股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年7月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 諾誠健華醫藥有限公司（於開曼群島註冊成立的有限公司） 呈交日期: 2025年8月5日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 09969 | 說明 | | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 25,000,000,000 | USD | | 0.000002 | USD | | 50,000 | | 增加 / 減少 (-) | | | | | | | USD | | | | 本月底結存 | | | 25,000,000,000 | USD | | 0.000002 | USD | | 5 ...

諾誠健華醫藥有限公司 （ 於 開 曼 群 島 註 冊 成 立 的 有 限 公 司 ） （股份代號：9969） InnoCare Pharma Limited 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部或任何部分內容而產生或 因依賴該等內容而引致的任何損失承擔任何責任。 承董事會命 於本公告日期，董事會包括主席兼執行董事崔霽松博士；執行董事趙仁濱博士；非執行董事 施一公博士及謝榕剛先生；以及獨立非執行董事胡蘭女士、董丹丹博士及及管坤良教授。 諾誠健華醫藥有限公司（「本公司」）董事會（「董事會」）謹此宣佈，本公司將於 2025年8月19日（星期二）舉行董事會會議，藉以（其中包括）考慮並批准本公司 及其附屬公司截至2025年6月30日止六個月中期業績及其發佈。 諾誠健華醫藥有限公司 主席兼執行董事 崔霽松博士 香港，2025年8月5日 董事會召開日期 ...

Core Viewpoint - The company, Innovent Biologics (09969.HK), has announced that it will hold a board meeting on August 19, 2025, to consider and approve its interim results for the six months ending June 30, 2025 [1] Summary by Relevant Categories - **Company Announcement** - Innovent Biologics will hold a board meeting on August 19, 2025 [1] - The meeting will focus on considering and approving the interim results for the six months ending June 30, 2025 [1]

FF301 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年7月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 諾誠健華醫藥有限公司（於開曼群島註冊成立的有限公司） 呈交日期: 2025年8月5日 I. 法定/註冊股本變動 FF301 II. 已發行股份及/或庫存股份變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 09969 | 說明 | | | | | | | | | 已發行股份（不包括庫存股份）數目 | | 庫存股份數目 | | 已發行股份總數 | | | 上月底結存 | | | 1,494,598,235 | | 1,686,000 | | 1,496,284,235 | | 增加 / 減少 (-) | | | | | | | | | 本月底結存 | | | 1,494,598,235 | | 1,686,000 | | 1,496,28 ...

（股份代號：9969） 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部或任何部分內容而產生或 因依賴該等內容而引致的任何損失承擔任何責任。 InnoCare Pharma Limited 諾誠健華醫藥有限公司 （ 於 開 曼 群 島 註 冊 成 立 的 有 限 公 司 ） 諾誠健華醫藥有限公司 主席兼執行董事 崔霽松博士 香港，2025年8月5日 董事會召開日期 於本公告日期，董事會包括主席兼執行董事崔霽松博士；執行董事趙仁濱博士；非執行董事 施一公博士及謝榕剛先生；以及獨立非執行董事胡蘭女士、董丹丹博士及及管坤良教授。 諾誠健華醫藥有限公司（「本公司」）董事會（「董事會」）謹此宣佈，本公司將於 2025年8月19日（星期二）舉行董事會會議，藉以（其中包括）考慮並批准本公司 及其附屬公司截至2025年6月30日止六個月中期業績及其發佈。 承董事會命 ...

中银证券指出，创新领域伴随2024年国家医保谈判的逐步落地，建议关注进入兑现或者放量阶段相关标 的，以及未来具备出海能力的企业，如信达生物、康方生物、诺诚健华等标的。 创新药概念8月1日盘中再度活跃，截至发稿，维康药业20%涨停，悦康药业涨超15%，热景生物涨超 12%续创新高，昂利康、福元医药等涨停，奇正藏药斩获3连板。 机构表示，当下医药板块，一方面政策端的态度正在逐步转向，集采规则逐步优化；另一方面，医药板 块经过几年的研发投入，在研管线逐步进入收获期，并且近期医药行业海外BD的趋势正在加速，这也 进一步体现出当下我国创新药在全球的竞争力，医药行业正逐步走出低谷，伴随后续政策面以及企业盈 利面的逐步改善，医药板块有望迎来估值重塑的机会。 （文章来源：证券时报网） ...

