Group 1 - Digital Zhengtong's subsidiary Baoding Jindi won a bid for a smart water project in Jinan, with a total contract value of 109 million yuan, of which Baoding Jindi's share is approximately 77 million yuan [1] - Lingzhi Software plans to acquire 100% equity of Kaimiride through a combination of cash and stock issuance, with the final transaction price yet to be determined [1] - Tianjin Port's subsidiary plans to transfer 60% equity of China Railway Storage and Transportation, with an estimated value of 37.54 million yuan for the entire equity [2] Group 2 - New Wufeng reported a 56.97% year-on-year increase in pig sales in October, selling 610,000 pigs [3] - New Peng Co. announced a joint investment of approximately 15 million USD with Jabil to build a battery storage box project in Thailand [4] - Maiwei Bio received approval for a clinical trial of its 9MW3811 injection for pathological scars [6] Group 3 - Jiangsu Sopo completed maintenance and resumed production of its methanol and acetic acid facilities [8] - Luoniushan reported a 24.65% year-on-year increase in pig sales revenue in October, totaling 116 million yuan [9][10] - Zhongbei Communication signed a 1 billion yuan comprehensive computing service framework agreement with Xiamen Hongxin Electronics [11] Group 4 - Huayang New Materials announced the resignation of its general manager, Wu Yuehua [12] - Zhongxin Co. used 50 million yuan of idle funds to purchase structured deposits with expected annual returns between 0.55% and 2.05% [14] - Huajian Group's subsidiary signed a construction engineering design contract worth 96.54 million yuan [16] Group 5 - Jianyou Co. received FDA approval for a new production site for its injectable drug [17] - Beilu Pharmaceutical obtained a drug registration certificate for its iodine mepivacaine injection, which is included in the national medical insurance catalog [19] - *ST Yuancheng's stock will be suspended due to falling below the market cap threshold for delisting [20] Group 6 - Xiantan Co. reported a 9.3% year-on-year increase in chicken product sales revenue in October, totaling 503 million yuan [21] - Huanxu Electronics reported an 8.93% year-on-year decrease in consolidated revenue for October, amounting to 5.598 billion yuan [23] - Yisheng Co. reported a 22.97% year-on-year decrease in white feather chicken seed sales revenue in October [25] Group 7 - Yuandong Bio initiated a Phase I/II clinical trial for its ADC drug YLSH003 targeting advanced solid tumors [25] - Xiaoming Co. reported a 34.89% year-on-year decrease in chicken product sales revenue in October [26] - Nanjiao Food reported a 5.27% year-on-year decrease in consolidated revenue for October, totaling 235 million yuan [28] Group 8 - Chuangye Huikang announced a potential change in control, leading to a temporary stock suspension [30] - Tangrenshen reported a 17.91% year-on-year decrease in pig sales revenue in October, totaling 828 million yuan [32][33] - Wancheng Group plans to distribute a cash dividend of 1.5 yuan per 10 shares to shareholders [34] Group 9 - Kangguan Technology plans to distribute a cash dividend of 3.6 yuan per 10 shares to shareholders [36] - Shoudu Online's executive plans to reduce holdings of up to 19,400 shares [38] - Maolai Optical received approval for the issuance of convertible bonds [40] Group 10 - Jinkai New Energy plans to distribute a cash dividend of 0.1 yuan per share to shareholders [41] - Tianchen Medical raised the upper limit for share repurchase to 70 yuan per share [42] - Tianmu Lake used 38 million yuan of idle funds to purchase structured deposits [43]

Core Viewpoint - Yuan Dong Biotech (688513) announced that its wholly-owned subsidiary, Shanghai Youluo, has initiated Phase I/II clinical trials for its self-developed Class I biological drug, YLSH003, targeting advanced solid tumors, with the first subject successfully enrolled for treatment recently [1] Group 1 - The company is advancing its clinical research with YLSH003, which is a significant step in its drug development pipeline [1] - The initiation of clinical trials indicates the company's commitment to addressing unmet medical needs in oncology [1] - The successful enrollment of the first subject marks a critical milestone in the development process of YLSH003 [1]

证券代码：688513 证券简称：苑东生物 公告编号：2025-079 目前，上海优洛已就该药品的相关技术提交了 1 项国际专利申请。针对 TF 靶点开发的 ADC 药物，国外已有 Tivdak®上市，用于治疗宫颈癌；国内则有乐 普生物、信诺维等公司正在开展不同阶段的临床研究，适应症主要集中于宫颈癌、 卵巢癌及胰腺癌。 1 成都苑东生物制药股份有限公司 关于自愿披露注射用 YLSH003 启动 I/II 期临床试验 并完成首例受试者入组的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 成都苑东生物制药股份有限公司（以下简称"公司"）全资子公司优洛生物（上 海）有限公司（以下简称"上海优洛"）自主研发的 1 类生物药注射用 YLSH003 正在开展用于晚期实体瘤的 I/II 期临床试验，首例受试者已于近日成功入组给药。 现将相关情况公告如下： 一、注射用 YLSH003 的基本情况 注射用 YLSH003 是一种靶向组织因子（Tissue Factor，TF）的新型抗体偶 联药物（antibody-drug conju ...

