Core Insights - The article discusses the enhancement of acid tolerance in industrial E. coli strains, which can reduce fermentation costs by improving robustness in low pH environments [1][8]. Group 1: Research Findings - A study from South China University of Technology developed acid-tolerance modules using a "toehold switch" approach, allowing E. coli to maintain lysine production at pH 5.5 comparable to pH 6.8 [1][5]. - The acid response module consists of two plasmids: one with acid-responsive promoters expressing trigger RNAs, and another with toehold switches expressing acid tolerance-related genes [3][5]. Group 2: Mechanisms and Components - The study identified four functional groups of acid tolerance genes: proton consumption system, protein protection system, cell membrane modification and redox homeostasis system, and peroxide clearance system [3][5]. - Key genes include gadB, gadE, and others for proton consumption, and degP and sthA for protein protection and hydrogenase activity, respectively [6][8]. Group 3: Experimental Results - The research utilized a high-throughput platform to create a library of acid tolerance modules, resulting in 1140 colonies after selection, with 26 combinations showing over 120% growth compared to wild-type strains [5][6]. - Two specific combinations were introduced into an industrial lysine-producing E. coli strain, leading to increased lysine yield and glucose conversion rates [5][6]. Group 4: Implications for Industry - The strategies developed in this research provide valuable insights for enhancing the robustness and productivity of industrial strains under moderate acidic conditions, potentially benefiting the biomanufacturing sector [8].

Core Viewpoint - Synthetic biology aims to "synthesize and design life," with significant advancements in genome synthesis and assembly, particularly in higher organisms, despite facing challenges related to repetitive sequences and cross-species DNA transfer [1][2]. Group 1: Technological Breakthroughs - Tianjin University's team achieved the first precise assembly and cross-species delivery of megabase-scale human DNA, marking a significant milestone in synthetic biology [2]. - The newly developed SynNICE technology enables the precise assembly of highly repetitive human genomic sequences in yeast and facilitates the efficient transfer of synthetic DNA into mouse embryos [3][5]. Group 2: Research Findings - The study successfully demonstrated de novo DNA methylation patterns in mouse embryos, indicating that the synthetic genome can be recognized and modified by the host cell environment [5][7]. - A hierarchical assembly strategy was employed to synthesize a 1.14 Mb region of the human Y chromosome, which is crucial for understanding male infertility [3][7]. Group 3: Implications for Disease Treatment - The research opens new avenues for treating chromosomal abnormalities and could lead to innovative therapeutic strategies for related diseases [7][9]. - The potential for using genetically modified pigs as organ donors for humans could be enhanced, addressing the global organ shortage issue by improving the longevity of transplanted organs [9][10]. Group 4: Future Prospects - The SynNICE technology platform is expected to facilitate large-scale genomic modifications, potentially transforming organ transplantation practices and enhancing the understanding of genetic diseases [11][12]. - The advancements in synthetic genome assembly and transfer techniques are anticipated to propel the field of synthetic biology forward, providing new models for studying epigenetic modifications and chromosomal disorders [10][11].

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing, along with four major application areas: green chemicals and new materials, future food, future agriculture, and beauty raw materials [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period and identify innovative technologies and products that will sustain the industry's vitality [1]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. It is supported by various professional committees and alliances in the field of biomanufacturing [2]. Group 3: Highlights of the Conference - The conference will feature forums and closed-door activities to gain insights into the development trends of biomanufacturing, explore new products and technologies, and foster new collaborations [4]. - There will be over 100 financing project roadshows to discover new cooperation opportunities and showcase innovative technological achievements [4]. - Key industry leaders, top universities, capital from parks, and the entire industry chain will gather to discuss advancements and opportunities in biomanufacturing [4]. Group 4: Agenda and Activities - The first day will include a closed-door seminar focusing on the development trends and growth points of biomanufacturing during the 14th Five-Year Plan, inviting 30 industry leaders and experts for in-depth discussions [9]. - The second and third days will feature a macro forum on biomanufacturing, specialized sub-forums on green chemicals, AI in biomanufacturing, future food and agriculture, and beauty raw materials, addressing various key topics and innovations in these fields [13]. - A special session for showcasing scientific achievements and project matchmaking will also be held, inviting 100 innovative projects in the biomanufacturing sector for display and collaboration [14].

