Core Insights - Hansoh Pharmaceutical (03692) announced that its innovative drug Amivantamab has successfully added two new indications to the 2025 National Medical Insurance Directory, which will be implemented on January 1, 2026 [1][2] Group 1: New Indications for Amivantamab - Amivantamab (brand name: 阿美乐) has received approval for two new indications for the treatment of adult non-small cell lung cancer (NSCLC) patients with specific EGFR mutations [1] - The new indications include treatment for patients who have previously undergone surgical resection and for those with locally advanced, unresectable NSCLC who have not shown disease progression during or after platinum-based chemotherapy [1] Group 2: Renewal of Other Drugs in the National Medical Insurance Directory - The drug Pemigatinib (brand name: 圣罗莱) has had its two indications renewed for inclusion in the 2025 National Medical Insurance Directory, specifically for treating anemia caused by chronic kidney disease [2] - The drug Adefovir Dipivoxil (brand name: 恒沐) has also been renewed for chronic hepatitis B treatment in adult patients [2] - Other innovative drugs such as Fluoromethylphenyl (brand name: 豪森昕福), Pegylated Liraglutide (brand name: 孚来美), and Inotuzumab Ozogamicin (brand name: 昕越) are currently under the National Medical Insurance Directory agreement until December 31, 2026 [2]

Core Insights - Hansoh Pharmaceutical (03692) announced that its innovative drug Amivantamab has successfully added two new indications to the 2025 National Medical Insurance Directory, effective January 1, 2026 [1][2] - The drug Pemigatinib (brand name: Saintrolai) has renewed its inclusion in the 2025 National Medical Insurance Directory for two indications related to anemia caused by chronic kidney disease [1] - The drug Adefovir Dipivoxil (brand name: Hengmu) has also renewed its inclusion for the treatment of chronic hepatitis B in adults [2] Summary by Category New Indications - Amivantamab (brand name: Amivale) has received approval for two new indications for the treatment of adult non-small cell lung cancer (NSCLC) patients with specific EGFR mutations [1] - The new indications include treatment for patients who have undergone surgical resection and those with locally advanced, unresectable NSCLC [1] Renewed Inclusion - Pemigatinib (brand name: Saintrolai) has renewed its inclusion for treating anemia in adults with chronic kidney disease, covering both non-dialysis and dialysis patients [1][2] - Adefovir Dipivoxil (brand name: Hengmu) has renewed its inclusion for chronic hepatitis B treatment in adults [2] Other Relevant Drugs - Other innovative drugs such as Fluoromethylphenidate (brand name: Haosenxinfu), Pegylated Liraglutide (brand name: Fulaimai), and Inalizumab (brand name: Xinyue) are currently under the National Medical Insurance Directory agreement until December 31, 2026 [2]

Core Viewpoint - The Hu Run Research Institute released the "2025 Hu Run Women Entrepreneurs List," highlighting that Zhong Huijuan and her daughter Sun Yuan topped the list as China's richest women with a wealth of 141 billion yuan, marking an increase of 64 billion yuan or 83% from the previous year. This is the first time a woman from the life and health sector has achieved this status [1][3]. Company Overview - Zhong Huijuan, 64, is from Lianyungang, Jiangsu, and is married to Sun Piaoyang, the founder of Heng Rui Medicine. Together, they are known as "China's most powerful pharmaceutical couple," each leading companies with market values exceeding 100 billion yuan [3]. - Over the past year, Hansoh Pharmaceutical's market value doubled, driven by the launch of innovative drugs and international collaborations. Since 2025, the company's stock price has increased by over 115%, reaching 35.78 HKD per share, with a market capitalization of 216.65 billion HKD [3][4]. Business Transformation - Hansoh Pharmaceutical transitioned from a generic drug manufacturer to a leader in innovative drugs, reflecting the evolution of China's pharmaceutical industry over the past three decades. As of the first half of 2025, innovative drug revenue accounted for 82.7% of total revenue, with frequent overseas licensing deals [3][7]. - The company faced significant challenges due to the implementation of centralized drug procurement policies, which drastically reduced profits from generic drugs. In response, the company shifted its focus to innovative drug development, increasing R&D investments and establishing multiple research centers [7][10]. Financial Performance - In 2024, Hansoh Pharmaceutical reported total revenue of 12.261 billion yuan, a year-on-year increase of 21.3%, with a net profit of 4.372 billion yuan, up 33.4%. Innovative drug and collaboration product sales reached 9.477 billion yuan, a 38.1% increase, making up 77.3% of total revenue [8][10]. - For the first half of 2025, the company achieved revenue of 7.434 billion yuan, a 14.3% increase, and a net profit of 3.135 billion yuan, up 15%. Innovative drug sales further increased to 6.145 billion yuan, representing 82.7% of total revenue [8][10]. R&D Investment - Hansoh Pharmaceutical's commitment to R&D is evident, with R&D expenditures of approximately 2.702 billion yuan in 2024, a 28.8% increase, accounting for over 20% of total revenue. In the first half of 2025, R&D spending was about 1.441 billion yuan, up 20.4% [10]. - The company has over 1,800 R&D professionals and is advancing more than 70 innovative drug clinical trials across various therapeutic areas, including oncology and autoimmune diseases [10][11]. Licensing and Collaborations - International pharmaceutical giants have increasingly sought partnerships with Hansoh Pharmaceutical, leading to significant licensing agreements. Notable deals include a $1.85 billion upfront payment from GSK for ADC drug HS-20093 and a $1.12 billion upfront payment from Merck for GLP-1 receptor agonist HS-10535 [11]. - The company has established a "R&D-licensing-reinvestment" cycle, ensuring stable revenue growth while funding further research initiatives [11][12]. Market Position - The wealth increase of Zhong Huijuan and her daughter is largely attributed to the rise in Hansoh Pharmaceutical's stock price, which has surged over 115% since 2025. However, compared to other major domestic pharmaceutical companies, Hansoh remains relatively under the radar, focusing on R&D rather than media attention [12].

