Core Viewpoint - Fosun International Limited maintains a robust fundamental performance in 2025, with strong growth in core sectors such as healthcare and insurance, driven by innovation and globalization [1][2] Financial Performance - Total revenue for the group reached RMB 173.43 billion, with adjusted operating profit of RMB 4 billion [1] - The four core subsidiaries generated revenue of RMB 128.2 billion, accounting for 74% of total revenue [1] - Fosun Pharma's net profit reached RMB 3.371 billion, a year-on-year increase of 21.69% [1] - The net profit of Fosun Portugal Insurance was EUR 201 million, up 15.8% year-on-year [1] Strategic Focus - The company is implementing a "streamlining and focusing on core business" strategy, resulting in a non-cash impairment charge of RMB 23.4 billion due to asset revaluation [1][2] - The impairment primarily affected real estate projects (55%) and non-core assets (45%) [1] Innovation and R&D - Fosun's R&D investment reached RMB 7.8 billion, with a focus on a three-pronged global innovation system [3] - Seven innovative drugs received approval for 16 indications, with six additional applications accepted [3][4] - Revenue from innovative drugs increased to RMB 9.893 billion, a growth of 29.59%, representing 33.16% of pharmaceutical business revenue [4] Globalization Efforts - Overseas revenue reached RMB 94.86 billion, accounting for 54.7% of total revenue, an increase of 5.4 percentage points year-on-year [6] - Fosun Pharma's core product, H drug, generated global sales of RMB 1.493 billion, a growth of 13.7% [6][7] - The company has established a global operational network covering multiple regions, enhancing its international business capabilities [7] Insurance Sector Performance - Fosun Portugal Insurance reported gross premium income of EUR 6.53 billion, with a net profit of EUR 201 million, reflecting a 15.8% increase [7][8] - The domestic insurance companies also showed significant growth, with Fosun Baodexin Life achieving a premium income of RMB 13.28 billion, up 41.6% [8] Commitment to ESG - Fosun is dedicated to sustainable development, with significant contributions to global health and rural revitalization initiatives [10] - The company received top ESG ratings, including MSCI ESG AAA rating and inclusion in various sustainability indices [10] Future Financial Goals - The company aims to restore a profit scale of RMB 10 billion and reduce total liabilities to below RMB 60 billion [11] - A plan to increase the dividend payout ratio from 20% to 35% for the fiscal year 2026 has been announced [11]

Core Insights - The company reported total revenue of RMB 173.43 billion and adjusted operating profit of RMB 4 billion for the fiscal year ending December 31, 2025 [1][2] - The overseas revenue reached RMB 94.86 billion, accounting for 54.7% of total revenue, an increase of 5.4 percentage points year-on-year [1][7] - The company aims to gradually restore profit levels to RMB 10 billion and reduce total liabilities to below RMB 60 billion [1][12] Financial Performance - The four core subsidiaries generated revenue of RMB 128.2 billion, representing 74% of total revenue [2] - The health sector subsidiary, Fosun Pharma, reported a net profit of RMB 3.371 billion, a year-on-year increase of 21.69% [2] - The insurance subsidiary, Fosun Portugal, achieved a net profit of EUR 201 million, up 15.8% year-on-year [2][8] Strategic Initiatives - The company is implementing a "streamlining and focusing on core business" strategy, resulting in a non-cash impairment charge of RMB 23.4 billion, primarily from real estate and non-core assets [2][3] - The company has invested RMB 7.8 billion in innovation, with seven innovative drugs approved for 16 indications domestically and internationally [4][5] Innovation and R&D - The company’s innovative drug revenue reached RMB 9.893 billion, a year-on-year increase of 29.59%, accounting for 33.16% of pharmaceutical business revenue [5] - The company has nearly 40 innovative drug clinical trials approved by regulatory agencies in China, the US, and Europe [5][6] Globalization Efforts - The company’s globalization strategy has evolved from "product export" to "system export," achieving significant breakthroughs in various dimensions [8] - The insurance segment has shown robust growth, with Fosun Portugal's gross premium income reaching EUR 6.53 billion, and net profit of EUR 201 million [8][9] ESG and Social Responsibility - The company has contributed to global malaria treatment, supplying over 440 million doses of its self-developed artemether injection [11] - The company received the highest MSCI ESG rating of AAA and was included in the S&P Global Sustainability Yearbook 2026 [11]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性或完整性亦不 發表任何聲明，並明確表示，概不對因本公告全部或任何部份內容而產生或因倚賴該等內容而引致的任何損 失承擔任何責任。 上 海 復 星 醫 藥（ 集 團 ）股 份 有 限 公 司 Shanghai Fosun Pharmaceutical (Group) Co., Ltd.* （於中華人民共和國註冊成立的股份有限公司） （股份代號：02196） 海外監管公告 本公告乃根據香港聯合交易所有限公司證券上市規則第13.10B條而作出。 茲載列上海復星醫藥（集團）股份有限公司（「本公司」）在上海證券交易所網站刊登的《2025 年年度報告》，僅供參閱。 承董事會命 上海復星醫藥（集團）股份有限公司 董事長 陳玉卿 中國，上海 2026 年3 月2 4 日 於本公告日期，本公司之執行董事為陳玉卿先生、關曉暉女士、文德鏞先生、王可心先生及劉毅先生；本公 司之非執行董事為陳啟宇先生及潘東輝先生；本公司之獨立非執行董事為余梓山先生、王全弟先生、Chen Penghui先生及楊玉成先生；以及本公司職工董事為嚴佳女士。 * 僅供識別 上海复星 ...

