Investment Rating - The industry investment rating is "Outperform" [2] Core Insights - The report highlights the issuance of the "Implementation Opinions on Promoting the Innovation and Development of Brain-Machine Interface Industry" by the Ministry of Industry and Information Technology and six other departments, which increases certainty in the related industry [5][14] - The pharmaceutical and biotechnology sector has shown a 3.08% increase this week, outperforming the CSI 300 index by 0.7 percentage points, ranking 10th among 31 sub-industries [20][21] - The report indicates that the brain-machine interface technology is in a period of accelerated transformation, with domestic companies expected to gradually achieve commercialization, leading to rapid market expansion [6][17] Summary by Sections Industry Overview - The closing index for the industry is 9029.09, with a 52-week high of 9029.09 and a low of 6070.89 [2] Weekly Performance - The medical research outsourcing sector had the highest increase this week at 7.77%, followed by the hospital sector at 5.59% and medical consumables at 4.47% [7][21] - The report notes a significant divergence in performance among sub-sectors, with offline pharmacies experiencing the largest decline at 1.82% [7][21] Beneficiary Stocks - Beneficiary stocks in the innovative drug sector include companies such as Innovent Biologics, Kintor Pharmaceutical, and BeiGene for H-shares, and Zai Lab, Eucure Biopharma, and others for A-shares [8] - In the medical device and consumables sector, companies like Mindray Medical, Weigao Group, and others are highlighted as beneficiaries [8] Sub-sector Analysis - The report emphasizes that the innovative drug sector is expected to continue performing well due to overseas business development expectations and supportive policy documents [26] - The medical device sector is projected to benefit from policies promoting the replacement of old equipment, with significant growth expected in the second quarter of 2025 [27][28] - The IVD sector is anticipated to see marginal improvements due to optimized procurement policies, with AI-assisted diagnostics being a promising direction [31][32] Market Trends - The report indicates that the overall trend for the medical device industry is positive, driven by innovation, mergers, and internationalization, with leading Chinese companies expected to grow into global leaders [28] - The report also notes that the traditional Chinese medicine sector is expected to see a turning point as inventory clears and procurement policies are implemented [40]

Investment Rating - The report assigns a "Buy" rating to Thermo Fisher, while other companies such as Danaher, Samsung Bio, and Lonza remain unrated [2]. Core Insights - The report highlights that the impact of tariffs on the life sciences upstream sector is less than expected, leading to an overall upward revision of performance guidance for 2025 by most companies [4][29]. - Clinical CRO orders have unexpectedly increased, driven by strong biotech client demand, although the sustainability of this trend remains uncertain [4][31]. - The revenue recovery is outpacing profit recovery, with cost control pressures increasing due to external macroeconomic challenges [6][14]. Summary by Sections Performance Analysis - In 1H25, the performance of overseas CXO and life sciences upstream companies remained under pressure, but a sequential improvement was observed in 2Q25, with 7 out of 10 tracked companies showing revenue growth compared to 1Q25 [6][31]. - The median and average revenue growth rates for 2Q25 were +4.3% and +7.1%, respectively, compared to +0.2% and +6.0% in 1Q25, primarily driven by clinical CRO companies [6][8]. Tariff Impact - The impact of tariffs on sales of instruments and equipment for drug development and production was reported to be less than anticipated, with management from major life sciences companies indicating a more favorable outlook [29][30]. - Companies like Thermo Fisher and Danaher have adjusted their performance guidance upwards, reflecting a more optimistic view on tariff impacts [29][30]. Demand Trends - The C(D)MO sector continues to see strong commercial production demand, while life sciences upstream companies benefit from a recovery in consumable demand as clients complete inventory destocking [31][32]. - Clinical CRO demand has been bolstered by unexpected growth from biotech clients, although the sustainability of this demand is still in question [33][34]. Financial Metrics - The average gross margin for heavy asset companies decreased from 50.2% in 2021 to 45.7% in 2024, but showed signs of recovery in 2Q25 [15]. - The report notes that capital expenditures are expected to reverse the declining trend observed in 2023-24, potentially increasing future depreciation pressures [17]. Market Reactions - Following the release of 2Q25 results, stock prices for most overseas CXO and life sciences companies reacted positively, particularly for clinical CROs, which saw significant price increases due to better-than-expected performance [24][25].

