Core Viewpoint - In 2025, the level of cash dividends from listed companies is expected to rise, transitioning capital returns from an "optional" to a "mandatory" aspect, influenced by strengthened regulatory constraints and a clearer preference for long-term capital [1][3] Group 1: Company Performance and Shareholder Returns - As of December 25, A-share listed companies have distributed over 2.61 trillion yuan in cash dividends this year, marking a historical high [1] - WuXi AppTec, as a leading CXO enterprise, has demonstrated a strong shareholder return strategy through a combination of cash dividends and share buybacks, signaling stable and clear returns to the market [1] - WuXi AppTec has announced a total cash dividend of 4.88 billion yuan for 2024 and 2025, along with two share buybacks totaling 2 billion yuan, enhancing shareholder value by reducing the number of shares outstanding [1][2] Group 2: Financial Stability and Cash Flow - WuXi AppTec's net cash flow from operating activities reached 10.87 billion yuan, reflecting a 35% year-on-year increase, which supports high levels of shareholder returns [2] - The company has maintained a stable cash dividend policy since its IPO in 2018, with a long-term payout ratio around 30%, further reinforcing its commitment to shareholder returns [2] Group 3: Market and Regulatory Context - Regulatory bodies have increasingly enforced cash dividend policies, shifting from "advisory arrangements" to "binding rules," which enhances the importance of capital return methods in valuation structures [3] - Sustainable and predictable dividend arrangements, along with share buyback strategies aligned with stock price cycles, are becoming key indicators of corporate governance quality and capital efficiency [3] - WuXi AppTec's approach to dividends and buybacks is viewed as a long-term commitment to providing tangible and sustainable capital returns, addressing market expectations for certainty and long-term value [3]

甬兴证券表示，在海内外创新药投融资环境改善大背景下，国内CXO行业景气度上行，随着新兴领域 如多肽、CGT、ADC、核酸药物市场规模持续扩大，技术复杂性催生对专业化CDMO服务的强劲需 求，中国CDMO企业通过产能扩产、技术布局与模式创新既在细分领域构建壁垒又通过规模化产能承接 全球订单，有望打开成长天花板。 CRO概念股表现强势，截至发稿，昭衍新药（603127）(06127)涨11.52%，报22.26港元；泰格医药 （300347）(03347)涨5.98%，报44.98港元；药明康德（603259）(02359)涨4.65%，报105.7港元；康龙化 成（300759）(03759)涨4.59%，报20.74港元。 华福证券发布研报称，外需CXO企业自24年订单已经显著改善，业绩上24Q4便恢复同比增长并延续至 25Q3，行业触底反弹趋势已经明确，我们认为外需CXO 26年有望延续25年的上行趋势；内需CXO 25年 初以来在业绩及股价表现相对外需较为弱势，行业整体复苏滞后，但从前端延续至后端确定性较强，当 前或处于左侧机会。 ...

Core Viewpoint - The medical sector is experiencing a strong performance, with the largest medical ETF (512170) showing significant gains, driven by positive market sentiment and news regarding Neuralink's plans for large-scale production of brain-computer interface devices starting in 2026 [1][3]. Group 1: Market Performance - On January 5, 2026, the medical ETF (512170) opened high and rose over 4%, potentially marking the largest single-day gain in nearly three months, with real-time transactions exceeding 650 million yuan [1]. - All 50 constituent stocks of the medical ETF saw increases, with notable surges in brain-computer interface stocks, including Sanbo Brain Science, Meihua Medical, and Lepu Medical, which hit the daily limit of 20% [1]. - The CXO sector also performed strongly, with Zhaoyan New Drug reaching the daily limit and WuXi AppTec increasing by nearly 6% [1]. Group 2: Fund and Index Details - The medical ETF (512170) has a total scale exceeding 25.259 billion yuan, making it the largest medical and healthcare ETF in the market, serving as a significant industry benchmark [3]. - The ETF focuses on "medical devices + medical services," with a CXO weight exceeding 26%, and includes leading companies in aesthetic medicine, private hospitals, and medical information technology [3]. - The current price-to-earnings ratio of the underlying index for the medical ETF is 32 times, which is lower than over 70% of the time in the past decade, indicating a favorable cost-performance ratio for investors [1].

