| 证券代码：688131 | 证券简称：皓元医药 | 公告编号：2025-120 | | --- | --- | --- | | 转债代码：118051 | 转债简称：皓元转债 | | 上海皓元医药股份有限公司 关于"皓元转债"预计满足赎回条件的提示性公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： 上海皓元医药股份有限公司（以下简称"公司"）股票自 2025 年 10 月 30 日至 2025 年 11 月 12 日期间，已有 10 个交易日的收盘价格不低于"皓元转 债"当期转股价格的 130%（即 52.61 元/股），若未来连续 20 个交易日内，仍有 5 个交易日公司股票的收盘价格不低于当期转股价的 130%（含 130%），将触发 《上海皓元医药股份有限公司向不特定对象发行可转换公司债券募集说明书》 （以下简称"《募集说明书》"）中规定的有条件赎回条款。届时，公司有权决定 是否按照债券面值加当期应计利息的价格赎回全部或部分未转股的"皓元转债"。 根据《上海证券交易所上市公司自律监管指引第 1 ...

Core Viewpoint - The medical services sector experienced a decline of 0.68% on November 11, with Haoyuan Pharmaceutical leading the drop. The Shanghai Composite Index closed at 4002.76, down 0.39%, while the Shenzhen Component Index closed at 13289.0, down 1.03% [1]. Group 1: Market Performance - The medical services sector saw significant individual stock movements, with Yinosh rising by 10.46% to a closing price of 50.15, while Haoyuan Pharmaceutical fell by 2.95% to 75.40 [1][2]. - The trading volume for Yinosh was 33,400 hands, resulting in a transaction amount of 163 million yuan, while Haoyuan Pharmaceutical had a trading volume of 21,800 hands and a transaction amount of 166 million yuan [1][2]. Group 2: Capital Flow - The medical services sector experienced a net outflow of 746 million yuan from institutional investors, while retail investors saw a net inflow of 562 million yuan [2]. - The capital flow data indicates that Sunshine Nuohe had a net outflow of 37.39 million yuan from institutional investors, while Meidi Xi saw a net inflow of 28.62 million yuan [3].

Market Overview - The medical services sector increased by 0.55% on November 6, with Haoyuan Pharmaceutical leading the gains [1] - The Shanghai Composite Index closed at 4007.76, up 0.97%, while the Shenzhen Component Index closed at 13452.42, up 1.73% [1] Top Gainers in Medical Services - Haoyuan Pharmaceutical (688131) closed at 77.71, up 4.13% with a trading volume of 44,300 shares and a transaction value of 338 million [1] - Bidai Pharmaceutical (688073) closed at 72.50, up 2.39% with a trading volume of 6,822 shares [1] - Innovative Medical (002173) closed at 24.25, up 2.32% with a trading volume of 448,800 shares and a transaction value of 1.077 billion [1] Top Losers in Medical Services - Baicheng Pharmaceutical (301096) closed at 54.08, down 3.41% with a trading volume of 128,600 shares and a transaction value of 706 million [2] - Berry Genomics (000710) closed at 13.79, down 2.41% with a trading volume of 277,400 shares [2] - Nossger (301333) closed at 64.59, down 2.05% with a trading volume of 33,800 shares [2] Capital Flow Analysis - The medical services sector experienced a net outflow of 472 million from institutional investors, while retail investors saw a net inflow of 280 million [2][3] - Notable net inflows from retail investors were observed in Innovative Medical and other companies, despite overall sector outflows [3] Individual Stock Capital Flow - Innovative Medical had a net outflow of 37.53 million from institutional investors, while retail investors contributed a net inflow of 47.58 million [3] - Haoyuan Pharmaceutical saw a net inflow of 12.35 million from institutional investors, with a slight net outflow from retail investors [3] - Bidai Pharmaceutical had a significant net inflow of 8.77 million from retail investors, despite a net outflow from institutional investors [3]

