宏观动态： 美国制造业及服务业景气恢复扩张，但价格压力仍高。8 月标普全球美国制造业 PMI 升至 53.3 的超过三年高位，新订单 及新出口订单均较 7 月积极改善，显示需求在扩张。原材料库存及产成品库存指数也分别升至 53.7 及 53.5，反映厂商补 库存意愿较强。关税带来的潜在通胀压力存在，购进价格指数大升至 67.1，而出厂价指数也维持在 60.1 的偏高水平，显 示商品通胀风险仍存。8 月的服务业 PMI 初值则小幅回落至 55.4，但仍处于高位，服务业新订单指数上升，服务价格指数 也保持在高位。 行业动态： 2025 年 8 月 25 日 星期一 每日大市点评 港股大盘上周高台窄幅震荡，恒生指数全周微升 0.3%，收报 25,339 点；恒生科指上升 1.9%，收报 5,647 点。大市日均成 交金额按周增加 3.6%至 2,804 亿港元，港股通全周净流入 178 亿港元。恒生综合行业分类指数表现分化，地产、公用事 业、能源及材料分类指数分别跌 0.6%至 2.2%不等。可选消费及信息科技均上升 1.6%，是表现最好的分类指数。 近期港股表现与 A 股出现背离，主因港股的整体估值已显著修复，叠 ...

Market Overview - The Hang Seng Index fell by 61 points or 0.2%, closing at 25,104 points, with narrow fluctuations around 25,200 points for five consecutive trading days[1] - The Hang Seng Tech Index decreased by 0.8%, ending at 5,498 points, with total market turnover dropping to HKD 239.5 billion[1] - Net inflow from the Hong Kong Stock Connect was HKD 7.46 billion, indicating continued domestic capital support[1] Sector Performance - The biopharmaceutical sector rebounded, with leading companies like Innovent Biologics (1801 HK) and CanSino Biologics (9926 HK) rising by 4.9% and 3.3% respectively[1] - Ping An Good Doctor (1833 HK) reported a 136.8% increase in mid-term net profit, leading to an 11.4% surge in its stock price, reaching a three-year high[1] - The telecommunications, engineering machinery, and certain power generation stocks showed upward movement, while major tech stocks like Alibaba (9988 HK) and Meituan (3690 HK) declined[1] Automotive Sector Insights - Li Auto (9863 HK) saw a significant 16% increase over the past month, but dropped 4.7% after rumors of a potential acquisition by FAW Group were denied[2] - Great Wall Motors (2333 HK) rose by 20% in the past week, attributed to the production launch of its Brazilian factory and a positive market outlook for fuel vehicles[2] - NIO (9866 HK) experienced a 15% increase in stock price ahead of the launch of its new ES8 model[2] Healthcare Sector Developments - The Hang Seng Healthcare Index rebounded by 2.3%, with most major companies seeing stock price increases[3] - Rongchang Biologics (9995 HK) signed a deal with Santen Pharmaceutical (4536 JP) worth a total of HKD 1.395 billion, including a prepayment of HKD 250 million[3] - The demand for the RC28-E injection, targeting age-related macular degeneration and diabetic macular edema, is expected to be strong due to its effectiveness[3] Energy Sector Analysis - China Resources Power (836 HK) fell by 5.9% after reporting a 15.9% year-on-year decline in net profit to HKD 7.87 billion for the first half of FY25[4] - The renewable energy segment showed a slight increase in core earnings, while thermal power core earnings decreased by 2.7% to HKD 2.64 billion[4] Coal Industry Forecast - Yancoal Australia (3668 HK) reported a 61.2% drop in net profit for the first half of FY25, with revenues down 14.8% to AUD 268 million[5][6] - The average coal price fell by 15.3% to AUD 149 per ton, but a rebound is expected in the second half due to seasonal demand[6] - The company maintains its FY25 production guidance of 35-39 million tons of coal[7] Pharmaceutical Sector Performance - Hansoh Pharmaceutical (3692 HK) reported a 14.3% increase in revenue to RMB 7.43 billion for the first half of 2025, with net profit rising by 15.0% to RMB 3.14 billion[11] - The company’s innovative drugs are expected to drive rapid revenue growth, with significant clinical advancements reported[12][13] - Target price for Hansoh Pharmaceutical has been raised to HKD 42.75, maintaining an "overweight" rating[15]

