的 法 律 意 见 书 上海兰迪律师事务所 关于荣昌生物制药(烟台)股份有限公司 2023 年 A 股限制性股票激励计划 首次授予部分第一个归属期归属条件成就 暨作废部分限制性股票 中国上海市虹口区东大名路 1089 号北外滩来福士广场东塔 16 楼（20082） 16th Floor, East Tower, Raffles City, No.1089, Dongdaming Road, Hongkou District, 200082, Shanghai, China Tel: 8621-66529952 Fax: 8621-66522252 www.landinglawyer.com 上海兰迪律师事务所 关于荣昌生物制药(烟台)股份有限公司 2023 年 A 股限制性股票激励计划 首次授予部分第一个归属期归属条件成就 暨作废部分限制性股票的 法律意见书 致:荣昌生物制药(烟台)股份有限公司 上海兰迪律师事务所接受荣昌生物制药(烟台)股份有限公司(以下简称"荣 昌生物"或"公司",证券代码为 688331）的委托,为公司实施 2023年 A 股限 制性股票激励计划(以下简称"本激励计划")所涉及的相关事宜 ...

荣昌生物制药（烟台）股份有限公司（以下简称"公司"）董事会薪酬与考核 委员会依据《中华人民共和国公司法》（以下简称"《公司法》"）《中华人民共和 国证券法》（以下简称"《证券法》"）《上市公司股权激励管理办法》（以下简称"《管 理办法》"）《上海证券交易所科创板股票上市规则》（以下简称"《上市规则》"） 等相关法律、法规及规范性文件和《荣昌生物制药（烟台）股份有限公司章程》 （以下简称"《公司章程》"）的有关规定对公司 2022 年 A 股限制性股票激励计 划（以下简称"2022 年激励计划"）A 类权益第三个、B 类权益首次授予第二个归 属期及 2023 年 A 股限制性股票激励计划（以下简称"2023 年激励计划"）首次授 予第一个归属期归属名单进行审核，发表核查意见如下： 本次拟归属的激励对象符合《公司法》《证券法》等法律、法规和规范性文 件以及《公司章程》规定的任职资格，符合《管理办法》《上市规则》等法律、 法规和规范性文件规定的激励对象条件，符合各项激励计划规定的激励对象范围， 其作为公司各项激励计划激励对象的主体资格合法、有效，激励对象获授限制性 股票的归属条件已成就。 荣昌生物制药（烟台）股份有 ...

二、董事会会议审议情况 （一）审议通过《关于公司 2022 年 A 股限制性股票激励计划之 A 类权益第 三个归属期及 B 类权益首次授予第二个归属期符合归属条件的议案》 根据《上市公司股权激励管理办法》《公司 2022 年 A 股限制性股票激励计 划》及其摘要的相关规定及公司 2022 年第二次临时股东大会、2022 年第一次 A 股类别股东大会及 2022 年第一次 H 股类别股东大会的授权，董事会认为公司 2022 年 A 股限制性股票激励计划之 A 类权益第三个归属期及 B 类权益首次授予 的第二个归属期规定的归属条件已经成就，同意公司为符合条件的激励对象办理 归属相关事宜。 | 证券代码：688331 | 证券简称：荣昌生物 公告编号：2025-059 | | --- | --- | | 港股代码：09995 | 港股简称：榮昌生物 | 荣昌生物制药（烟台）股份有限公司 第二届董事会第三十三次会议决议公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 一、董事会会议召开情况 荣昌生物制药（烟台）股份有限公司（以 ...