Core Insights - Haoyuan Pharmaceutical experienced a 5.2% increase in stock price, reaching 78.51 CNY per share, with a trading volume of 313 million CNY and a turnover rate of 1.94%, resulting in a total market capitalization of 16.652 billion CNY [1] Company Overview - Shanghai Haoyuan Pharmaceutical Co., Ltd. was established on September 30, 2006, and went public on June 8, 2021. The company specializes in the discovery of small molecule drugs, focusing on molecular building blocks and tool compounds, as well as the development and production of active pharmaceutical ingredients (APIs) and intermediates [1] - The main business revenue composition includes molecular building blocks, tool compounds, and biochemical reagents at 68.97%, with product sales contributing 63.42%, APIs and intermediates at 30.46%, technical services at 5.55%, and other supplementary services at 0.57% [1] Fund Holdings - According to data, one fund under GF Fund has a significant holding in Haoyuan Pharmaceutical. The GF Medical Selected Stock A (017479) held 39,000 shares in the third quarter, accounting for 5.25% of the fund's net value, ranking as the eighth largest holding [2] - The GF Medical Selected Stock A (017479) was established on July 6, 2023, with a latest scale of 41.6154 million CNY. Year-to-date returns stand at 44.25%, ranking 797 out of 4216 in its category, while the one-year return is 37.56%, ranking 854 out of 3909 [2] Fund Manager Profile - The fund manager of GF Medical Selected Stock A (017479) is Wang Ruidong, who has been in the position for 5 years and 172 days. The total asset scale of the fund is 4.817 billion CNY, with the best fund return during his tenure being 59.03% and the worst at -12.32% [3]

Core Insights - The pharmaceutical industry is experiencing a structural change driven by the growth cycles of major products, with significant opportunities emerging in innovative drugs, medical devices, and consumer healthcare [3][6][31] - The demand for pharmaceuticals is expected to improve in 2026, supported by policies encouraging innovation and a recovery in domestic consumption [3][7] - The supply side of the pharmaceutical industry is characterized by high entry barriers due to patent protections and government regulations, which helps maintain a stable competitive environment [4][5] Group 1: Industry Trends - The aging population, urbanization, and changing disease patterns are making the pharmaceutical industry a perpetual growth sector [3] - The global pharmaceutical market has seen rapid expansion from 2009 to 2019, followed by a surge in demand due to COVID-19, and is now entering a phase of recovery and growth [3][6] - The Chinese pharmaceutical industry is expected to gradually produce world-class companies, with increasing recognition of Chinese innovative drug assets by multinational corporations (MNCs) [4][5] Group 2: Investment Opportunities - Opportunities in innovative drugs are highlighted, particularly in oncology, metabolic diseases, and autoimmune diseases, with a focus on next-generation therapies and precision medicine [6][31] - The demand for innovative drugs is expected to remain strong, with policies improving medical insurance payments and the upcoming launch of commercial insurance drug catalogs [7][31] - The medical device sector is anticipated to recover, with a focus on domestic demand and international expansion, particularly in areas with low domestic production rates [7][8] Group 3: Company Performance - Major pharmaceutical companies like Eli Lilly, AbbVie, and AstraZeneca are experiencing significant growth driven by key products, with Eli Lilly's Tirzepatide generating $24.8 billion in sales [12][15] - The report identifies specific companies such as Hengrui Medicine, Hansoh Pharmaceutical, and BeiGene as outperformers in the market, with strong pipelines and global competitiveness [7][8] - The report emphasizes the importance of mergers and acquisitions (M&A) and business development (BD) strategies for MNCs, with China becoming a significant source of projects for top global pharmaceutical companies [22][24]