Core Viewpoint - The company's 1H25 performance exceeded expectations, driven by milestone payments from collaboration with GSK, with revenue of 7.434 billion yuan and a net profit of 3.135 billion yuan, reflecting year-on-year growth of 14.3% and 15.0% respectively [1] Financial Performance - Revenue from innovative drugs and collaboration products reached 6.145 billion yuan, up 22.1% year-on-year, accounting for 82.7% of total revenue, an increase of 5.3 percentage points year-on-year [1] - The company reported collaboration revenue of 1.656 billion yuan, primarily from the upfront payment for oral GLP-1 licensed to Merck and milestone payments from GSK [1] - Excluding collaboration revenue, sales revenue was 5.777 billion yuan, reflecting a year-on-year increase of 13.2% [1] - By segment, oncology revenue was 4.53 billion yuan (up 21.3% YoY), driven by strong growth of Ameluz and GSK collaboration milestone revenue [1] - The company expects Ameluz's annual sales to reach 6 billion yuan [1] - Other segments included anti-infection revenue of 740 million yuan (up 4.8% YoY), central nervous system revenue of 770 million yuan (up 4.8% YoY), and metabolic revenue of 1.4 billion yuan (down 0.2% YoY) [1] - Gross margin remained stable at 91.1%, with selling expenses of 1.82 billion yuan (up 5.7% YoY), management expenses of 340 million yuan (up 135% YoY), and R&D expenses of 1.44 billion yuan (up 20.4% YoY) [1] Development Trends - The company is advancing its R&D pipeline, with core product Ameluz approved for four indications in China, and expects NDA approval for Ameluz in combination with chemotherapy for NSCLC in 2H25 [1] - HS-20093 (B7H3 ADC) has initiated Phase III clinical trials for SCLC in 2H24, with GSK planning to start key clinical studies by the end of 2025 [1] - HS-20089 (B7H4 ADC) has begun Phase III clinical trials for ovarian cancer in 1H25 [1] - HS-20094 (GLP-1/GIP dual-target) has started Phase III clinical trials for obesity or overweight in 2H24 [1] - The company has eight innovative drug pipelines approved for clinical trials in 1H25, including EGFR/c-Met ADC and KRAS G12D [1] - Future plans include accelerating license-in projects and overseas licensing of proprietary pipelines [1] Profit Forecast and Valuation - The company raised its profit forecast for 2025 and 2026 by 4.8% and 3.4% to 4.617 billion yuan and 4.841 billion yuan respectively, due to strong growth of Ameluz and BD-related payments [1] - The current stock price corresponds to 45.8x and 43.1x P/E for 2025 and 2026 [1] - The target price has been raised by 93.1% to 45.00 HKD, corresponding to 53.1x and 50.0x P/E for 2025 and 2026, indicating a potential upside of 15.9% [1]

Core Viewpoint - The company, Hansoh Pharmaceutical, reported a 14.3% year-on-year revenue growth in the first half of 2025, reaching 7.43 billion yuan, with a net profit attributable to shareholders increasing by 15.0% to 3.14 billion yuan, exceeding expectations due to the strong sales of innovative drugs and BD collaboration income [1] Group 1: Financial Performance - In the first half of 2025, the company's comprehensive gross margin remained stable at 91.1% [1] - The sales expense ratio decreased by 2.0 percentage points to 24.5% year-on-year [1] - R&D expenses increased by 20.4% to 1.44 billion yuan, with the R&D expense ratio rising from 18.4% in the first half of 2024 to 19.4% [1] Group 2: Innovative Drug and Collaboration Revenue - The revenue from innovative drugs and collaboration increased by 22.1% year-on-year to 6.15 billion yuan, contributing 82.7% to total revenue, up from 77.3% in the first half of 2024 [2] - The sales of oncology products reached 4.53 billion yuan, accounting for 61% of total revenue, driven by the sales growth of Ameluz and Huasenxinfu [2] - Two new indications for Ameluz received NMPA approval, which are expected to further boost sales [2] Group 3: Innovation Pipeline - The company has over 40 innovative drugs in development and more than 70 clinical trials ongoing, covering both oncology and non-oncology areas [3] - Eight innovative drugs entered clinical stages for the first time in the first half of 2025, including HS-10561 (BTK inhibitor) and HS-20108 (ADC) [3] - Three new pivotal Phase III clinical trials were initiated, including HS-20093 (B7-H3 ADC for bone and soft tissue sarcoma) [3] Group 4: Licensing Agreements - In June 2025, the company granted global rights (excluding Greater China) for HS-20094 (GLP-1/GIP) to Regeneron, including an upfront payment of 80 million USD and milestone payments totaling 1.93 billion USD [4] - The company previously licensed two ADC drugs to GSK and HS-10535 to MSD [4] - Ongoing clinical trials for HS-20093 and HS-20089 are targeting various cancers, with HS-20094 and HS-10374 also in advanced clinical research stages [4] Group 5: Earnings Forecast and Target Price - The earnings per share forecast for 2025 was raised from 0.73 yuan to 0.88 yuan, with subsequent years also seeing upward adjustments [4] - The target price was increased from 25.1 HKD to 43.8 HKD, indicating a 22% upside potential, while maintaining a buy rating [4]

