北京市天元律师事务所 关于华润博雅生物制药集团股份有限公司控股股东 增持股份的 专项法律意见 北京市天元律师事务所 北京市西城区金融大街 35 号 国际企业大厦 A 座 509 单元 邮编：100033 北京市天元律师事务所 关于华润博雅生物制药集团股份有限公司控股股东 增持股份的 北京市天元律师事务所（以下简称"本所"）接受华润医药控股有限公司（以 下简称"华润医药控股"或"增持人"）的委托，根据《中华人民共和国公司法》 （以下简称"《公司法》"）、《中华人民共和国证券法》（以下简称"《证券法》"）、 《上市公司收购管理办法》（以下简称"《收购管理办法》"）《深圳证券交易所上 市公司自律监管指引第2号——创业板上市公司规范运作》以及其他相关法律法 规的有关规定，就华润博雅生物制药集团股份有限公司（以下简称"博雅生物"、 "公司"）控股股东华润医药控股增持博雅生物股份的事宜（以下简称"本次增持"） 出具法律意见。为出具本法律意见，本所律师声明如下： 本所及经办律师依据《证券法》、《律师事务所从事证券法律业务管理办法》 和《律师事务所证券法律业务执业规则》等规定及本法律意见出具日以前已经发 生或者存在的事实，严 ...

市 场 研 究 [Table_Title] 万联晨会 [Table_MeetReportDate] 2025 年 05 月 08 日 星期四 [Table_Summary] 概览 核心观点 【市场回顾】 证 券 研 究 报 告 周三 A 股三大指数集体收涨，截止收盘，沪指收涨 0.8%，深成指收 涨 0.22%，创业板指收涨 0.51%。沪深两市成交额 14680.98 亿元。申 万行业方面，国防军工、银行、基础化工领涨，传媒、计算机、电子 领跌；概念板块方面，兵装重组概念、成飞概念、转基因涨幅居前， 中国 AI 50、华为盘古、Sora 概念跌幅居前。港股方面，恒生指数收 涨 0.13%，恒生科技指数收跌 0.75%；海外方面，美国三大指数集体 收涨，道指收涨 0.7%，标普 500 收涨 0.43%，纳指收涨 0.27%。 【重要新闻】 【三部门发布一揽子金融政策稳市场稳预期】央行宣布推出十项政策 措施，其中包括全面降准 0.5 个百分点，下调政策利率 0.1 个百分 点，降低结构性货币政策工具利率和公积金贷款利率 0.25 个百分点， 设立 5000 亿元"服务消费与养老再贷款"等。金融监管总局将推出 ...

华润博雅生物制药集团股份有限公司 证券代码：300294 证券简称：博雅生物 公告编号：2025-032 公司董事会对陈兵先生在任职期间为公司发展做出的努力和贡献表示衷心 感谢！ 关于公司高级管理人员辞职的公告 本公司及董事会全体成员保证公告内容真实，准确和完整，没有虚假记载， 误导性陈述或重大遗漏。 特此公告。 华润博雅生物制药集团股份有限公司董事会 2025 年 5 月 7 日 华润博雅生物制药集团股份有限公司（以下简称公司）董事会于2025年5月7 日收到公司高级管理人员陈兵先生递交的书面《辞职报告》，陈兵先生因个人原 因申请辞去公司副总裁职务。根据《中华人民共和国公司法》《公司章程》等相 关规定，陈兵先生的辞职报告自送达公司董事会之日起生效。陈兵先生辞职后将 不再担任公司任何职务，不会影响公司相关工作的正常开展。 截至本公告披露日，陈兵先生持有公司股份71,300股，占公司总股本的 0.01%，其不存在应履行而未履行的承诺事项。陈兵先生就任时确定的任期为2024 年03月21日至2027年03月20日，辞职后，其在就任时确定的任期内和任期届满后 六个月内，继续遵守《上市公司董事、监事和高级管理人员所持 ...

