以下文章来源于36氪Pro ，作者胡香赟 海若镜 36氪Pro . 文 ｜ 胡香赟 编辑 ｜ 海若镜 来源｜ 36氪Pro（ID：krkrpro） 封面来源 ｜ Pexels 我想"再高一点" 春日，宜万物生长，包括人类幼崽的身高。 在讲究科学的时代，孩子的身高理所应当地也应遵循某种可量化的生长公式。 一个颇受大众认可的方法是，根据父母身高来预测孩子未来的身高区间。比如，男孩子的身高区间=（父亲身高+母亲身高+13厘米）÷2±7.5厘米。 公式前半部分就是所谓的"遗传靶身高"，即由遗传决定的无法改变的身高基数。而后半部分的"±7.5厘米"，则是可以通过后天努力改变的部分——只需 要"充分发挥孩子的生长潜能"。 梁宇在一家药企从事研发工作，出于职业敏感，女儿萱萱还在上幼儿园时，就开始关注她的身高问题。她坦言自己和先生都不算高，对孩子未来的身 高"没有过大期待，她个子不高，这点从小就能看出来"。 尽管如此，萱萱上大班后，梁宇还是开始给她报了跳绳兴趣班。运动、光照、补充维生素D，最初梁宇选择的是最朴素的科学"长个儿"方法。 36氪旗下官方账号。深度、前瞻，为1%的人捕捉商业先机。 如果可以，谁都希望自己的孩子 是人 ...

Core Insights - Changchun High-tech's 2024 annual report shows a decline in both revenue and net profit for the first time in a decade, with revenue at 13.466 billion yuan, down 7.55%, and net profit at 2.583 billion yuan, down 43.01% [1] - The company heavily relies on its subsidiary, Jinsai Pharmaceutical, which accounted for 79.24% of total revenue in 2024, but also experienced a revenue decline of 3.73% [2][3] - The introduction of centralized procurement for growth hormone products has significantly impacted Jinsai Pharmaceutical's profitability, leading to a net profit decline of 40.67% [2][3] Revenue and Profit Performance - Changchun High-tech's total revenue for 2024 was 13.466 billion yuan, a decrease of 7.55% year-on-year, while net profit fell to 2.583 billion yuan, a drop of 43.01% [1] - Jinsai Pharmaceutical's revenue was 10.671 billion yuan, down 3.73%, with a net profit of 2.678 billion yuan, down 40.67% [2] - Baike Biological's revenue decreased by 32.64% to 1.229 billion yuan, with net profit down 53.67% to 232 million yuan [5] Market Challenges - Jinsai Pharmaceutical faces increased competition and pricing pressures due to the entry of new players in the long-acting water injection market [4] - The decline in sales of the shingles vaccine has significantly affected Baike Biological's performance, with its shingles vaccine revenue dropping 71.54% [5][6] - The overall market for vaccines is shrinking due to declining birth rates and increased competition, posing risks to product pricing and sales [6] Cost Structure and Expenses - Sales expenses for Changchun High-tech increased by 11.81% to 4.439 billion yuan, while management expenses rose by 25.59% to 1.202 billion yuan [6] - The increase in expenses is attributed to the expansion of the sales team and adjustments in management structures within Jinsai Pharmaceutical [6] R&D and Future Outlook - Changchun High-tech is attempting to diversify its product offerings, with R&D expenses rising to 2.690 billion yuan, an increase of 11.20%, representing 19.97% of total revenue [7] - The company has several products in clinical stages, including new indications for growth hormone and other innovative drugs [8] - Despite the challenges, the company aims to reduce its reliance on growth hormone and explore new business opportunities in various therapeutic areas [7]

