Investment Rating - The report maintains an "Overweight" rating for the innovative pharmaceutical and medical device industry chain [3][5][6]. Core Insights - The report emphasizes the continuous recommendation of innovative drugs and medical devices, highlighting the high growth potential in the innovative pharmaceutical sector. It maintains "Overweight" ratings for companies such as Heng Rui Medicine, Hansoh Pharmaceutical, and others, indicating a potential for value re-evaluation [3][5]. - The report notes that the National Medical Insurance Administration has officially announced the 2025 medical insurance drug catalog, which includes 114 new drugs, 50 of which are first-class innovative drugs. This adjustment is seen as a validation of the support for innovation in the healthcare sector [3][5]. - The A-share pharmaceutical sector underperformed the broader market in the second week of December 2025, with the SW Pharmaceutical Biotechnology index declining by 1.0% compared to a 0.3% drop in the Shanghai Composite Index [7][18]. Summary by Sections Section 1: Continuous Recommendation of Innovative Drugs and Medical Devices - The report highlights the sustained recommendation of innovative drugs and medical devices, with a focus on companies that are expected to see performance growth and value re-evaluation [5][6]. Section 2: A-share Pharmaceutical Sector Performance - In the second week of December 2025, the A-share pharmaceutical sector's performance was weaker than the overall market, ranking 16th among the primary industries [7][18]. Section 3: Hong Kong and US Market Performance - The report indicates that the Hong Kong pharmaceutical sector also underperformed, while the US pharmaceutical sector showed stronger performance compared to the broader market [18].

Group 1: Style Rotation Insights - The Q4 style rotation model indicates signals for small-cap and growth stocks [2][3] - The dual-driven rotation strategy for Q4 has a composite score of -1, predicting a focus on small-cap stocks [3] - The value-growth style rotation model shows a composite score of -3, suggesting a preference for growth stocks [4] Group 2: Industry Rotation Analysis - In November, the composite factor strategy yielded an excess return of -0.58%, while the single-factor long strategy had an excess return of -0.83% [4] - For December, the recommended long industries based on single-factor strategies include banking, construction, non-bank financials, and electric equipment & new energy [4] - The composite factor strategy recommends long positions in telecommunications, comprehensive finance, computers, electric equipment & new energy, and utilities [4] Group 3: Pharmaceutical Sector Performance - In November 2025, the pharmaceutical sector underperformed the broader market, with the SW pharmaceutical and biological index declining by 3.6% compared to a 1.7% drop in the Shanghai Composite Index [7] - The relative premium level of the pharmaceutical sector is currently at 72.6%, indicating a normal valuation level compared to all A-shares [7] - In the Hong Kong market, the pharmaceutical sector performed similarly to the market, with the Hang Seng Medical Care index at -0.1% and the biotechnology sector at +0.4% [7] Group 4: U.S. Pharmaceutical Market Trends - In November 2025, the U.S. pharmaceutical sector outperformed the broader market, with the S&P Healthcare Select Sector Index rising by 9.1% compared to a 0.1% increase in the S&P 500 [8] - Notable gainers in the S&P 500 healthcare component included Eli Lilly (+25%) and Solventum (+23%) [8]

Summary of Conference Call Records Industry Overview - The pharmaceutical sector underperformed the broader market in November, with pharmaceutical commerce, traditional Chinese medicine, and raw materials performing relatively well [1][5] - The S&P Healthcare Select Sector Index in the US rose by 9.1%, outperforming the S&P 500 Index by 0.1% [5] Key Companies and Recommendations New Additions to Investment Portfolio - **Jin Xin Pharmaceutical**: Added due to its low valuation and stable core business; its LPA project ranks among the top two in China, expected to act as a catalyst [1][6] - **Yi Fang Bio**: Stock price has reached a low point; TIKTOO product is expected to have potential authorization in the next six months, with similar product data from Takeda acting as a catalyst [1][7] - **Te Bao Bio**: Main product Pegasys for hepatitis B has received approval, with new patient numbers increasing; expected to continue high growth next year [1][8][9] Continued Recommendations - **Hengrui Medicine**: Strong R&D pipeline and favorable procurement situation; R&D Day on December 5 is a key event to watch [1][10] - **Medical Device Leaders**: Long-term investment value due to stable competitive landscape and recovery in terminal bidding; many companies reported revenue turning points in Q3 [1][11] Market Trends and Projections - The medical device industry is expected to see a recovery trend in Q4 2025 and 2026, with strong performance in neuro-intervention and neurosurgery sectors [1][12] - The IVD industry may face volume and price pressures in 2025 but is expected to see a turning point in 2026 [1][12][13] Competitive Landscape - China's medical device market is gaining global competitiveness due to advantages in engineering, industrial clusters, supply chains, and clinical resources [1][14] - Despite complexities, Chinese medical devices are competitive globally due to cost-effectiveness; leading companies are increasing overseas revenue [1][14] Individual Company Insights - **Kelong Pharmaceutical**: Faced challenges due to procurement price reductions but is expected to stabilize with rising demand for large-volume infusions [1][16] - **BeiGene**: Anticipated to achieve profitability for the first time, with strong sales performance from its drug Zebrutinib [1][16] Investment Recommendations - Recommended stocks include **United Imaging**, **Lepu Medical**, **Hui Tai**, **Chun Li**, and **New Industry** in the IVD sector [1][15] - **United Imaging**: Expected to continue high growth with new product contributions [1][15] - **Lepu Medical**: Stable core business with growth potential in new sectors [1][15] Future Catalysts - TIK2 inhibitors are expected to show potential in various indications, with significant data releases anticipated [1][18] - Jin Xin Pharmaceutical has completed Phase I clinical trials with satisfactory results, indicating strong potential in the cardiovascular field [1][20][21] Conclusion - The pharmaceutical and medical device sectors are poised for recovery, with specific companies showing strong potential for growth and investment opportunities in the coming years.

