Core Viewpoint - The credit rating agency has downgraded the long-term credit rating of Blue Sail Medical Co., Ltd. to AA- and the rating of "Blue Sail Convertible Bonds" to AA-, with a stable outlook, reflecting concerns over the company's financial performance and debt levels [1][4]. Financial Performance - In 2024, Blue Sail Medical achieved total revenue of 6.253 billion yuan, a year-on-year increase of 26.91%, with a gross margin of 16.48%, up by 4.18 percentage points [7][24]. - The company reported a total profit loss of 402 million yuan in 2024, an improvement from a loss of 623 million yuan in 2023 [11][23]. - The production of health protection products reached 48.306 billion units, a year-on-year increase of 28.61%, while cardiovascular products saw production of 1.137 million units, up by 25.39% [7][24]. Debt and Liquidity - The company faces significant debt repayment pressure, with 2.845 billion yuan of long-term debt due in 2026, including the outstanding "Blue Sail Convertible Bonds" [8][10]. - As of the end of 2024, the company had total debts of 4.956 billion yuan, with a debt-to-asset ratio of 41.67%, an increase of 2.74 percentage points from the previous year [8][10]. Market Position and Competitive Advantage - Blue Sail Medical maintains a competitive advantage in the cardiovascular and health protection sectors, with a significant market share in disposable gloves and cardiovascular products [4][19]. - The company’s subsidiary, Biosensors International Group, Ltd., is recognized as a global competitor in cardiovascular product development and sales [18]. Strategic Developments - The company has attracted strategic investments, receiving 1 billion yuan and 100 million USD from investors for its subsidiaries, enhancing its cash reserves to 1.954 billion yuan [4][7]. - The health protection product segment is expected to face sales pressure in the U.S. market due to changes in international trade policies [19]. Industry Outlook - The cardiovascular intervention device market is projected to grow, with a global market size expected to reach 11.24 billion USD in 2024, driven by increasing demand and technological advancements [14]. - The disposable glove industry is recovering, with a significant increase in production and sales expected in 2024, following a period of capacity reduction [14][19].

Market Review - The overall market performance for the week saw the CITIC Pharmaceutical Index decline by 4.16%, underperforming the CSI 300 Index by 3.71 percentage points, ranking last among 30 CITIC first-level industries [5] - The top ten stocks by increase included Angli Kang, Yuekang Pharmaceutical, and Innovation Medical, with gains of 21.21%, 19.34%, and 18.96% respectively [4][5] - The bottom ten stocks included Aoyang Health and Kanghui Pharmaceutical, with declines of 1% and 2% respectively [5] Overall Viewpoint and Investment Themes - The pharmaceutical sector is currently undervalued, with public funds (excluding pharmaceutical funds) having low allocations to this sector. The company remains optimistic about the growth of the pharmaceutical industry by 2025, driven by macroeconomic factors and the performance of major products [9] - In the innovative drug sector, there is a shift from quantity to quality, emphasizing differentiated products and international pipelines. Companies that can deliver profitable products are recommended for attention [9] - In the medical device sector, there is a notable recovery in bidding volumes for imaging equipment, and the home medical device market is supported by subsidy policies. The company suggests focusing on key players in this area [9] - The innovation chain (CXO + life sciences services) is expected to see a rebound in overseas investment and a bottoming out in domestic investment, indicating a potential for high growth in 2025 [9] - The pharmaceutical industry is anticipated to enter a new growth cycle, with a focus on specialty raw materials and the expiration of patents leading to new opportunities [10] Orthopedic Consumables Industry Update - The orthopedic consumables market is categorized into joint, spine, trauma, and sports medicine segments, with joint and spine categories holding approximately 90% market share in 2022 [16] - The market size for joint products is projected to grow from 187 billion yuan in 2024 to 408 billion yuan by 2029, with a CAGR of approximately 16.9% [24] - The spine products market is expected to grow from 171 billion yuan in 2024 to 335 billion yuan by 2029, with a CAGR of about 14.4% [24] - The trauma products market is forecasted to increase from 170 billion yuan in 2024 to 315 billion yuan by 2029, with a CAGR of around 13.2% [24] - The sports medicine market is anticipated to grow from 41 billion yuan in 2022 to 145 billion yuan by 2027, with a CAGR of 28.7% [24] Procurement Progress - The national procurement for orthopedic consumables has led to significant price reductions, with average price drops of 82% for joint products and 84% for spine products [30][31] - The procurement process has seen a high participation rate, with 171 companies bidding for spine products and a 98% success rate in the latest sports medicine procurement [35] - The domestic market is experiencing a rapid increase in the localization rate of orthopedic products, with joint product localization rising from 47% in 2020 to 79% in 2024 [25] International Expansion - The global orthopedic consumables market is projected to reach 48.6 billion USD (approximately 348.9 billion yuan) in 2024, with China's market share expected to be 17% [37] - Domestic companies are increasingly focusing on international markets, with significant growth in overseas revenue share for companies like Spring Medical and Dabo Medical [38]