Core Viewpoint - Yuan Dong Biotech (688513.SH) announced that its wholly-owned subsidiary, Shanghai Youluo, has initiated Phase I/II clinical trials for its self-developed antibody-drug conjugate, YLSH003, targeting advanced solid tumors, with the first patient successfully enrolled for treatment [1] Group 1: Product Development - YLSH003 is a novel antibody-drug conjugate designed to target Tissue Factor (TF), which plays a crucial role in the coagulation process and is highly expressed in advanced solid tumors [1] - The development of YLSH003 aims to address the recurrence and metastasis issues associated with high TF expression in late-stage solid tumors [1]

Core Viewpoint - Yuan Dong Biotech (688513.SH) announced that its wholly-owned subsidiary, You Luo Biotech (Shanghai) Co., Ltd., has initiated I/II clinical trials for its self-developed antibody-drug conjugate, YLSH003, targeting advanced solid tumors, with the first patient successfully enrolled for treatment [1] Group 1: Product Development - YLSH003 is a novel antibody-drug conjugate designed to target Tissue Factor (TF), which plays a crucial role in the coagulation process and is highly expressed in advanced solid tumors [1] - The development of YLSH003 aims to address the recurrence and metastasis issues associated with high TF expression in late-stage solid tumors [1] Group 2: Clinical Trials - The I/II phase clinical trials for YLSH003 are currently underway, marking a significant step in the company's research and development efforts in oncology [1] - The successful enrollment of the first patient indicates progress in the clinical trial process and potential future advancements in treatment options for patients with advanced solid tumors [1]

Core Viewpoint - The company announced that its wholly-owned subsidiary, Shanghai Youlu, has initiated clinical trials for a new biopharmaceutical, YLSH003, targeting advanced solid tumors, with the first patient successfully enrolled for treatment [1] Group 1: Product Development - YLSH003 is a novel antibody-drug conjugate targeting tissue factor, and the company has submitted an international patent application for the related technology [1] - The clinical trials consist of Phase I and Phase II studies, with Phase I focusing on safety and tolerability, while Phase II will assess efficacy [1] - The drug is expected to be accepted and approved by 2025, with the first patient already enrolled in Phase I and recruitment for additional subjects ongoing [1] Group 2: Market Context - The pharmaceutical development process is characterized by high risks, and the timeline for project approval and outcomes remains uncertain [1]

二、交易进展情况 成都苑东生物制药股份有限公司 关于向参股公司增资暨关联交易完成的进展公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 一、已披露的增资暨关联交易概述 为加快公司创新转型战略的实施步伐，公司分别于 2025 年 9 月 23 日召开第 四届董事会第八次会议、于 2025 年 10 月 9 日召开 2025 年第二次临时股东大会， 审议通过了《关于向参股公司增资暨关联交易的议案》，由公司全资子公司苑东 生物投资管理（上海）有限公司（以下简称"上海投资公司"）作为投资主体以货 币资金的形式对上海超阳药业有限公司（以下简称"上海超阳"）实施增资，增资 价格为 2.27 元/注册资本，增资总金额 8,571.00 万元（对应上海超阳注册资本 3,771.00 万元），资金来源均为自有资金。本次增资完成后，上海超阳的注册资 本将由原 8,800.00 万元增加至 12,571.00 万元，公司间接持有上海超阳的股权比 例将由 30.68%增加至 51.48%，上海超阳将变更为公司控股子公司，纳入公司合 并报表范围 ...