Investment Rating - The report maintains an "Outperform" rating for A-Shares including Jiangsu Heng Rui Medicine, Sichuan Kelun Pharmaceutical, Huadong Medicine, Jiangsu Nhwa Pharmaceutical, Xiamen Amoytop Biotech, Zhejiang Jingxin Pharmaceutical, Innovent Biologics, WuXi AppTec, Hangzhou Tigermed Consulting, Lepu Medical, and APT Medical [2][4][29] - The report also maintains an "Outperform" rating for H-Shares including Hansoh Pharmaceutical Group, 3SBio, PATEO, Akeso, and related targets such as Innovent Biologics and WuXi AppTec (H-Shares) [2][7][29] Core Insights - The report continues to recommend the innovative drug and device industry chain [1][2] - In November 2025, the pharmaceutical sector underperformed the broader market, with the SW Pharma Bio index falling by 3.6% compared to a 1.7% drop in the SHCOMP [2][10] - The premium of the pharmaceutical sector to all A-Shares is currently at a normal level of 72.6% as of the end of November 2025 [17][22] Summary by Sections A-Shares Performance - The report highlights the A-Shares that are recommended for investment, maintaining an "Outperform" rating for several companies, including Jiangsu Heng Rui Medicine and Sichuan Kelun Pharmaceutical, among others [4][5] - The report notes that the pharmaceutical sector's performance was ranked 23rd among Shenwan's first-level industries in November 2025 [10][12] H-Shares Performance - The report indicates that the H-Shares pharmaceutical sector performed in line with the market, with the Hang Seng Healthcare index down by 0.1% and the biotech sector up by 0.4% in November 2025 [2][23] - Top gainers in the H-Shares market included Laekna, Inc. (+40%) and Clover Biopharmaceuticals, Ltd. (+22%) [23] U.S. Market Performance - The U.S. pharmaceutical sector outperformed the broader market in November 2025, with the S&P Healthcare Select Sector rising by 9.1% compared to a 0.1% increase in the S&P 500 [23]

Investment Rating - The report maintains an "Overweight" rating for the innovative pharmaceutical and medical device industry chain [3][5]. Core Viewpoints - The innovative pharmaceutical sector is experiencing high prosperity, with a recommendation for companies like Heng Rui Medicine, Hansoh Pharmaceutical, Sanofi Pharmaceutical, Kelun Pharmaceutical, and Enhua Pharmaceutical to maintain an "Overweight" rating. The report also suggests that Biopharma/Biotech companies such as Kelun Biotech, BeiGene, Baillie Gifford, Yimeng Biotech, Jingxin Pharmaceutical, Teva Biotech, WuXi Biologics, and Ailisi should also be rated "Overweight" as their innovative pipelines are gradually being realized and their performance is entering a growth phase. Additionally, it recommends CXO and upstream pharmaceutical companies like Haoyuan Medicine, Baipusais, WuXi AppTec, WuXi AppTec, and Tigermed to maintain an "Overweight" rating. The report highlights leading medical device companies such as United Imaging, Lepu Medical, Spring Medical, and Huatai Medical as having potential for recovery, also maintaining an "Overweight" rating [5][6]. Summary by Sections - **A-Share Market Performance**: In the third week of November 2025, the A-share pharmaceutical sector underperformed the broader market, with the Shanghai Composite Index falling by 3.9% and the SW Pharmaceutical and Biological Index declining by 6.9%, ranking 23rd among Shenwan's primary industries [7][9]. - **Hong Kong and US Market Performance**: The Hong Kong pharmaceutical sector also underperformed, with the Hang Seng Healthcare Index and the Hong Kong Biotechnology Index both down by 7.5%, while the US healthcare sector outperformed, with the S&P Healthcare Select Sector Index rising by 1.8% [17]. - **Valuation Metrics**: As of November 21, 2025, the pharmaceutical sector's premium level relative to the entire A-share market is at a normal level, with a current relative premium rate of 71.8% [13][16].

