Group 1: Policy Release - The report includes three domestic policies related to the bio-based industry released in May 2025, focusing on carbon reduction projects [7][18]. - Key projects include a 110,000-ton biodegradable polyester rubber demonstration project and a 1 million-ton waste oil processing sustainable aviation fuel project [8]. Group 2: Industry Dynamics - The report highlights two domestic bio-based chemical company updates, including a 120 million yuan investment in a lactic acid production demonstration line by Heilongjiang Guoke Bio-based New Materials [9]. - Wanhu Chemical has established a new company focusing on food additives, with a registered capital of 20 million yuan [10]. Group 3: Capital Events - Several financing events in the bio-based sector are reported, including a Series B round raising several million yuan for Senqi New Materials, focusing on bio-based high barrier film materials [11]. - Other notable investments include a multi-million yuan angel round for Zhongke Kexuan, specializing in fully natural degradable plastics [11]. Group 4: Scientific Research Progress - Significant breakthroughs in bio-based materials research are noted, including a study on lignin-derived carbon improving catalytic performance [12]. - Research on bio-inspired reconfigurable electronic skin has been developed, showcasing antibacterial properties for health sensing applications [12]. Group 5: Upcoming Events - The Fourth Synthetic Biology and Green Bio-manufacturing Conference will be held from August 20-22, 2025, in Jinan, Shandong, focusing on the development trends of the bio-manufacturing industry [25].

#全球政策进展 | 上海市 关于上海市2025年度关键技术研发计划"合成生物学"项目拟立项项目的公示 根据市科技计划项目管理办法有关规定，现将上海市2025年度关键技术研发计划"合成生物学"项目拟 立项项目予以公示。 | 图源：上海市科学技术委员会 | | --- | 公示链接：http://svc.stcsm.sh.gov.cn/public/guide 公示期：2025年6月12日至2025年6月18日 对公示内容持有异议的，请于公示期内以书面形式向我委反映。按照市科研失信行为调查处理办法有关 规定，个人提出异议的，请在异议材料上注明姓名和联系电话；单位提出异议的，请在异议材料上加盖 单位公章，并注明联系人和联系电话。我委对异议者的信息予以保密。为保证异议处理客观、公正、公 平，保护被公示者的合法权益，我委对匿名且无明确证据和可查线索的异议，不予受理。 材料寄送至：市科委科技人才处（上海市人民大道200号，邮编200003）。 投诉举报电话：60286858 业务咨询电话：8008205114（座机）、4008205114（手机） 上海市科学技术委员会 2025年6月12日 上海市2025年度关键技术研发 ...

Core Viewpoint - The company Xinghuo Technology plans to invest up to 3.3 billion RMB in a new amino acid production project in Daqing, Heilongjiang, with an expected annual revenue of approximately 3.9 billion RMB upon reaching full production capacity [1][10]. Project Information - Project Name: 450,000 tons amino acid and supporting engineering project [3] - Location: Daqing, Heilongjiang Province, covering approximately 483 acres [3] - Investment Entities: The project will be developed by the company's subsidiaries Heilongjiang Yipin Biotechnology and Heilongjiang Yipin Energy [3][4]. Project Construction Details - The project includes a new production line for 450,000 tons of amino acids, primarily producing 200,000 tons of feed-grade threonine and 250,000 tons of monosodium glutamate, along with related by-products [5]. - Supporting engineering will involve the construction of cogeneration and public service facilities to meet the project's heating and power needs [6]. Financial Overview - Total Investment: Up to 3.3 billion RMB, with approximately 2.95 billion RMB allocated for the amino acid production line and about 340 million RMB for supporting engineering [7]. - Funding Sources: The investment will be financed through a combination of the company's own funds and bank loans, each accounting for approximately 50% [8]. - Construction Timeline: The project is expected to take 22 months to complete [9]. Economic Benefits - Estimated Annual Revenue: Upon reaching full production and sales, the project is expected to generate around 3.9 billion RMB in annual sales, with a gross margin of approximately 10% [10]. - Investment Recovery: The estimated payback period for the investment is about 8.5 years, excluding the construction period [10]. Market Analysis - The demand for feed amino acids is increasing due to national policies promoting reduced soybean meal usage, alongside rising consumer demand for animal products [11]. - Monosodium glutamate, as a fundamental seasoning in the food industry, continues to see stable growth in production and consumption, particularly driven by the expanding ready-to-eat meal market [11]. 2024 Business Outlook - Projected Revenue: In 2024, the company anticipates revenues of 4.248 billion RMB from food additives, 11.734 billion RMB from feed additives, and other segments contributing smaller amounts [12]. - Profitability: Despite a slight decline in overall revenue due to falling market prices, increased sales volume is expected to mitigate some of the revenue loss, with gross and net profit margins improving [12].

