信息披露义务人名称：上海加财投资管理有限公司 住所：上海市嘉定区安亭镇曹安公路 5128 号 1 幢 1 层 1155 室 通讯地址：上海市黄浦区龙华东路 868 号办公 A1204 室 信息披露义务人名称：Greenland Financial Overseas Investment Group Co., Ltd 住所：Unit 8, 3/F., Qwomar Trading Complex, Blackburne Road, Port Purcell, Road Town,Tortola, British Virgin Islands 通讯地址：上海市黄浦区龙华东路 868 号办公 A 楼 1508 室 股份变动性质：H 股股份出借导致权益比例降低至 5%以下。 签署日期：2025 年 12 月 3 日 上市地点：上海证券交易所/香港联合交易所 股票简称：君实生物 股票代码：688180（A 股）、01877（H 股） 信息披露义务人声明 一、信息披露义务人根据《中华人民共和国证券法》（以下简称"《证券法》"）、 《上市公司收购管理办法》（以下简称"《收购办法》"）、《公开发行证券的公司 信息披露内容与格 ...

君实生物公告称，2025年12月3日收到持股5%以上股东绿地金融、上海加财及Greenland通知，因经营需 要，Greenland于12月2日进行H股股份出借，致三者合计持股由5138.64万股降至4838.64万股，占总股本 比例由5.0051%降至4.7129%，权益变动触及5%刻度。本次变动不触及要约收购，不涉及资金来源，也 不会使公司控股股东及实际控制人发生变化。 ...

每经AI快讯，12月2日，港股生物医药板块持续走低，泰格医药、君实生物跌超3%，百济神州跌超 2%。 ...

Group 1 - The core viewpoint of the news is that Junshi Biosciences experienced a decline in stock price and significant trading activity, indicating high levels of financing and short selling [1] - On December 1, Junshi Biosciences' stock fell by 1.59%, with a trading volume of 209 million yuan, and a net financing outflow of 207.43 million yuan [1] - The total financing and securities balance for Junshi Biosciences reached 1.378 billion yuan, with the financing balance accounting for 4.89% of the circulating market value, indicating a high level compared to the past year [1] Group 2 - Junshi Biosciences, established on December 27, 2012, focuses on the research and commercialization of monoclonal antibody drugs, with 90.67% of its revenue coming from drug sales [2] - For the period from January to September 2025, Junshi Biosciences reported a revenue of 1.806 billion yuan, representing a year-on-year growth of 42.06%, while the net profit attributable to shareholders was -596 million yuan, an increase of 35.72% year-on-year [2] - As of September 30, 2025, the number of shareholders increased by 15.17% to 35,900, while the average circulating shares per person decreased by 12.96% to 21,361 shares [2]

Core Insights - Junshi Bioscience has transformed from a small laboratory in Zhangjiang, Shanghai, to a leading player in the global biopharmaceutical industry, with over 50 innovative drug pipelines in just 13 years [1][2] - The company's core product, the PD-1 monoclonal antibody Toripalimab, has gained global recognition, becoming the first self-developed innovative biopharmaceutical from China to receive FDA approval [1][2] R&D and Innovation - Junshi Bioscience shifted from "single-point breakthroughs" to "platform innovation," focusing on multiple therapeutic areas and developing a robust pipeline of over 50 new drugs [4][5] - The company has successfully developed Toripalimab, which addresses local high-incidence cancers and has broken the monopoly of imported drugs in China [2][4] - The company plans to advance several innovative drugs, including JS212 and JS213, into clinical trials by 2025, aiming for a comprehensive drug pipeline [5][6] Global Expansion and Commercialization - Junshi Bioscience is transitioning from a "R&D-focused company" to a "full-chain operator," with a strong emphasis on internationalization as a key highlight for the next five years [6] - The company has established a commercial network covering over 80 countries through partnerships and self-built teams, aiming to penetrate emerging markets in Southeast Asia [6][7] - The production capabilities at the Shanghai Lingang base support the company's ambition for global commercialization, with a fully autonomous production process [6] Market Position and Future Outlook - The success of Toripalimab marks a significant shift in the landscape of Chinese innovative drugs, moving from "importing" to "exporting" [1][2] - The company aims to redefine treatment boundaries with next-generation therapies, including bispecific antibodies and antibody-drug conjugates, supported by AI-assisted research [5][6] - Junshi Bioscience is committed to pushing more products into late-stage clinical trials and registration phases during the 14th Five-Year Plan period [5][6]