Investment Rating - The report assigns an "Accumulate" rating for the company, indicating a positive outlook based on its growth potential in the precision motion control solutions sector [5]. Core Insights - The company specializes in customized precision motion control solutions, benefiting from the anticipated acceleration of the humanoid robot industry. In Q1 2025, the company's net profit attributable to shareholders increased by 136% year-on-year [5]. - The company has established a long-term strategic partnership with Mindray Medical, focusing on domestic substitution in the medical equipment sector, which is supported by favorable policies [5]. - The humanoid robot sector is seeing active product platform development, with the company making significant advancements in core technologies [5][6]. Financial Performance - In 2024, the company is projected to achieve revenue of 224 million yuan, with a net profit of 39 million yuan. For Q1 2025, revenue reached 59 million yuan, reflecting a year-on-year growth of 35.76% [5]. - The company forecasts revenues of 265 million yuan in 2025, with a net profit of 46 million yuan, and expects continued growth in subsequent years [7][8]. Strategic Initiatives - The company has launched a stock incentive plan to motivate its core team, reflecting confidence in its growth trajectory [5]. - It is actively expanding its product offerings in the medical device sector and humanoid robotics, with ongoing collaborations with various industry players [5][8]. - The company is investing in new manufacturing facilities and establishing a global marketing network to enhance supply chain security and support business growth [8].

Core Viewpoint - The company, Xi'an Dayi Group Co., Ltd., has submitted an application for listing on the Hong Kong Stock Exchange, aiming to leverage the growing demand in the medical device industry and address its financial challenges, including increasing accounts receivable and ongoing losses [1][2][6][14]. Company Overview - Xi'an Dayi Group was established in 2011 and is a global leader in innovative radiotherapy solutions, focusing on building a new generation of intelligent radiotherapy ecosystems [1]. - The company's core products include CybeRay, the world's first real-time image-guided gamma radiotherapy system, and TaiChiRT Pro, the first FDA-designated breakthrough medical device for integrated X/gamma radiation therapy [1][10]. Financial Performance - The company has not yet achieved profitability, with projected revenues of approximately 261 million RMB and 264 million RMB for 2023 and 2024, respectively, alongside losses of about 69.78 million RMB and 94.57 million RMB for the same periods [2][3]. - The overall gross margin is expected to increase from 49.2% in 2023 to 52.7% in 2024, driven by higher contributions from the TaiChi and GMD platform solutions [4]. Accounts Receivable and Cash Flow - Accounts receivable have grown significantly, from 166 million RMB in 2023 to 298 million RMB in 2024, with turnover days increasing from 172 to 322 days, primarily due to conservative payment practices from public hospitals [6]. - Cash and cash equivalents decreased from 334 million RMB to 126 million RMB year-on-year, indicating tight cash flow [6]. Market Opportunity - The medical device industry in China is experiencing a domestic substitution opportunity, with a market size of 1.31 trillion RMB in 2023 and a compound annual growth rate of 10% from 2014 to 2023, positioning it as the second-largest globally [7]. - The market for high-end medical devices remains largely dominated by foreign companies, presenting significant growth potential for domestic players like Xi'an Dayi Group [7][10]. Competitive Landscape - Xi'an Dayi Group ranks second among domestic participants and fifth overall in the Chinese radiotherapy medical device market, with a market share of 4.7%, and leads the gamma radiotherapy market with a 75.8% share [10]. - The company faces competition from established players like Mindray Medical and United Imaging, which have broader product lines and higher revenue scales [11][14]. Future Outlook - The company aims to enhance its market presence and financial performance through continued innovation and product development, particularly in expanding the applications of its existing products [6][14].