Market Overview - On September 15, the Hong Kong stock market experienced narrow fluctuations, with the Hang Seng Index rising by 58 points or 0.2% to close at 26,446 points. The Hang Seng Tech Index increased by 0.9% to 6,043 points. The market turnover decreased to over HKD 290.2 billion, with a net inflow of HKD 14.47 billion from the Stock Connect, continuing to support the market [1] - Economic data from China in August indicated a slowdown in growth momentum, with moderate consumption growth, significant investment slowdown, and ongoing downward pressure in the real estate sector. Notably, the credit pulse index in August declined for the first time in nine months, which may exert pressure on the Hong Kong stock market [1] Macroeconomic Dynamics - In August, China's retail sales growth slowed significantly, with a year-on-year increase of only 3.4%, the lowest since November of the previous year. Fixed asset investment growth from January to August was only 0.5%, with real estate investment declining by 12.9% [2] - The new housing transaction volume in major cities showed a mixed performance, with a year-on-year decline of 6.3% in the last week, contrasting with a rise in first-tier cities [2] Industry Dynamics - The Hong Kong automotive sector saw a rebound after a period of stagnation, with companies like BYD and NIO experiencing stock price increases. NIO is set to launch its new E8 model on September 20 [4] - The healthcare index in Hong Kong rose by 0.2%, driven by the CXO sector. Recent government meetings emphasized the promotion of biomedical technology innovation and the upgrading of the biopharmaceutical industry [4] Pharmaceutical Sector Insights - The innovative drug and CXO sectors are expected to maintain robust growth, with leading companies in these areas showing strong performance in the first half of 2025. The demand for innovative drugs in oncology, metabolism, and autoimmune diseases is anticipated to grow steadily [6][7] - Traditional medical service sectors are expected to recover gradually, although the impact of medical insurance cost control remains a concern. Government policies aimed at alleviating financial issues for medical institutions are expected to improve the operating environment over time [8] Key Company Recommendations - China Biologic Products (1177 HK) reported a 10.7% increase in revenue to RMB 17.57 billion in the first half of 2025, with a net profit increase of 12.3% to RMB 3.39 billion. The company is expected to achieve double-digit growth in product sales revenue [10] - Hansoh Pharmaceutical (3692 HK) saw a 14.3% increase in revenue to RMB 7.43 billion, with a net profit increase of 15.0% to RMB 3.14 billion, driven by strong performance in its oncology products [10] - WuXi AppTec (2359 HK) reported a 20.6% increase in revenue to RMB 20.80 billion, with a net profit increase of 95.5% to RMB 8.29 billion, reflecting strong core business performance [11] Environmental Sector Insights - Gree Power (1330 HK) reported a 24.5% increase in net profit to RMB 380 million in the first half of 2025, driven by increased waste processing and electricity generation [12] - The company has rationally expanded its capacity, with waste processing capacity growing from 33,710 tons/day in FY21 to 40,310 tons/day in FY24, indicating a compound annual growth rate of 6.1% [13]

