Core Viewpoint - Shenzhen Chipscreen Biosciences Co., Ltd. is preparing for a specific issuance of A-shares in 2024, with Guotou Securities acting as the sponsor, ensuring compliance with relevant laws and regulations [1][2]. Group 1: Issuance Details - Guotou Securities has been appointed as the sponsor for the issuance of A-shares for Shenzhen Chipscreen in 2024, with representatives Hu Jiabin and Song Qian responsible for the due diligence and ongoing supervision [2][3]. - The issuance will involve a maximum of 58,125,305 shares, not exceeding 30% of the total share capital prior to the issuance [23][24]. Group 2: Company Overview - Shenzhen Chipscreen was established on March 21, 2001, with a registered capital of 408.54 million yuan and is listed on the Shanghai Stock Exchange's Sci-Tech Innovation Board [5]. - The company focuses on drug technology development, new drug research, and related services, with a commitment to innovation in the biopharmaceutical sector [5]. Group 3: Financial Performance - As of March 31, 2025, the total assets of the company amounted to 331,170.31 million yuan, with total liabilities of 174,984.07 million yuan [8]. - The company reported a total revenue of 16,226.37 million yuan for the first quarter of 2025, with a net loss attributable to shareholders of 1,915.47 million yuan [8]. Group 4: Shareholder Structure - As of March 31, 2025, the top ten shareholders collectively hold 41.48% of the company's shares, with significant stakes held by various investment partnerships [5][11]. - The actual controller, Xianping Lu, holds 5.45% of the shares directly and controls a total of 22.00% through various partnerships [11][12]. Group 5: Future Plans and Use of Proceeds - The funds raised from the issuance will be allocated to innovative drug research and development projects, including the establishment of a new drug manufacturing base [23][24]. - The company has not distributed profits from 2022 to 2024, focusing on reinvestment for growth and development [6].

Economic Policy and Development - The National Development and Reform Commission (NDRC) emphasized the need to cultivate new productive forces and promote the "AI+" initiative, aiming for high-quality development in the low-altitude economy and digital economy innovation [5] - A press conference on the current economic situation and work will be held by the NDRC on August 1 [2][5] Healthcare and Insurance - The National Healthcare Security Administration issued a trial regulation for immediate settlement of basic medical insurance funds, allowing eligible medical institutions to be included in the immediate settlement range [3][5] - The regulation aims to enhance the efficiency of medical expense settlements for insured individuals [5] Gaming Industry - The "China Game Industry Report" forecasts that the domestic gaming market will achieve actual sales revenue of 168 billion yuan in the first half of 2025, marking a year-on-year growth of 14.08% [3][6] - The number of gaming users is expected to reach approximately 679 million, reflecting a growth of 0.72% year-on-year [3][6] AI and Robotics - The AI agent concept is gaining traction, with companies like Baidu testing AI applications on their platforms, which is expected to drive industry growth [8] - IDC predicts that the global robotics market will exceed $400 billion by 2029, with China accounting for nearly half of the market share and a compound annual growth rate of nearly 15% [6] Pharmaceutical and Innovation - The innovative drug sector is experiencing significant activity, with companies like Shiyao Group entering into a major licensing agreement valued at up to $2.075 billion [11] - The National Healthcare Security Administration is holding discussions to support the development of innovative drugs and medical devices [11][12] Investment Trends - Long-term funds are increasingly investing in advanced manufacturing sectors, with notable increases in holdings in companies like DingTong Technology and SuShi Testing [23] - There has been a significant inflow of 70 billion yuan into Hong Kong-themed ETFs, indicating a structural bull market in the region [24]

Group 1 - Jiejia Weichuang expects a net profit of 1.7 billion to 1.96 billion yuan for the first half of 2025, representing a year-on-year increase of 38.65% to 59.85% [1] - Micron Biotech's CS231295 clinical trial application has been approved by the FDA for treating advanced solid tumors [1] - Sinopec anticipates a net profit of 20.1 billion to 21.6 billion yuan for the first half of 2025, a decrease of 39.5% to 43.7% year-on-year [2] Group 2 - High Energy Environment has obtained a loan commitment letter from a financial institution for share repurchase [2] - Electric Power Investment Energy received a warning letter from the Inner Mongolia Securities Regulatory Bureau for inadequate disclosure in its semi-annual report [3] - Zhejiang University Net New won a bid for an intelligent engineering project worth 94.2712 million yuan [5] Group 3 - Daodaoquan reported a net profit of 181 million yuan for the first half of 2025, a year-on-year increase of 563.15% [8] - New Light Optoelectronics expects a net loss of 19 million to 23 million yuan for the first half of 2025 [9] - Aihua Pharmaceutical's two probiotic powder registration applications have been accepted [10] Group 4 - Xinhui Electric's subsidiary signed a product sales framework contract for commercial and household robots [11] - Baida Precision Engineering's subsidiary obtained 134,500 square meters of industrial land use rights [12] - Haiyang Technology's chief engineer resigned for personal reasons [13] Group 5 - Tianhe Magnetic Materials received a project filing notice for a 12,000-ton magnetic material deep processing project [22] - Wanlima is the pre-selected unit for a procurement project worth 43.835 million yuan from China Southern Airlines [24] - Yipin Hong's subsidiaries obtained two drug registration certificates [25] Group 6 - Zhejiang Jiaoke's subsidiary signed new construction projects worth 4.783 billion yuan in the second quarter [27] - Shenglan Co. received approval for issuing convertible bonds [29] - Jimi Technology expects a net profit of 88.6622 million yuan for the first half of 2025, a year-on-year increase of 2062.33% [31] Group 7 - Dingtong Technology reported a net profit of 115 million yuan for the first half of 2025, a year-on-year increase of 134.06% [32] - Huaheng Biological is planning to list on the Hong Kong Stock Exchange [34] - Yuntian Lihui submitted an application for H-share issuance and listing on the Hong Kong Stock Exchange [36] Group 8 - Nanchip Technology expects a net profit of 108.8 million to 133.1 million yuan for the first half of 2025, a decrease of 35.09% to 47.03% year-on-year [43] - Anglikang's Mesobam injection has received a drug registration certificate [44] - Jida Zhengyuan's shareholder plans to reduce their stake by up to 0.998% [45]

