Core Viewpoint - Haoyuan Pharmaceutical experienced a 5.1% increase in stock price, reaching 74.00 CNY per share, with a total market capitalization of 15.695 billion CNY as of September 12 [1] Company Overview - Shanghai Haoyuan Pharmaceutical Co., Ltd. was established on September 30, 2006, and went public on June 8, 2021. The company specializes in the discovery of small molecule drugs, focusing on molecular building blocks and tool compounds, as well as the development and production of active pharmaceutical ingredients (APIs) and intermediates [1] - The main revenue sources for the company include molecular building blocks, tool compounds, and biochemical reagents, accounting for 68.97% of total revenue. Product sales contribute 63.42%, while APIs and intermediates, along with formulations, account for 30.46%. Technical services make up 5.55%, and other sources contribute 0.57% [1] Shareholder Information - Among the top circulating shareholders of Haoyuan Pharmaceutical, a fund under China Europe Fund holds a significant position. The China Europe Healthcare Mixed A Fund (003095) reduced its holdings by 2.7776 million shares in the second quarter, retaining 6.1185 million shares, which represents 2.97% of the circulating shares. The estimated floating profit from this transaction is approximately 21.9653 million CNY [2] - The China Europe Healthcare Mixed A Fund was established on September 29, 2016, with a current scale of 15.638 billion CNY. Year-to-date returns stand at 31.02%, ranking 2473 out of 8174 in its category, while the one-year return is 47.65%, ranking 3246 out of 7981. Since its inception, the fund has achieved a return of 126.12% [2] Fund Management - The fund manager of China Europe Healthcare Mixed A is Ge Lan, who has been in the position for 10 years and 230 days, overseeing assets totaling 39.908 billion CNY, with the best fund return during her tenure being 126.12% and the worst being -35.13% [3] - Co-manager Zhao Lei has been in the role for 71 days, managing assets of 30.801 billion CNY, with the best return being 17.59% and the worst being 17.42% during his tenure [3]

Group 1 - The A-share market experienced fluctuations on September 12, with a rebound in the innovative drug concept in the afternoon [1] - The Tianhong Innovative Drug ETF (517380) showed a "W" shaped reversal in the morning and continued to strengthen in the afternoon, rising by 1.50% with a trading volume exceeding 58 million yuan [1] - Notable stocks within the Tianhong Innovative Drug ETF included Nocare Pharma-U, which rose over 14%, and Zhaoyan New Drug, which hit the daily limit [1] Group 2 - The Biopharmaceutical ETF (159859) increased by 0.88%, with a trading volume exceeding 90 million yuan, featuring stocks like Junshi Biosciences-U and WuXi AppTec among the top gainers [1] - As of September 11, the Tianhong Innovative Drug ETF had seen a net inflow of over 79 million yuan over four consecutive days, while the Biopharmaceutical ETF had a net inflow of over 220 million yuan over three days [1] Group 3 - The Tianhong Innovative Drug ETF is the largest in the market, covering both A-shares and Hong Kong stocks, and is the only ETF tracking the Hang Seng-Hushen-Hong Kong Innovative Drug Select 50 Index [1] - The Biopharmaceutical ETF closely tracks the Guozheng Biopharmaceutical Index, which covers various sectors including innovative drugs, CXO, vaccines, and blood products [1] Group 4 - The National Medical Products Administration announced measures to optimize the review and approval of clinical trials for innovative drugs, aiming to complete reviews within 30 working days for eligible applications [1] - This initiative supports key national research and encourages global early-stage synchronized research and international multi-center clinical trials [1] Group 5 - Short-term outlook suggests that many innovative drug stocks have seen significant gains since the beginning of the year, which may lead to profit-taking in response to negative news [2] - The biotech sector in China is expected to maintain high investment value due to continuous innovation breakthroughs and improved profitability [2] Group 6 - The Hong Kong innovative drug sector reported a net profit of 1.8 billion yuan in the first half of the year, marking its first profit since turning around [2] - The industry is entering a new cycle driven by profitability, with leading companies achieving profits through the commercialization of products and accelerating the conversion of research value [2]