Market Overview - The Hang Seng Index rose by 0.3% last week, closing at 25,339 points, while the Hang Seng Tech Index increased by 1.9% to 5,647 points[1] - Average daily trading volume increased by 3.6% to HKD 280.4 billion, with a net inflow of HKD 17.8 billion through the Stock Connect[1] - The real estate, utilities, energy, and materials sectors saw declines between 0.6% and 2.2%, while consumer discretionary and information technology sectors rose by 1.6%[1] Economic Dynamics - The US manufacturing PMI rose to 53.3, indicating expansion, while the services PMI slightly decreased to 55.4, remaining at a high level[2] - Price pressures persist, with the purchasing price index soaring to 67.1, indicating ongoing inflation risks[2] Industry Insights - Xpeng Motors reported better-than-expected earnings, leading to a 13.1% increase in its stock price last Friday[3] - The healthcare sector saw a 0.9% increase in the Hang Seng Healthcare Index, with notable performances from companies like China Biologic Products and WuXi Biologics[4] Company Performance - Yancoal Australia reported a 61.2% drop in net profit for H1 FY25, with revenue down 14.8% to AUD 268 million[6] - The company expects a rebound in coal prices in H2 FY25, with average prices projected to decline by 7.1% for thermal coal and 20.7% for metallurgical coal[7] Forecast Adjustments - Target price for Yancoal Australia adjusted from HKD 38.55 to HKD 34.70, reflecting a 22.9% upside potential[9] - HanSung Pharmaceutical's revenue for H1 2025 increased by 14.3% to RMB 7.43 billion, with net profit rising by 15.0% to RMB 3.14 billion[12]

Market Overview - The Hang Seng Index fell by 61 points or 0.2%, closing at 25,104 points, with narrow fluctuations around 25,200 points for five consecutive trading days[1] - The Hang Seng Tech Index decreased by 0.8%, ending at 5,498 points, with total market turnover dropping to HKD 239.5 billion[1] - Net inflow from the Hong Kong Stock Connect was HKD 7.46 billion, indicating continued domestic capital support[1] Sector Performance - The biopharmaceutical sector rebounded, with leading companies like Innovent Biologics (1801 HK) and CanSino Biologics (9926 HK) rising by 4.9% and 3.3% respectively[1] - Ping An Good Doctor (1833 HK) reported a 136.8% increase in mid-term net profit, leading to an 11.4% surge in its stock price, reaching a three-year high[1] - The telecommunications, engineering machinery, and certain power generation stocks showed upward movement, while major tech stocks like Alibaba (9988 HK) and Meituan (3690 HK) declined[1] Automotive Sector Insights - Li Auto (9863 HK) saw a significant 16% increase over the past month, but dropped 4.7% after rumors of a potential acquisition by FAW Group were denied[2] - Great Wall Motors (2333 HK) rose by 20% in the past week, attributed to the production launch of its Brazilian factory and a positive market outlook for fuel vehicles[2] - NIO (9866 HK) experienced a 15% increase in stock price ahead of the launch of its new ES8 model[2] Healthcare Sector Developments - The Hang Seng Healthcare Index rebounded by 2.3%, with most major companies seeing stock price increases[3] - Rongchang Biologics (9995 HK) signed a deal with Santen Pharmaceutical (4536 JP) worth a total of HKD 1.395 billion, including a prepayment of HKD 250 million[3] - The demand for the RC28-E injection, targeting age-related macular degeneration and diabetic macular edema, is expected to be strong due to its effectiveness[3] Energy Sector Analysis - China Resources Power (836 HK) fell by 5.9% after reporting a 15.9% year-on-year decline in net profit to HKD 7.87 billion for the first half of FY25[4] - The renewable energy segment showed a slight increase in core earnings, while thermal power core earnings decreased by 2.7% to HKD 2.64 billion[4] Coal Industry Forecast - Yancoal Australia (3668 HK) reported a 61.2% drop in net profit for the first half of FY25, with revenues down 14.8% to AUD 268 million[5][6] - The average coal price fell by 15.3% to AUD 149 per ton, but a rebound is expected in the second half due to seasonal demand[6] - The company maintains its FY25 production guidance of 35-39 million tons of coal[7] Pharmaceutical Sector Performance - Hansoh Pharmaceutical (3692 HK) reported a 14.3% increase in revenue to RMB 7.43 billion for the first half of 2025, with net profit rising by 15.0% to RMB 3.14 billion[11] - The company’s innovative drugs are expected to drive rapid revenue growth, with significant clinical advancements reported[12][13] - Target price for Hansoh Pharmaceutical has been raised to HKD 42.75, maintaining an "overweight" rating[15]