Core Viewpoint - The article highlights a groundbreaking achievement in neuroscience, specifically in gene editing for treating rare genetic disorders like Alternating Hemiplegia of Childhood (AHC), marking a significant milestone in personalized gene therapy [1][2]. Group 1: Research Breakthrough - Researchers successfully corrected gene mutations in the brain associated with AHC using a single injection technique, significantly improving symptoms and extending the lifespan of affected mice [1][2]. - The study, published in the journal Cell, involved a collaboration among institutions including the Jackson Laboratory and the Broad Institute, focusing on two common mutation sites in the ATP1A3 gene [2][3]. Group 2: Gene Editing Technology - The research tested next-generation gene editing technologies, with Prime Editing showing remarkable results by repairing up to 85% of mutated brain cells and restoring normal protein function [2][3]. - The use of a harmless virus, AAV9, as a delivery vehicle to cross the blood-brain barrier was a key innovation, allowing for effective gene editing in the brain [4][6]. Group 3: Implications for Treatment - This advancement opens new possibilities for treating not only AHC but also other hereditary neurological disorders, potentially transforming the approach to previously deemed "incurable" diseases [5][6]. - The combination of the viral delivery system and Prime Editing technology is seen as a revolutionary step in making precise brain gene editing a reality, with ongoing tests exploring the feasibility of intervention after symptoms appear [6].

Core Insights - A new copper-doped molybdenum-nickel alloy catalyst has been developed to address cathode corrosion issues during the start-stop process of anion exchange membrane fuel cells [1][2] - The catalyst exhibits excellent catalytic activity for hydroxyl reactions and inertness to redox reactions in alkaline media, effectively suppressing transient interfacial potential spikes caused by parasitic redox reactions [1] Group 1: Catalyst Development - The research team successfully prepared the molybdenum-nickel alloy catalyst using microwave heating and subsequent thermal treatment [2] - This catalyst was utilized as an anode catalyst in the membrane electrode assembly of anion exchange membrane fuel cells for simulated start-stop cycling tests [2] Group 2: Performance Comparison - The results showed that the cathode potential transition during start-stop processes significantly decreased from 1.4 volts to a safer range when using the new catalyst compared to traditional platinum/carbon anodes [2] - After 10 start-stop cycles, the thickness of the cathode catalyst layer remained nearly unchanged, and the increase in cathode charge transfer resistance was much lower than that of platinum/carbon, with peak power density retention reaching 61%, significantly outperforming platinum/carbon's 28% and undoped molybdenum-nickel alloy's 47% [2] Group 3: Industry Implications - This research provides an efficient non-precious metal anode catalyst that offers a simple and effective solution to the critical reverse current decay issue during fuel cell start-stop processes, enhancing battery durability without complex system modifications [2]

这种双向画像的匹配效果十分显著。西北农林科技大学园艺学院学生刘缘的成长档案显示，她 在"果树生理与栽培"课程中表现突出，但沟通能力评分较低。系统据此为她推送了北京中环易达设施园 艺科技有限公司的研发助理岗，并建议优先参加AI言语表达训练营。"过去我一直觉得自己适合研发， 现在才知道企业更看重'技术+沟通'的复合能力。"刘缘说。 他的经历正是该校将AI大模型、数字人等技术深度融入就业育人全链条，构建数智化就业服务体 系的生动写照。近日，西北农林科技大学正式对外发布AI大学生成长档案赋能系统，经过一年的试运 行，一场以"精准匹配"为核心的高质量人才培养变革正在这里悄然发生。 打破就业"信息差" "四川郎酒股份有限公司正在招聘科研技术员……"记者看到，西北农林科技大学葡萄酒学院学生周 佳辉的手机上刚收到一条岗位推送信息。他正有意寻找一份酒企科研技术岗的工作，而AI大学生成长 档案赋能系统经过筛选后推送的岗位，与他心仪的地区、专业方向高度契合。 "企业发布的招聘信息太多了。以前我们找工作就像大海捞针，浪费很多时间，也不见得适合自 己。"周佳辉说。 在传统就业服务中，学生"海投"简历、企业"盲选"人才的现象十分常见。那 ...

