香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 就 因 本 公 告 全部或任何部份內容而產生或因倚賴該等內容而引致之任何損失承擔任何責 任。 本 公 告 僅 供 參 考，並 不 構 成 收 購、購 買 或 認 購 任 何 證 券 的 邀 請 或 要 約。 本公告並不構成在美國境內或在任何其他司法管轄區提呈出售要約或招攬購 買 任 何 證 券 的 要 約，倘 未 根 據 任 何 該 等 司 法 管 轄 區 的 證 券 法 辦 理 登 記 或 未 獲 批 准 而 於 上 述 地 區 進 行 上 述 要 約、招 攬 或 出 售 即 屬 違 法。本 公 告 所 述 的 證 券 將 不會根據經修訂的1933年 美 國 證 券 法（「證券法」）登 記，亦 不 得 在 美 國 境 內 作 出 要 約 或 出 售，惟 根 據 證 券 法 登 記 規 定 獲 豁 免 或 毋 須 遵 守 證 券 法 的 登 記 規 定 進 行 的 交 易 除 外。於 美 國 公 開 發 售 任 何 證 券 將 須 以 招 ...

Market Overview - The Hong Kong stock market experienced a collective decline, with the Hang Seng Index falling 0.67% to close below 27,000 points, the Hang Seng Tech Index down 1.1%, and the National Enterprises Index decreasing by 0.88% [1][3]. Gold and Silver Market - Spot gold surged over $50, reaching a historic high of $3,940 per ounce, leading to a strong performance in gold stocks, with Shandong Gold up over 5%, Chifeng Jilong Gold up over 4%, and Zijin Mining up over 2%. Zijin Gold International saw an increase of over 8%, with its stock price doubling since its IPO [1]. - Silver prices also hit a record high, with NY silver reaching $48 per ounce. China Silver Group experienced a significant intraday increase of 20%, ultimately closing up 14.29% [1]. Semiconductor Sector - The demand for AI data centers has driven semiconductor stocks higher, with SMIC rising over 2% and Hua Hong Semiconductor increasing nearly 7%, both reaching historical highs. Goldman Sachs raised the target prices for SMIC and Hua Hong Semiconductor, citing the expanding AI ecosystem in China as a growth opportunity for the semiconductor sector [1]. Cryptocurrency Market - Bitcoin reached a new all-time high, while cryptocurrency-related stocks saw mixed performance, with OK Group Chain closing up 1.3% after an intraday surge of over 18% [1]. Company Performance - In the Hong Kong Stock Connect, Jihong Co. saw an increase of 8.77%, with a reported profit growth of up to 65% in the first three quarters. MicroPort Medical gained 6.62% following the announcement of a restructuring of its cardiac management business, and Four Seasons Pharmaceutical rose 6.7% after its "Frozen Preservation" product received approval for listing [1]. - In Macau, the gaming sector showed a year-on-year revenue growth of 6%, falling short of Morgan Stanley's expected 16% growth, leading to declines in major gaming stocks such as Melco International Development down over 6% and Galaxy Entertainment down nearly 3% [2]. Consumer Sector - The consumer sector showed overall weakness, with Mengniu Dairy down 2.77%. Concerns over slowing automotive demand negatively impacted the performance of new energy vehicle stocks, with Li Auto down over 3%, XPeng down 1.84%, and NIO down 0.17% [2].

Group 1 - The core stock price of Sihuan Pharmaceutical (00460) increased by 4.47%, reaching HKD 1.87, with a trading volume of HKD 66.5181 million [1] - Xuan Zhu Biotechnology is set to launch its IPO from October 6 to October 10, planning to globally offer 67.3335 million shares, with trading expected to commence on October 15 [1] - Xuan Zhu Biotechnology is a spin-off from Sihuan Pharmaceutical [1] Group 2 - Sihuan Pharmaceutical's subsidiary, Meiyan Space, has developed a new product, "Frozen Beauty," which is an injectable sodium hyaluronate composite solution that recently received a Class III medical device registration from the National Medical Products Administration [1] - This marks the introduction of the first domestic water-light needle containing L-carnosine composite solution into the capital market [1]

Group 1 - The core point of the article is that Sihuan Pharmaceutical (00460) has seen its stock price increase by over 4%, currently trading at HKD 1.87 with a transaction volume of HKD 66.5181 million [1] - Xuan Zhu Biotechnology is set to launch an initial public offering (IPO) from October 6 to October 10, planning to globally offer 67.335 million shares, with trading expected to commence on October 15 [1] - Xuan Zhu Biotechnology is a spin-off from Sihuan Pharmaceutical, indicating a strategic move to enhance its market presence [1] Group 2 - Sihuan Pharmaceutical's subsidiary, Meiyan Space, has developed a new product, "Frozen Beauty," which is an injectable sodium hyaluronate composite solution that has recently received a Class III medical device registration certificate from the National Medical Products Administration [1] - This product marks the first domestic launch of a water-light needle containing L-carnosine composite solution, highlighting innovation in the medical aesthetics market [1]

