Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" and the rating has been maintained [2] Core Insights - The pharmaceutical and biotechnology industry index increased by 5.30%, outperforming the CSI 300 index which rose by 3.52% during the reporting period [3][14] - The PE ratio (TTM, excluding negative values) for the pharmaceutical and biotechnology industry as of July 4, 2025, is 28.52x, up from 27.28x in the previous period, indicating an upward trend in valuation [3][19] - Notable sub-industries include "Other Biological Products" and "Medical R&D Outsourcing," which saw increases of 11.20% and 9.37% respectively, while "Medical Equipment" and "Blood Products" lagged with increases of only 0.98% [3][14] Industry Trends - The report highlights significant policy measures from the National Healthcare Security Administration and the National Health Commission aimed at supporting the high-quality development of innovative drugs [5][6] - The introduction of a commercial health insurance innovative drug directory is a key breakthrough, facilitating better pricing and reimbursement mechanisms for high-value drugs [6] - The report emphasizes the importance of the innovative drug industry chain, particularly focusing on platform pharmaceutical companies, clinical CROs, and high-barrier CDMOs [6] Important Industry News - The approval of several innovative drugs, including "ZEGFROVY" by Dize Pharmaceutical and "TQG203" by Zhengda Tianqing, marks significant advancements in the industry [41][42][46] - The report notes that the global number of hemophilia patients is expected to increase by 25% by 2025, highlighting the growing market for innovative treatments [42] - The approval of "Mastrudep" by Innovent Biologics for weight management in adults showcases the expanding therapeutic applications of GLP-1R/GCGR dual agonists [49][50] Investment Recommendations - Continuous attention is recommended for the innovative drug industry chain, particularly for companies that can navigate the new dual directory system and have international expansion capabilities [6] - The report suggests that the recent policy changes and the successful IPO of a biotech company signal a positive outlook for the innovative drug sector [6]

Investment Rating - The report maintains a "Buy" rating for multiple companies in the pharmaceutical sector, including Junshi Bioscience, Hualing Pharmaceutical-B, and others [2]. Core Insights - The report emphasizes the broad market for lipid-lowering treatments, particularly focusing on the competitive landscape of PCSK9-targeted drugs, with approximately 500 million adults in China suffering from dyslipidemia, including 120 million with high cholesterol [3][15]. - The pharmaceutical sector saw a 1.60% increase this week, underperforming the CSI 300 index by 0.35 percentage points, with sub-sectors like medical infrastructure and life sciences performing better than generics and innovative drugs [4][31]. Summary by Sections 1. Industry Perspective and Investment Recommendations - The lipid-lowering market is vast, with intense competition in PCSK9-targeted drugs [15]. - Investment strategies should focus on innovative drugs, particularly in the context of increased liquidity and risk appetite in the market [4][31]. 2. Pharmaceutical Sector Performance - The pharmaceutical sector's performance was mixed, with medical infrastructure and life sciences leading, while generics and innovative drugs lagged [4][37]. - The overall P/E ratio for the pharmaceutical industry is 27.69, with a premium of 35.26% compared to the broader A-share market [37]. 3. Company Dynamics - Notable company announcements include Baiyoutai's licensing agreement for BAT2406 in Latin America and Yifan Pharmaceutical's approval for clinical trials of a growth hormone injection [38][40]. - Companies like WuXi AppTec and Lijun Group have made significant moves, including share buybacks and new product approvals [39][41]. 4. Industry Trends - The report highlights the upcoming patent expirations for major small molecule drugs, which could lead to increased demand for raw materials [5][32]. - The report also notes the expected recovery in overseas demand, which may improve the performance of CXO companies [34]. 5. Research and Development Focus - The report discusses the clinical progress of various PCSK9-targeted therapies, including monoclonal antibodies and gene editing approaches, indicating a strong pipeline in this area [3][23][25]. - The competitive landscape for PCSK9 drugs in China is characterized by pricing and adherence challenges, with several products already on the market [27].

证券代码：301230 证券简称：泓博医药 公告编号：2025-043 上海泓博智源医药股份有限公司 2024年年度权益分派实施公告 本公司及董事会全体成员保证信息披露的内容真实、准确和完整，没有虚假记 载、误导性陈述或重大遗漏。 特别提示： 1、上海泓博智源医药股份有限公司（以下简称"公司"或"本公司"）回购专用证券账 户中的股份 2,046,200 股不参与本次权益分派。公司 2024 年年度权益分派方案为：以公 司现有总股本 139,586,605 股扣除回购专用账户中已回购股份 2,046,200 股后的 137,540,405 股为基数，向全体股东每 10 股派发现金红利 3.3 元（含税），不进行资本 公积金转增股本，不送红股。公司本次实际现金分红总额（含税）=实际参与现金分红 的股本*每股现金分红金额=（139,586,605 股-2,046,200 股）*0.33=45,388,333.65 元。 2、本次权益分派实施后，按 A 股除权前总股本（含回购专用证券账户中的股份） 计算的每 10 股 派 息 （ 含 税 ） ＝ 现 金 分 红 总 额 /A 股 除 权 前 总 股 本 *10=45, ...

