SynBioCon 大会 | 生物制造青年论坛 特色专场 生物制造青年论坛 8月20日，浙江·宁波 生物制造领域有哪些 "潜力股" 团队、技术和产品值 得关注？ 为发掘合成生物学和生物制造科研团队创新成果、 促进生物制造领域优秀科研工作者成果交流和产业方对接， 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 同期将举办特色专场——" 生物制造青年论坛 "，于8月20日在浙江宁波举办。 助力行业 15分钟了解一个方向 ，重点阐述研究领域存在的科学问题、解决思路、成果、放大可行性以及未来发展方向。 欢迎高校、科研院所申报分享！ 扫码报名，请选择参会形式 报名请选择：青年论坛、科技成果展示 SynBioCon 2 025 8月20-22日，浙江·宁波 01 论坛信息 时 间： 8月20日（周三） 席 位 ： 仅 30 席！ 报告时间： 第一场：13:30-17:30； 第二场：19:00-20:30 报名须知 ：扫描以上二维码，会务组将第一时间与您确认，并对接报告信息表等； 02 科技成果展示与对接专场 （同期活动） SynBioCon 2025 将设置 「科技成果展示与对接」专场 （ ...

Core Insights - The Ministry of Industry and Information Technology (MIIT) of China has released a public notice listing the first batch of typical application cases of artificial intelligence in the field of biological manufacturing, involving 15 companies and 1 research institute [1] - The focus of this initiative is on the integration of AI in biological manufacturing, particularly in areas such as innovative research and development, pilot scale-up, and production [1] - More than half of the 16 cases listed are related to the design and construction of high-performance protein components, indicating a strong emphasis on this area [1] Summary by Categories AI Applications in Biological Manufacturing - The MIIT's initiative aims to showcase how AI can enhance various stages of biological manufacturing, including high-performance protein design and production processes [1] - Notable companies involved include Beijing Zhaoyan Biological, Beijing Chengyitong, and Shanghai Tianhu Technology, which are recognized for their contributions to the field [1] Key Case Studies - **Beijing Zhaoyan Biological**: Developed an AI-driven platform for constructing stable high-expression cell lines, integrating machine learning and big data [3] - **Shanghai Tianhu Technology**: Created a protein engineering model AIACCLBIO™, which utilizes 9 billion protein data points for end-to-end predictions [4] - **Anhui Yuanguo Biological**: Implemented AI technology for de novo protein design, addressing complex structural challenges [4] - **Baitou Biotechnology**: Utilized AI models to enhance the efficiency of medicinal enzyme modifications for enzyme replacement therapies [4] Industry Trends and Future Directions - The upcoming SynBioCon 2025 conference will focus on AI and biological manufacturing, exploring trends and innovations that could drive the industry forward [7] - The conference aims to facilitate technology transfer and product scaling, highlighting the importance of collaboration among industry leaders, experts, and government entities [7]

Core Viewpoint - Jiangnan Huanyi is a high-end synthetic biotechnology skincare and cosmetic company focusing on the development and production of innovative materials, particularly supermolecular elastic proteins, which aim to revolutionize the skincare industry by providing multifunctional, high-activity, and green manufacturing solutions [3]. Company Overview - Jiangnan Huanyi Biotech (Changzhou, Jiangsu) is an innovative enterprise that integrates synthetic biology, supramolecular chemistry, nanotechnology, and protein materials science [3]. - The company has developed the world's first high-purity (≥95%) supermolecular elastic protein, addressing industry challenges related to the insufficient functionality of small molecules and absorption limitations of large molecules [3]. - Jiangnan Huanyi holds four national invention patents covering protein purification, supramolecular structure design, functionalization, and green fermentation systems [3]. Product Details - The core product, the "supermolecular elastic protein" gel, is designed specifically for skin elasticity enhancement, combining the benefits of hyaluronic acid, collagen, mussel protein, and natural elastic protein [5]. - The product features include anti-wrinkle properties, improvement of skin elasticity, tightening, wrinkle reduction, and deep hydration [5]. - The theoretical annual production capacity of the product is 10,000 boxes, priced at 400 yuan per box [5]. Industrial Collaboration - Jiangnan Huanyi has partnered with Tongkang Youdao Supply Chain (Guangzhou) Co., Ltd. to utilize its 35 GMPC standardized production lines, which have an annual capacity of 400 million units, ensuring high-quality packaging services for the supermolecular elastic protein gel [6]. - The collaboration aims to create a sustainable and efficient industrial chain, enhancing market promotion and supply capabilities [6]. - Additionally, Jiangnan Huanyi is working with Yangzhong Jiao Cheng Biotechnology Research Co., Ltd. to establish a dedicated strain expression system for the industrial production of supermolecular elastic proteins [6]. Industry Platform - Jiangnan Huanyi has joined the global bio-based and bio-manufacturing industry service platform, bio-basedlink, which aims to provide efficient supplier matching services across various sectors, including materials, energy, and synthetic biology [2][7].