Core Viewpoint - The approval of "Frozen" marks a significant milestone for the company, indicating the successful implementation of its "medical beauty + biopharmaceutical" dual-engine strategy, which is expected to enhance the company's investment value across multiple dimensions [1][10]. Product Value - "Frozen" is positioned in a high-growth market, specifically the water light needle segment, which is recognized as a "golden track" in the medical beauty sector, driven by increasing consumer demand for skin quality management [1][2]. - The market for water light needle products in China is projected to grow from approximately 4.5 billion RMB in 2025 to 8 billion RMB in 2027, with a compound annual growth rate (CAGR) of 21.5%, significantly outpacing the global market's 10.8% CAGR [2]. - The regulatory tightening in the medical beauty sector presents a historic opportunity for compliant innovative products like "Frozen," allowing it to capture both incremental and existing market shares [2][3]. Financial Value - The launch of "Frozen" is expected to create substantial incremental revenue, enhancing the company's profit structure and providing a strong, predictable new growth driver for its medical beauty segment [5][6]. - "Frozen" is anticipated to contribute significantly to net profit, with its profit structure offering considerable advantages, leading to potential exponential growth in net profit rather than linear increases [6]. - The introduction of "Frozen" signifies an upgrade in the company's profit model, enhancing sustainability and maximizing customer lifetime value, which is crucial for long-term profitability [6]. Strategic Value - The successful launch of "Frozen" indicates that the company's dual-track strategy of self-research and business development (BD) has entered an efficient execution phase, establishing a long-term competitive barrier in the medical beauty sector [7][10]. - The company has developed a dual-engine model combining regenerative products and skin quality management, creating a self-reinforcing ecosystem within its medical beauty business [8]. - The company has a robust pipeline of products in development, with five regenerative micro-sphere products and eight hyaluronic acid products in the registration phase, ensuring continuous growth and market presence [9]. Summary - The success of "Frozen" represents a new phase in the company's medical beauty strategy, reflecting its strong research and development capabilities and substantial pipeline reserves, which are critical for long-term value [10][11]. - The investment logic surrounding the company is shifting from a focus on profitability to high-quality growth, as the medical beauty segment now accounts for over 50% of revenue and continues to grow [11][12]. - The company has transitioned from relying on a single blockbuster product to becoming a platform-based medical beauty enterprise, enhancing its growth potential and valuation premium [12].

Core Viewpoint - The introduction of "Miracle Youth 3.0 - Plastic Beauty" by the domestic medical beauty service platform New Oxygen, priced at 2999 yuan, is considered the lowest price in history, breaking the previous market average of over 10,000 yuan, indicating a significant shift in the market dynamics of youth-enhancing injections [1][2]. Market Competition Landscape - The market for youth-enhancing injections, categorized as "medical beauty regenerative injectables," is experiencing intense competition with nine products currently approved in China, consisting of three imported and six domestic brands [3]. - The global market for medical beauty regenerative injectables is projected to reach approximately 11.52 billion yuan by 2027, with a compound annual growth rate (CAGR) of about 31.2% from 2025 to 2027 [2]. Pricing Strategies and Market Dynamics - The current market is characterized by a "mixed battle" phase, with various brands adopting different pricing strategies, including low-dose products to capture market share [6][8]. - The price of existing products typically starts at over 10,000 yuan, with some products like Jiangsu Wuzhong's Aisufei priced at 18,800 yuan before discounts [3]. Future Market Trends - The entry of New Oxygen and the increase in the number of certified manufacturers and qualified doctors are expected to lead to a price reduction in the youth-enhancing injection market, marking a transition towards market maturity [7]. - The Chinese market is anticipated to become a price lowland compared to neighboring countries, where prices are significantly lower [7]. Sales Performance and Market Size - Despite the competitive landscape, companies like Changchun Shengboma and Aimeike have reported substantial sales figures, with Aimeike's revenue from gel injection products reaching 6.38 billion yuan in 2022, and projected to grow to 1.2 billion yuan in 2024 [10]. - The overall market size for youth-enhancing injections is estimated to be in the millions of units, with a rapid increase in market participants from one or two to potentially twenty in the future [11]. Selection Criteria for Products - The selection of products in the market is increasingly based on consumer reputation, price-performance ratio, and the manufacturer's overall strength, as the number of approved products continues to rise [12]. - Brands must focus on building a strong consumer base and professional barriers to survive in the competitive market, emphasizing the importance of doctor expertise in the application of youth-enhancing injections [13]. Emerging Products and Competition - Several new products are in the pipeline for approval, including those from Hangzhou Gai Biological and Huadong Pharmaceutical, which will further intensify competition in the market [14].