Group 1 - The pharmaceutical and chemical drug industry is undergoing policy deepening and globalization transformation, with a focus on drug and consumable procurement optimization, payment reform, and medical service price adjustments [1] - The pharmaceutical supply chain emphasizes innovation transformation and supply chain security, with optimism in the medical device sector regarding import substitution and the application of new technologies like AI [1] - China's pharmaceutical industry competitiveness is continuously enhancing due to demographic dividends, manufacturing advantages, and improved innovation capabilities, with a clear trend of innovative drugs and devices going global [1] Group 2 - The CXO industry is experiencing a turning point after adjustments, with a recovery in overseas orders and domestic innovative drug clinical progress, indicating a potential demand revival [1] - Small molecule drugs continue to dominate new drug research and development, with the outsourcing penetration rate expected to reach 65% by 2033 [1] - The industry is accelerating consolidation, with an increase in concentration among leading enterprises and gradual improvement in capacity utilization [1] Group 3 - The ETF tracking the innovative drug index focuses on high R&D investment and significant innovation achievements in the biopharmaceutical and chemical drug sectors, highlighting the research capabilities and long-term growth value of constituent companies [1]

（文章来源：每日经济新闻） 每经AI快讯，中信建投研报称，国内CXO行业经历医药市场投融资遇冷以及新冠大订单带来的高基数 影响，2023—2024年行业进入调整阶段，业绩承压。海外市场需求2023年底开始出现复苏，2024年国内 头部企业海外订单出现恢复性增长，率先迎来经营拐点。国内诸多创新药资产近年来陆续进入临床中后 期，临床数据不断通过概念验证，出海趋势逐渐明确，诸多首付款以及潜在里程碑的确认成为国内创新 药企资金重要来源。同时随着今年上半年港股市场的活跃以及科创板未盈利企业上市渠道再次开启，国 内需求有望迎来进一步恢复，带动CXO产业链进入新一轮发展阶段。 ...

Group 1 - The People's Bank of China emphasizes the importance of promoting a reasonable recovery in prices as a key consideration for monetary policy [4] - The central bank plans to implement a moderately loose monetary policy, focusing on supply-side efforts to create effective demand [4] Group 2 - The U.S. government has announced an expansion of the 50% tariffs on steel and aluminum imports, including hundreds of derivative products [7] - President Trump indicated that semiconductor tariffs could be announced within two weeks, potentially reaching 300% [8] Group 3 - Southbound funds recorded a net purchase of 35.876 billion HKD on August 15, setting a new single-day record [9] - This surpasses the previous record of 35.586 billion HKD set on April 9, 2025 [9] Group 4 - Hong Kong's Financial Secretary, Paul Chan, announced plans to develop an international gold trading center, with a proposal expected to be released within the year [10] - The government has established a dedicated team to review various aspects related to gold financial transactions [10] Group 5 - The China Securities Regulatory Commission has approved the registration of futures and options for five products, including printing paper and fuel oil, marking the launch of the world's first financial derivatives for cultural paper [11][12] - This move aims to enrich the product system of the Shanghai Futures Exchange [12] Group 6 - The CXO industry in China is entering an adjustment phase due to a cooling investment environment and high base effects from COVID-19 orders, with performance under pressure [18] - A recovery in overseas market demand is expected by the end of 2023, leading to a rebound in orders for leading domestic companies in 2024 [18]

Core Viewpoint - The CXO industry in China is entering an adjustment phase due to a cooling in pharmaceutical market investments and the high base effect from COVID-related orders, with performance under pressure in 2023-2024 [1] Group 1: Industry Trends - The overseas market demand is expected to show signs of recovery starting at the end of 2023, leading to a rebound in overseas orders for leading domestic companies in 2024 [1] - Many innovative drug assets in China have entered late-stage clinical trials, with clinical data increasingly validated, indicating a clear trend towards internationalization [1] Group 2: Financial Opportunities - The confirmation of various upfront payments and potential milestone payments is becoming an important source of funding for domestic innovative pharmaceutical companies [1] - The active Hong Kong stock market in the first half of this year and the reopening of listing channels for unprofitable companies on the Sci-Tech Innovation Board are expected to further boost domestic demand [1]

证 券 研 究 报 告 行业周报 医药行业周报 全球GLP-1市场稳定扩容，关注国内企 业的授权机会 投资评级： 报告日期： 推荐 （维持 ） 2025年08月17日 分析师：胡博新 SAC编号：S1050522120002 分析师：吴景欢 SAC编号：S1050523070004 医 药 行 业 观 点 1. 东升西落，出海将是长期趋势 根据医药魔方数据，2025年上半年，全球医药交易数量达456笔，同比增长32%；首付款总额达118亿美元，同比激增 136%；交易总金额高达1304亿美元，同比增长58%。全球交易数量与金额均呈现显著上升态势。其中，涉及中国的交易 贡献了近50%的总金额和超过30%的交易数量。无论交易金额和总数，中国企业在全球创新药中价值得到进一步认可。中 国的研发效率优势正逐步显现，而且工程师数量和临床资源优势叠加。展望未来十年，中国的效率优势还将持续扩大，中 国企业参与的创新药交易预计超过全球的50%以上。根据wind数据，医药生物行业最近1月涨幅为11.07%，跑赢沪深300指 数6.51个百分点，截止8月15日，医药生物行业指数当期PE（TTM）39.94倍；高于5年历史平均估值3 ...