Group 1 - A 26-year-old patient experienced symptoms of dizziness, vomiting, and weakness after transitioning from an air-conditioned environment to high outdoor temperatures, leading to acute cerebral infarction due to brain vascular spasm [1] - Cold heatstroke, a special type of heatstroke, can occur when moving from a cold environment to a hot one, causing symptoms such as dizziness, nausea, and abdominal pain [1] Group 2 - To prevent cold heatstroke, it is recommended to avoid large temperature differences when transitioning between environments, gradually adjusting indoor temperatures before going outside [2] - Staying hydrated is crucial, with a suggested daily water intake of at least 2.5 liters, and it is advised to consume warm water in small amounts rather than large quantities of cold drinks [2] - Individuals who enjoy swimming should be cautious, as pool temperatures are often lower than air-conditioned rooms, and they should allow time to adjust before entering hot environments [2] Group 3 - Consuming cold drinks immediately after moving from a cold to a hot environment can lead to "brain freeze," which may cause symptoms like headache, nausea, and weakness [3] - If "brain freeze" occurs, it is important to stop consuming cold drinks and apply gentle pressure to the head or sip warm water to alleviate symptoms [3] - Persistent headaches accompanied by visual disturbances may indicate abnormal vascular contraction and require immediate medical attention [3]

Core Insights - The research team from Westlake University has revealed a new mechanism by which tumor microenvironments inhibit dendritic cell migration in tissue interstices, proposing a novel tumor immunotherapy strategy using the PDE5 inhibitor sildenafil to restore dendritic cell function [1][2] Group 1: Research Findings - Dendritic cells, acting as "informants" of the immune system, are responsible for conveying tumor antigen information to draining lymph nodes, activating T cells to attack [1] - Analysis of samples from patients with pancreatic, breast, and colorectal cancers showed a significant reduction in mature dendritic cells in draining lymph nodes as tumor progression occurred [1] - The research identified PDE5 as the most significant regulatory factor affecting dendritic cell entry into draining lymph nodes, with experiments confirming that knocking out PDE5 significantly promotes dendritic cell migration [1] Group 2: Mechanism of Action - PDE5 functions to degrade cyclic guanosine monophosphate (cGMP), which promotes cell migration; the study found that low levels of nitric oxide in the tumor microenvironment lead to insufficient cGMP synthesis, reducing dendritic cell migration and weakening tumor immune response [2] - The PDE5 inhibitor sildenafil was found to significantly enhance dendritic cell migration and boost tumor-specific T cell responses, controlling tumor growth [2] - This research is the first to uncover the immunological mechanism of sildenafil, providing a new theoretical basis for its use as an immunotherapy drug [2]

入夏以来，全国多地桑拿馆推出"夏季汗蒸排毒养颜"项目，吸引了大量消费者。然而，近期各大医 院因过度出汗就诊的患者不断增多，其中不乏连续汗蒸数小时导致脱水的案例。专家提醒：夏季适当出 汗有利于健康，但切勿盲目追求"大汗淋漓"。 "微似汗出"才祛病 一周前，王女士因连续三天在桑拿馆汗蒸超过8小时，出现头晕、心悸症状，检查显示其体内钠离 子浓度明显低于正常值。无独有偶，哈尔滨市民马先生在桑拿馆连续汗蒸数小时后突发昏厥，送医时血 压降至80/50mmHg，诊断为"重度脱水合并电解质紊乱"。 "夏季适当排汗确实有益健康，但过度则适得其反。"黑龙江省医院中西医结合科护理门诊副主任医 师刘平说。流汗可以润泽皮肤，保持毛孔通畅，还有助于排出体内废物，舒筋通络，使气血流畅。此 外，研究还发现，汗液中含有的抗菌肽能有效抵御病毒、细菌和真菌。 二是半身汗，也叫偏汗，表现为上半身出汗而下半身不出汗，或者左半身出汗而右半身不出汗。这 种情况可能是由于植物神经紊乱引起的。 适当出汗还能稳定血压。"运动出汗有助于扩张毛细血管，加速血液循环，增加血管壁弹性，从而 达到降低血压目的。"刘平说。 三是出冷汗，出冷汗主要表现为畏寒、精神不振、面色 ...

Core Insights - The national-level experimental teaching demonstration centers are focusing on reforming experimental education to meet the needs of new engineering disciplines and enhance innovation talent cultivation [2][3][4] Group 1: Importance of Experimental Teaching - Experimental teaching is crucial in higher education for fostering scientific spirit, practical skills, and innovative awareness among students, serving as a pathway to cultivate top innovative talents [2] - The Ministry of Education initiated the establishment of national-level experimental teaching demonstration centers to enhance students' practical and innovative capabilities, accelerate experimental teaching reforms, and improve educational quality [2] Group 2: Challenges in Traditional Teaching Models - Traditional experimental teaching models are increasingly inadequate for meeting the demands of innovative talent cultivation in the context of new engineering and medical disciplines [3][4] - The Ministry of Education has called for in-depth research on experimental teaching and laboratory construction to support the development of a new experimental teaching system that meets contemporary talent cultivation needs [2] Group 3: Reform Initiatives - Various universities are advancing experimental teaching reforms by integrating knowledge across traditional courses to enhance problem-solving skills [4][6] - The use of digital technologies, such as AI and virtual simulation, is being implemented to create innovative experimental teaching environments [6][7] Group 4: Action Plans and Future Directions - Experts have identified three main challenges in new engineering experimental teaching: regional resource imbalance, insufficient depth of technology integration, and outdated evaluation systems [8] - The national-level experimental teaching demonstration centers are planning three major action initiatives, including the establishment of a "New Engineering Experiment Cloud" platform for resource sharing, the creation of "AI+Experiment" demonstration bases, and the development of a process evaluation system based on experimental data [9]