Group 1: Policy Release - The report includes three domestic policies related to the bio-based industry released in May 2025, focusing on carbon reduction projects [7][18]. - Key projects include a 110,000-ton biodegradable polyester rubber demonstration project and a 1 million-ton waste oil processing sustainable aviation fuel project [8][19]. Group 2: Industry Dynamics - The report highlights two domestic bio-based chemical company updates, including a 120 million yuan investment in a lactic acid production demonstration line by Heilongjiang Guoke Bio-based New Materials [9][20]. - Wanhu Chemical has established a new company focusing on food additives, with a registered capital of 200 million yuan [10]. Group 3: Capital Events - Several financing events in the bio-based sector are reported, including a multi-million yuan investment in Senqi New Materials for bio-based high barrier film materials [11][22]. - Other notable investments include a joint investment exceeding 100 million yuan in Juyuan Bio for recombinant collagen [22]. Group 4: Scientific Research Progress - Significant breakthroughs in bio-based materials research are noted, including a study on lignin-derived carbon improving catalytic performance [12][23]. - Research on a new type of printable conductive "E-skin" with antibacterial properties has been developed, mimicking slime mold characteristics [12][23]. Group 5: Upcoming Events - The Fourth Synthetic Biology and Green Bio-manufacturing Conference will be held from August 20-22, 2025, in Jinan, Shandong, focusing on the development trends of the bio-manufacturing industry [25][26].

# SynBio团队 | 中科院苏州医工所马富强 在人工生命体精准编程的"黄金时代"，合成生物学作为融合工程学、计算机科学与分子生物学的交叉学科， 正通过"设计-构建-测试"的循环模式重塑生物制造范式。这一领域不仅被列为全球科技竞争的战略高地，更在 医药研发、碳中和、农业升级等关乎国计民生的赛道上展现出颠覆性潜力。 其核心突破点聚焦 三大支柱 ： 三大支柱技术如同精密咬合的齿轮，共同决定了细胞合成工厂的效率 。 【SynBioCon】 获 悉，近日， 苏州医工所马富强研究团队 围绕上述合成生物学三大支柱技术开展了系统工 作： 图2. 利用深度学习辅助生成新型启动子的两种方法 ： 左 图 ， 通过对现有启动子引入突变或随机生成新序列 来创建新的序列。这些新生成的序列通过启动子识别模型进行筛选，以验证其功能 ；右 图 ， 使用扩散模型 或生成对抗网络（GANs）来生成新的启动子。扩散模型通过添加高斯噪声逐步生成启动子序列。GANs 由生 成器和判别器组成，生成器负责生成假样本，而判别器用于区分真实样本和生成的假样本。通过训练过程不 断优化生成器的性能，使其能够生成更逼真的启动子序列。 工作1 ： 新型酶资源 的 ...