Group 1 - AstraZeneca announced a strategic research collaboration with CSPC focusing on high-priority targets to advance the discovery and development of novel oral drug candidates for multiple chronic diseases [1] - The collaboration will utilize CSPC's AI-driven drug discovery platform to identify and optimize small molecules with therapeutic potential for immune diseases [1] - The AI pharmaceutical sector is experiencing rapid iteration and transformation, with significant applications in preclinical drug discovery, indicating a promising long-term growth potential for AI in the pharmaceutical industry [1][2] Group 2 - Traditional pharmaceutical companies are increasingly recognizing the importance of AI technology in drug development, leading to deeper collaborations with AI firms [2] - Companies like Heng Rui Medicine are leveraging AI to enhance the efficiency and reduce costs in the drug development process, focusing on innovative drugs for oncology and autoimmune diseases [3] - WuXi AppTec is positioning itself as a leader in AI pharmaceuticals by integrating self-developed technology platforms and strategic partnerships to facilitate intelligent transformation in drug development [3]

Investment Rating - The report recommends a "Buy" rating for multiple companies in the pharmaceutical sector, including Junshi Biosciences, Hualing Pharmaceutical-B, and others [3]. Core Insights - The pharmaceutical sector has outperformed the market, with a focus on the potential of innovative drugs and the CD73 target in cancer immunotherapy [4][5]. - The report highlights the promising clinical progress of CD73 inhibitors, with several products in various stages of clinical trials [21][25]. Summary by Sections Industry Investment Rating - The report provides a list of recommended companies with "Buy" and "Hold" ratings, indicating strong investment potential in the pharmaceutical sector [3]. Industry Performance - The pharmaceutical sector rose by 1.13%, outperforming the CSI 300 index by 0.25 percentage points, with innovative drugs and vaccines leading the performance [5][32]. Company Dynamics - Companies such as Lepu Medical and Sunshine Nuohua have made significant announcements regarding new product approvals and clinical trial progress, indicating a robust pipeline and growth potential [33][34]. Industry Trends - The report discusses the increasing focus on innovative drugs and the impact of regulatory changes on the pharmaceutical landscape, suggesting a shift towards high-efficiency business models in the industry [31][40].

Investment Rating - Investment Rating: Positive [2] Core Insights - The pharmaceutical and biotechnology industry index increased by 3.36%, ranking 6th among 31 primary industries, outperforming the CSI 300 index, which decreased by 0.21% [5][17] - The valuation of the pharmaceutical and biotechnology industry as of June 6, 2025, is 28.24x (TTM, excluding negative values), up from 27.60x in the previous period, indicating an upward trend but still below the average [5][23] - Notable sub-industry performance includes chemical preparations and other biological products, with increases of 5.77% and 4.68% respectively, while offline pharmacies saw a decline of 1.15% [5][17] Industry Review - The report highlights three major investment opportunities: 1) Companies with dual-antibody/multi-antibody technology platforms that have differentiated target design capabilities and clinical advancement efficiency are likely to attract international giants [9] 2) Areas with unmet clinical needs, such as advanced liver cancer and non-small cell lung cancer, are promising for dual-antibody therapy development [9] 3) Potential license-out candidates, as domestic innovative pharmaceutical companies continue to engage in global collaborations [9] Important Industry News - CDE launched the "Star Plan" to encourage the development of pediatric anti-cancer drugs, addressing significant unmet clinical needs in this area [7][32] - Alcon's dry eye medication "Tryptyr" received FDA approval, marking it as the first of its kind globally [39] - Hansoh Pharmaceutical's third-generation EGFR-TKI "Amivantamab" was approved in the UK for first-line treatment of NSCLC, becoming the first domestically developed EGFR-TKI approved overseas [42] - BMS and BioNTech entered a collaboration for the dual-antibody candidate BNT327, with an upfront payment of $1.5 billion and potential milestone payments of $7.6 billion [51] Company Dynamics - Stone Pharmaceutical is negotiating three potential deals totaling $5 billion, involving several products including EGFR ADCs [49] - BMS's "Rotecip" was approved for treating lower-risk myelodysplastic syndromes, marking a significant innovation in this therapeutic area [45] - AbbVie’s JAK inhibitor "Upadacitinib" was approved for treating giant cell arteritis, becoming the first approved treatment for this condition in China [48]