Core Insights - Fosun Pharma has successfully treated over 84 million severe malaria patients in Africa with its artemisinin-based products, showcasing its commitment to addressing unmet clinical needs [1] - The company has established a clear strategic focus for the 14th Five-Year Plan, emphasizing innovation, deep internationalization, and embracing AI as key pillars for high-quality development [1][7] - Fosun Pharma has achieved significant milestones in innovation, including the launch of 12 self-developed and licensed innovative drugs during the 14th Five-Year Plan [1][4] Innovation and Product Development - Fosun Pharma has developed several firsts in the industry, including China's first self-developed biosimilar drug Hanlikang and the first CAR-T cell therapy product Yikaida [2][3] - The company has built a comprehensive innovation system with four core technology platforms: small molecules, antibodies, ADCs, and cell therapy, enabling full-cycle innovation from R&D to commercialization [3] Financial Performance - In the first three quarters of 2025, Fosun Pharma's innovative drug revenue exceeded 6.7 billion yuan, reflecting an 18.09% year-on-year growth [4] - The company aims to continue optimizing its innovation pipeline value over the next five years, focusing on unmet clinical needs [4] Global Expansion Strategy - Fosun Pharma has actively expanded its global market presence, with its anti-tumor innovative drug approved in approximately 40 countries and regions during the 14th Five-Year Plan [5][6] - The company has established a marketing team of over 1,000 people and a network covering more than 110 countries, emphasizing localized strategies for different markets [6] Embracing AI in Development - Fosun Pharma is committed to integrating AI into its operations, viewing it as a tool for enhancing R&D efficiency and organizational evolution [7][8] - The company has launched its internally developed PharmAID decision-making platform, which is already being utilized in various stages of drug development [7][8]

Core Viewpoint - Fosun Pharma will showcase its innovative pharmaceutical products and high-end medical devices at the 8th China International Import Expo, emphasizing its commitment to global innovation and collaboration in the healthcare sector [1]. Group 1: Company Innovations - Fosun Pharma will present a range of products focused on key therapeutic areas such as oncology, immune inflammation, central nervous system disorders, and kidney diseases, covering the entire spectrum from diagnosis to treatment [1]. - The highlight of Fosun Pharma's exhibition will be the Marie vertical particle therapy system, which represents a revolutionary advancement in tumor treatment, allowing for rapid deployment in existing medical spaces and offering various cutting-edge particle radiation therapy technologies [1]. Group 2: CAR-T Cell Therapy Developments - The first CAR-T cell therapy product in China, Yikaida (Acilutamide Injection), has improved accessibility and affordability, being included in over 110 provincial and municipal health insurance plans and more than 80 commercial insurance policies, with over 190 registered treatment centers and treatment of over 1,000 lymphoma patients [2]. - Fosun Pharma's second CAR-T product, Brexucabtagene Autoleucel Injection, has had its drug registration application accepted by the National Medical Products Administration, targeting relapsed or refractory precursor B-cell acute lymphoblastic leukemia in adult patients [2]. Group 3: Future Directions - Fosun Pharma aims to lead with technological innovation, deepen global operations, and promote localized innovation, contributing to the high-quality development of the pharmaceutical industry and supporting the "Healthy China 2030" initiative [3].