Core Viewpoint - The article discusses the establishment of pilot testing platforms for biomanufacturing, focusing on key product areas such as food additives, biopharmaceuticals, cosmetics, chemicals, energy, and enzyme preparations, with a goal to support innovation and commercialization in the industry [1][2]. Group 1: Pilot Testing Platforms - The Ministry of Industry and Information Technology and the National Development and Reform Commission aim to cultivate over 20 pilot testing platforms by 2027, serving more than 200 enterprises and incubating over 400 products [1]. - The initiative emphasizes market-driven and demand-led approaches, encouraging national laboratories and innovation platforms to develop pilot testing capabilities [1][2]. - The platforms will focus on addressing the shortcomings and pain points in the pilot testing phase of biomanufacturing, particularly in the development of new raw materials such as lignocellulosic and one-carbon compounds [2]. Group 2: Guidelines and Events - The article includes attachments such as the "Biomanufacturing Pilot Testing Capability Construction Platform Cultivation Guidelines (2025 Edition)" and an application form for the platform [3]. - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) is scheduled for August 20-22 in Jinan, Shandong, aiming to discuss trends in biomanufacturing and promote technology transfer and commercialization [4].

Core Viewpoint - The bio-basedlink platform is officially launched to provide precise and efficient supplier matching services for the bio-based and biomanufacturing industry, featuring four main categories: industry news, research reports, new product database, and supply-demand database [1]. Group 1: Platform Features - The new product database includes eight subfields such as materials, energy and chemicals, synthetic biology, and biomanufacturing [1]. - The supply-demand database covers upstream and downstream demand, supply, technology achievements, and talent matching [1]. - Companies can join the new product database to gain a dedicated company page showcasing their logo, positioning, product keywords, and advantages, with free updates available for information changes [4]. Group 2: Accessing the Platform - Users can find the official website by following the WeChat public account "Synthetic Biology and Green Biomanufacturing" or by searching for www.bio-basedlink.net [2]. - Companies that have participated in relevant activities can join the new product database for free, and DT members receive priority recommendations for one year of platform cooperation [8]. Group 3: Supply-Demand Database - The supply-demand database allows users to publish and match their industry needs, including products, technologies, and talents [10]. - The platform will collect and publicly share information on industry "new technological achievements" and "end-user brand demands" [10]. Group 4: Research and Reports - The DT Industry Research Institute will publish monthly, quarterly, and annual reports on the bio-based and biomanufacturing industry, providing insights based on real-time information and industry surveys [14]. - The platform aims to help users maintain a competitive edge through systematic and in-depth observations and research [15]. Group 5: Marketing and Exposure - New products and related articles will be promoted across various channels, including the bio-basedlink platform website and multiple WeChat public accounts [16]. - The platform aims to facilitate exposure and networking opportunities for companies in the bio-based materials sector [17].

Core Viewpoint - The research group led by Yu Tao focuses on utilizing synthetic biology to address major issues such as sustainable manufacturing, green energy, and food security through innovative methods of converting CO2 into valuable compounds [1][2]. Group 1: CO2 Conversion and Sustainable Production - Significant progress has been made in converting CO2 into simple low-carbon compounds (C1-3) through various methods, but producing complex compounds remains challenging [1]. - The research group successfully demonstrated the conversion of CO2 into glucose and fatty acids using an electrochemical-coupled microbial cell factory, providing a viable method for sustainable production of sugar-derived food and chemicals [1]. - This achievement was recognized as one of the "Top Ten Scientific Advances in China" in 2022 [1]. Group 2: Synthetic Energy Systems - The research team constructed a synthetic energy system within yeast cells, supporting cell growth and efficient fatty acid synthesis [2]. - Low-carbon compounds such as methanol and ethanol were converted into sugars and sugar derivatives, including glucose and starch, through synthetic biology and metabolic engineering techniques [2]. Group 3: Upcycling Chemical Byproducts - The research group collaborated with other institutions to address the challenge of surplus byproducts in the chemical industry, specifically converting excess acetone into high-value natural products using a tandem electro-biosystem [3]. - The results of this work were published in Nature Sustainability, showcasing a novel approach to upcycling surplus acetone into long-chain chemicals [3][6]. Group 4: Electrochemical and Biological Catalysis - A synergistic strategy combining electrochemical and synthetic biology was proposed, where acetone is first converted into high-purity isopropanol (IPA) through electrochemical hydrogenation, followed by fermentation to produce high-value natural products [6][8]. - The research demonstrated a maximum IPA Faradaic efficiency of 95.6% and a current density of -240 mA cm-2 using a specially designed catalyst [8][10]. Group 5: Future Directions - Future research will focus on optimizing the bipolar membrane electrode reactor design, regulating metabolic pathways for fermentation, and expanding the application of electro-biosynthetic coupling systems [15].