Core Viewpoint - Changchun High-tech has reported a significant decline in both revenue and net profit for the first time in 20 years, indicating a challenging financial situation for the company amid industry pressures [2][4][5]. Financial Performance - In the past year, Changchun High-tech achieved revenue of 13.466 billion yuan and a net profit of 2.583 billion yuan, representing declines of 7.55% and 43.01% year-on-year, respectively [2]. - The first quarter of 2025 continued this downward trend, with revenue and net profit again decreasing, with net profit dropping by 44.95% year-on-year [4]. Business Segments - The company operates in four main segments: biological products, vaccines, traditional Chinese medicine, and real estate, with the majority of its performance driven by its subsidiary, Jinsai Pharmaceutical, particularly in growth hormone products [7]. - In Q1 2025, Jinsai Pharmaceutical reported revenue of 2.617 billion yuan, a year-on-year increase of 5.94%, but its net profit fell by 38.31% [7]. Market Dynamics - The growth hormone market is facing increased competition with new entrants and products, which has led to a significant drop in Changchun High-tech's stock price from a peak of 497.54 yuan per share in 2021 to 85.24 yuan per share [5][9]. - The company is under pressure to diversify its product offerings, with plans to reduce the contribution of growth hormone products to 60% in five years and 30% in ten years [8]. Product Development - Changchun High-tech has been expanding the indications for its growth hormone products, which now cover 11 conditions, but this has not yet translated into improved financial performance [8]. - The long-acting growth hormone formulations are gaining traction, with their revenue share increasing to approximately 32% in 2024 and 35% in Q1 2025 [13]. Competitive Landscape - The growth hormone market is becoming increasingly competitive, with several new products approved for market entry, indicating a shift in the industry dynamics [9][10]. - The market remains focused on pediatric applications, but there is potential for expansion into adult indications, which could reshape the competitive landscape [10][12].

Core Viewpoint - The article discusses the challenges faced by Changchun High-tech, a major player in the growth hormone market, due to declining performance and increased competition, particularly from national procurement policies that have significantly reduced profit margins [5][10][12]. Financial Performance - In Q1 2025, Changchun High-tech reported revenue of 2.997 billion yuan, a year-on-year decline of 5.66%, and net profit dropped to 473 million yuan, a decrease of 44.95% [7]. - For the full year 2024, the company recorded revenue of 13.466 billion yuan, down 7.55%, and net profit of 2.583 billion yuan, down 43.01% [7]. - This marks the first time in nearly 20 years that the company has reported a decline in both revenue and net profit [7]. Market Dynamics - The growth hormone market has been significantly impacted by national procurement policies, which began in 2022, leading to substantial price reductions for Changchun High-tech's products [10]. - The introduction of volume-based procurement in 2023 further eroded profit margins, with prices for certain products dropping from 1,000 yuan to 300 yuan, resulting in a loss of approximately 70% of profit space [10]. Strategic Challenges - The company has heavily relied on its subsidiary, Jinsai Pharmaceutical, which has contributed around 80% of its revenue, but this segment has also seen declining performance [8][10]. - Jinsai Pharmaceutical's revenue for 2024 was 10.671 billion yuan, a decrease of 3.73%, and net profit fell by 40.67% to 2.678 billion yuan [7]. Cost Structure - Increased operational costs have been noted, with sales expenses rising by 30.60% to 1.212 billion yuan, management expenses up by 40.68% to 332 million yuan, and R&D expenses increasing by 21.80% to 514 million yuan [8]. - The number of sales personnel for Jinsai Pharmaceutical increased from 3,155 to 4,995, yet this did not prevent the decline in performance [8]. Future Strategies - The company is attempting to diversify its product offerings and expand the indications for its growth hormone products, including new approvals for various growth disorders [12][15]. - Changchun High-tech is also pursuing a multi-faceted transformation strategy, focusing on pediatric care, women's health, adult endocrinology, dermatology, and oncology [15]. - The company is investing in R&D for innovative drugs, such as an IL-1β drug for arthritis, which is expected to be approved this year [15]. Industry Context - The overall pharmaceutical industry is facing challenges related to innovation-driven transformation, with pressures from healthcare cost controls and a declining birth rate impacting market demand for growth hormones [16]. - The need for companies to balance investment and returns during this transition is critical, as not all firms will successfully navigate the shift towards innovative drug development [16].