上海皓元医药股份有限公司 2025年第五次临时股东会会议资料 转债代码：118051 转债简称：皓元转债 证券代码：688131 证券简称：皓元医药 上海皓元医药股份有限公司 2025年第五次临时股东会会议资料 二〇二五年九月 上海皓元医药股份有限公司 2025年第五次临时股东会会议资料 2025年第五次临时股东会会议资料 目 录 上海皓元医药股份有限公司 2025年第五次临时股东会会议须知 为维护全体股东的合法权益，确保股东会的正常秩序和议事效率，保证会议的顺 利进行，依据《中华人民共和国公司法》（以下简称"《公司法》"）《中华人民共 和国证券法》（以下简称"《证券法》"）《上市公司股东会规则》及《上海皓元医 药股份有限公司章程》（以下简称"《公司章程》"）《上海皓元医药股份有限公司股 东会议事规则》等相关规定，上海皓元医药股份有限公司（以下简称"公司"）特制定 本次股东会会议须知。 一、为确认出席会议的股东、股东代理人或其他出席者的出席资格，会议工作人员将 对出席会议者的身份进行必要的核对工作，请被核对者给予配合。为保证本次股东会的 严肃性和正常秩序，切实维护与会股东（或股东代理人）的合法权益，除出席会议 ...

Summary of Key Points Core Viewpoint - A total of 135 stocks received buy ratings from institutions today, with 17 stocks receiving initial attention from institutions, indicating a strong interest in the market and potential investment opportunities [1]. Institutional Ratings - 140 buy rating records were published today, with 29 of these providing future target prices. 13 stocks have an upside potential exceeding 20%, with AVIC Optoelectronics showing the highest potential at 61.62% [1]. - Notable stocks with high upside potential include Noli Shares at 48.46% and United Imaging Healthcare at 37.22% [1]. - 17 stocks received initial buy ratings from institutions, including Haimeixing and Hengli Hydraulic [1]. Market Performance - Stocks rated with buy ratings saw an average increase of 3.27%, outperforming the Shanghai Composite Index. 119 stocks experienced price increases, with several hitting the daily limit up [1]. - Stocks with significant declines included Noli Shares, Agricultural Bank, and Shoufang Environmental Protection, with declines of 3.23%, 2.93%, and 1.26% respectively [1]. Industry Focus - The most favored industries include power equipment and machinery, each with 17 stocks listed in the buy rating category. The pharmaceutical and communication sectors also attracted attention, with 15 and 6 stocks respectively [2]. - Specific stocks receiving multiple buy ratings include Betaini, Kebo Da, AVIC Optoelectronics, and Yunnan Baiyao, each with two buy ratings [2][3]. Detailed Stock Information - A selection of stocks with buy ratings includes: - Betaini (2 ratings, +2.22% today, PE 40.30) in beauty care - Kebo Da (2 ratings, +10.00% today, PE 27.44) in automotive - AVIC Optoelectronics (2 ratings, +0.57% today, PE 28.83) in defense and military [2][3]. - Other notable stocks include: - Yunnan Baiyao (2 ratings, +1.06% today, PE 14.56) in pharmaceuticals - Zhonglian Heavy Industry (2 ratings, +0.41% today, PE 11.39) in machinery [2][3]. Additional Stock Ratings - Additional stocks with single buy ratings include: - Xuji Electric (1 rating, +2.09% today, PE 18.44) in power equipment - Xugong Machinery (1 rating, -0.20% today, PE 13.29) in machinery - China Rare Earth (1 rating, +2.33% today, PE 174.07) in non-ferrous metals [3][4].

Market Overview - On September 4, the medical services sector declined by 4.28%, with Bid Pharma leading the drop [1] - The Shanghai Composite Index closed at 3765.88, down 1.25%, while the Shenzhen Component Index closed at 12118.7, down 2.83% [1] Stock Performance - Notable gainers in the medical services sector included: - Zihua Pharmaceutical (600721) with a closing price of 11.07, up 6.24% [1] - Innovation Medical (002173) with a closing price of 24.99, up 5.31% [1] - Wisdom Pharmaceutical (300149) with a closing price of 13.17, up 4.36% [1] - Major decliners included: - Bid Pharma (688073) with a closing price of 62.65, down 9.44% [2] - WuXi AppTec (603259) with a closing price of 101.94, down 8.06% [2] - Zhaoyan New Drug (603127) with a closing price of 30.92, down 7.48% [2] Capital Flow - The medical services sector experienced a net outflow of 1 billion yuan from institutional investors, while retail investors saw a net inflow of 359 million yuan [2][3] - Key stocks with significant capital flow included: - Innovation Medical (002173) with a net inflow of 136 million yuan from institutional investors [3] - Wisdom Pharmaceutical (300149) with a net inflow of 79 million yuan from institutional investors [3] - Meinian Health (002044) with a net inflow of 64 million yuan from institutional investors [3]

