股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 | 截至月份: | 2025年7月31日 | | | | 狀態: 新提交 | | --- | --- | --- | --- | --- | --- | | 致：香港交易及結算所有限公司 | | | | | | | 公司名稱: | 信達生物製藥 | | | | | | 呈交日期: | 2025年8月6日 | | | | | | I. 法定/註冊股本變動 | | | | | | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | 於香港聯交所上市 (註1) | 是 | | 證券代號 (如上市) | 01801 | 說明 | 普通股 | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 5,000,000,000 | USD | | 0.00001 | USD | | 50,000 | | 增加 / 減少 (-) | ...

Core Insights - The report from JPMorgan highlights that external licensing has become one of the most significant driving forces in the domestic biopharmaceutical industry this year [1] - The firm identifies Innovent Biologics as the most capable company to benefit from this trend among those covered by the bank [1] Company Summary - Innovent Biologics has a strong product pipeline that includes assets in oncology, cardiovascular, autoimmune, and ophthalmology, creating a diversified portfolio of early and late-stage assets [1] - The company is expected to continue achieving external licensing deals in the coming years [1] - JPMorgan has raised its forecast for potential licensing revenue as a percentage of total revenue to 5% to 7%, which is anticipated to positively impact gross margin expansion [1] - The valuation of early-stage assets has been increased by 43% due to growing market recognition of the company's R&D capabilities [1] - The target price for Innovent Biologics has been raised from HKD 90 to HKD 109, with a rating of "Overweight" and classified as a top pick in the industry [1]

Group 1 - The core viewpoint of the news is that the China Securities Hong Kong 100 Pharmaceutical and Health Index has shown significant growth, with a year-to-date increase of 90.32% [1] - The index has risen by 18.48% in the past month and 36.79% in the last three months, indicating strong performance in the pharmaceutical sector [1] - The index is composed entirely of securities listed on the Hong Kong Stock Exchange, with a base date of December 31, 2004, and a base point of 1000.0 [1] Group 2 - The index sample is adjusted biannually, with changes implemented on the next trading day following the second Friday of June and December [2] - Weight factors are generally fixed until the next scheduled adjustment, but can be temporarily modified under special circumstances [2] - Adjustments to the index sample occur in response to events such as delistings, mergers, or changes in industry classification [2]

考虑到信达生物对授权许可的战略重视及其创新产品线，小摩提高对其潜在授权收入的预期，预计将占 信达生物未来总收入的5-7%。这种有利的销售组合亦正推动集团毛利率的扩张。同时，小摩表示，授 权许可已成为今年中国生物制药行业最重要的推动因素之一，该行认为信达生物是最能从这一趋势中受 益的公司之一。 智通财经APP获悉，摩根大通发布研报称，将集团早期资产的估值上调43%，因考虑到信达生物(01801) 的研发能力，且这些资产越来越得到市场认可。通过提高玛仕度肽(Mazdutide)(GLP-1/GIP)获批后的销 售成功率(PoS)、调整经营费用，上调目标价21%，由90港元升至109港元。并维持"增持"评级。 ...

Core Viewpoint - The stock of Innovent Biologics (01801) rose over 3% following the announcement of FDA approval for its innovative oral small molecule GLP-1R agonist IBI3032, indicating positive market sentiment towards the company's advancements in drug development [1] Group 1: Company Developments - Innovent Biologics announced that its oral small molecule GLP-1R agonist IBI3032 received IND approval from the FDA on August 5 [1] - IBI3032 is designed to preferentially activate the cAMP signaling pathway and is based on a globally validated molecular framework with complete independent intellectual property rights [1] - The Phase I clinical trial for IBI3032 will be conducted simultaneously in China and the United States, starting in the second half of 2025, involving healthy subjects and individuals who are overweight or obese [1] Group 2: Market Impact - Following the announcement, Innovent Biologics' stock price increased by 3.12%, reaching HKD 95.8, with a trading volume of HKD 219 million [1] - The initiation of clinical research for IBI3032 is considered a significant step in the evolution of the company's metabolic product matrix, leveraging the foundation of the drug Masitide [1] - The IND application for IBI3032 has also been accepted by the National Medical Products Administration (NMPA) in China, indicating a strong regulatory pathway for the drug [1]