Core Viewpoint - Shanghai is emerging as a global hub for biopharmaceutical innovation, with local companies leveraging innovation, transformation, and internationalization to enhance their competitiveness on the world stage [4][6]. Group 1: Innovation - Junshi Bioscience has focused on unmet clinical needs, successfully launching its PD-1 monoclonal antibody, which has reshaped the landscape for domestic innovative drugs in international markets [4][5]. - Fosun Pharma has achieved significant milestones in innovation, including the development of China's first self-developed CAR-T cell therapy product and the first PD-1 monoclonal antibody approved for first-line treatment of small cell lung cancer [8][9]. - The company has established a comprehensive innovation system, with over 12 innovative drugs launched during the 14th Five-Year Plan period, focusing on oncology, immune inflammation, and chronic diseases [11][12]. Group 2: Transformation - First Pharmaceutical has adapted to the challenges posed by e-commerce in the pharmaceutical retail sector by integrating smart healthcare services, revitalizing its traditional pharmacy model [5][30]. - Fosun Pharma's transformation journey aligns with the rapid evolution of China's innovative drug industry, emphasizing a combination of generics and original innovations [5][11]. - Seer Bio has expanded its research into broader biotoxin treatments after mastering snake venom therapies, indicating a strategic shift towards a wider range of biological toxin therapies [5][26]. Group 3: Internationalization - Fosun Pharma has successfully penetrated international markets, with its anti-tumor innovative drug, Slulizumab, approved in approximately 40 countries, showcasing the company's global strategy [12][13]. - Junshi Bioscience has transitioned from a "single-point breakthrough" to "platform innovation," with its core product, Toripalimab, now available in major markets including the US and EU [16][17]. - The company is building a global commercialization network through partnerships and local teams, aiming to enhance its international presence [22][23]. Group 4: Market Challenges and Opportunities - First Pharmaceutical faces significant challenges in the pharmaceutical distribution industry, including regulatory changes, evolving sales models, and increased consumer expectations for professional services [32][33]. - Despite these challenges, First Pharmaceutical has reported substantial revenue growth, with sales increasing from 1.398 billion yuan in 2021 to 1.915 billion yuan in 2024 [32]. - The company is strategically focusing on the silver economy, aiming to develop integrated services for the elderly, aligning with national policies on aging [34][35].

Investment Rating - The report does not explicitly state an investment rating for the industry [2] Core Views - The pharmaceutical and biotechnology sector saw a weekly increase of 2.67%, underperforming the Wind All A index (2.9%) but outperforming the CSI 300 index (1.64%). The raw material drug sector experienced a decline of 4.27%, while chemical preparations and pharmaceutical circulation products increased by 4.18% and 3.71%, respectively [3][8] - Recent policies in Shanghai and Beijing aim to support the high-quality development of the medical device industry, indicating a shift towards innovation and global competitiveness in this sector. The report suggests monitoring the transformation progress of leading companies in the medical device field [3][12] - Flu activity is on the rise, with the percentage of flu-like cases reported by sentinel hospitals in southern provinces reaching 7.8%, up from 6.8% the previous week, and higher than the same period in 2022 and 2024 [3][11] Summary by Sections Market Weekly Review - The pharmaceutical and biotechnology sector increased by 2.67% from November 24 to November 28, 2025, with raw material drugs declining by 4.27% and chemical preparations increasing by 4.18% [8][9] - Individual stock performances included significant gains for Haiwang Biological (38.2%), Yue Wannianqing (36.2%), and Guangji Pharmaceutical (31.7%), while *ST Changyao (-15.3%), Huitai Medical (-9.6%), and Kangwei Century (-8.8%) saw notable declines [11] Industry News and Key Company Announcements Important Industry Events - The report highlights the increase in flu-like illness percentages in both southern (7.8%) and northern (8.6%) provinces, indicating a significant rise in flu activity compared to previous years [11][12] Industry News - Significant approvals were noted, including the NMPA's approval of Xinmeiyue® for treating moderate to severe plaque psoriasis and the FDA's accelerated approval of Sibeprenlimab for IgAN treatment [12][14] Company Announcements - Notable announcements include the FDA approval of a generic injectable drug by Jianyou Co. and the successful completion of a Phase III trial for JS001sc, a subcutaneous PD-1 monoclonal antibody for non-small cell lung cancer [15][16]