Core Insights - The pharmaceutical industry is positioned as a perennial growth sector due to aging populations, urbanization, and changing disease profiles, with a strong recovery expected in 2025 after a downturn from 2022 to 2024, driven by both innovative drugs and medical devices [2][3] - Demand and supply dynamics will remain central to the pharmaceutical industry's research, with innovation cycles and policy adjustments influencing demand growth [2][3] - The supply side is characterized by limited supply and high entry barriers, with increasing participation of Chinese companies in international competition, leading to the emergence of world-class enterprises in the pharmaceutical sector [3][4] Industry Overview - The pharmaceutical industry is expected to see significant growth in 2025, driven by a resurgence in demand for innovative drugs and a recovery in domestic medical device needs, alongside strong external demand [2] - The demand for pharmaceuticals typically fluctuates with innovation and policy cycles, with a notable increase in overseas business development (BD) opportunities anticipated in 2025 [2][5] - The Chinese pharmaceutical sector is increasingly recognized globally, with local companies making strides in various niche markets [3][4] Investment Opportunities - Opportunities in innovative drugs are highlighted, particularly in oncology, metabolic diseases, and autoimmune diseases, with a focus on next-generation therapies and precision medicine [5][29] - The report emphasizes the importance of understanding the supply-demand structure and industry upgrades when conducting detailed research on specific segments within the pharmaceutical industry [4][5] - The report identifies key players and segments for investment, including CXO services, medical devices, and consumer healthcare, with specific companies recommended for increased holdings [6][5] Market Dynamics - The report outlines the competitive landscape among top global pharmaceutical companies, noting significant changes in rankings due to the performance of key products [11][19] - Chinese companies are becoming a major source of projects for multinational corporations (MNCs), with increasing transaction volumes and values in recent years [19][21] - The report discusses the strategic focus of MNCs on acquiring innovative assets and technologies to strengthen their market positions, particularly in oncology and metabolic disease sectors [12][18] Future Trends - The report anticipates breakthroughs in various therapeutic areas, including oncology, metabolic diseases, and autoimmune diseases, with a focus on innovative treatment modalities such as TCE and in vivo CAR-T [29][30] - The small nucleic acid field is expected to accelerate, with significant advancements anticipated in 2026 across multiple indications [29][30] - The report highlights the importance of collaboration and co-development models as a means for Chinese companies to enhance their global competitiveness [25][28]

Core Viewpoint - Haoyuan Pharmaceutical emphasizes its commitment to industrialization, globalization, and branding strategies while effectively advancing its operational management to enhance company performance and value, aiming to reward investors with better operational results [1] Group 1 - The company is focused on industrialization as a key part of its development strategy [1] - Globalization is a significant aspect of the company's growth approach [1] - The company aims to strengthen its brand as part of its strategic initiatives [1] Group 2 - Haoyuan Pharmaceutical is actively working on improving its operational management [1] - The company is dedicated to continuously enhancing its performance and value [1] - There is a clear intention to provide better operational results to investors [1]

Investment Rating - The investment rating for the company is "Buy" (maintained) [1] Core Insights - The company reported strong performance in Q3 2025, with revenue of 2.059 billion yuan for the first three quarters, representing a year-on-year growth of 27.18%. The net profit attributable to shareholders reached 237 million yuan, up 65.09% year-on-year, indicating significant improvement in profit quality [4][7] - The front-end life science reagent business is the main growth driver, contributing 70% of total revenue in the first three quarters, with a revenue increase of over 31% [7] - The back-end business, focusing on specialty generic drug APIs and related intermediates, has a solid order backlog exceeding 590 million yuan, reflecting a 40.1% year-on-year increase [7] Financial Data and Profit Forecast - Total revenue is projected to reach 2.815 billion yuan in 2025, with a year-on-year growth rate of 24.0% [6] - The net profit attributable to shareholders is expected to be 321 million yuan in 2025, with a growth rate of 59.4% [6] - The gross margin for the front-end business reached 63.05% in the first half of 2025, an increase of 3.48 percentage points compared to the same period in 2024 [7] Business Development - The company has established a comprehensive service system in the ADC field, with its CDMO base in Chongqing successfully operational and passing EU QP audit [7] - The company is expected to see improved capacity utilization in the back-end business as existing orders are gradually converted into revenue, enhancing overall profitability [7] Valuation and Target Price - The target market capitalization for 2025 is estimated at 20.8 billion yuan, representing an upside potential of 22.62% from the current market value [7]

