Core Viewpoint - The company has received approval for clinical trials of its "lyophilized Haemophilus influenzae type b (Hib) conjugate vaccine," which is aimed at preventing invasive infections caused by Hib bacteria [1][2]. Group 1: Clinical Trial Approval - The company's subsidiary, Hualan Biological Vaccine Co., Ltd., has obtained the "Drug Clinical Trial Approval Notice" from the National Medical Products Administration for the Hib vaccine [1]. - The clinical trial application for the vaccine was accepted on May 21, 2025, and has met the requirements for drug registration [1]. - The vaccine is intended to prevent invasive infections such as meningitis, pneumonia, sepsis, cellulitis, arthritis, and epiglottitis caused by Hib [1]. Group 2: Vaccine Development - The Hib vaccine is developed using purified Hib capsular polysaccharide combined with tetanus toxoid protein, and it is in a lyophilized form [2]. - The vaccine is expected to induce an immune response against Hib, providing protection to the vaccinated individuals [2]. - The company is also developing a combination vaccine based on the DTP (diphtheria, tetanus, and pertussis) framework, with the Hib vaccine as one of its components [2].

（文章来源：证券日报） 证券日报网讯 8月13日晚间，华兰疫苗发布关于部分首次公开发行前已发行股份上市流通的提示性公告 称，本次上市流通的限售股为公司部分首次公开发行前已发行股份；本次解除限售股东户数共计2户， 为华兰生物工程股份有限公司和科康有限公司，解除限售的股份数量共计459，000，000股，占公司总 股本的76.37%。本次解除限售的股份上市流通日期为2025年8月18日（星期一）。 ...

Group 1 - The company Hualan Vaccine announced that 459 million restricted shares will be unlocked and listed for circulation on August 18, 2025, which accounts for 76.37% of the company's total share capital [2]

经深圳证券交易所《关于华兰生物疫苗股份有限公司人民币普通股股票在创业 板上市的通知》（深证上[2022]154 号）同意，华兰生物疫苗股份有限公司（以下简 称"公司"或"华兰疫苗"）首次公开发行人民币普通股（A 股）股票 40,010,000 股， 并于 2022 年 2 月 18 日在深圳证券交易所创业板上市交易。公司首次公开发行股票 前总股本为 360,000,000 股，首次公开发行完成后，公司总股本为 400,010,000 股。 每 10 股转增 5 股，共计 200,005,000 股，转增后公司总股本由 400,010,000 股变为 一个归属期归属的 1,012,500 股股份上市流通，公司总股本由 600,015,000 股变为 截至本公告披露日，公司总股本为 601,027,500 股，其中无限售条件流通股为 占总股本的比例为 76.43%。 证券代码：301207 证券简称：华兰疫苗 公告编号：2025-035 华兰生物疫苗股份有限公司 关于部分首次公开发行前已发行股份上市流通的提示性公告 本公司及董事会全体成员保证信息披露的内容真实、准确和完整，没有虚假 记载、误导性陈述或重大遗漏。 ...

Core Viewpoint - The approval of the clinical trial for the freeze-dried Hib vaccine marks a significant milestone for the company, enhancing its product portfolio and supporting its strategic development in the vaccine sector [1] Group 1: Clinical Trial Approval - The company received the clinical trial approval notice from the National Medical Products Administration for the freeze-dried Hib vaccine [1] - The approval indicates that the Hib vaccine meets the requirements for drug registration and allows for clinical trials aimed at preventing invasive infections caused by Hib, including meningitis, pneumonia, sepsis, cellulitis, arthritis, and epiglottitis [1] Group 2: Strategic Significance - The approval of the freeze-dried Hib vaccine is seen as a successful step in the company's product research and development strategy [1] - This development not only enriches the company's product lineup but also represents an important move towards achieving multi-valent products [1] - The approval is expected to strengthen the company's position in the domestic second-class vaccine market and contribute to the sustainable development of its vaccine business [1]

Core Viewpoint - The company has received approval from the National Medical Products Administration for clinical trials of its lyophilized Haemophilus influenzae type b conjugate vaccine, indicating progress in its vaccine development pipeline [1] Group 1: Company Developments - The company's subsidiary, Hualan Biological Vaccine Co., Ltd., has been granted a clinical trial approval notice for the lyophilized Haemophilus influenzae type b conjugate vaccine [1] - The clinical trial application was accepted on May 21, 2025, and meets the requirements for drug registration [1] - The vaccine aims to prevent invasive infections caused by Haemophilus influenzae type b, including meningitis, pneumonia, sepsis, cellulitis, arthritis, and epiglottitis [1]