Core Viewpoint - The financial report of Haoyuan Pharmaceutical reveals a contradiction of "increased revenue and profit but decreased cash flow," indicating a shortfall in the quality of profitability amid scale expansion, raising alarms about the company's operational health [1] Financial Performance - In the first half of 2025, Haoyuan Pharmaceutical reported operating revenue of 1.311 billion yuan, a year-on-year increase of 24.20%, and a net profit attributable to shareholders of 155 million yuan, a significant year-on-year surge of 115.55% [1] - However, the operating cash flow turned negative, reaching -10.43 million yuan, a sharp decline of 113% year-on-year [1][2] - The company’s inventory impairment provision stood at 332 million yuan, accounting for 20.24% of the inventory book balance [1][3] Cash Flow and Inventory Issues - The negative cash flow is primarily attributed to high accounts receivable and inventory levels, with accounts receivable reaching 610 million yuan, up 16.89% year-on-year, and over 18.7% of accounts receivable being over one year old [2] - Inventory increased to 1.309 billion yuan, a 12.54% year-on-year rise, with over 80% consisting of raw materials and finished goods [2] - The inventory turnover days extended from 186 days in 2022 to 243 days in the first half of 2025, significantly higher than peers such as WuXi AppTec and Kanglong Chemical [2] Business Structure and Profitability - The company’s business is divided into front-end life science reagents and back-end raw materials and intermediates, with the front-end segment achieving revenue of 904 million yuan, a 29.2% increase, and a gross margin of 63.0%, contributing 69.4% of total revenue [5] - The back-end segment generated revenue of 399 million yuan, a 13.6% increase, but its gross margin fell to 17.8%, down from 20.05% in 2024, indicating competitive weaknesses [5] Sales and Marketing Expenses - Sales expenses surged to 130 million yuan, a 33.56% increase year-on-year, with the sales expense ratio rising from 9.25% in 2024 to 9.9% [7] Strategic Challenges - The company faces strategic challenges due to a lack of clear direction following a board reshuffle, with the new leadership failing to establish a coherent strategy for either maintaining traditional markets or advancing into high-end sectors [11][12] - The ongoing price competition from centralized procurement and the inability to secure significant orders due to underutilized capacity further complicate the company's operational landscape [11][12] R&D and Innovation - Haoyuan Pharmaceutical's R&D expenditure was 117 million yuan in the first half of 2025, a 4.23% increase, but the R&D expense ratio decreased from 9.0% in 2024 to 8.9%, falling below industry peers [12] - The company is at risk of being outpaced by technological advancements in the industry, particularly in areas like recombinant technology and synthetic biology, which could threaten its existing business model [13]

Group 1 - The article discusses the financial performance of a Contract Development and Manufacturing Organization (CDMO), highlighting a significant loss of 1,043.09 million, indicating a decline of 113.53% [1] - The CDMO sector shows a revenue figure of 7,709.98 million, suggesting a substantial market presence despite the reported losses [1] - The article mentions various segments within the CDMO industry, including GMP, IND, NDA&ANDA, and MAH, indicating a diverse operational focus [1] Group 2 - The document references specific projects and codes such as XDC and PROTAC, which may indicate ongoing research and development efforts within the CDMO sector [1] - There is a mention of CRO (Contract Research Organization), suggesting collaboration or integration within the CDMO framework [1] - The year 2024 is highlighted with specific codes, possibly indicating future projections or planned initiatives within the industry [1]