Core Insights - The "14th Five-Year Plan" has concluded, and the "15th Five-Year Plan" is being formulated, highlighting a clear and distinct evolution in China's strategic layout in the field of biomanufacturing [1] Group 1: Development Goals - The "15th Five-Year Plan" is a critical period for the comprehensive rise of China's biomanufacturing industry, with a key goal of achieving an added value of over 4 trillion yuan in advanced biomanufacturing and related services, and a biomanufacturing penetration rate exceeding 8% [3] Group 2: Industry Structure - The plan aims to establish three major systems: innovation, industry, and management services, accelerating the development of a "7+1" biomanufacturing industry system, which includes biopharmaceuticals, bio-based chemicals and materials, bioenergy, fermentation, bioengineering food, animal feed, biotechnology equipment, and bio-services [4] Group 3: Future Opportunities - The upcoming SynBioCon 2025 conference will focus on the intersection of AI and biomanufacturing, exploring trends in green chemicals, new materials, future food, future agriculture, and beauty raw materials, while inviting various stakeholders to discuss innovative technologies and products that will sustain the vitality of the biomanufacturing industry [14]

Core Viewpoint - Wuhan Heyuan Biotechnology Co., Ltd. has submitted its IPO registration application and is expected to become the first successful listed recombinant protein company this year [1][2]. Group 1: Company Overview - Heyuan Biotechnology focuses on plant-based recombinant protein expression technology, specifically developing recombinant human serum albumin using rice endosperm cell bioreactor systems [4][12]. - The company was founded in 2006 and has a leading global plant bioreactor technology platform, with its founder being a professor at Wuhan University [8]. Group 2: Financial Performance - The company has reported continuous losses, with revenues of 13.40 million yuan, 24.26 million yuan, and 25.22 million yuan for 2022, 2023, and 2024 respectively, and net losses of -144 million yuan, -187 million yuan, and -151 million yuan for the same years [9][10]. - As of the end of 2024, the cumulative unabsorbed losses reached 851 million yuan [9]. Group 3: Product Development and Market Potential - Heyuan Biotechnology's lead product, recombinant human serum albumin injection (HY1001), is expected to be approved for market soon, which could reduce reliance on imported products in China [11]. - The company has established a pilot-scale production capacity and is building a commercial-scale production line with an annual output of 10 tons of OsrHSA raw liquid and formulations [12]. - A strategic cooperation framework has been signed to establish a production line with an annual capacity of 20 tons in Western China [12][13]. Group 4: Technological Advancements - The company has achieved a breakthrough in its "rice-based blood production" technology, which has garnered significant attention in the capital market [7]. - The rice expression system can yield 15-20 grams of protein per kilogram of brown rice, providing advantages in high yield, simple processes, low costs, and scalability [12].

Core Viewpoint - The article emphasizes the significance of biomanufacturing as a transformative technology for sustainable industrial development, highlighting its potential to replace traditional production methods and contribute to carbon neutrality goals [3][4]. Summary by Sections Definition and Importance of Biomanufacturing - Biomanufacturing is defined as a process that utilizes industrial biotechnology, enzymes, and microbial cells, combined with chemical engineering techniques, to produce bio-based materials, chemicals, and bioenergy [3]. - It is recognized by the OECD as one of the most promising technologies for sustainable industrial development [3]. Global and Domestic Development Trends - Major economies worldwide have set strategic goals for the biomanufacturing industry, with China possessing unique advantages due to its robust industrial foundation and large consumer market [4]. Future Directions and Key Initiatives - China needs to focus on developing next-generation biomanufacturing technologies and key innovations, including: - Accelerating the development of important biochemicals and materials while reducing carbon emissions throughout their lifecycle [5][6]. - Enhancing independent innovation capabilities and addressing core technologies for strategic products [6]. Industry Events and Collaborations - The upcoming SynBioCon 2025 conference will focus on the intersection of AI and biomanufacturing, exploring trends and innovations in green chemistry, new materials, future food, agriculture, and beauty ingredients [8]. - The event aims to facilitate the scaling of products and the transfer of technological achievements [8].

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan and identify innovative technologies and products that will sustain the industry's vitality [1]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and supported by various institutions, including the Chinese Society of Biotechnology and the Zhejiang Synthetic Biology Industry Technology Alliance [2]. Group 3: Conference Highlights - Key highlights include forums and closed-door discussions on biomanufacturing trends, youth innovation technology sharing, and over 100 financing project roadshows to discover new cooperation opportunities [4]. - The event will gather leading enterprises, top universities, investment institutions, and industry stakeholders to foster collaboration [4]. Group 4: Agenda and Activities - The first day features a closed-door seminar focusing on the development trends and growth points of biomanufacturing, inviting 30 industry leaders and experts for in-depth discussions [9]. - The second and third days will include a macro forum on biomanufacturing, specialized sub-forums on green chemicals, AI in biomanufacturing, future food and agriculture, and beauty raw materials [13]. Group 5: Specialized Topics - Sub-forums will cover various topics, including the development of bio-based chemicals, AI applications in enzyme discovery, and the biomanufacturing of high-value food ingredients [13]. - The conference will also showcase innovative projects and facilitate connections between research teams and industry players [12][14].