Investment Rating - The investment rating for the company is "Buy" with expectations of a relative price increase of over 15% in the next six months [4][15]. Core Insights - The company reported a total revenue of 1.735 billion yuan in 2024, a decrease of 34.58% year-on-year, while the net profit attributable to shareholders was 397 million yuan, an increase of 67.18% [1][2]. - In Q1 2025, the company achieved a total revenue of 536 million yuan, reflecting a year-on-year growth of 19.49%, but the net profit attributable to shareholders decreased by 8.25% to 139 million yuan [1][2]. - The company has a stable growth in plasma collection, with a total collection of 630.6 tons in 2024, representing a year-on-year increase of 10.4% [2]. - The company has 11 product varieties and 31 specifications, including imported recombinant factor VIII, and operates 20 plasma stations with one under construction [2]. - The revenue from blood products in 2024 was 1.514 billion yuan, a slight increase of 0.86% year-on-year, despite a competitive market leading to a decline in product gross margins [2][3]. Summary by Sections Financial Performance - The company’s revenue is projected to grow to 1.971 billion yuan in 2025, with a growth rate of 13.62%, and further to 2.242 billion yuan in 2026 [3][10]. - The net profit is expected to reach 519 million yuan in 2025, reflecting a growth rate of 30.86%, and 597 million yuan in 2026 [3][10]. - The earnings per share (EPS) are forecasted to be 1.03 yuan in 2025 and 1.18 yuan in 2026 [3][10]. Research and Development - The company is expanding its research pipeline with a focus on both long-term and short-term strategies, including the approval of drug registration certificates for certain products expected to launch in 2025 [3]. - The company has received drug registration approval for its immunoglobulin product in Pakistan, which is anticipated to enhance overseas revenue [3]. Market Position - The company is experiencing pressure on gross margins due to rising costs and increased competition in the blood products sector, with gross margins reported at 64.65% in 2024 [3][9]. - The company’s sales, management, and financial expense ratios were 33.47% in 2024, indicating an increase in operational costs [9].

降本增效显著，采浆快速增长 ——派林生物 2024 年报&2025 年一季报点评 核心观点 盈利预测与投资建议 ⚫ 考虑到公司产能扩增带来的短期影响，我们下调盈利预期，预测公司 2025-2027 年 每股收益分别为 1.23、1.42、1.60 元（原预测值 2025-2026 年分别为 1.28/1.47 元），参考可比公司平均市盈率，我们给予公司 2025 年 23 倍 PE 估值，对应目标价 28.29 元，维持"买入"评级。 风险提示 ⚫ 行业估值水平波动的风险；采浆量不达预期风险；新品上市不达预期风险；行业政 策变动风险；商誉减值风险等。 公司主要财务信息 | | 2023A | 2024A | 2025E | 2026E | 2027E | | --- | --- | --- | --- | --- | --- | | 营业收入(百万元) | 2,329 | 2,655 | 3,217 | 3,637 | 4,043 | | 同比增长 (%) | -3.2% | 14.0% | 21.2% | 13.1% | 11.2% | | 营业利润(百万元) | 695 | 880 | 1,018 | 1 ...

Investment Rating - The report maintains a "Buy" rating for the company [5] Core Views - The company has shown significant cost reduction and efficiency improvement, leading to rapid growth in plasma collection [1] - The company has adjusted its earnings forecast for 2025-2027, predicting earnings per share of 1.23, 1.42, and 1.60 yuan respectively, with a target price of 28.29 yuan based on a 23x PE valuation for 2025 [2] Financial Performance Summary - Revenue for 2023 was 2,329 million yuan, with a projected increase to 2,655 million yuan in 2024 (+14.0%), and further growth to 3,217 million yuan in 2025 (+21.2%) [4] - Operating profit is expected to rise from 695 million yuan in 2023 to 880 million yuan in 2024 (+26.6%), and to 1,018 million yuan in 2025 (+15.6%) [4] - Net profit attributable to the parent company is forecasted to grow from 612 million yuan in 2023 to 745 million yuan in 2024 (+21.8%), reaching 899 million yuan in 2025 (+20.6%) [4] - The company achieved a net profit margin of 28.1% in 2024, an increase of 1.8 percentage points from the previous year [8] - The company aims to collect over 1,600 tons of plasma in 2025, building on a collection of over 1,400 tons in 2024 [8]