Investment Rating - The report maintains a "Buy" rating for Hansoh Pharmaceutical [2][9][16] Core Views - Hansoh Pharmaceutical's 1H25 revenue increased by 14.3% year-on-year to Rmb7.43 billion, with net profit rising by 15.0% to Rmb3.14 billion, exceeding expectations due to strong sales of innovative drugs and BD collaboration revenue [5][12][16] - The company's gross margin remained stable at 91.1%, while the selling expense ratio decreased by 2.0 percentage points to 24.5% [5][12] - R&D expenses grew by 20.4% to Rmb1.44 billion, with the R&D expense ratio increasing to 19.4% from 18.4% in 1H24 [5][12] Revenue and Profitability - Innovative drugs and collaborative products contributed Rmb6.15 billion in revenue, a 22.1% increase year-on-year, accounting for 82.7% of total revenue [6][13] - Oncology product sales reached Rmb4.53 billion, representing 61% of total revenue, driven by the sales ramp-up of Ameile and Hansoh Xinfu [6][13] - The CNS and anti-infective sectors generated Rmb768 million and Rmb735 million in sales, respectively, together accounting for 20% of total revenue [6][13] Future Growth Drivers - The company has over 40 innovative drugs in development and more than 70 ongoing clinical trials across oncology and non-oncology fields [7][14] - Eight innovative drugs entered clinical stages for the first time in 1H25, with three new phase III pivotal registration trials initiated [7][14] - Successful licensing of HS-20094 (GLP-1/GIP) to Regeneron, with significant upfront and milestone payments, indicates strong collaboration potential [8][15] Financial Forecasts - EPS forecasts for 2025, 2026, and 2027 have been raised to Rmb0.88, Rmb0.95, and Rmb1.06, respectively [9][16] - The target price has been adjusted from HK$25.1 to HK$43.8, indicating a 22% upside potential [9][16] - Projected revenue and net profit growth rates for the coming years are 15.13% and 20.13% for 2025, respectively [10][19]

Core Viewpoint - The report from CMB International maintains a "Buy" rating for Hansoh Pharmaceutical (03692), highlighting its leadership in innovative drugs and international expansion, with a target price increase from HKD 33 to HKD 48, reflecting a projected dynamic P/E ratio of 2.2 times for next year [1] Group 1: Company Performance - Hansoh Pharmaceutical achieved strong double-digit sales growth in the first half of the year, particularly in its ADC and GLP-1 product lines, which continue to generate significant collaboration revenue [1] - The company has raised its full-year revenue guidance to a high double-digit percentage, previously set at a double-digit increase, with specific sales targets of RMB 6 billion for Amelot and RMB 10 billion for overall innovative drugs [1] Group 2: Future Outlook - CMB International expects Amelot's annual sales to have a growth potential of RMB 3 billion to RMB 4 billion, and is optimistic about the contribution of international performance following the normalization of business development activities [1] - The company plans to increase its R&D investment in the second half of the year, with an anticipated growth in R&D expenses of over 38%, leading to an overall increase of more than 30% for the year [1]

交银国际指，翰森制药上半年产品销售延续双位数的强劲增长，同时在ADC和GLP-1产品系列上的 BD(产品授权、收购、合作及战略拓展)合作继续贡献可观的合作收入。该行预计阿美乐的年销售额仍 有30亿至40亿元人民币的增长空间，并看好BD常态化后产品国际化业绩贡献。 报告指，翰森制药上调全年收入指引至高双位数百分比，此前为双位数，阿美乐和整体创新药销售指引 分别维持在60亿及100亿元人民币。公司将在下半年加大研发投入，预计研发费用增长38%以上，全年 增长30%以上。 智通财经APP获悉，交银国际发布研报称，翰森制药(03692)作为创新药占比和出海进程遥遥领先同行的 龙头处方药企，维持"买入"评级及行业重点推荐，目标价由33港元升至48港元，相当于预测明年动态市 盈率2.2倍。 ...

Core Viewpoint - The company has raised its profit forecasts for 2025 and 2026 by 4.8% and 3.4% respectively, due to the growth of Amgen's product and BD-related payments, leading to a target price increase of 93.1% to HKD 45.00, reflecting a significant upside potential [1] Group 1: Financial Performance - The company's 1H25 performance exceeded expectations, with revenue of CNY 74.34 billion, a year-on-year increase of 14.3%, and a net profit of CNY 31.35 billion, up 15.0% [2] - The innovative drug revenue reached CNY 61.45 billion, growing by 22.1% year-on-year, accounting for 82.7% of total revenue, an increase of 5.3 percentage points year-on-year [3] - The oncology segment generated revenue of CNY 45.3 billion, a 21.3% increase year-on-year, primarily driven by the growth of Amgen's product and milestone payments from GSK [3] Group 2: Product Pipeline and Development - The core product Amgen has received approval for four indications in China, with expectations for additional approvals in 2H25 [4] - The company has initiated several clinical trials for its innovative drugs, including HS-20093 and HS-20089, with plans for further clinical research by partners [4] - The company aims to accelerate its license-in projects and overseas authorizations for its pipeline [4]