Group 1 - The core viewpoint emphasizes the importance of technology-driven new consumption in stimulating economic growth and expanding domestic demand [1][2] - The integration of advanced technologies such as AI and digital innovations is reshaping consumer experiences and creating new market opportunities [1][2] - The government is actively promoting new consumption models, focusing on areas like AI, health consumption, and innovative product development to drive growth [2] Group 2 - Continuous enhancement of corporate innovation capabilities is essential to keep pace with the rapid development of new products and meet consumer demands [2] - Establishing a supportive policy environment, including standardization and quality assurance for new technologies, is crucial for fostering consumer confidence [2] - The future of technology consumption is expected to expand significantly with advancements in AI, biotechnology, quantum technology, and other emerging fields [3]

Group 1: Internet Development in China - As of June, China's internet user base reached 1.123 billion, with an internet penetration rate of 79.7% [1] - The number of "silver-haired" internet users aged 60 and above is 161 million, while rural internet users stand at 322 million, showing stable growth [1] - The report highlights that China's internet development is at a higher level globally, with significant advancements in accessibility and application richness [1] Group 2: Information Infrastructure - The Ministry of Industry and Information Technology (MIIT) is promoting the deployment of 10G optical networks and has achieved over 4.55 million 5G base stations, with over 90% of administrative villages having 5G access [1][2] - Mobile internet traffic has seen double-digit growth for six consecutive months, indicating a robust increase in data consumption [1] Group 3: Digital Inclusion Efforts - The internet penetration rate among the elderly population is 52%, while rural areas have a penetration rate of 69.2%, reflecting a 1.9 percentage point increase compared to December 2024 [2] - The government and enterprises are making efforts to balance digital dividends and the digital divide, which is crucial for fostering new economic growth points [2] Group 4: Artificial Intelligence Advancements - By the first half of 2025, China's generative AI products have seen significant advancements in technology and application, with 346 generative AI services registered by March [3] - DeepSeek, a generative AI application, gained over 30 million daily active users within 20 days of launch, topping the app markets in 140 countries [3] Group 5: AI Market Growth - As of June, 80.9% of users utilized generative AI products for answering questions, indicating high engagement [4] - The AI industry in China is projected to exceed 700 billion yuan in 2024, maintaining a growth rate of over 20% for several years [4] - Domestic AI products are achieving breakthroughs in various fields, contributing to a comprehensive intelligent application ecosystem [4]

Core Viewpoint - The Chinese Academy of Sciences has developed the world's first high temporal and spatial resolution Brillouin microscope, significantly enhancing imaging speed and providing a crucial tool for mechanical research in life sciences [1][2]. Group 1: Technological Advancements - The new Brillouin microscope achieves sub-millisecond temporal resolution and sub-micron spatial resolution, marking a two-order-of-magnitude increase in imaging speed while maintaining excellent imaging quality and spectral specificity [1]. - The system utilizes a 780-nanometer wavelength and a peak power of 267 watts, achieving over 31 decibels of noise suppression through a high noise-reduction self-balancing detection scheme [1]. Group 2: Applications and Validation - The performance of the enhanced Brillouin microscope has been validated on various biological samples, including single cells, organoids, zebrafish embryos, and follicles [2]. - The research team observed dual Brillouin peaks in zebrafish embryos, revealing mechanical differences in heterogeneous extracellular matrices and cavities, and captured dynamic mechanical changes during early cell division in Caenorhabditis elegans embryos [2]. Group 3: Future Implications - This breakthrough addresses the technical bottlenecks of traditional Brillouin microscopy in terms of imaging speed and sensitivity, showcasing significant performance advantages across multiple biological models [2]. - The enhanced system is expected to become a new tool for revealing the mechanisms of life mechanics, exploring disease occurrence, and studying tissue and organ development, thus expanding the application of Brillouin microscopy in both basic research and clinical settings [2].