Group 1: Core Insights - The article introduces the "Global Bio-based Industry Monthly Report," providing insights into the latest trends and opportunities in the bio-based sector [1][2][3] - The report is available for free to industry peers, highlighting the importance of collaboration and information sharing within the bio-based industry [1][3] Group 2: Policy Releases - The report includes three domestic bio-based related policies, emphasizing projects focused on carbon reduction and sustainable materials [7][19] - Key projects mentioned include a 110,000-ton biodegradable polyester rubber demonstration project and a 1 million-ton sustainable aviation fuel project [8][19] Group 3: Industry Dynamics - The report details two domestic bio-based chemical company updates, including a 120 million yuan investment in a lactic acid production demonstration line [9][10] - It also highlights the establishment of a new company focused on food additives, indicating growth in the bio-based chemicals sector [10] Group 4: Capital Events - The report outlines several financing events in the bio-based sector, including a multi-million yuan investment in a company specializing in bio-based high barrier film materials [11][22] - Notable investments include over 100 million yuan in a company focused on recombinant collagen and near 100 million yuan in a company producing bioactive ingredients [22] Group 5: Scientific Research Progress - The report presents significant research breakthroughs in the bio-based field, such as the development of a new method for synthesizing high-order carbohydrates from low-carbon molecules [12][23] - It also discusses advancements in bioremediation techniques using engineered bacteria to address environmental pollution [12][23] Group 6: Upcoming Events - The "Fourth Synthetic Biology and Green Bio-manufacturing Conference" is scheduled for August 20-22, 2025, in Jinan, Shandong, focusing on the future of bio-manufacturing [25][26] - The conference aims to foster collaboration among industry leaders, researchers, and investors to explore innovative technologies and applications in the bio-manufacturing sector [25]

Project Overview - The project is named "Baikaiseng (Jiangsu) Biotechnology Co., Ltd. New Green Biosynthesis Industrialization Project" with a total investment of 120 million yuan, including 6.13 million yuan for environmental protection [2] - The project will be located in Lianyungang City, Jiangsu Province, covering an area of 29,597 square meters (approximately 44.39 acres) [2] - Construction is planned to start in June 2025 and be completed by December 2025 [2] Production Capacity and Products - The project will establish an automated flexible fermentation production line with a total annual production capacity of: - Squalene: 180 tons - Ergothioneine: 10 tons - Rebaudioside M: 50 tons - Valencene: 20 tons - Ectoine: 40 tons [2][3] - The production lines will operate for varying hours annually, with Squalene production running for 4,728 hours and Ergothioneine for 600 hours [3] Product Applications - Squalene: Used as a dietary supplement to improve fatigue and enhance immunity, suitable for high-pressure or hypoxic environments [5] - Ergothioneine: A natural antioxidant used as a dietary supplement with anti-inflammatory and neuroprotective effects [6] - Ectoine: A natural amino acid derivative with antioxidant and anti-inflammatory properties, aiding in post-exercise recovery [6] - Rebaudioside M: A natural sweetener derived from stevia, approved as a food additive, suitable for various food and beverage applications [6][7] - Valencene: A food additive used to enhance citrus aroma in food products [7] Company Background - Baikaiseng (Jiangsu) Biotechnology Co., Ltd. is a subsidiary of Baikaiseng (Shanghai) Biotechnology Co., Ltd., established on March 15, 2024 [8] - The company focuses on the research and development of biomanufacturing technologies across pharmaceuticals, cosmetics, and food sectors [8]