数据显示，截至2025年7月31日，国证公共卫生与医疗健康指数(980016)前十大权重股分别为药明康德 (603259)、恒瑞医药(600276)、迈瑞医疗(300760)、联影医疗(688271)、片仔癀(600436)、爱尔眼科 (300015)、科伦药业(002422)、泰格医药(300347)、复星医药(600196)、新和成(002001)，前十大权重股 合计占比53.05%。 医疗健康ETF泰康(159760)，场外联接(A类：020093；C类：020094)； 截至2025年8月15日 13:04，国证公共卫生与医疗健康指数(980016)上涨0.86%，成分股神州细胞(688520) 上涨7.38%，华大智造(688114)上涨4.59%，信立泰(002294)上涨3.76%，健康元(600380)上涨3.50%，新 产业(300832)上涨3.14%。 医疗健康ETF泰康(159760)上涨1.23%，最新价报0.66元。截至2025年8月14日，医疗健康ETF泰康近3个 月超越基准年化收益为5.26%。 中信建投证券认为，CXO行业拐点显现，估值修复，有望进入新一轮发展阶段。国内CXO ...

Group 1 - The Shanghai Stock Exchange Sci-Tech Innovation Board 100 Index increased by 0.71%, with notable stock performances including Zhuhai Guanyu up 6.42% and BZJ Engineering up 5.88% [1] - The Huaxia Sci-Tech 100 ETF (588800) rose by 0.62%, with a recent price of 1.13 yuan, and has seen a cumulative increase of 2.55% over the past week [1] - The Huaxia Sci-Tech 100 ETF's trading volume reached 50.33 million yuan, with an average daily trading volume of 265 million yuan over the past year [1] Group 2 - The National Healthcare Security Administration announced the latest progress in the adjustment of the 2025 National Basic Medical Insurance Directory, with 534 drug names passing the preliminary review, a significant increase from 249 in 2024 [2] - The CXO industry in China is experiencing an adjustment phase due to a cooling in pharmaceutical market investments and high base effects from COVID-19 orders, with a recovery in overseas market demand expected by the end of 2023 [2] - The active Hong Kong stock market and the reopening of listing channels for unprofitable companies on the Sci-Tech Innovation Board are anticipated to further stimulate domestic demand, leading to a new development phase for the CXO industry chain [2]

Summary of WuXi AppTec Conference Call Company Overview - WuXi AppTec is a leading global provider in the small molecule Contract Research, Development, and Manufacturing Organization (CRDMO) sector, with a revenue scale exceeding 40 billion yuan and a market share of approximately 8%-9% globally, which is expected to double in the future [2][29]. Financial Performance - The company is projected to achieve revenues of 42.5 to 43.5 billion yuan in 2025, reflecting a mid-double-digit growth rate, with an adjusted net profit margin expected to improve [2][9]. - The adjusted net profit margin reached 30% in the first half of 2025, driven by revenue structure optimization and cost reduction efforts [2][11]. - Capital expenditures are anticipated to be between 7 to 8 billion yuan in 2025, focusing on overseas markets and new molecular businesses, particularly peptides [2][10]. Business Segments - The chemical segment continues to be the core revenue and profit source, with its revenue share increasing to nearly 80% by 2024 and expected to rise further in 2025 [2][15]. - The small molecule CLDMO integrated business model covers the entire chain from drug discovery to commercial production, with early R&D contributing 20% of revenue, small molecule CDMO accounting for 62%, and rapidly growing peptide business reaching 20% [2][16]. Market Dynamics - The company has maintained a growth trajectory despite geopolitical risks, such as US-China tariffs, which have had limited actual impact on operations [2][7][13]. - The peptide business is a key growth driver, with expected revenue growth exceeding 80% in 2025, supported by demand for GLP-1 class products [2][19]. Operational Challenges - The testing business has faced challenges due to intense domestic competition, leading to a decline in revenue and gross margins [2][20][21]. - The clinical CRO and SMO sectors are experiencing significant competitive pressure, particularly in the CRO space, which has seen a 15% decline in revenue [2][23]. Future Outlook - WuXi AppTec is expected to continue its upward trajectory, with a strong order backlog and anticipated revenue growth of over 30% in 2025 [2][27]. - The company is well-positioned to capitalize on the global small molecule CMO market, with significant capital investments planned to enhance production capacity [2][31][32]. Key Risks - Geopolitical risks, particularly related to tariffs and regulations affecting Chinese suppliers, remain a concern but are being managed effectively [2][6][7]. - The company’s personnel size is expected to shrink in 2025 due to business divestitures, yet it will maintain the largest technical team globally [2][14]. Conclusion - WuXi AppTec is poised for robust growth driven by its strategic focus on high-demand sectors, effective management of geopolitical risks, and a strong operational foundation, making it a key player in the CRDMO industry [2][32].