智通财经APP讯，微芯生物(688321.SH)公告，的全资子公司微芯生物科技(美国)有限公司于7月31日收 到美国食品药品监督管理局("FDA")签发的关于允许公司自主研发的CS231295开展治疗晚期实体瘤的I 期临床试验的通知。 公告显示，CS231295作为透脑AuroraB选择性抑制剂，一方面通过精准抑制肿瘤特异性过表达的 AuroraB激酶，诱导合成致死效应，直击RB1基因脆弱性;另一方面，凭借良好的血脑屏障穿透能力，对 脑部原发或脑转移性肿瘤存在明显的治疗优势。同时，该分子还兼具改善肿瘤微环境的广谱抗肿瘤活 性，有望为存在类似遗传缺陷的不同类型肿瘤，以及肿瘤脑转移这一全球难题提供全新解题思路。 【免责声明】本文仅代表作者本人观点，与和讯网无关。和讯网站对文中陈述、观点判断保持中立，不 对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考，并请自行承担 全部责任。邮箱：news_center@staff.hexun.com ...

人民财讯7月31日电，微芯生物(688321)7月31日晚间公告，公司的全资子公司微芯生物科技(美国)有限 公司于7月31日收到美国食品药品监督管理局(简称"FDA")签发的关于允许公司自主研发的CS231295开 展治疗晚期实体瘤的I期临床试验的通知。 ...

公告显示，CS231295作为透脑AuroraB选择性抑制剂，一方面通过精准抑制肿瘤特异性过表达的 AuroraB激酶，诱导合成致死效应，直击RB1基因脆弱性;另一方面，凭借良好的血脑屏障穿透能力，对 脑部原发或脑转移性肿瘤存在明显的治疗优势。同时，该分子还兼具改善肿瘤微环境的广谱抗肿瘤活 性，有望为存在类似遗传缺陷的不同类型肿瘤，以及肿瘤脑转移这一全球难题提供全新解题思路。 微芯生物(688321.SH)公告，的全资子公司微芯生物科技(美国)有限公司于7月31日收到美国食品药品监 督管理局("FDA")签发的关于允许公司自主研发的CS231295开展治疗晚期实体瘤的I期临床试验的通 知。 ...

Group 1: Policy Support for Innovative Drugs - The National Healthcare Security Administration and the National Health Commission issued measures to support the high-quality development of innovative drugs, focusing on five areas and sixteen specific measures [1] - The measures aim to create a clinical value-oriented environment for innovative drug research and development, establish a diversified payment system, and enhance the accessibility of innovative drugs [1] Group 2: Longhua High-Tech's H-Share Listing - Changchun High-Tech announced plans to issue H-shares and list on the Hong Kong Stock Exchange to deepen its global strategy and accelerate internationalization [2] - The move aligns with the trend of domestic pharmaceutical companies pursuing both domestic and international growth, potentially enhancing the company's international financing capabilities and brand image [2] Group 3: IPO Approval for He Yuan Bio - Wuhan He Yuan Bio's IPO was approved by the Shanghai Stock Exchange, marking the first company to pass under the newly restarted fifth set of listing standards for the Sci-Tech Innovation Board [3] - The company focuses on recombinant human albumin, with its core product expected to be the first recombinant human albumin drug approved in China [3] Group 4: Clinical Trial Acceptance for Microchip Bio - Microchip Bio announced that its clinical trial application for CS231295, a selective Aurora B inhibitor for advanced solid tumors, was accepted by the FDA [4] - This drug is the first of its kind to enter clinical trials globally, showcasing the company's technological strength in innovative drug development [4] Group 5: Angli Kang's Innovation Drug Pipeline - Angli Kang reported that it currently has only one innovative drug project, ALK-N001, which is in the I phase of clinical trials as of the announcement date [5][6] - The company highlighted the long cycle, high investment, and uncertainty associated with innovative drug development, which may temper market speculation [6]

Core Viewpoint - Micron Biomedical (688321.SH) announced that its wholly-owned subsidiary, Micron Biomedical Technology (USA) Co., Ltd., received a written response from the FDA, indicating that the clinical trial application for its self-developed drug CS231295 for advanced solid tumors has been accepted by the FDA [1] Group 1 - The drug CS231295 is a selective Aurora B inhibitor that may provide new solutions for various types of tumors and brain metastases with similar genetic defects [1] - Currently, there are no similar designed drugs entering the clinical trial phase globally [1] - The application is for a new drug clinical trial, and if the FDA does not respond within 30 days of submission or provides consent to proceed within that timeframe, the company can commence clinical trials as per the submitted plan [1]