Core Insights - New Oxygen has launched a new product, "Miracle Youth 3.0 - Plastic Beauty Needle," priced at 2999 yuan, which is considered the lowest price in the industry, breaking the previous market average of over 10,000 yuan [1][2] - The introduction of this affordable "youth needle" indicates a significant shift in the market, suggesting that the industry is on the brink of a price war as competition intensifies with more brands entering the space [2][3] Market Overview - The youth needle, classified as a "medical beauty regenerative injection," stimulates the body's collagen regeneration for skin tightening and anti-aging effects [3] - The global market for medical beauty regenerative injections is projected to reach approximately 11.52 billion yuan by 2027, with a compound annual growth rate (CAGR) of about 31.2% from 2025 to 2027 [4] - Currently, there are nine approved youth needle products in China, consisting of three imported and six domestic brands, indicating a competitive landscape [4] Pricing Dynamics - Most existing products are priced starting from over 10,000 yuan, with examples like Jiangsu Wuzhong's Aisufei priced at 11,597 yuan during promotional events, while other products range from 17,000 to 20,000 yuan [5] - The introduction of lower-priced options is expected to disrupt the existing pricing structure, leading to a more competitive environment [14][15] Competitive Landscape - The market is described as entering a "mixed battle" phase, with multiple brands competing aggressively [15] - The current market dynamics show a wide range of product specifications and pricing strategies, with some brands opting for smaller doses at lower prices to capture market share [15][16] - The competitive landscape is evolving, with brands needing to establish strong consumer trust and professional barriers to succeed [19][20] Future Trends - Analysts predict that the Chinese market for youth needles may become a price haven compared to other countries, where prices are significantly lower [15] - The market is expected to continue expanding, with more products in the pipeline for approval, further intensifying competition [20] - Companies are advised to focus on building brand reputation and ensuring product quality to maintain market share in a rapidly changing environment [19][20]

Core Viewpoint - Four Seasons Pharmaceutical (00460) saw a nearly 9% increase in stock price, reaching HKD 1.75 with a trading volume of HKD 137 million, following the approval of its product "Frozen Beauty" by the National Medical Products Administration of China [1] Group 1: Product Approval - The company announced that its subsidiary, Meiyan Space Biotechnology (Jilin) Co., Ltd., received a Class III medical device registration certificate for its self-developed injectable transparent sodium hyaluronate composite solution, branded as "Frozen Beauty" [1] - "Frozen Beauty" is the first approved product in China that contains L-carnosine, designed for temporary improvement of skin dryness and dull complexion [1] Group 2: Strategic Development - The approval of "Frozen Beauty" marks another milestone for Meiyan Space, following the earlier launches of "Youthful Needle" and "Girl Needle" within the year [1] - The company is building a strategic product matrix focused on compliant regenerative materials (Youthful Needle, Girl Needle) and skin quality management (Water Light Needle), enhancing its position in the light medical beauty sector [1] Group 3: Product Portfolio - Meiyan Space has over 30 approved products, establishing a comprehensive product layout in the light medical beauty field [1] - The company aims to provide an integrated solution from skin quality improvement to contour modification, reinforcing its leading position in comprehensive anti-aging solutions [1]

Core Viewpoint - Four Seasons Pharmaceutical (00460) experienced a nearly 9% increase in stock price, closing at 1.75 HKD, following the announcement of its product approval by the National Medical Products Administration of China [1] Group 1: Product Approval - The company’s subsidiary, Meiyan Space Biotechnology (Jilin) Co., Ltd., received a Class III medical device registration certificate for its self-developed injectable transparent sodium hyaluronate composite solution, branded as "Dongyan" [1] - "Dongyan" is the first approved compound solution in China that contains L-carnosine, designed for temporary improvement of skin dryness and dull complexion [1] Group 2: Strategic Product Matrix - The approval of "Dongyan" marks another milestone for Meiyan Space, following the earlier launches of "Tongyan Injection" and "Shaonian Injection" within the year [1] - The company is building a strategic product matrix that combines compliant regenerative materials (Tongyan and Shaonian injections) with skin quality management (water light needle) as dual engines [1] Group 3: Market Position - Meiyan Space has over thirty approved products, establishing a comprehensive product layout in the light medical beauty sector [1] - The company has achieved an integrated layout from skin quality improvement to contour modification, reinforcing its leading position in comprehensive anti-aging solutions [1]

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年9月30日 狀態: 新提交 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 00460 | 說明 | 普通股 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 100,000,000,000 | HKD | | 0.01 | HKD | | 1,000,000,000 | | 增加 / 減少 (-) | | | | | | | HKD | | | | 本月底結存 | | | 100,000,000,000 | HKD | | 0.01 | HKD | | 1,000,000,000 | 本月底法定/註冊股本總額： HKD 1,000,000,000 第 1 頁 共 10 頁 ...