Core Viewpoint - The approval of IBI3032 for clinical trials by the FDA marks a significant advancement for the company in its metabolic product pipeline, potentially enhancing its market position and growth prospects [1] Company Summary - Company shares of Innovent Biologics (01801) rose by 3.12%, reaching HKD 95.8, with a trading volume of HKD 219 million [1] - The company announced on August 5 that its innovative oral small molecule GLP-1R agonist, IBI3032, received IND approval from the FDA [1] - IBI3032 is developed independently by the company and is designed to preferentially activate the cAMP signaling pathway, based on a globally validated molecular framework with complete independent intellectual property rights [1] - The Phase I clinical trial for IBI3032 will be conducted simultaneously in China and the U.S., starting in the second half of 2025, involving healthy subjects and overweight or obese populations [1] - The initiation of clinical research for IBI3032 is a crucial step in the evolution of the company's metabolic product matrix, leveraging the foundation of the drug Masitide [1] Industry Summary - The approval of IBI3032's IND by both the NMPA in China and the FDA in the U.S. indicates a positive regulatory environment for innovative drug development in the metabolic sector [1] - The company's strategic focus on expanding its metabolic pipeline through IBI3032 aligns with current trends in the pharmaceutical industry towards developing effective treatments for obesity and related metabolic disorders [1]

每经AI快讯，8月4日，香港交易所信息显示，贝莱德（BlackRock）在信达生物H股的持股比例于7月29 日从4.70%升至5.17%。 ...

（股份代號：1801） 董事會召開日期 信達生物製藥（「本公司」）董事（「董事」）會（「董事會」）謹此宣佈，本公司將於 2025年8月27日（星期三）舉行董事會會議，以考慮及批准（其中包括）本公司及其 附屬公司截至2025年6月30日止六個月之中期業績及其發佈，並考慮建議派發中 期股息（如有）。 承董事會命 信達生物製藥 主席兼執行董事 俞德超博士 中國，香港，2024年8月4日 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 信達生物製藥 INNOVENT BIOLOGICS, INC. （於開曼群島註冊成立的有限公司） 於本公告刊發日期，董事會包括主席兼執行董事俞德超博士及執行董事奚浩先生 及張倩女士；及獨立非執行董事Charles Leland Cooney博士、許懿尹女士、Gary Zieziula先生、陸舜博士及陳樹云先生。 ...

Group 1 - Southbound funds had a significant net purchase of 12.207 billion yuan today [1] - In the Hong Kong Stock Connect (Shanghai), the Hang Seng China Enterprises and the Tracker Fund of Hong Kong received net purchases of 1.72 billion HKD and 1.675 billion HKD respectively [1] - Alibaba-W had the highest net sell amount, totaling 416 million HKD [1] Group 2 - In the Hong Kong Stock Connect (Shenzhen), the Tracker Fund of Hong Kong and Southern Hang Seng Technology received net purchases of 2.069 billion HKD and 856 million HKD respectively [1] - Sinopharm had the highest net sell amount in this segment, amounting to 402 million HKD [1]

信达生物日前注册一项有关IBI363的二期临床试验。该行认为试验反映公司对IBI363作为新一代免疫治 疗基石药物的信心，并有望扩大适应症范围。另外，行业数据显示，公司今年1至5月的销售同比增长 33%，保持强劲势头; 该行预期信达生物上半年收入将同比增长36%，并实现盈亏平衡。 智通财经APP获悉，瑞银发布研报称，将信达生物(01801)的目标价由105.1港元上调至120.1港元，维 持"买入"评级。假设IBI363有新适应症被纳入，将该药物在中国及全球的销售高峰预测分别上调至57亿 及203亿元人民币。 ...