Core Viewpoint - The company has increased its investment in Shanghai Chaoyang Pharmaceutical Co., Ltd., resulting in a controlling stake and consolidation into its financial statements [1] Group 1: Investment Details - The company’s wholly-owned subsidiary, Yuandong Bio Investment Management (Shanghai) Co., Ltd., has invested 85.71 million yuan in Shanghai Chaoyang Pharmaceutical [1] - The investment price is set at 2.27 yuan per registered capital, corresponding to a registered capital of 37.71 million yuan for Shanghai Chaoyang [1] - Following this investment, the registered capital of Shanghai Chaoyang will increase from 88 million yuan to 126 million yuan [1] Group 2: Ownership Changes - The company's indirect ownership stake in Shanghai Chaoyang will rise from 30.68% to 51.48% [1] - As a result of this increase, Shanghai Chaoyang will become a controlled subsidiary of the company [1] - The financial results of Shanghai Chaoyang will now be included in the company’s consolidated financial statements [1]

Core Viewpoint - Yuan Dong Bio, established in 2009 and listed in 2020, specializes in the research, production, and sales of chemical raw materials and formulations, particularly in anesthetic and analgesic drugs, showcasing a technical advantage in the domestic chemical pharmaceutical sector [1] Financial Performance - In Q3 2025, Yuan Dong Bio achieved a revenue of 1.019 billion yuan, ranking 49th among 110 companies in the industry, with the industry leader, Huadong Medicine, reporting 32.664 billion yuan [2] - The net profit for the same period was 220 million yuan, placing the company 31st in the industry, while the top performer, Heng Rui Medicine, reported a net profit of 5.76 billion yuan [2] Financial Ratios - As of Q3 2025, the company's debt-to-asset ratio was 19.47%, down from 21.68% year-on-year and below the industry average of 35.26%, indicating strong solvency [3] - The gross profit margin was 75.69%, slightly lower than the previous year's 77.55%, but still above the industry average of 57.17% [3] Executive Compensation - The chairman, Wang Ying, received a salary of 1.4022 million yuan in 2024, an increase of 302,700 yuan from the previous year [4] - The general manager, Yuan Mingxu, saw his compensation rise to 1.5363 million yuan, up by 370,400 yuan from 2023 [4] Shareholder Information - As of September 30, 2025, the number of A-share shareholders increased by 18.67% to 6,482, while the average number of shares held per shareholder decreased by 15.74% to 27,200 shares [5] - Notable new shareholders include Boshi Research Preferred Mixed A and Great Wall Pharmaceutical Industry Selected Mixed Initiated A [5] Business Highlights - The company reported a revenue decline of 2.00% year-on-year for the first three quarters of 2025, while net profit increased by 1.45% [5] - R&D investment averaged over 20% of revenue in the past three years, with at least 10 new formulation products approved annually since 2023 [5] - The company increased its stake in Shanghai Chaoyang in September 2025, which is expected to enhance its core pipeline clinical research [5] - The core pipeline HP-001 is currently undergoing Phase I clinical trials, showing promising safety characteristics [5] Future Projections - Revenue projections for 2025 to 2027 are 1.359 billion, 1.564 billion, and 1.855 billion yuan, respectively, with net profits expected to be 245 million, 280 million, and 333 million yuan [5] - Another analysis estimates revenues of 1.528 billion, 1.766 billion, and 2.086 billion yuan for the same period, with net profits of 271 million, 319 million, and 382 million yuan [6]

Core Insights - The latest round of national centralized drug procurement in China has successfully awarded contracts for 55 drugs, with 453 products from 272 companies qualifying for selection, expanding the total number of covered drugs to 490 [1] Group 1: Company Participation - Kelun Pharmaceutical and Yuandong Biological, two listed pharmaceutical companies from Chengdu, announced a total of 14 products that are likely to be selected in the recent procurement round [1] - Kelun Pharmaceutical reported that it and its subsidiaries participated in the 11th national drug procurement, with 12 products likely to be selected across various treatment areas including liver disease, oncology, and mental health [3][4] Group 2: Product Details - The 12 products from Kelun Pharmaceutical cover a range of diseases, including chronic liver disease, ovarian cancer, depression, and chronic obstructive pulmonary disease, showcasing the company's diverse product portfolio [3] - The proposed winning prices for Kelun's products vary significantly, from 2.11 yuan per bag for a specific injection to 195.37 yuan per box for an oncology drug, indicating a wide range of medication price points [3] Group 3: Financial Impact - For the 12 products proposed for selection by Kelun, most had zero sales revenue prior to this procurement, with only a few products generating minimal revenue in 2023 or 2024 [3] - Yuandong Biological announced that its selected products, including a specific injection and a tablet, contributed to a small percentage of the company's total revenue for the first nine months of 2025 [4] Group 4: R&D Investment - Yuandong Biological has maintained an average R&D investment of over 20% of its revenue in the past three years, leading to a high conversion efficiency with at least 10 new formulations approved for market each year [4]