Core Viewpoint - The financial report of Haoyuan Pharmaceutical reveals a contradiction of "increased revenue and profit without increased cash flow," indicating concerns about the company's operational health amid its expansion efforts [2][4]. Financial Performance - In the first half of 2025, Haoyuan Pharmaceutical reported revenue of 1.311 billion yuan, a year-on-year increase of 24.20%, and a net profit attributable to shareholders of 155 million yuan, a significant year-on-year surge of 115.55% [2][4]. - However, the operating cash flow turned negative, reaching -10.43 million yuan, a sharp decline of 113% year-on-year [2][4]. - Inventory impairment provisions stood at 332 million yuan, accounting for 20.24% of the inventory balance, indicating potential issues with unsold products [5][7]. Cash Flow and Inventory Concerns - The company's accounts receivable exceeded 610 million yuan, up 16.89% year-on-year, with over 18.7% of receivables aged over one year [4][7]. - Inventory levels rose to 1.309 billion yuan, a 12.54% increase year-on-year, with over 80% consisting of raw materials and finished goods [4][7]. - The inventory turnover days increased from 186 days in 2022 to 243 days in the first half of 2025, significantly higher than competitors [4][7]. Business Structure and Profitability Risks - The business is divided into high-margin life science reagents and lower-margin raw materials and intermediates, with the former generating 904 million yuan in revenue (up 29.2%) and a gross margin of 63.0%, while the latter generated 399 million yuan (up 13.6%) with a gross margin of 17.8% [7][9]. - The disparity in profitability between the two segments raises concerns about the overall business health [7][9]. Increased Sales Expenses - Sales expenses surged to 130 million yuan, a 33.56% increase year-on-year, with the sales expense ratio rising from 9.25% in 2024 to 9.9% in 2025 [9][10]. Strategic Challenges and Market Position - The company faces challenges in transitioning from traditional markets to high-end sectors, with a lack of clear strategic direction following a board restructuring [11][14]. - The competitive landscape is tightening due to price wars initiated by centralized procurement, impacting the company's ability to secure significant orders [13][15]. - R&D investment remains below industry standards, with a research expense ratio declining from 9.5% in 2022 to 8.9% in the first half of 2025, which is lower than peers [14][15]. Industry Context - The challenges faced by Haoyuan Pharmaceutical reflect broader issues within the Chinese CDMO industry, as companies struggle to transition from "scale dividends" to "innovation dividends" amid evolving market dynamics [15].

2025 2024 12 19 2024 12 19 2026 12 31 2025 1-6 | 1 | | --- | | 2 | | 3 | | 4 | | 5 | | --- | | 6 | | 7 | | 8 | | 9 | | 10 | | 11 | | 12 | | 13 | | --- | | 14 | | 15 | | 16 | | 50% | 21 1 234 14.7 CDMO 33,219.50 20.24% 6,147.09 5,674.58 2024 28.15% 1 2025 | 2025 1-6 | 2024 1-6 | | | --- | --- | --- | | | | % | | 131,094.28 | 105,554.91 | 24.20 | | 15,176.15 | 7,040.77 | 115.55 | | 14,057.11 | 6,649.58 | 111.40 | | -1,043.09 | 7,709.98 | -113.53 | | 2025-6-30 | 2024-12-31 | | | | | % | | 302,310.91 | 287,787. ...

Group 1 - The recombinant protein concept sector rose by 0.03%, ranking fifth among concept sectors, with 17 stocks increasing in value [1] - Leading stocks in the sector included Chengdu Xian Dao, Baipu Sais, and Rejing Bio, which saw increases of 13.74%, 12.10%, and 5.07% respectively [1] - Stocks with the largest declines included Saiseng Pharmaceutical, *ST Wanfang, and Huiyu Pharmaceutical, which fell by 5.45%, 4.89%, and 3.31% respectively [1] Group 2 - The main capital flow into the recombinant protein concept sector showed a net outflow of 86 million yuan, with 15 stocks experiencing net inflows [2] - The stock with the highest net inflow was Dezhan Health, which saw a net inflow of 124 million yuan, followed by Yipin Hong, Chengdu Xian Dao, and Haoyuan Pharmaceutical with net inflows of 96.47 million yuan, 79.22 million yuan, and 65.75 million yuan respectively [2][3] Group 3 - In terms of capital inflow ratios, Dezhan Health, Haoyuan Pharmaceutical, and Yipin Hong had the highest net inflow rates at 15.06%, 10.07%, and 9.66% respectively [3] - The top stocks in the recombinant protein concept based on capital flow included Dezhan Health, Yipin Hong, Chengdu Xian Dao, and Haoyuan Pharmaceutical, with respective daily price changes of 4.85%, 1.29%, 13.74%, and 4.14% [3]