Core Viewpoint - The company has approved a plan to manage temporarily idle raised funds through cash management, aiming to enhance fund utilization efficiency while ensuring the safety and intended use of the funds [1][3][7] Cash Management Overview - The purpose of cash management is to improve the efficiency of raised fund usage and generate additional returns for the company and its shareholders, without affecting the normal operation of investment projects [1][3] - The company plans to invest up to RMB 2.4 billion in safe, liquid principal-protected investment products, including but not limited to time deposits and structured deposits, within a 12-month period [1][3] - The funds for cash management will come from temporarily idle raised funds from the company's 2022 A-share issuance [1][3] Implementation and Oversight - The board of directors has authorized the chairman to make investment decisions and sign relevant legal documents, with the finance department responsible for implementation [2][3] - The company will adhere to regulatory requirements for information disclosure and will not change the intended use of the raised funds [2][3] Impact on Daily Operations - The cash management plan will not affect the normal cash flow needs or the operation of investment projects, ensuring that the company's main business continues to develop normally [6][7] - As of June 30, 2025, all initial public offering projects have been completed, and the raised funds will be used in accordance with the overall project schedule [6][7] Opinions from Intermediaries - The company's sponsor, Guotai Junan Securities, has confirmed that the cash management plan complies with relevant regulations and will not change the intended use of the raised funds, thus benefiting the company and its shareholders [7]

Core Viewpoint - Junshi Biosciences plans to utilize up to 2.4 billion yuan of temporarily idle raised funds for cash management to enhance fund efficiency and returns for the company and its shareholders [1] Group 1: Cash Management Purpose - The purpose of cash management is to improve the efficiency of raised funds and to reasonably utilize temporarily idle funds while ensuring that it does not affect the construction and use of investment projects [1] - The company aims to increase returns for both the company and its shareholders through this cash management strategy [1] Group 2: Investment Strategy - Junshi Biosciences will strictly control risks according to relevant regulations and intends to invest in high-safety, liquid principal-protected investment products [1] - The investment products include but are not limited to notice deposits, time deposits, agreement deposits, combination deposits, certificates of deposit, and structured deposits [1] - The funds will not be used for pledging or for investment purposes in securities [1]

Core Viewpoint - Junshi Biosciences (01877) plans to invest temporarily idle raised funds in low-risk, high-liquidity principal-protected investment products, adhering to relevant regulations [1] Group 1: Investment Strategy - The company intends to use a maximum of RMB 2.4 billion (including principal) of temporarily idle raised funds for cash management [1] - Investment products include but are not limited to notice deposits, time deposits, agreement deposits, combination deposits, certificates of deposit, and structured deposits [1] - The investment will not be used for pledging or for securities investment purposes [1] Group 2: Investment Duration and Management - The company plans to invest the idle funds in tranches with varying maturities, with the longest maturity not exceeding 12 months [1] - Within the specified limit and duration, the funds can be used in a rolling manner [1]