Investment Rating - The investment rating for the company is maintained at "Buy" with a target price of RMB 328.30 [7][8]. Core Views - The company reported a revenue of RMB 367.26 billion and a net profit attributable to the parent company of RMB 116.68 billion for 2024, reflecting a year-on-year growth of 5.1% and 0.7% respectively. The profit was below market expectations due to delays in domestic equipment upgrade policies [1]. - The company is expected to achieve steady growth in 2025, driven by the acceleration of domestic equipment upgrade policies and ongoing efforts in product promotion both domestically and internationally [1]. - The company’s three core business segments are projected to perform well in 2025: 1. IVD segment revenue reached RMB 137.65 billion in 2024, with a year-on-year increase of 10.8% and strong overseas growth [2]. 2. Medical imaging segment revenue was RMB 74.98 billion, up 6.6% year-on-year, supported by the launch of high-end products [2]. 3. Life information and support segment revenue was RMB 135.57 billion, down 11.1% year-on-year, but expected to rebound in 2025 due to improving domestic policies [2]. Summary by Sections Financial Performance - The company’s revenue for 1Q25 was RMB 82.37 billion, with a net profit of RMB 26.29 billion, showing a year-on-year decline of 12.1% and 16.8% respectively, but a quarter-on-quarter increase of 13.8% and 154.9% [1]. - The company’s revenue forecast for 2025 is RMB 40.545 billion, with a projected net profit of RMB 12.84 billion, reflecting a growth of 10.04% [6]. Market Expansion - The company’s overseas revenue reached RMB 164.34 billion in 2024, growing by 21.3%, with significant contributions from the Asia-Pacific and European regions [3]. - Domestic revenue was RMB 202.92 billion, down 5.1% year-on-year, but expected to improve in 2025 due to the release of medical infrastructure orders and enhanced competitiveness [3]. Profitability and Valuation - The EPS forecast for 2025 is adjusted to RMB 10.59, with a PE ratio of 31x for 2025, leading to a target price of RMB 328.30 [4]. - The company is recognized as a leading domestic medical device manufacturer with strong brand influence and a continuously improving global sales network [4].

证券研究报告 | 医药生物 | 2025年4月26日 www.hczq.com 华创医药投资观点&研究专题周周谈·第123期 华海药业创新研发进入收获期 本周周专题联系人：王宏雨 | 华创医药团队： | | | --- | --- | | 首席分析师 郑辰 | 执业编号: S0360520110002 邮箱: zhengchen@hcyjs.com | | 联席首席分析师 刘浩 | 执业编号: S0360520120002 邮箱: liuhao@hcyjs.com | | 医疗器械组组长 李婵娟 | 执业编号: S0360520110004 邮箱: lichanjuan@hcyjs.com | | 中药和流通组组长 高初蕾 | 执业编号：S0360524070002 邮箱：gaochulei@hcyjs.com | | 分析师 王宏雨 | 执业编号: S0360523080006 邮箱: wanghongyu@hcyjs.com | | 分析师 朱珂琛 | 执业编号: S0360524070007 邮箱: zhukechen@hcyjs.com | 本报告由华创证券有限责任公司编制 报告仅供华创证券有限责任公 ...

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点击注册小程序 特别申明： 本订阅号中所涉及的证券研究信息由光大证券研究所编写，仅面向光大证券专业投资者客户，用作新媒体形势下研究 信息和研究观点的沟通交流。非光大证券专业投资者客户，请勿订阅、接收或使用本订阅号中的任何信息。本订阅号 难以设置访问权限，若给您造成不便，敬请谅解。光大证券研究所不会因关注、收到或阅读本订阅号推送内容而视相 关人员为光大证券的客户。 报告摘要 免责声明 查看完整报告 上周，A股医药生物指数下跌0.36%，跑输沪深300指数0.94pp，跑赢创业板综指0.17pp，在31个子行业中排名 第24，表现较差。港股恒生医疗健康指数上周收涨0.57%，跑输恒生国企指数0.66pp。 上市公司研发进度跟踪： 上周，百济神州的BGB-C354、恒瑞医药的SHR-4506注射液的临床申请新进承办；百济神州的BGB-21447片、 海思科的HSK45030分散片的IND申请新进承办。上周，石药集团的IBI3002、正大天晴的HRS-5817正在进行三 期临床；海思科的TQB3473正在进行二期临床、康方生物的CMS-D001正在进行一期临床。 本周观点：我国对美加征关税全面执行，建议关注医疗器械国 ...