Core Insights - Shanghai Haoyuan Pharmaceutical Co., Ltd. reported a revenue of 2.06 billion yuan for the first three quarters of 2025, marking a year-on-year increase of 27.2%, and a net profit attributable to shareholders of 240 million yuan, up 65.1% year-on-year [2] - The company achieved a comprehensive gross margin of 49.7%, an increase of 2.2 percentage points compared to the previous year [2] - The company’s front-end life science reagent business generated 1.45 billion yuan in revenue, growing over 31.0% year-on-year, accounting for over 70% of the company's main business revenue [2] Business Segments - The front-end life science reagent business is thriving, with over 13,000 global partners and significant revenue growth [2] - The back-end business, focusing on high-difficulty and high-barrier specialty technologies, achieved 600 million yuan in revenue, a year-on-year increase of 16.9% [2] - The back-end small molecule business has an order backlog of 630 million yuan, reflecting a 50% year-on-year increase and consistent quarter-on-quarter growth for four consecutive quarters [2] Technological Advancements - The company has developed an integrated service platform for ADC payload-linker CMC and established a comprehensive service system centered in Shanghai, Ma'anshan, and Chongqing, successfully undertaking over 90 ADC projects in the first three quarters [3] - Haoyuan Pharmaceutical is leveraging its extensive high-value data to integrate AI technology into drug development, creating a one-stop drug screening platform that offers various screening technologies and optimization services [3] Future Outlook - The company anticipates that the innovation wave in the biopharmaceutical industry and global market opportunities will provide significant growth potential [4] - With ongoing synergy across business segments and deep integration of cutting-edge technologies and industry resources, the company aims to expand its competitive edge in innovative drug services [4] - The long-term strategy focuses on globalization and technological iteration to seize industry transformation opportunities and contribute more value to pharmaceutical innovation [4]

Investment Rating - The report maintains a "Buy" rating for the company [5] Core Views - The company reported better-than-expected performance for Q3 2025, with revenue of 7.48 billion yuan, representing a year-over-year growth of 32.76%, and a net profit of 0.85 billion yuan, up 16.39% year-over-year [1] - The strong performance is attributed to high growth in the front-end business, which generated 5.4 billion yuan in revenue, a year-over-year increase of over 36% [1][2] - The company has improved efficiency and strictly controlled costs, contributing to the positive financial results [1] Summary by Sections Front-end Business - The front-end business, including tool compounds and biochemical reagents, serves as the primary growth engine, maintaining high revenue growth [2] - The molecular building blocks segment has seen a significant increase in customer and order numbers, marking it as a secondary growth engine [2] - As of June 2025, the company has a reserve of over 52,000 tool compounds and biochemical reagents, and approximately 95,000 molecular building blocks, creating a comprehensive compound library [2] Back-end Business - The back-end business, which includes APIs, intermediates, and formulations, has a strong order backlog exceeding 5.9 billion yuan, reflecting a year-over-year growth of 40.1% [3] - The company is enhancing its competitive edge in the XDC segment and has established a strategic layout across Shanghai, Ma'anshan, and Chongqing [3] Financial Forecast and Valuation - The company’s net profit forecasts for 2025 and 2026 have been adjusted to 2.88 billion yuan and 4.00 billion yuan, respectively, with a new forecast for 2027 set at 5.19 billion yuan [3] - The estimated EPS for 2025, 2026, and 2027 are 1.36 yuan, 1.89 yuan, and 2.45 yuan, respectively, with corresponding P/E ratios of 62, 45, and 35 [3]