关于部分首次公开发行前已发行股份上市流通的提示性公告 本公司及董事会全体成员保证信息披露的内容真实、准确和完整，没有虚假 记载、误导性陈述或重大遗漏。 证券代码：301207 证券简称：华兰疫苗 公告编号：2025-035 华兰生物疫苗股份有限公司 特别提示： 1、本次上市流通的限售股为公司部分首次公开发行前已发行股份； 2、本次解除限售股东户数共计 2 户，为华兰生物工程股份有限公司（以下简称 "华兰生物"）和科康有限公司（以下简称"香港科康"），解除限售的股份数量 共计 459,000,000 股，占公司总股本的 76.37%。 3、本次解除限售的股份上市流通日期为 2025 年 8 月 18 日（星期一）。 一、首次公开发行前已发行股份概况 经深圳证券交易所《关于华兰生物疫苗股份有限公司人民币普通股股票在创业 板上市的通知》（深证上[2022]154 号）同意，华兰生物疫苗股份有限公司（以下简 称"公司"或"华兰疫苗"）首次公开发行人民币普通股（A 股）股票 40,010,000 股， 并于 2022 年 2 月 18 日在深圳证券交易所创业板上市交易。公司首次公开发行股票 前总股本为 360,000, ...

核查意见 华泰联合证券有限责任公司 关于华兰生物疫苗股份有限公司 部分首次公开发行前已发行股份上市流通的核查意见 华泰联合证券有限责任公司（以下简称"华泰联合证券"或"保荐人"）作为华 兰生物疫苗股份有限公司（以下简称"华兰疫苗"或"公司"）首次公开发行股票并 在创业板上市持续督导阶段的保荐人，根据《证券发行上市保荐业务管理办法》 《深圳证券交易所创业板股票上市规则》《深圳证券交易所上市公司自律监管指 引第 2 号——创业板上市公司规范运作》及《深圳证券交易所上市公司自律监管 指引第 13 号——保荐业务》等规定，对华兰疫苗部分首次公开发行前已发行股 份上市流通事项进行了审慎核查，并出具核查意见如下： 一、首次公开发行前已发行股份概况 经深圳证券交易所《关于华兰生物疫苗股份有限公司人民币普通股股票在创 业板上市的通知》（深证上[2022]154 号）同意，公司首次公开发行人民币普通 股（A 股）股票 40,010,000 股，并于 2022 年 2 月 18 日在深圳证券交易所创业板 上市交易。公司首次公开发行股票前总股本为 360,000,000 股，首次公开发行完 成后，公司总股本为 400,010,00 ...

Group 1 - Kaizhong Precision plans to invest up to 250 million yuan to establish a subsidiary and build a production base in Thailand, focusing on overseas connector and precision component business [1] - Longbo Technology reported a 60.18% year-on-year increase in net profit for the first half of 2025, with revenue of 122 million yuan, up 18.03% [2] - Dingyang Technology achieved a net profit of 76.88 million yuan in the first half of 2025, a year-on-year increase of 31.54%, with revenue of 279 million yuan, up 24.61% [4] Group 2 - Heng Rui Pharmaceutical received approval for clinical trials of two drugs, SHR-A2102 and Adebeli monoclonal antibody injection [6] - Maolai Optical plans to use up to 100 million yuan of idle funds for entrusted wealth management to improve fund utilization efficiency [8] - Shiji Information signed a major contract with MGM Grand, providing a next-generation cloud-based hotel information management system [7] Group 3 - Yunnan Germanium's subsidiary received a government subsidy of 6.8 million yuan related to revenue [9] - Jizhi Co. received a warning letter from the Zhejiang Securities Regulatory Bureau for failing to disclose significant government subsidies [10] - Dongfang Precision reported a net profit of approximately 397 million yuan for the first half of 2025, a year-on-year increase of 142.52% [11] Group 4 - Aolaide expects a net profit decrease of 68.41% to 72.77% for the first half of 2025, with revenue projected between 270 million and 290 million yuan [12] - Feilong Co. used 111 million yuan of idle funds for cash management through structured deposit products [13] - Anhui Construction won two major projects with a total investment exceeding 6.6 billion yuan [15] Group 5 - Yunnan Germanium's subsidiary received a government subsidy of 6.8 million yuan related to revenue [9] - Jizhi Co. received a warning letter from the Zhejiang Securities Regulatory Bureau for failing to disclose significant government subsidies [10] - Dongfang Precision reported a net profit of approximately 397 million yuan for the first half of 2025, a year-on-year increase of 142.52% [11] Group 6 - China Medical's subsidiary received approval for the listing of fumaric acid volnora raw materials [20] - Huayuan Vaccine's subsidiary received approval for clinical trials of Hib vaccine [29] - Ganfeng Lithium plans to integrate lithium salt lake projects in Argentina and provide financial support of up to 130 million USD [41]

Core Viewpoint - Hualan Biological's subsidiary has received approval for a clinical trial of a new vaccine, indicating progress in its vaccine development pipeline [2] Group 1: Company Announcement - Hualan Biological announced on August 13 that its subsidiary, Hualan Biological Vaccine Co., Ltd., received a clinical trial approval notice from the National Medical Products Administration [2] - The approved clinical trial is for a "lyophilized type b Haemophilus influenzae conjugate vaccine" [2]