报告摘要 点击注册小程序 查看完整报告 特别申明： 本订阅号中所涉及的证券研究信息由光大证券研究所编写，仅面向光大证券专业投资者客户，用作新媒体形势下研究 信息和研究观点的沟通交流。非光大证券专业投资者客户，请勿订阅、接收或使用本订阅号中的任何信息。本订阅号 难以设置访问权限，若给您造成不便，敬请谅解。光大证券研究所不会因关注、收到或阅读本订阅号推送内容而视相 关人员为光大证券的客户。 风险分析： 控费政策超预期、研发失败风险、政策支持不及预期、板块估值下挫风险。 行情回顾： 发布日期： 2025-04-20 上周，A股医药生物指数下跌0.36%，跑输沪深300指数0.94pp，跑赢创业板综指0.17pp，在31个子行业中排名 第24，表现较差。港股恒生医疗健康指数上周收涨0.57%，跑输恒生国企指数0.66pp。 上市公司研发进度跟踪： 上周，百济神州的BGB-C354、恒瑞医药的SHR-4506注射液的临床申请新进承办；百济神州的BGB-21447片、 海思科的HSK45030分散片的IND申请新进承办。上周，石药集团的IBI3002、正大天晴的HRS-5817正在进行三 期临床；海思科的TQB3473正 ...

Investment Rating - The report maintains an optimistic outlook on the pharmaceutical industry, suggesting a potential for diverse investment opportunities by 2025 [11]. Core Insights - The pharmaceutical sector is currently undervalued, with public funds showing low allocation to this sector. Positive macroeconomic factors, such as the recovery of U.S. Treasury rates, are expected to drive growth in the industry [11]. - The report emphasizes a shift from quantity to quality in the domestic innovative drug sector, highlighting the importance of product differentiation and internationalization [11]. - The medical device market is experiencing a rebound in bidding volumes, particularly in imaging equipment, and there is a growing focus on home medical devices [11]. - The report identifies a recovery in the innovative chain (CXO + life sciences services) and anticipates a return to high growth for the sector by 2025 [11]. - The traditional Chinese medicine sector is expected to benefit from the introduction of new essential drug directories and state-owned enterprise reforms [13]. - The report highlights the potential for the pharmacy sector to thrive due to prescription outflow and market optimization [13]. - The blood products industry is projected to grow significantly during the 14th Five-Year Plan period, with increased approval for plasma stations [13]. Summary by Sections Market Review - The report notes that the CITIC pharmaceutical index rose by 1.15%, outperforming the CSI 300 index by 2.52 percentage points, ranking third among 30 primary industries [8]. - The top ten stocks by growth include Duorui Pharmaceutical, Oukang Pharmaceutical, and Weisi Medical, while the bottom ten include Dongfang Biological and Nengte Technology [8]. Overall View and Investment Themes - The report suggests that the pharmaceutical industry is at a low valuation, with public fund allocations also low, indicating a potential for growth driven by macroeconomic factors [11]. - It highlights the importance of focusing on differentiated products and internationalization in the innovative drug sector, recommending companies like Hengrui, BeiGene, and others [11]. - The medical device sector is seeing a recovery in bidding volumes, particularly in imaging and home medical devices, with a focus on domestic companies [11]. - The innovative chain is expected to see a rebound in investment, with CXO and life sciences services poised for growth [11]. - The report emphasizes the potential for traditional Chinese medicine and pharmacies to benefit from regulatory changes and market dynamics [13]. Company-Specific Insights - Yuan Dong Biological has maintained a high R&D investment intensity, with 22% of its revenue allocated to R&D in 2023, indicating a strong focus on innovative drug development [17]. - The company has a robust pipeline of high-end generic drugs and is exploring innovative drug candidates, particularly in the area of small molecules and monoclonal antibodies [17][20]. - Yuan Dong's internationalization strategy is focused on the U.S. opioid detoxification market, with several products expected to contribute to revenue by 2025 [23]. - The company is also developing a range of innovative drugs, including NGF monoclonal antibodies and TL1A monoclonal antibodies, which are in various stages of clinical development [32][38].