甬兴证券表示，在海内外创新药投融资环境改善大背景下，国内CXO行业景气度上行，随着新兴领域 如多肽、CGT、ADC、核酸药物市场规模持续扩大，技术复杂性催生对专业化CDMO服务的强劲需 求，中国CDMO企业通过产能扩产、技术布局与模式创新既在细分领域构建壁垒又通过规模化产能承接 全球订单，有望打开成长天花板。 智通财经APP获悉，CRO概念股表现强势，截至发稿，昭衍新药(06127)涨11.52%，报22.26港元；泰格 医药(03347)涨5.98%，报44.98港元；药明康德(02359)涨4.65%，报105.7港元；康龙化成(03759)涨 4.59%，报20.74港元。 华福证券发布研报称，外需CXO企业自24年订单已经显著改善，业绩上24Q4便恢复同比增长并延续至 25Q3，行业触底反弹趋势已经明确，我们认为外需CXO 26年有望延续25年的上行趋势；内需CXO 25年 初以来在业绩及股价表现相对外需较为弱势，行业整体复苏滞后，但从前端延续至后端确定性较强，当 前或处于左侧机会。 ...

据央视新闻消息，记者从国家药监局获悉，2025年我国已批准上市的创新药达76个，大幅超过2024年全 年48个，创历史新高。此外，2025年我国创新药对外授权交易总金额超过1300亿美元，授权交易数量超 过150笔，同样创历史新高。 东海证券认为，2026年我国医药生物行业将正式步入创新药大时代，创新药将逐渐占据我国医药生物行 业的主导地位，医保商保的互补结合将长期打开支付空间的天花板，创新药将持续蓬勃发展。国内方 面，2026年将更多关注创新药的上市放量节奏，热门靶点布局的领先程度，竞争格局的拥挤程度，关键 临床数据的读出情况等；海外方面，随着BD交易的常态化，将更多关注首付款项等对现金流的改善程 度，关注已授权项目的海外临床进展情况，海外上市产品的放量情况等。CXO、上游科学试剂等创新 药产业链行业，受益于创新药的快速发展预计仍将保持良好增长势头。 兴业证券认为，近期创新药板块情绪回落，随着BD持续落地，当前板块景气度可持续，"创新+国际 化"创新药产业趋势不变，短期调整后创新药板块弹性进一步提升。同时，可继续重点关注基本面已开 始改善的创新药产业链，当前在投融资数据、订单和业绩层面均看到向好趋势。 ...

Group 1: H-Shares and Semiconductor Sector - H-shares of technology stocks surged on the first trading day of 2026, driven by Baidu's announcement of Kunlun Chip's independent listing and Wall Street's 75% increase in Wall Street Technology stocks [1] - The semiconductor sector experienced a significant rally, with major players like SMIC and Hua Hong benefiting from increased orders, leading to a bullish outlook for their performance [1] - The demand for industrial metals is expected to rise due to AI's energy requirements, resulting in price increases for copper and aluminum, with companies like Jiangxi Copper, Luoyang Molybdenum, and Zijin Mining seeing substantial gains [1] Group 2: Emerging Investment Opportunities - Four key investment directions are highlighted: non-ferrous metals, semiconductor industry chain, commercial aerospace, and robotics [2][4] - The commercial aerospace sector is seen as an extension of the AI industry, with significant speculative interest due to government support and the nascent stage of the industry [2] - Robotics is identified as a key area where AI and semiconductor industries converge, presenting further investment opportunities [2] Group 3: Market Predictions and Strategies - Predictions for the market from January 5 to January 9 indicate a potential upward trend, with key resistance levels identified at 3950 and 4034 [3] - The focus for 2026 includes dividend stocks, new technologies, new pharmaceuticals, and new consumer trends, with a strategy to reduce positions if the Shanghai Composite Index exceeds 5178 points [3] - Emphasis is placed on identifying industry performance turning points, particularly in sectors like CXO and medical devices, as well as individual stock opportunities in lithium batteries and energy metals [4]