Investment Rating - The report maintains a focus on innovative pharmaceuticals and medical devices, highlighting key A-share and H-share targets for investment [6][32]. Core Insights - The pharmaceutical sector showed a good recovery in Q3 2025, with overall revenue increasing by 0.6% year-on-year and net profit attributable to shareholders rising by 0.3% year-on-year [11][32]. - Medical equipment benefited from procurement recovery, with Q3 revenue and net profit growth of 10.6% and 0.6% year-on-year, respectively [11][32]. - Medical R&D outsourcing continued to achieve high growth, with Q3 revenue and net profit growth of 10.9% and 47.9% year-on-year [11][32]. - The offline pharmacy sector improved, with Q3 revenue and net profit growth of 2.1% and 37.8% year-on-year [11][32]. Summary by Sections 1. Focus on Innovative Pharmaceuticals and Medical Devices - Key A-share targets include Jiangsu Heng Rui Medicine, Sichuan Kelun Pharmaceutical, Huadong Medicine, Changchun High-tech Industry, Jiangsu Nhwa Pharmaceutical, WuXi AppTec, Hangzhou Tigermed Consulting, Lepu Medical, APT Medical, and related target Guangdong Zhongsheng Pharmaceutical [6][32]. - Key H-share targets include Hansoh Pharmaceutical Group, 3SBio, Akeso, and related target Innovent Biologics, WuXi AppTec [6][32]. 2. Q3 2025 Pharmaceutical Sector Recovery - The pharmaceutical sector's overall revenue increased by 0.6% year-on-year, with net profit attributable to shareholders up by 0.3% year-on-year [11][32]. - Specific segments such as medical devices and medical R&D outsourcing showed significant growth [11][32]. 3. October 2025 Market Performance - In October 2025, the pharmaceutical sector underperformed the market, with the SW Pharmaceutical and Biological index falling by 1.8% while the SHCOMP rose by 1.9% [14][32]. - The relative premium of the pharmaceutical sector compared to all A-shares was at a normal level, with a current relative premium rate of 76.7% [23][32]. 4. Hong Kong and U.S. Market Performance - The Hong Kong pharmaceutical sector underperformed, with the Hang Seng Healthcare index falling by 11.1% [24][32]. - In contrast, the U.S. S&P 500 healthcare sector rose by 3.5% [24][32].

Investment Rating - The report maintains an "Overweight" rating for several pharmaceutical companies including Jiangsu Heng Rui Medicine, Hansoh Pharmaceutical Group, 3SBio, and Jiangsu Nhwa Pharmaceutical, with related targets such as CSPC Innovation Pharmaceutical [6][28]. Core Insights - The innovative drug sector is experiencing high prosperity, and the report continues to recommend innovative drugs and their industry chain. It highlights the recent global strategic collaboration between Innovent Biologics and Takeda, which is expected to catalyze the innovative drug market [6][29]. - The report notes that the A-Shares pharmaceutical sector underperformed the market in the fourth week of October 2025, with the SW Pharmaceutical and Biological index rising only 0.6% compared to a 2.9% increase in the SHCOMP [8][30]. - In the same period, the Hong Kong pharmaceutical sector also underperformed, while the U.S. pharmaceutical sector performed in line with the market [31][19]. Summary by Sections Continuous Recommendation of Innovative Drugs and Industry Chain - The report emphasizes the ongoing recommendation of innovative drugs and the industry chain, maintaining "Overweight" ratings for various companies including Heng Rui Medicine, Hansoh Pharmaceutical, 3SBio, and Nhwa Pharmaceutical. It also recommends Biopharma/Biotech companies with innovative pipelines and increasing performance, maintaining "Overweight" ratings for Innovent Biologics, Xiamen Amoytop Biotech, and others [6][28]. Performance of A-Shares Pharmaceutical Sector - In the fourth week of October 2025, the A-Shares pharmaceutical sector's performance was weaker than the overall market, with a 0.6% increase compared to the SHCOMP's 2.9% rise. The medical service, pharmaceutical commerce, and medical equipment sub-sectors showed relatively better performance [8][30]. Performance of Hong Kong and U.S. Pharmaceutical Sectors - The Hong Kong pharmaceutical sector underperformed the market with a decline of 0.8%, while the U.S. pharmaceutical sector matched the market performance with a 1.9% increase. Notable stock movements included significant gains for companies like WuXi AppTec and declines for Alphamab Oncology in Hong Kong [31][19].