Core Viewpoint - The article emphasizes the importance of green biosynthesis of aromatic compounds for sustainable development, addressing the limitations of traditional production methods that are resource-intensive and environmentally harmful [1]. Group 1: Green Biosynthesis of Aromatic Compounds - Aromatic compounds are crucial in various industries such as materials, food, pharmaceuticals, and cosmetics, but traditional production methods face sustainability and pollution issues [1]. - The development of efficient cell factories is identified as a key factor in overcoming challenges such as low yield, poor cell tolerance, and low production intensity in the biosynthesis of aromatic chemicals [1]. Group 2: Research and Development Achievements - Professor Yuan Qipeng's team at Beijing University of Chemical Technology has constructed advanced cell factories for synthesizing over twenty important aromatic compounds, surpassing natural theoretical yields [1]. - Strategies to enhance the synthesis capabilities of compounds like arbutin and ferulic acid have been proposed, significantly improving their production efficiency [1]. - The establishment of industrial production lines for compounds such as arbutin and 5-hydroxytryptophan demonstrates the potential of synthetic biology in green biosynthesis [1]. Group 3: Upcoming Conference - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, focusing on the future of food and agriculture, where Professor Yuan will present on the construction of efficient cell factories for aromatic compound production [2][4]. - The conference aims to explore trends in biomanufacturing, innovative technologies, and products that can sustain the industry's vitality, involving various stakeholders including industry leaders and experts [4].

SynBioCon 大会 | 生物制造青年论坛 特色专场 生物制造青年论坛 8月20日，浙江·宁波 生物制造领域有哪些 "潜力股" 团队、技术和产品值 得关注？ 为发掘合成生物学和生物制造科研团队创新成果、 促进生物制造领域优秀科研工作者成果交流和产业方对接， 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 同期将举办特色专场——" 生物制造青年论坛 "，于8月20日在浙江宁波举办。 助力行业 15分钟了解一个方向 ，重点阐述研究领域存在的科学问题、解决思路、成果、放大可行性以及未来发展方向。 欢迎高校、科研院所申报分享！ 扫码报名，请选择参会形式 报名请选择：青年论坛、科技成果展示 SynBioCon 2 025 8月20-22日，浙江·宁波 01 论坛信息 时 间： 8月20日（周三） 席 位 ： 仅 30 席！ 报告时间： 第一场：13:30-17:30； 第二场：19:00-20:30 报名须知 ：扫描以上二维码，会务组将第一时间与您确认，并对接报告信息表等； 02 科技成果展示与对接专场 （同期活动） SynBioCon 2025 将设置 「科技成果展示与对接」专场 （ ...

Core Insights - The Ministry of Industry and Information Technology (MIIT) of China has released a public notice listing the first batch of typical application cases of artificial intelligence in the field of biological manufacturing, involving 15 companies and 1 research institute [1] - The focus of this initiative is on the integration of AI in biological manufacturing, particularly in areas such as innovative research and development, pilot scale-up, and production [1] - More than half of the 16 cases listed are related to the design and construction of high-performance protein components, indicating a strong emphasis on this area [1] Summary by Categories AI Applications in Biological Manufacturing - The MIIT's initiative aims to showcase how AI can enhance various stages of biological manufacturing, including high-performance protein design and production processes [1] - Notable companies involved include Beijing Zhaoyan Biological, Beijing Chengyitong, and Shanghai Tianhu Technology, which are recognized for their contributions to the field [1] Key Case Studies - **Beijing Zhaoyan Biological**: Developed an AI-driven platform for constructing stable high-expression cell lines, integrating machine learning and big data [3] - **Shanghai Tianhu Technology**: Created a protein engineering model AIACCLBIO™, which utilizes 9 billion protein data points for end-to-end predictions [4] - **Anhui Yuanguo Biological**: Implemented AI technology for de novo protein design, addressing complex structural challenges [4] - **Baitou Biotechnology**: Utilized AI models to enhance the efficiency of medicinal enzyme modifications for enzyme replacement therapies [4] Industry Trends and Future Directions - The upcoming SynBioCon 2025 conference will focus on AI and biological manufacturing, exploring trends and innovations that could drive the industry forward [7] - The conference aims to facilitate technology transfer and product scaling, highlighting the importance of collaboration among industry leaders, experts, and government entities [7]