services sector experienced a decline of 2.71% on November 21, with Baihua Pharmaceutical leading the drop [1] - The Shanghai Composite Index closed at 3834.89, down 2.45%, while the Shenzhen Component Index closed at 12538.07, down 3.41% [1] Stock Performance - Notable gainers included Yangguang Nuohua, which rose by 4.47% to a closing price of 61.21, with a trading volume of 86,300 shares and a transaction value of 530 million [1] - Baihua Pharmaceutical saw a significant decline of 9.67%, closing at 9.06, with a trading volume of 292,400 shares and a transaction value of 275 million [2] - Other notable decliners included Chengda Pharmaceutical (-9.58%), Berry Genomics (-8.67%), and Guangzheng Eye Hospital (-7.26%) [2] Capital Flow - The medical services sector experienced a net outflow of 1.325 billion in institutional funds, while retail investors saw a net inflow of 1.332 billion [2] - The table of capital flow indicates that major stocks like Yangguang Nuohua had a net inflow of 10.986 million from institutional investors, while retail investors had a net inflow of 1.374 million [3]

Investment Rating - The report rates the industry as "Outperform" [2] Core Insights - The global market for Antibody-Drug Conjugates (ADC) is projected to exceed $100 billion, driven by the dual advantages of targeted therapy and potent cytotoxic effects [2][3] - ADCs are recognized as a promising new therapy in oncology, with the potential to redefine standard treatments for major cancers like lung and breast cancer [2][3] - China has emerged as a key player in ADC innovation, with over 50% of global ADC pipelines originating from Chinese companies, showcasing significant cost and efficiency advantages [2][3][5] Summary by Sections Section 1: ADC as a Targeted Prodrug - ADCs utilize a "Trojan horse" strategy for targeted delivery of cytotoxic agents to tumor cells, minimizing damage to normal tissues [11][13] - The mechanism involves several steps, including circulation, target binding, internalization, and release of the active drug within the tumor cell [11][13] Section 2: Market Growth and Trends - The ADC market is expected to enter a product explosion phase, with rapid growth anticipated in the coming years [2][3] - The global ADC market size is forecasted to reach $115.1 billion by 2032 [2] Section 3: Investment Opportunities - Investment in ADCs should focus on companies with innovative technology platforms and promising product candidates [2][3] - Key players to watch include those with leading ADC technology platforms and robust pipelines, such as Kelun-Biotech, Innovent Biologics, and WuXi AppTec [2][3] Section 4: Technological Advancements - ADC technology is characterized by modular upgrades and innovative combinations, with a variety of ADC types currently in development [2][3] - The report highlights the potential for ADC technology to extend into broader categories of conjugated drugs (XDC) [2][3] Section 5: Competitive Landscape - The report emphasizes the competitive nature of the ADC industry, with numerous players vying for market share and innovation [2][3] - Chinese ADC companies are recognized for their ability to lead in innovation and capture significant market opportunities [2][3][5]

Core Viewpoint - Haoyuan Pharmaceutical announced the issuance of convertible bonds, which will start paying interest from November 28, 2025 [2] Group 1 - The company will issue convertible bonds to unspecified recipients on November 28, 2024 [2] - The interest payment period for the bonds will be from November 28, 2024, to November 27, 2025 [2]

| 证券代码：688131 | 证券简称：皓元医药 | 公告编号：2025-123 | | --- | --- | --- | | 转债代码：118051 | 转债简称：皓元转债 | | 上海皓元医药股份有限公司 关于"皓元转债"2025 年付息公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： 上海皓元医药股份有限公司（以下简称"公司"）于 2024 年 11 月 28 日向不 特定对象发行的可转换公司债券（以下简称"皓元转债"）将于 2025 年 11 月 28 日开始支付自 2024 年 11 月 28 日至 2025 年 11 月 27 日期间的利息。根据《上海 皓元医药股份有限公司向不特定对象发行可转换公司债券募集说明书》（以下简 称"《募集说明书》"）有关条款的规定，现将有关事项公告如下： 一、可转债发行上市概况 （一）可转债发行情况 经中国证券监督管理委员会《关于同意上海皓元医药股份有限公司向不特定 对象发行可转换公司债券注册的批复》（证监许可[2024]1289 号）同意，公司于 2024 ...