Core Viewpoint - Changchun High-tech's financial performance has significantly declined, with a 7.55% drop in revenue and a 43.01% plunge in net profit for 2024, marking the company's darkest period in its 28-year history [1][2]. Financial Performance - In 2024, Changchun High-tech reported a total revenue of 13.466 billion yuan, down 7.55% year-on-year, and a net profit of 2.583 billion yuan, down 43.01% year-on-year [2]. - The first quarter of 2025 continued the downward trend, with revenue decreasing by 5.66% and net profit falling by 44.95% [2]. Subsidiary Performance - Key subsidiaries include Jinsai Pharmaceutical, Baike Biological, Huakang Pharmaceutical, and Gaoxin Real Estate, with Jinsai Pharmaceutical and Baike Biological being the main revenue contributors [4]. - Jinsai Pharmaceutical generated revenue of 10.671 billion yuan in 2024, a decrease of 3.73%, and a net profit of 2.678 billion yuan, down 40.67% [4]. - Baike Biological's revenue was 1.229 billion yuan, down 32.64%, with a net profit of 232 million yuan, down 53.67% [4]. Market Dynamics - The decline in performance is primarily attributed to the significant drop in profits from Jinsai Pharmaceutical, which accounted for 99.60% of Changchun High-tech's net profit in 2023 [5]. - Jinsai Pharmaceutical's core products include various growth hormone products, with approximately 90% of Changchun High-tech's total revenue coming from this subsidiary [5]. Competitive Landscape - Jinsai Pharmaceutical held an 84.2% market share in the growth hormone industry in 2023, but competition has intensified due to the impact of centralized procurement [6]. - The introduction of centralized procurement for short-acting water injections in 2024 is expected to further affect the company's performance [7]. Vaccine Performance - Baike Biological's shingles vaccine initially showed strong growth, with a revenue increase of 70.30% in 2023, but faced a significant decline in 2024, with revenue dropping by 32.64% [8]. - The shingles vaccine revenue fell to 251 million yuan in 2024, a decrease of 71.54%, with sales volume down by 69.8% [8].

Core Viewpoint - Changchun High-tech's financial performance has significantly declined, with both revenue and net profit showing substantial decreases in 2024 and the first quarter of 2025 [4][6][10]. Financial Performance Summary - In 2024, Changchun High-tech reported revenue of 13.47 billion yuan, a decrease of 7.6% year-on-year, and a net profit attributable to shareholders of 2.58 billion yuan, down 43% from the previous year [6][7]. - The fourth quarter of 2024 saw a revenue drop to 3.08 billion yuan, a decline of 20.8% year-on-year, with a net profit loss of 206 million yuan, a decrease of 122.4% [7]. - For the first quarter of 2025, the company achieved revenue of 2.99 billion yuan, down 5.66% year-on-year, and a net profit of 472 million yuan, a decrease of 44.95% [9][10]. Subsidiary Performance - Jinsai Pharmaceutical, the core subsidiary of Changchun High-tech, reported a revenue of 10.67 billion yuan in 2024, a decrease of 3.73%, and a net profit of 2.68 billion yuan, down 40.67% [10]. - In the first quarter of 2025, Jinsai Pharmaceutical's revenue was 2.62 billion yuan, an increase of 5.94%, but its net profit decreased by 38.31% to 535 million yuan [10]. Shareholder Information - As of March 31, 2025, Changchun High-tech had a total of 125,097 shareholders, reflecting a decrease of 1.80% from the previous quarter [11].