Core Viewpoint - The company maintains a positive outlook on its operational performance and future growth despite challenges in stock price and market conditions [1][2][3]. Financial Performance - In 2024, the company achieved a revenue of 81.76 billion yuan, representing a year-on-year increase of 2.67% [31]. - The net profit attributable to shareholders was 21.93 billion yuan, up 23.25% year-on-year [31]. - The net profit excluding non-recurring gains was 20.60 billion yuan, reflecting a 13.47% increase compared to the previous year [31]. Operational Insights - The company reported a significant decrease in operating cash flow, primarily due to changes in customer payment terms and increased cash outflows for imported goods [1]. - The increase in accounts receivable indicates a potential relaxation of credit policies to boost sales [1]. - Inventory levels rose due to slower sales of human albumin and increased reserves of imported albumin [1]. Market Position and Strategy - The company is recognized as a leading player in the blood products industry, with a focus on enhancing its return on equity (ROE) through improved asset efficiency and profitability [1][2]. - The company holds a 44% share of its revenue from imported human albumin, with significant imports from the US, Spain, and Ireland [2]. - The company is actively pursuing a dual strategy of "expanding plasma sources" and "reducing plasma processing" to enhance its market position [11][27]. Industry Trends - The blood products market is expected to maintain a stable demand, influenced by supply-demand dynamics and healthcare policies [20][24]. - The company is closely monitoring the impact of trade tariffs on its imported products, although the exact effects remain uncertain [3][23]. Future Outlook - The company is committed to ongoing innovation and development in the biopharmaceutical sector, with a focus on clinical research and product diversification [11][27]. - The management expresses confidence in the company's ability to navigate market challenges and enhance shareholder value through strategic initiatives [12][31].

Group 1: Company Performance - In Q1 2025, the company reported a revenue of 2.006 billion, a decrease of 2.45% year-on-year, and a net profit of 566 million, down 25.20% year-on-year [5] - The company’s revenue in 2024 was 8.176 billion, with a year-on-year growth of 2.67%, and a net profit of 2.193 billion, an increase of 23.25% [17] - The company’s inventory as of March 31, 2025, was 4.12 billion, primarily consisting of raw materials and finished goods [4] Group 2: Market Dynamics - The blood product industry is experiencing stable demand, with human albumin in a balanced state and immunoglobulin in a tight balance [2] - The pricing of blood products is influenced by supply-demand relationships and healthcare policies, with expectations of continued rigid demand in the future [3][11] Group 3: Research and Development - The company is focusing on key R&D projects, including SR604, which is currently in Phase II clinical trials [4] - The company has initiated R&D on products like protein C and activated prothrombin complex, which have not yet entered clinical trials [2] Group 4: Strategic Initiatives - The company is pursuing a dual strategy of "expanding plasma collection" and "innovative drug development" to enhance its market position [21] - The company plans to utilize a share buyback program, with a total budget of 250 million to 500 million RMB, to boost investor confidence [23] Group 5: Financial Management - The company has implemented measures to enhance shareholder returns, including stock buybacks and cash dividends [24] - The company’s financial leverage and asset efficiency will be optimized to improve its return on equity (ROE) [26]