Core Insights - 2025 marks a pivotal year for China's innovative pharmaceuticals, with a significant increase in international collaborations and licensing agreements, indicating a shift from a pharmaceutical giant to a stronghold in the industry [1][3] - The total amount of outbound licensing agreements exceeded $100 billion, with upfront payments reaching $8.1 billion, showcasing a transition to multi-layered cooperation models [1][3] - China's biopharmaceutical market remains the second largest globally, with innovative drugs accounting for approximately 30% of global research, reflecting a critical leap from following to competing on a global scale [1][3] Internationalization - The internationalization of China's pharmaceutical industry saw explosive growth in 2025, highlighted by a surge in business development (BD) transactions and the popularity of "A+H" listings [3][4] - The total amount of outbound licensing for innovative drugs reached over $100 billion, a 75% increase from 2024, indicating a shift from merely selling products to actively engaging in global markets [3][4] - Notable BD transactions include significant agreements between major Chinese pharmaceutical companies and international firms, such as a $12.5 billion deal between Hengrui Medicine and GSK [3][4] Innovation - In 2025, advancements in cutting-edge technologies such as antibody-drug conjugates (ADC) and dual antibodies have shown promising results in cancer treatment [7][8] - The third-generation ADC technology has become mainstream, with significant efficacy demonstrated in treating solid tumors [7] - The dual antibody sector continues to lead, with Chinese companies achieving remarkable results in clinical trials, such as a 91% improvement in progression-free survival compared to existing treatments [8] Policy Support - The policy support for innovative drugs in China has reached unprecedented levels, with a notable increase in the number of approved innovative drugs [10][11] - The National Medical Products Administration approved 69 innovative drugs in 2025, a 44% increase from the previous year, covering various therapeutic areas [10] - The payment system for innovative drugs has been significantly upgraded, enhancing accessibility and affordability for patients [10][11] Mergers and Acquisitions - The pharmaceutical sector has seen a surge in mergers and acquisitions, with over 400 transactions announced globally, totaling approximately $111 billion, marking a 50% increase from 2024 [13][14] - Domestic mergers also showed strong activity, with significant deals indicating a shift towards quality improvement and resource consolidation among leading companies [13][14] - The trend reflects a transition from scale expansion to enhancing quality and efficiency, with companies focusing on high-value clinical pipelines [14]

Group 1 - The biopharmaceutical sector increased by 0.18% on December 25, with Jindike leading the gains [1] - The Shanghai Composite Index closed at 3959.62, up 0.47%, while the Shenzhen Component Index closed at 13531.41, up 0.33% [1] - Key stocks in the biopharmaceutical sector showed various performance, with Jindike (688670) rising by 4.66% to a closing price of 22.45 [1] Group 2 - The biopharmaceutical sector experienced a net outflow of 307 million yuan from institutional investors, while retail investors saw a net inflow of 359 million yuan [2] - Notable declines included Te Bao Biological (688278), which fell by 3.14% to a closing price of 80.90 [2] - The trading volume and turnover for various stocks in the sector varied significantly, with Wan Ze Co. (000534) achieving a turnover of 488 million yuan [1][2] Group 3 - Jindike (688670) had a net inflow of 25.23 million yuan from institutional investors, while retail investors had a net outflow of 23.95 million yuan [3] - Other stocks like Zhi Xiang Jin Tai (688443) and Shen Zhou Cell (688520) also showed mixed net inflows and outflows from different investor categories [3] - The overall trend indicates a divergence in investor sentiment, with institutional investors pulling back while retail investors increased their positions [2][3]

Core Viewpoint - Rongchang Biopharmaceuticals has shown significant stock price growth this year, but recent trading data indicates a decline in the short term, raising questions about future performance and investor sentiment [1][3]. Group 1: Stock Performance - As of December 24, Rongchang Biopharmaceuticals' stock price increased by 2.07% to 81.76 CNY per share, with a market capitalization of 46.09 billion CNY [1]. - The stock has risen 171.54% year-to-date, but has experienced a decline of 0.17% over the last five trading days, 11.37% over the last 20 days, and 20.83% over the last 60 days [1]. - The company has appeared on the "Dragon and Tiger List" four times this year, with the most recent instance on June 26, where it recorded a net buy of -137 million CNY [1]. Group 2: Company Overview - Rongchang Biopharmaceuticals, established on July 4, 2008, and listed on March 31, 2022, is based in Yantai, Shandong, China, focusing on innovative biopharmaceuticals, particularly in antibody-drug conjugates (ADC) and therapeutic antibodies [2]. - The company aims to develop first-in-class and best-in-class biopharmaceuticals to address significant unmet clinical needs in autoimmune diseases, oncology, and ophthalmology [2]. - The revenue composition shows that 99.46% comes from product sales, with minimal contributions from material sales and leasing services [2]. Group 3: Financial Performance - For the period from January to September 2025, Rongchang Biopharmaceuticals reported revenue of 1.72 billion CNY, reflecting a year-on-year growth of 42.27%, while the net profit attributable to shareholders was -551 million CNY, an increase of 48.60% year-on-year [3]. Group 4: Shareholder Structure - As of September 30, 2025, the number of shareholders increased by 18.33% to 15,300, with an average of 10,639 circulating shares per person, down 15.54% from the previous period [3]. - The second-largest shareholder is Hong Kong Central Clearing Limited, holding 8.84 million shares, a decrease of 510,800 shares from the previous period [4]. - Other notable shareholders include Wanjiayou Selected and Industrial Bank Frontier Medical Stock A, with varying changes in their holdings [4].