证券代码：301230 证券简称：泓博医药 公告编号：2025-042 上海泓博智源医药股份有限公司 关于持股5%以上股东权益变动触及1%整数倍暨减持计划 实施完毕的公告 公司持股 5%以上股东沈阳富邦投资有限责任公司保证向本公司提供的信息内 容真实、准确、完整，没有虚假记载、误导性陈述或者重大遗漏。 本公司及董事会全体成员保证公告内容与信息披露义务人提供的信息一致。 注：减持比例为占当前扣除回购股份后总股本比例。 3、股东本次减持前后持股情况详见"二、权益变动触及 1%整数倍的具体情况。" 上海泓博智源医药股份有限公司（以下简称"公司"）于 2025 年 5 月 6 日在巨潮资 讯网（http://www.cninfo.com.cn）对外披露了《关于持股 5%以上股东减持计划的预披露 公告》（公告编号：2025-039）。沈阳富邦投资有限责任公司（以下简称"沈阳富邦"） 计划在减持计划公告发布之日起 15 个交易日后的 3 个月内以集中竞价或大宗交易方式 减持公司股份不超过 1,370,000 股，即减持比例不超过公司扣除最新披露的回购专户股 份后总股本的 1.00%。 公司于近日收到沈阳富邦出具的《关于权 ...

Core Viewpoint - The innovative pharmaceutical concept stocks are experiencing significant growth, with notable companies reaching historical highs [1] Group 1: Stock Performance - Xinlitai and Kelun Pharmaceutical both achieved historical highs in stock prices [1] - Yangguang Nuohe is approaching a 20% daily limit increase [1] - Zhongsheng Pharmaceutical previously hit a daily limit increase [1] - Haichen Pharmaceutical, Beida Pharmaceutical, and Hongbo Pharmaceutical saw stock prices rise over 10% [1] - Shutaishen, Haixiang Pharmaceutical, Tigermed, and Huahai Pharmaceutical experienced stock price increases of over 5% [1]

Group 1: Company Growth and Strategy - The company focuses on enhancing core competitiveness by tracking technological advancements and increasing market expansion efforts [2] - Plans to improve production efficiency and profitability through optimized manufacturing processes and capacity utilization [2] - The CRO industry is experiencing rapid growth due to rising R&D costs and efficiency demands, with China becoming a key market for overseas R&D orders [2] Group 2: AI Integration and Development - The company has integrated AI technology into drug development, achieving significant progress in drug design and molecular screening [3] - AI drug development is a core innovation direction, with ongoing investments to overcome challenges such as data quality and model generalization [3] - The ADMET prediction model is based on proprietary technology, utilizing both public and proprietary data to enhance accuracy [4] Group 3: Financial Performance and Shareholder Value - The company emphasizes that the financial performance should be referenced from the disclosed periodic reports [5] - A major shareholder's reduction in holdings is driven by personal financial needs, with no expected impact on the company's operations [5] - The company is implementing share buybacks and increasing dividend frequency to stabilize market expectations and enhance shareholder returns [5]

北京市嘉源律师事务所 关于上海泓博智源医药股份有限公司 2024 年年度股东大会的 法律意见书 西城区复兴门内大街 158 号远洋大厦 4 楼 中国 · 北京 e 点律师事务所 YUAN LAW OFFICES 北京 BEIJING ·上海 SHANGHAI ·深圳 SHENZHEN · 香港 HONG KONG · 广州 GUANGZHOU · 西安 XI'AN 致:上海泓博智源医药股份有限公司 北京市嘉源律师事务所 关于上海泓博智源医药股份有限公司 2024 年年度股东大会的 法律意见书 嘉源(2025)-04-295 北京市嘉源律师事务所(以下简称"本所")接受上海泓博智源医药股份有 限公司(以下简称"公司")的委托,根据《中华人民共和国公司法》(以下简称 "《公司法》")《上市公司股东会规则》(以下简称"《股东会规则》")等现行有效 的法律、行政法规、部门规章、规范性文件(以下简称"法律法规")以及《上 海泓博智源医药股份有限公司章程》(以下简称"《公司章程》")的有关规定,指 派本所律师对公司 2024年年度股东大会(以下简称"本次股东大会")进行见证, 并依法出具本法律意见书。 为出具本法律意见书 ...