在年内大盘整体上涨的背景下，部分权益类基金也交出了亮眼的成绩单。公开数据显示，截至7月29日，共有23只基金（份额分开计算，下同） 的年内收益率实现翻倍，其中有七成为医药相关基金。若拉长时间至近一年来看，则有多达134只"翻倍基"，其中，医药相关基金占比超四成，收 益率最高超160%。展望后市，业内人士仍看好创新药等细分方向，但也有观点提醒需注意短期回调可能带来的风险。 15只医药基金年内收益翻倍 业内仍看好创新药领域 从主动型医药主题基金的最新重仓情况来看，部分涨幅较高的产品重仓股大致相同。例如，截至2025年二季度末，前述提及的长城医药产业精选 混合发起式的前十大重仓股包括三生制药、信达生物、热景生物、一品红、石药集团、泽璟制药、益方生物、诺诚健华、科伦博泰生物-B、康弘 药业。 同期，永赢医药创新智选混合发起式、中欧医疗创新股票的前十大重仓股中也均持有三生制药、科伦博泰生物-B。交易行情数据显示，截至7月 30日收盘，三生制药、科伦博泰生物-B在年内累计上涨428.9%、138%。 对于当前医药板块的投资机遇，前海开源基金首席经济学家杨德龙表示，"上半年创新药板块带动相关医药基金上涨或是中长期趋势，下半 ...

Group 1 - The global market for Multiple Sclerosis (MS) products is approximately $20 billion, with a significant focus on Relapsing Multiple Sclerosis (RMS) treatments [1][2] - The existing approved products primarily target RMS, while there is a notable unmet clinical need in the Progressive Multiple Sclerosis (PMS) area, with only one product, Ocrelizumab, approved for Primary Progressive Multiple Sclerosis (PPMS) [2][3] - The patient base for MS is substantial, with projections indicating that the number of MS patients globally will reach 3.71 million by 2030 [1] Group 2 - BTK inhibitors are expected to address the treatment gap in PMS, with their ability to penetrate the blood-brain barrier and modulate key immune cells [3] - Sanofi's Tolebrutinib and Roche's Fenebrutinib are anticipated to release Phase III clinical trial data in the second half of 2025, which could enhance the value of BTK inhibitors in PMS [3][4] - Tolebrutinib has received priority review from the FDA for the treatment of non-relapsing Secondary Progressive Multiple Sclerosis (nrSPMS), with a PDUFA date set for September 28, 2025 [4]

Core Insights - The report maintains a positive outlook on small molecule drug conjugates (SMDCs) and related companies, highlighting their potential in cancer treatment due to their ability to enhance efficacy while reducing toxicity [1][5][17] - The report emphasizes the clinical advantages of SMDCs, including better tumor penetration, reduced toxicity to normal cells, and easier control over synthesis and costs compared to antibody-drug conjugates (ADCs) [5][11][12] - The report identifies domestic biopharmaceutical companies, particularly Affinivax, as leaders in the SMDC space, showcasing significant advancements in innovative cancer drug development [5][12][17] Industry Overview - The pharmaceutical and biotechnology sector has shown a relative price-to-earnings (P/E) ratio of 51.14 as of July 25, 2025, which is significantly higher than its historical low of 24.38, indicating a premium valuation compared to the broader market [19] - The report notes that the healthcare sector's valuation is 279% higher than the Shanghai Composite Index, reflecting strong investor interest and confidence in the industry [19] - Recent market performance indicates a 1.90% increase in the pharmaceutical and biotechnology sector from July 21 to July 25, 2025, ranking it 16th among 27 sub-industries [26][29] Company Focus - The report suggests monitoring companies involved in the SMDC space, including Affinivax, and those collaborating with them, such as Innovent Biologics and others, which are expected to benefit from the growing interest in innovative cancer therapies [5][17][18] - Specific companies highlighted for their innovative drug development capabilities include Innovent Biologics, Shunyi Pharmaceutical, and others, which are positioned to capitalize on the advancements in SMDC technology [5][18]

Investment Rating - The report recommends a "Buy" rating for multiple companies in the pharmaceutical sector, including Junshi Biosciences, Hualan Biological Engineering-B, and others [3]. Core Insights - The pharmaceutical sector has shown a 1.90% increase this week, outperforming the CSI 300 index by 0.21 percentage points. Sub-sectors such as pharmaceutical outsourcing, vaccines, and medical consumables performed well, while innovative drugs lagged behind [6][42]. - The report emphasizes the potential of the 4-1BB target in cancer treatment, particularly the PD-L1/4-1BB bispecific antibodies, which may address the limitations of PD-1/PD-L1 monotherapy [5][16][17]. Summary by Sections Industry Viewpoints and Investment Recommendations - 4-1BB is recognized as a promising target for tumor therapy, enhancing T cell activation and survival, which is crucial for effective immune responses against cancer [16]. - Investment strategies focus on the innovative drug sector, driven by increased liquidity and risk appetite, with a recommendation to pay attention to companies with strong pipelines in bispecific antibodies and ADCs [6][38]. Pharmaceutical Industry Market Performance - The pharmaceutical sector's overall P/E ratio is reported at 30.67 times, with a premium of 40.37% compared to the overall A-share market excluding financials [42]. Company Dynamics - Notable company developments include: - LIZHU Group's successful Phase III trial for a monoclonal antibody for psoriasis [43]. - Baiyang Pharmaceutical's planned share reduction by its major shareholder [43]. - Mylab's new medical device approval, enhancing market competitiveness [44]. Industry Dynamics - The report highlights the increasing focus on innovative drug development and the potential for significant market opportunities in the context of upcoming patent expirations for key small molecule drugs [38].