Core Viewpoint - The Hong Kong stock market experienced a strong upward trend in 2025, with the Hang Seng Index rising by 27.77% and the Hang Seng Tech Index increasing by 23.45%, driven by active trading and improved market sentiment [1][12]. Market Performance - The trading volume in the Hong Kong stock market significantly increased compared to previous years, indicating heightened trading activity and a broad release of market profit potential [1]. - The year saw a clear phase rotation in the market, with different sectors driving the market's upward movement at various times, including AI technology, innovative pharmaceuticals, and non-competitive policies leading to industrial optimization [3][5]. Sector Analysis - The technology sector was a major player in the market, with the Hang Seng Tech Index rising by 20.74% in Q1 2025, outperforming the Hang Seng Index's 15.25% increase during the same period [4]. - The innovative pharmaceutical sector gained momentum due to a surge in business development (BD) transactions, benefiting from improved global liquidity as the Federal Reserve began its rate-cutting cycle [4][5]. - The metals sector, particularly non-ferrous metals, emerged as the strongest performer by year-end, with copper stocks rising by 261.85%, gold and precious metals by 197.85%, and other metals and mining stocks by 187.91% [6][7]. Individual Stock Performance - Notable individual stock performances included Zijin Mining (02899.HK) rising by 162%, Shandong Gold (01787.HK) increasing by over 183%, and Jiangxi Copper (00358.HK) climbing nearly 281% [9]. - The stock of珠峰黄金 (01815.HK) skyrocketed by over 1286%, marking it as a rare "tenfold" stock in a year [9]. Investment Drivers - The rise in non-ferrous metals was attributed to multiple favorable factors, including the global trend of "de-dollarization," supply-demand imbalances in industrial metals, and domestic policies optimizing supply structures [6][10]. - The rapid development of emerging industries such as AI, new energy, and innovative pharmaceuticals provided a wealth of high-growth investment opportunities, supporting long-term stock price increases [12][13]. Future Outlook - Analysts expect the Hong Kong stock market to continue its upward trend in 2026, driven by improved liquidity and corporate profit recovery, with a potential shift in market driving logic from valuation recovery to profit growth [13].

Core Insights - The CXO sector in A/H shares shows signs of fundamental recovery ahead of expectations in 2025 after three years of valuation downgrades [1] - The recovery is uneven, with the clinical CRO segment still facing challenges, indicating a divergence in industry recovery [1][7] Group 1: Financial Performance - WuXi AppTec (药明康德) reported a revenue of 32.857 billion yuan in the first three quarters of 2025, a year-on-year increase of 18.61%, and a net profit of 12.076 billion yuan, up 84.84% [1] - The company had a backlog of orders amounting to 59.880 billion yuan as of September 2025, reflecting a 37.2% year-on-year growth [1] - The average price of clinical research services in China has decreased by approximately 30% since 2022, impacting gross and net profit margins [2] Group 2: Order Fulfillment and Business Model - The business model of CXO leads to a natural lag in order fulfillment, with revenue recognition often taking multiple quarters or years [2] - WuXi AppTec's backlog at the end of 2024 was 49.310 billion yuan, 1.26 times its revenue for that year, indicating visible future revenue growth potential [2] - The order-to-revenue ratio is crucial for assessing conversion efficiency, with a healthy range identified between 1.2 to 1.3 times [3] Group 3: Market Dynamics and Challenges - The global pharmaceutical R&D investment continues to grow, but structural fluctuations are evident, particularly among innovative drug startups [1] - The clinical CRO segment is heavily influenced by funding constraints and project strategy adjustments, leading to a situation where project numbers increase but individual project outputs decline [8] - The international expansion of clinical CROs raises higher standards for organizational capability and compliance, making short-term recovery challenging [8] Group 4: Emerging Opportunities - The global expansion of GLP-1 and related indications has led to unexpected order increases in upstream peptide and related processes, maintaining high demand in 2025 [9] - Core stock Novartis Bio (诺泰生物) achieved a revenue of 1.527 billion yuan in the first three quarters of 2025, with a net profit of 445 million yuan, reflecting a year-on-year growth of 21.95% and 26.92% respectively [9] - The market for cell and gene therapy (CGT) is still growing, but profitability remains elusive, with significant investments required before becoming a core profit driver [10][11]

