撰文丨王聪 编辑丨王多鱼 排版丨水成文 引导骨再生 （Guided Bone Regeneration，GBR） 是一项重要的牙科及颌面外科技术，主要用于修复因牙周病、创伤或种植手术等导致的骨缺损。其核心原理 是利用屏障膜 （GBR 膜） 创造一个受保护的空间，引导具有成骨潜能的细胞优先迁入骨缺损区，同时阻挡迁移速度更快的纤维结缔组织长入，从而促进骨骼的 自体再生。 迄今为止，已有众多 GBR 膜被研发并投入市场，其中基于胶原蛋白的膜 （例如 Bio-Gide） 因其良好的生物相容性和生物降解性而备受青睐。然而，目前的胶 原膜存在降解过快和机械性能不足的问题，导致膜移位/塌陷进入缺损处，骨移植物丢失，以及骨增量减少。此外，在伤口闭合过程中施加的外力可能会使膜和下 面的移植物移位，进一步降低骨增量的质量。鉴于这些挑战，迫切需要开发出具有卓越机械性能的天然聚合物基材料来构建 GBR 膜。 2025 年 10 月 7 日，天津大学 刘文广 教授、 徐子扬 博士及 山东大学齐鲁医学院 高飞 等，在 Cell 子刊 Cell Biomaterials 上发表了题为： Tea polyphenol- regulated ...

Group 1 - The article discusses the development of a "bionic band-aid" using snail mucus, which offers new hope for treating diabetic foot ulcers [2][3] - Snail mucus contains proteins and polysaccharides, with glycosaminoglycans being the main effective component that promotes wound healing [2][3] - The structure of glycosaminoglycans varies among different snail species, with the "French snail" having a newly discovered type that resembles human extracellular matrix components [3] Group 2 - The bionic band-aid is designed to create a suitable healing environment for tissue growth by constructing a three-dimensional gel network using snail-derived glycosaminoglycans and gelatin [3] - The band-aid incorporates dynamic borate ester technology to release tea polyphenols from tea tree plants when glucose levels rise at the wound site, addressing issues of oxidation and low bioavailability [3][4] - In experiments on diabetic mouse models, the band-aid showed a 72.6% epidermal regeneration rate after 7 days, more than double that of the saline group, with collagen fiber arrangement closer to normal skin [3][4]

Group 1: Modern Agriculture - The first key highlight is modern agriculture, with a total planting area of 600,000 acres for tea, citrus, and kiwi in Pujiang, which was approved as a national modern agricultural industrial park in 2019 [2] - Pujiang has implemented the "two substitutions" project, replacing chemical fertilizers with organic fertilizers and chemical pest control with green prevention methods, making it the only county in the country with all three regional public brand values in the top 40 [2] - Annual sales revenue from agricultural products exceeds 12 billion yuan, with significant contributions from cold chain logistics, which has an annual turnover of 1 million tons [2] Group 2: Industrial Development - The second key highlight is industrial development, with Pujiang being the only small and medium-sized enterprise cooperation zone in Western China approved by the Ministry of Industry and Information Technology [3] - The contribution rate of the industrial sector to the county's economy is 37%, which is 7 percentage points higher than the provincial average, particularly driven by the biomanufacturing industry, which has maintained double-digit growth for several years [3] - Global market share for products like brassinosteroids, hesperidin, and tea polyphenols exceeds 70% [3] Group 3: Ecological Development - The third key highlight is ecological development, with Pujiang being the first national ecological civilization construction demonstration county in Sichuan [3] - The county has proposed the concept of a "rural ecological business district" and aims to transform ecological value into economic benefits, with its experience recognized as an excellent case nationwide [3] - The logistics port in Pujiang is part of the national western land-sea new passage, with trade import and export volume growing at double-digit rates for three consecutive years, and exports accounting for 94% of the total [3]