Investment Rating - The report maintains an "Overweight" rating for the industry [3] Core Viewpoints - The report continues to recommend innovative pharmaceuticals and medical devices along the industry chain [2][7] - The performance of the pharmaceutical sector in September 2025 was weaker than the broader market, with the SW Pharmaceutical Biotech index declining by 1.7% compared to a 0.6% increase in the Shanghai Composite Index [16][22] - The report highlights that the medical service sub-sector performed relatively well, increasing by 1.8%, while medical devices and chemical preparations saw slight declines [22] Summary by Sections - **Investment Recommendations**: The report includes a list of A-share stocks with an "Overweight" rating, including Heng Rui Pharmaceutical, Kelun Pharmaceutical, East China Pharmaceutical, Changchun High-tech, Enhua Pharmaceutical, WuXi AppTec, Tigermed, Lepu Medical, United Imaging Healthcare, and Huatai Medical [7][9] - **Performance Analysis**: The report notes that the monthly portfolio of Guotai Junan Pharmaceuticals outperformed the pharmaceutical index in September 2025, with an average increase of 1.1% compared to a 0.7% increase in the overall pharmaceutical index [12][13] - **Market Comparison**: The report indicates that the pharmaceutical sector's premium level relative to all A-shares is currently at a normal level, with a relative premium rate of 77.5% as of the end of September 2025 [26][28]

Core Insights - The article highlights the recent movements of prominent fund managers in the public fund sector, focusing on their investment strategies and the performance of their funds in 2025 [1][2]. Group 1: Zhang Kun's Strategy - Zhang Kun has reduced his holdings in Meituan by 46.43% while increasing his position in Beike, indicating a continued focus on domestic demand logic [2][3]. - The E Fund Blue Chip Select Fund, managed by Zhang Kun, has a current scale of 34.943 billion and a year-to-date return of 12.85% [3]. - The fund's hidden heavyweights include Focus Media and Meituan, with Focus Media's holdings increasing by 13.76% [3]. - Zhang Kun believes that the current pessimism regarding domestic demand is unfounded and anticipates a positive feedback loop in domestic consumption [4]. Group 2: Ge Lan's Focus on Innovation - Ge Lan's China Europe Medical Health Fund has achieved a year-to-date return of 28.82%, with significant investments in the innovative drug sector [5]. - The fund's hidden heavyweights include Huadong Medicine and Zai Lab, with a notable increase of 2627.32% in holdings of Ailisi [5][6]. - Ge Lan emphasizes that innovation, consumption recovery, and domestic substitution will drive growth in the pharmaceutical industry in the second half of 2025 [6]. Group 3: Fu Pengbo's Growth Strategy - Fu Pengbo's Ruiyuan Growth Value Fund has a year-to-date return of 48.50%, leading among large-scale public funds [7]. - The fund has significantly increased its holdings in Alibaba and BYD by 161.10% and 184.78%, respectively, focusing on high-growth sectors like technology and manufacturing [7]. - Fu Pengbo plans to continue emphasizing sectors such as electronics, internet technology, and precision manufacturing, while also adapting to market conditions [8].

Core Viewpoint - The recent trend of fund subscription limits in China is aimed at ensuring stable fund operations and protecting the interests of existing fund holders, with nearly 50 active equity funds implementing subscription limits since July 2023 [2][11]. Fund Subscription Limits - On August 9, 2023, China Europe Fund announced subscription limits for two of its products: the China Europe Medical Innovation Fund with a limit of 100,000 yuan per single account and the China Europe Science and Technology Innovation Fund with a limit of 1,000,000 yuan, effective from August 11, 2023 [2][3]. - Prior to this, the China Europe Digital Economy Fund had already suspended large subscriptions over 1,000,000 yuan starting August 6, 2023 [2][11]. - The limits are seen as a response to the hot market conditions, with fund companies aiming to protect existing investors from dilution of returns due to large inflows [2][11]. Market Sentiment and Fund Management - Industry experts interpret the subscription limits as a cautious approach to the current high market levels, suggesting that fund companies are not necessarily pessimistic about the market but are focusing on stable fund management [2][11]. - The sentiment in the market is at a high level, and experts recommend maintaining a balanced allocation to manage potential volatility and rapid rotations in the market [11]. Performance and Strategy Insights - Fund manager Ge Lan expressed a long-term optimistic view on the innovative drug sector, highlighting the increasing global competitiveness of domestic companies in areas like ADC and dual antibodies [7]. - The China Europe Science and Technology Innovation Fund, managed by Shao Jie, focuses on the technology innovation sector, which has seen explosive growth this year due to advancements in AI [7][9]. - The subscription limits reflect a broader trend in the industry, with many funds adopting strict limits on daily subscriptions to ensure effective investment strategies and stable operations [9][11].