Core Viewpoint - Changchun High-tech has reported its first annual revenue decline in nearly 20 years, with a 7.55% decrease in revenue and a 43.01% drop in net profit for 2024 compared to the previous year [1][2]. Financial Performance - In 2024, the company achieved revenue of 13.466 billion yuan, down 7.55% year-on-year, and a net profit of 2.583 billion yuan, down 43.01% year-on-year [1]. - For Q1 2025, revenue was 2.997 billion yuan, a decrease of 5.66% year-on-year, with a net profit of 473 million yuan, down 44.95% year-on-year [1]. - The company’s main subsidiary, Jinsai Pharmaceutical, saw total revenue decrease by 3.73% to 10.671 billion yuan, despite a 454% increase in overseas sales [2]. - Baike Biological, another subsidiary, reported a revenue decline of 32.64% to 1.229 billion yuan and a net profit drop of 53.67% [2]. - Gaoxin Real Estate experienced a revenue decline of 17.32% to 756 million yuan and a net profit drop of 80.09% [3]. Business Segments - The company operates in four main segments: genetic engineering pharmaceuticals, biological vaccines, traditional Chinese medicine, and real estate, corresponding to its four subsidiaries [1]. - The only subsidiary showing positive growth was Huakang Pharmaceutical, but its revenue contribution is minimal, making it insufficient to offset the overall decline [3]. Investment and Strategy - To counteract the revenue decline, the company has increased its R&D investment by 11.20% to 2.690 billion yuan, which now accounts for 19.97% of revenue [3]. - Sales expenses also rose by 11.81% to 4.439 billion yuan, with the number of sales personnel increasing by nearly 60% from 3,155 to 4,995 [3]. - However, the number of R&D personnel decreased by 4.89%, from 1,329 to 1,264 [3]. Product Development - The company has several key products in development, including a new pediatric cough syrup and treatments for gout and other conditions, with some products expected to be approved this year [4][5]. - Notably, the company decided to terminate a U.S. application for a long-acting growth hormone, resulting in a 133 million yuan impairment charge that affected 2024 profits [6].

Core Viewpoint - Changchun High-tech (000661.SZ) announced that its subsidiary, Jinsai Pharmaceutical, has received approval from the National Medical Products Administration for a supplemental application of a new specification of recombinant human follicle-stimulating hormone injection, specifically the 66μg (900IU) dosage [1] Group 1 - The new specification is intended to meet the same indications as the previously approved specifications, enhancing individualized treatment options for different patients [1] - This approval is seen as a supplement to the already approved specifications, which will further satisfy market demand and improve the company's market competitiveness [1] - However, the sales of the product are subject to various influencing factors, leading to inherent uncertainties [1]

Core Viewpoint - The article discusses the rising anxiety among parents regarding their children's height, leading to increased demand for growth hormone treatments, despite many children not meeting the criteria for such interventions [4][7][22]. Group 1: Market Dynamics - The market for growth hormones is experiencing significant demand, with parents willing to spend substantial amounts, such as 100,000 yuan annually, to ensure their children achieve desired heights [9][6]. - The sales distribution of growth hormones shows that over 70% of sales occur in private medical institutions, with a growing trend towards this channel as public hospitals' reliance decreases [11]. - Companies like Changchun High-tech and its subsidiary, Jinsai Pharmaceutical, reported substantial revenues, with Jinsai achieving 5.152 billion yuan in revenue in the first half of 2024, reflecting a 0.25% year-on-year growth [11]. Group 2: Clinical Insights - Clinical observations indicate that less than 20% of children seeking treatment actually require growth hormone therapy, highlighting a disconnect between parental anxiety and medical necessity [7][20]. - The use of growth hormones can lead to significant side effects, including metabolic disorders and potential diabetes, especially when used inappropriately [21][22]. - Medical professionals emphasize the importance of thorough assessments before initiating treatment, including monitoring growth rates and overall health indicators [20][22]. Group 3: Technological and Treatment Innovations - Future developments in the growth hormone market are expected to focus on innovative delivery methods, expanding indications beyond pediatric growth hormone deficiency, and optimizing existing long-acting technologies [14][21]. - The article mentions various technical paths for long-acting growth hormones, including PEGylation and protein fusion technologies, which could enhance product competitiveness [14][21]. Group 4: Consumer Behavior and Marketing Strategies - Private medical institutions are capitalizing on parental anxiety through promotional strategies, such as low-cost check-ups, which may lead to unnecessary treatments [15]. - There is a noted trend of parents seeking growth hormones through informal channels, often at discounted prices, raising concerns about the safety and appropriateness of such practices [17].