Core Viewpoint - The blood products industry, once considered a "golden track," is facing significant challenges in Q1 2025, with major companies experiencing over 20% declines in net profits, contrasting sharply with their strong performance in 2024. This downturn is attributed to a combination of price wars, inventory buildup, and technological substitution [1]. Group 1: Financial Performance - TianTan Bio reported a revenue increase of 7.84% to 1.318 billion yuan, but its net profit plummeted by 22.9%. Operating cash flow fell by 65.75%, and accounts receivable surged by 1093%, indicating deteriorating sales collection efficiency [2]. - Boya Bio's revenue grew by 19.49%, yet its net profit decreased by 8.25%, with core products like human albumin seeing price declines of 2.65% to 12% [2]. - Pailin Bio experienced a revenue drop of 14% and a net profit decline of 26.95%, with operating expenses rising to 18.04%, indicating a failure in cost control [2]. - Shanghai Laishi's net profit growth rate fell from 23.25% to -25.20%, highlighting operational pressures despite expansion efforts [2]. Group 2: Industry Dynamics - The industry's sudden performance decline is driven by price wars, inventory accumulation, and technological substitution. In 2024, blood product inventory growth (36.02%) significantly outpaced cost growth (7.12%), forcing companies to lower prices to clear stock. The terminal price of human albumin has dropped to 350-380 yuan per bottle [3]. - Although not included in national procurement, regional alliance negotiations and competition from imported products create "invisible procurement pressure," with imported albumin's market share rising to 69% and over 70% in tertiary hospitals [3]. - Disruptive technologies are eroding the industry's competitive advantages, with plant-based recombinant albumin potentially reducing costs to below 10 yuan per gram, halving current blood-derived product prices. Additionally, recombinant coagulation factor VIII has captured a 30 billion yuan market share, further compressing the premium space for blood-derived products [3]. Group 3: Opportunities and Challenges - The reliance on imports and the threat from recombinant technologies make domestic production crucial for overcoming current challenges. Tariffs on imports from the U.S. could increase imported albumin prices by 10%-15%, highlighting the cost-effectiveness of domestic products, which currently hold a 31% market share that needs to rise above 50% [4]. - Leading companies are accelerating technological advancements, with TianTan Bio achieving a revenue of over 6 million yuan per ton of plasma and aiming for a 50% domestic production rate for coagulation factors. Shanghai Laishi is investing 4.2 billion yuan to acquire Nanyue Bio, increasing its plasma collection stations to over 50, with the top five companies controlling over 80% of plasma collection [4]. - However, the disruptive threat from recombinant technologies remains, with the clinical adaptation and market education for recombinant albumin expected to take 5-8 years, providing traditional companies with a valuable window for transformation [4]. Group 4: Conclusion - The blood products industry's challenges are not coincidental but rather a painful transition in market logic. As price wars and inventory pressures push companies towards efficiency competition, the race for survival in this trillion-yuan market will test not only the number of plasma collection stations but also product quality, cost control, and strategic foresight [5].

Core Viewpoint - The blood products industry is experiencing a significant divergence in performance among companies, with some reporting growth while others face declines in revenue and profit [1][2]. Group 1: Company Performance in 2024 - Shanghai Laisai (002252) and Tiantan Biological (600161) reported revenue growth of 2.67% and 16.44% respectively, with net profits increasing by 23.25% and 39.58% [1]. - Hualan Biological (002007), Boya Biological (300294), and Bohui Innovation (300318) experienced revenue declines of 18.02%, 34.58%, and 18.53% respectively, while Hualan's net profit fell by 26.57% [1]. - Bohui Innovation managed to turn a profit with a net profit of 0.09 billion yuan, compared to a loss in the previous year [1]. Group 2: Q1 2025 Performance - In Q1 2025, Tiantan Biological, Hualan Biological, and Boya Biological continued to show revenue growth, while Shanghai Laisai, Tiantan Biological, and Paillin Biological saw revenue declines of 2.45%, 0.57%, and 14% respectively [1]. - Hualan Biological's net profit increased by 19.62%, while Shanghai Laisai and Tiantan Biological reported net profit declines of 25.2% and 22.9% respectively [1]. - The decline in profits for Tiantan Biological was attributed to a decrease in product prices that outweighed the benefits of increased sales volume [1]. Group 3: Market Dynamics - The blood products market is expected to maintain stable growth in 2024, with significant competition in the human albumin market due to increased imports [2][3]. - The cancellation of certain medical insurance restrictions is expected to release market demand for coagulation factor products, contributing to their growth [2]. - The overall price trend for blood products is declining, influenced by increased competition and supply exceeding demand for certain products [3]. Group 4: Industry Consolidation - The blood products industry is characterized by high entry barriers, with fewer than 30 companies currently operating due to strict regulations on blood product production [6][7]. - Recent mergers and acquisitions are expected to enhance industry concentration, with leading companies gaining competitive advantages through resource acquisition [6][7]. - Companies like Tiantan Biological and Shanghai Laisai have made significant acquisitions to expand their production capabilities and market presence [7]. Group 5: Market Size and Growth Projections - The blood products market in China reached a scale of 600 billion yuan in 2024, with projections to grow to 780 billion yuan by 2027, reflecting a compound annual growth rate of 11.6% from 2022 to 2027 [8].