| 证券代码：688131 | 证券简称：皓元医药 | 公告编号：2025-124 | | --- | --- | --- | | 转债代码：118051 | 转债简称：皓元转债 | | 上海皓元医药股份有限公司 关于子公司开立可转换公司债券募集资金专项账户 并签订募集资金专户存储监管协议的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者 重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 一、募集资金基本情况 经中国证券监督管理委员会（以下简称"中国证监会"）出具的《关于同意 上海皓元医药股份有限公司向不特定对象发行可转换公司债券注册的批复》（证 监许可[2024]1289 号）同意，上海皓元医药股份有限公司（以下简称"公司"） 向不特定对象发行 82,235.00 万元的可转换公司债券，期限 6 年，每张面值为人 民币 100 元，发行数量为 822,350 手（8,223,500 张），募集资金总额为人民币 822,350,000.00 元，扣除不含税的发行费用 10,612,390.15 元，实际募集资金净额 为 811,737,609.85 元。上述募集资金已 ...

Core Viewpoint - Haoyuan Pharmaceutical announced the approval of a capital increase of 50 million yuan to its subsidiary, Ouchuang Biotechnology, for the implementation of the fundraising project "New Drug Technology R&D Center" [2] Group 1 - The fourth meeting of the Audit Committee of the fourth Board of Directors was held on November 19, 2025 [2] - The company plans to use part of the raised funds for the development of new drug technology [2] - The decision was made to support the subsidiary's project aimed at enhancing research and development capabilities [2]

Core Points - Haoyuan Pharmaceutical announced that its stock has triggered the conditional redemption clause for its convertible bonds due to the closing price exceeding 130% of the conversion price for 15 out of 30 trading days [2] - The company decided not to exercise the early redemption rights for the "Haoyuan Convertible Bonds" during the upcoming six-month period [2] - Future assessments for potential redemption will be conducted after May 20, 2026, if the redemption clause is triggered again [2]

Investment Rating - The report suggests focusing on globally competitive CXO companies such as WuXi AppTec, WuXi XDC Cayman, WuXi Biologics Cayman, Pharmaron, Asymchem Laboratories, Porton Pharma Solutions, and Zhejiang Jiuzhou Pharmaceutical [29][30] Core Insights - The overseas CXO industry has confirmed a bottom in prosperity and is showing signs of structural recovery. The industry has passed the cyclical bottom, but recovery is characterized by significant structural differentiation [30] - Clinical CROs like IQVIA and Medpace are leading the recovery with strong orders and guidance, while CDMOs such as Lonza demonstrate resilience through long-term contracts. Preclinical CROs and research services are still stabilizing, with improving inquiry or order cancellation rates [30][31] - The overall recovery strength and sustainability will depend on the continuation of enthusiasm in biotech financing [30] Summary by Sections 1. Overseas CXO Industry Q3 2025 Performance Review - The overseas CXO industry has shown a structural recovery trend, with significant differentiation in recovery across sectors. Clinical CROs are leading the recovery, while preclinical CROs and research services are still in a stabilization phase [8][30] 2. Leading Company Analysis 2.1 Charles River - The company is nearing a performance bottom, with Q3 revenue at $1 billion and an organic growth rate of -1.6%. The management has raised the full-year revenue and EPS guidance, indicating a positive outlook for 2026 [15][16] 2.2 Samsung Biologics - The company reported a strong Q3 performance with revenue of 1.66 trillion KRW, a 40% YoY increase. The CDMO segment continues to grow, with a full-year revenue growth guidance of 25%-30% [19][20] 2.3 Lonza - Lonza's Q3 performance met expectations, with CDMO business projected to grow by 20%-21% YoY. The company is experiencing strong demand in its core business segments [24][25] 3. Key Financial Metrics - The report includes financial forecasts for various companies, indicating expected revenue growth and profitability metrics for 2025-2027. For instance, WuXi AppTec is expected to have an EPS of 5.42 in 2025, with a PE ratio of 18 [26]

Core Viewpoint - The company, Haoyuan Pharmaceutical, has approved a capital increase of 50 million yuan to its subsidiary, Ouchuang Biotechnology, for the implementation of a new drug technology research and development center project [1] Group 1 - The fourth meeting of the Audit Committee and the fourteenth meeting of the Board of Directors were held on November 19, 2025 [1] - The decision to use part of the raised funds for the capital increase was made during these meetings [1] - The funds will specifically support the "New Drug Technology R&D Center" project [1]