Core Viewpoint - Fosun Pharma's subsidiary, Fosun Kairui, is raising funds through a Series A financing round, with Shenzhen Biopharmaceutical Industry Fund committing to invest a total of 600 million yuan, aiming to enhance its operational capabilities and product pipeline [1][2]. Financing Details - The financing agreement involves a total investment of 600 million yuan, with a pre-money valuation of 2.2 billion yuan for Fosun Kairui [1]. - The investment will be made in three phases: an initial payment of 300 million yuan, followed by two subsequent payments of 200 million yuan and 100 million yuan, linked to specific milestones [3]. Financial Performance - Fosun Kairui is projected to generate revenues of 328 million yuan in 2024, with a net loss of 337 million yuan. For the first half of 2025, revenues are expected to be 220 million yuan, with a net loss of 161 million yuan [1]. - The company has yet to achieve profitability due to high treatment costs and limited insurance coverage for CAR-T therapies [1]. Product Development - Fosun Kairui's lead product, Aikeda (Acilin), is the first CAR-T therapy approved in China, currently approved for two indications and undergoing clinical trials for a third indication [1][2]. - The second CAR-T product, FKC889, has had its drug registration application accepted for treating acute lymphoblastic leukemia [2]. Market Context - The CAR-T market in China is becoming increasingly competitive, with seven approved CAR-T products primarily targeting large B-cell lymphoma and multiple myeloma, leading to a phenomenon of homogenized competition [4]. - The sales performance of competing CAR-T products, such as the one from King’s Ray Biotech, indicates a growing market, with significant sales figures reported [3]. Strategic Focus - Fosun Kairui aims to focus on clinical needs and expand the value of its indications through real-world research, rather than following popular targets in the CAR-T space [5].

Core Viewpoint - The recent appointment of Wu Yifang as Executive Operating Partner at Kangqiao Capital marks a significant shift in the leadership landscape of Fosun Pharma, indicating a potential new direction for both companies in the biopharmaceutical sector [1][2][3]. Group 1: Leadership Changes - Wu Yifang has over 30 years of experience in the pharmaceutical industry and previously served as the CEO and Chairman of Fosun Pharma, where he played a crucial role in transforming the company into a global leader [2][3]. - His departure from Fosun Pharma, which includes a series of high-profile resignations, signifies the end of an era for the company, as he was a key figure in its recent successes [3][4]. - The management shake-up at Fosun Pharma has seen multiple executives leave, including the resignation of the Executive President and several senior vice presidents, indicating a comprehensive restructuring of the leadership team [5][6][7]. Group 2: Company Performance - During Wu Yifang's tenure as Chairman from 2020 to 2024, Fosun Pharma achieved revenues of 30.31 billion yuan, 39.01 billion yuan, 43.95 billion yuan, 41.40 billion yuan, and 41.07 billion yuan, showcasing significant growth [3][4]. - Despite the leadership changes, Fosun Pharma reported a revenue of 19.514 billion yuan in the first half of 2025, a year-on-year decrease of 4.63%, while net profit attributable to shareholders increased by 38.96% to 1.702 billion yuan, primarily due to asset sales [7][8]. - The company is focusing on increasing investment in innovative drugs to mitigate the impact of centralized procurement on its performance, with innovative drug revenue exceeding 4.3 billion yuan in the first half of 2025, a year-on-year increase of 14.26% [8].