Core Viewpoint - The Hong Kong Stock Connect innovative drug sector is experiencing a rebound, with significant trading activity and price increases among leading innovative drug companies, indicating a positive shift in market sentiment towards this sector [1][3]. Group 1: Market Performance - The Hong Kong Stock Connect innovative drug ETF (520880) reached a peak increase of 1.53% and traded over 140 million yuan during the session [1]. - Leading companies in the innovative drug sector, such as CSPC Pharmaceutical Group, recorded gains exceeding 5%, while others like 3SBio and Hengrui Medicine saw increases of over 2% [1]. Group 2: Investment Insights - Analysts from Zhongtai Securities noted that the current innovative drug market differs from the 2019-2021 period, as the sector is transitioning from narrative to actual performance, with trading volumes hitting new highs [1]. - Long-term support from domestic policies for innovative drugs is evident, with the introduction of commercial insurance directories enhancing payment capabilities [1][3]. - Changjiang Securities emphasized the emergence of a new policy support cycle for the pharmaceutical industry, particularly for innovative drugs, suggesting a focus on high-quality assets with strong overseas potential [3]. Group 3: ETF Characteristics - The Hong Kong Stock Connect innovative drug ETF (520880) is designed to track the Hang Seng Hong Kong Stock Connect Innovative Drug Select Index, which has three key advantages: it exclusively includes innovative drug companies, has a high concentration of leading firms, and employs risk control measures for less liquid stocks [3][4]. - The top ten holdings in the ETF account for over 72% of its weight, showcasing the dominance of leading innovative drug companies [4]. Group 4: Alternative Investment Options - For investors seeking to mitigate volatility while still focusing on innovative drugs, the only ETF in the market (562050) offers a mix of innovative and traditional Chinese medicine stocks, providing a balanced approach [4].

每经AI快讯，荣昌生物(09995.HK)涨超3%，截至发稿涨3.41%，报78.8港元，成交额9838.12万港元。 ...

Core Viewpoint - Rongchang Biologics (09995) has seen a stock increase of over 3%, currently at 78.8 HKD, with a trading volume of 98.38 million HKD, following the release of promising clinical trial data for its PD-1/VEGF bispecific antibody RC148 [1] Group 1: Clinical Research and Development - According to Huaxi Securities (002926), the clinical research data for RC148, both as a monotherapy and in combination therapy for non-small cell lung cancer (NSCLC), has demonstrated outstanding clinical efficacy and manageable safety [1] - The early data from the RC148-C001 study has led to the drug receiving Breakthrough Therapy Designation (BTD) in China for the treatment of locally advanced or metastatic NSCLC that has failed prior PD-1/PD-L1 inhibitors and platinum-based chemotherapy [1] - The company is actively advancing its clinical trials, with the Phase II trial for RC148 in combination therapy for first-line NSCLC having completed patient enrollment and plans to initiate a Phase III clinical study [1]

Core Viewpoint - Rongchang Biopharmaceutical (09995) has seen a stock increase of over 3%, currently at 78.8 HKD, with a trading volume of 98.38 million HKD, following the release of promising clinical trial data for its PD-1/VEGF bispecific antibody RC148 in treating non-small cell lung cancer [1] Group 1: Clinical Research and Development - The research report from Huaxi Securities highlights that the clinical data for RC148, both as a monotherapy and in combination therapy, demonstrates significant clinical efficacy and manageable safety, achieving a dual-pathway breakthrough [1] - Based on early data from the RC148-C001 study, the drug has received Breakthrough Therapy Designation (BTD) in China for treating locally advanced or metastatic non-small cell lung cancer that has failed prior PD-1/PD-L1 inhibitors and platinum-based chemotherapy [1] - The company is actively advancing its clinical trials, with the Phase II trial for RC148 in combination therapy for first-line non-small cell lung cancer having completed patient enrollment, and plans to initiate a Phase III clinical study [1]