Group 1: Hansoh Pharmaceutical (3692 HK) - The company is experiencing strong growth driven by innovative drugs and business development (BD) collaborations, with a 14% year-on-year revenue increase to 7.4 billion RMB in 1H25, including 1.7 billion RMB from collaborations [1] - Product sales, excluding collaboration income, grew by 13%, with innovative drug revenue increasing by 22% to 6.1 billion RMB, accounting for 82.7% of total revenue [1] - The company raised its full-year revenue guidance to a high double-digit percentage, maintaining sales targets for Amelot and overall innovative drugs at 6 billion and 10 billion RMB, respectively [1] Group 2: Amelot's Clinical Applications - Amelot's rapid market penetration is primarily driven by its first-line NSCLC indication, with additional approvals for adjuvant and III phase maintenance treatments in the first half of the year [2] - The sales peak forecast for Amelot has been raised to 9.7 billion RMB, with expectations of limited price reductions during the upcoming medical insurance negotiations [2] Group 3: China Biologic Products (1177 HK) - The company reported an 11% year-on-year revenue growth to 17.6 billion RMB in 1H25, driven by innovative product sales and investment income, with adjusted net profit increasing by 101% [3] - Revenue from innovative products grew by 27% to 7.8 billion RMB, contributing 44.4% to total revenue, an increase of 5.8 percentage points year-on-year [3] - The company maintains its guidance for full-year revenue to achieve double-digit growth [3] Group 4: Long-term Growth Drivers - The company is developing a comprehensive pipeline with differentiated self-research products, expecting significant BD opportunities from 2H25 to 2026, focusing on various innovative drug candidates [4][6] - The acquisition of Lixin Pharmaceutical has further expanded the company's oncology pipeline, with management projecting over 35 innovative products by 2027, contributing 60% to revenue [6] Group 5: Tongcheng Travel (780 HK) - The company’s Q2 performance met expectations, with a projected 15% year-on-year revenue growth in core OTA business for Q3, driven by a 10-15% increase in accommodation nights [7] - The full-year core OTA business is expected to grow by 16%, with operating profit margins improving by approximately 2 percentage points due to strategic shifts towards enhancing user ARPU and profitability in new business areas [7]

Core Viewpoint - Hansoh Pharmaceutical reported a strong performance in the first half of 2025, with significant revenue growth driven by innovative drugs and collaboration products Financial Performance - In the first half of 2025, Hansoh Pharmaceutical's revenue was approximately RMB 7.434 billion, a year-on-year increase of about 14.3% [1] - The profit was approximately RMB 3.135 billion, reflecting a year-on-year growth of about 15.0% [1] - Basic earnings per share were approximately RMB 0.53, up by about 14.8% year-on-year [1] - The interim dividend declared was HKD 0.2316 per share [1] Product Sales - Sales revenue from innovative drugs and collaboration products reached RMB 6.145 billion, a year-on-year increase of 22.1%, accounting for 82.7% of total revenue [1] - The anti-tumor product Amelot, representing innovative drugs, generated approximately RMB 4.531 billion in revenue, making up about 60.9% of total revenue [2] - Amelot has been approved for four indications and is expanding its application to early and mid-stage NSCLC [2] Research and Development - R&D expenditure was approximately RMB 1.441 billion, a year-on-year increase of 20.4%, representing about 19.4% of total revenue [1] - The company is advancing over 70 innovative drug clinical trials across more than 40 candidate drugs [1] - Notable candidates entering Phase III clinical trials include B7-H3 targeted ADC (HS-20093) and B7-H4 targeted ADC (HS-20089) [1] Collaborations and Licensing - Hansoh Pharmaceutical has engaged in significant licensing agreements, including a global exclusive license with MSD for HS-10535, receiving an upfront payment of USD 112 million [3] - In June 2025, the company granted Regeneron exclusive overseas rights for HS-20094, receiving an upfront payment of USD 80 million and potential milestone payments of up to USD 1.93 billion [3] - The company has also made progress in ADC research, with HS-20093 and HS-20089 being recognized as breakthrough therapy drugs in China [4] Cash Flow and Financial Stability - The net cash inflow from operating activities was RMB 3.605 billion [4] - The company held cash and bank deposits of RMB 27.104 billion, indicating a strong financial position to support ongoing R&D investments [4]