Core Insights - The introduction of a dual-track payment system for innovative drugs in China marks a significant shift in the healthcare landscape, allowing high-priced CAR-T therapies to enter both the basic medical insurance and commercial insurance innovation drug directories [1][4][5] Group 1: Policy Changes - The National Healthcare Security Administration (NHSA) announced that five CAR-T drugs have passed expert review and are expected to be included in the basic medical insurance and commercial insurance innovation drug directories [1][5] - The establishment of the commercial insurance innovation drug directory provides a separate pathway for high-value, innovative drugs that exceed the basic insurance coverage [1][5] Group 2: Market Dynamics - The dual-track system aims to address the challenges of high-priced drug payments, as traditional basic medical insurance has struggled to accommodate the rising costs of innovative therapies [4][5] - The commercial insurance directory is designed to complement the basic medical insurance directory, allowing companies to choose to apply for either or both directories [5][8] Group 3: CAR-T Drug Insights - The five CAR-T products that passed the review include therapies from companies such as Fosun Kite, WuXi AppTec, and others, with each treatment priced around 1 million yuan per dose [7][8] - The inclusion of CAR-T therapies in the commercial insurance directory is expected to alleviate the financial burden on patients, as seen with Fosun Kite's product, which has been covered by various commercial health insurance plans [7][8] Group 4: Future Implications - The commercial insurance innovation drug directory is anticipated to serve as a transitional phase for innovative drugs before they potentially enter the basic medical insurance directory, based on real-world data and market validation [8] - The establishment of this directory is reshaping the Chinese innovative drug market, making previously inaccessible high-priced therapies more available to a broader patient population [8]

Overview - Shanghai Fosun Pharmaceutical (Group) Co., Ltd. has received acceptance from the National Medical Products Administration for the drug registration application of FKC889, a targeted CAR-T cell therapy product for treating relapsed or refractory precursor B-cell acute lymphoblastic leukemia (ALL) in adult patients [2][3]. Product Information and Research Status - FKC889 is a CAR-T cell therapy product targeting CD19, developed by Fosun Kerry based on technology transferred from Kite Pharma, Inc., a subsidiary of Gilead Sciences, Inc. Tecartus, the original product, was approved for marketing in the US and Europe in July and December 2020, respectively [3]. - As of September 24, 2025, FKC889 is in the bridging clinical trial phase for another indication, which is for adult patients with relapsed or refractory mantle cell lymphoma (r/r MCL) who have previously received second-line or higher treatment [3]. - The cumulative R&D investment for FKC889 by the group is approximately RMB 183 million (unaudited) as of August 2025 [3]. - Multiple CAR-T cell therapy products, including Fosun Kerry's Yikaida (Acilin injection), have been approved for marketing in mainland China, but the overall market situation is difficult to ascertain due to limitations in public database coverage [3].

Core Viewpoint - WuXi AppTec's revenue for the first half of 2025 was 106.3 million yuan, with sales of its CAR-T drug, Regiokyuran, amounting to 81 million yuan, which is lower than the sales figures from the same period in 2024 and 2023 [1][2]. Group 1: Company Performance - WuXi AppTec's CAR-T drug sales of 81 million yuan in the first half of 2025 were below the 86.8 million yuan in 2024 and 87.7 million yuan in 2023 [2]. - Legend Biotech reported a global sales figure of 439 million USD (approximately 3.1 billion yuan) for its CAR-T drug in Q2 2025, with total sales for the first half reaching 808 million USD (approximately 5.7 billion yuan), marking a year-on-year growth of 100% [4]. - Legend Biotech's CAR-T product, Carvykti, achieved sales of 4.39 billion yuan in Q2 2025, outperforming major competitors [18]. Group 2: Market Dynamics - The Chinese CAR-T market has seven approved products, with Legend Biotech's sales being significantly higher than its competitors, indicating a strong market presence [3]. - The high cost of CAR-T treatments remains a barrier to market penetration in China, with most patients unable to afford the treatment priced over one million yuan [29]. - The lack of a mature commercialization path for CAR-T products in China is a common challenge faced by companies in this sector [7]. Group 3: Regulatory and Insurance Landscape - Companies are attempting to improve payment capabilities for CAR-T treatments in China, with some products undergoing dual-line applications for basic medical insurance and commercial insurance [31]. - WuXi AppTec's Regiokyuran is priced at 1.29 million yuan, making it one of the most expensive CAR-T products in the market [28]. - The ongoing efforts to include CAR-T products in insurance coverage highlight the industry's struggle to balance pricing and accessibility for patients [30][34]. Group 4: Future Outlook - Legend Biotech's CEO anticipates the company will achieve profitability by 2026, indicating a positive outlook for future financial performance [20]. - The industry is exploring innovative production methods to reduce costs, with WuXi AppTec beginning to source key raw materials from domestic suppliers [35]. - The emergence of in-body CAR-T cell preparation technology may offer new avenues for cost reduction and accessibility in the future [36][37].