Core Viewpoint - The A-share pharmaceutical sector in 2025 exhibits structural differentiation, with innovative drugs and CXO sectors thriving due to overseas demand and business development, while traditional Chinese medicine, medical devices, and pharmaceutical commerce face performance pressures [3][20]. Summary by Category Overall Market Performance - The A-share pharmaceutical and biotechnology sector saw an overall increase of 25.64% from January 1 to December 30, 2025, despite a slight decline in revenue and a stabilization in profits, with total revenue of 18,544.52 billion yuan, down 1.42% year-on-year, and net profit of 1,407.32 billion yuan, down 1.65% year-on-year [4][21]. Innovative Drug Sector - The innovative drug sector was a standout performer in 2025, with the chemical pharmaceutical segment rising by 32.58% and the medical services segment by 32.91% [4][21]. - Companies like BeiGene (百济神州) reported significant growth, achieving revenue of 27.595 billion yuan, a 44.2% increase year-on-year, surpassing the total revenue of 27.21 billion yuan for 2024 [4][22]. Business Development (BD) Trends - The business development landscape for innovative drug companies is evolving, with significant partnerships such as the 11.4 billion USD deal between Innovent Biologics and Takeda, and a 12.5 billion USD collaboration between Hengrui Medicine and GlaxoSmithKline [5][22][24]. - The total value of business development transactions reached approximately 94.158 billion USD in the first three quarters of 2025, significantly exceeding the total for 2024 [25]. CXO Sector Performance - The CXO sector, driven by the demand for innovative drug research, achieved a 32.91% increase in 2025, with total revenue of 1,365.72 billion yuan, up 3.63% year-on-year, and net profit of 209.12 billion yuan, up 36.47% year-on-year [10][27]. - Leading companies like WuXi AppTec (药明康德) and Kanglong Chemical (康龙化成) returned to growth, with WuXi AppTec reporting a revenue increase of 18.61% and net profit growth of 84.84% [28][31]. Traditional Chinese Medicine and Medical Devices - The traditional Chinese medicine sector experienced a modest increase of 6.75% in 2025, with total revenue of 2,590.69 billion yuan, down 4.33% year-on-year, and net profit of 294.99 billion yuan, down 1.53% year-on-year [36]. - The medical device sector reported a revenue of 1,792.10 billion yuan, down 2.24% year-on-year, with notable performance differences among sub-sectors, where companies like Mindray Medical (迈瑞医疗) showed strong overseas revenue growth [33][34].

Group 1: Core Insights - The report maintains a strong market rating for the pharmaceutical industry, indicating a clear upward trend driven by recovering demand and improved performance in the CXO sector [1][2] - The CXO sector has shown significant stock price increases, with some companies experiencing nearly 100% growth since the beginning of 2025, driven by the innovative drug market and a recovery in orders [3][6] Group 2: CXO Sector Analysis - The CXO sector's overall revenue increased by 11.8% year-on-year in the first three quarters of 2025, with a notable profit increase of 58.1% [13] - External demand for CXO services has rebounded, with significant order growth from leading CDMO companies, indicating a clear recovery trend [22][31] - Internal demand for CXO services has lagged behind external demand, but there are signs of strong growth in domestic innovative drug projects and increased investment in the domestic market [3][22] Group 3: Life Sciences Upstream - The life sciences upstream sector has seen a 37.7% increase in stock prices year-to-date, outperforming the pharmaceutical and biotechnology index by 18% [3] - Revenue for the upstream sector increased by 8.8% year-on-year in the first three quarters of 2025, with net profit rising by 27.7% [3] Group 4: Investment Recommendations - The report suggests a strategic investment focus on companies such as WuXi AppTec, WuXi Biologics, and Tigermed, while also highlighting more flexible investment options like Zhaoyan New Drug and Nossan [3]