Core Viewpoint - The article discusses the innovative strategies for enhancing CO2-to-lipid bioconversion in microalgae, specifically focusing on the oleaginous Coccomyxa subellipsoidea, to address the challenges of biomass and lipid accumulation for sustainable biodiesel production [1][2]. Summary by Sections Research Findings - The study achieved a biomass concentration of 10.00 g/L, a carbon fixation rate of 1.42 g/L/d, a lipid content of 51.84% dry weight, and a lipid yield of 401.75 mg/L/d under high light intensity (300 μmol/m²/s) [2]. - Chlorophyll fluorescence analysis indicated that high light intensity initially suppressed photosynthetic activity but later activated non-photochemical quenching (NPQ), enhancing the algae's high light tolerance [4]. - Metabolomics analysis showed that high light conditions upregulated protein and free amino acid degradation, facilitating the recycling of nitrogen and carbon resources, which maintained basic cellular metabolism and directed carbon flow towards acetyl-CoA for lipid synthesis [5]. Implications for Biofuel Production - The fatty acid methyl esters produced from this algal strain meet the biodiesel reference standards of China, the USA, and the EU, providing a significant theoretical basis and application case for the development of carbon neutrality and biofuel production technologies [6].

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan, discussing innovative technologies and products that can sustain the industry's vitality [1]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. - Supporting organizations include the Chinese Society of Biotechnology's Biobased Materials Committee and various local industry alliances [2]. Group 3: Highlights of the Conference - The conference will feature forums and closed-door activities to gain insights into the development trends of biomanufacturing and explore new products, technologies, and collaborations [5]. - There will be over 100 financing project roadshows to discover new cooperation opportunities [5]. - Key industry leaders, top universities, and investment institutions will gather to discuss advancements in the biomanufacturing sector [5]. Group 4: Agenda and Activities - The first day will include a closed-door seminar focusing on the development trends and growth points of biomanufacturing [10]. - The second and third days will feature a macro forum on biomanufacturing, specialized sub-forums on green chemicals, AI in biomanufacturing, future food and agriculture, and beauty raw materials [14]. - A special session for showcasing scientific achievements and project matchmaking will also be held, inviting innovative projects from the biomanufacturing field [15].

集"膜材料生产-工艺研发及装备制造-工艺设计-技术服务"为一体的物料分离全产业链企 业—— 同舟纵横 将出席 2025年8月20-22日，浙江·宁波 举办的 SynBioCon 2025 第四届合成生物与绿色生物制造大会 展示 最新解决方案。 同舟纵横(厦门)流体技术有限公司专注于工业流体领域的分离纯化，是一家集材料生产--工艺研发- --设备制造--药剂生产--EPC设计及工程总包为一体的国家级 高新技术企业和国家级专精特新小 巨人企业。 多年来同舟纵横不断探索已经完成了数百工程项目，涉及医药、化工、食品添加剂、淀粉糖、生物 发酵、植物提取、新能源、环保等各个领域，在实战中公司积累了大量的工程经验，树立了良好的 行业口碑，已经成为了利用压力驱动膜技术板块、电驱动膜技术板块和连续离交技术板块为客户提 供一站式解决方案的综合服务商。 T H E S I M P L E L I F E 产品特点 （4）氨基酸行业 （5）天然产物提取领域 （6）淀粉糖领域 （7）调味品行业 （8）农药行业 （9）兽药行业 （10）化工行业 （11）新能源行业 （12）废水深度处理行业 多样性：包括技术的多样性和产品的多样性，（1） ...

Core Viewpoint - The article discusses the development of a novel orthogonal transcription mutation system (OTM) by a research team led by Professor Chen Guoqiang from Tsinghua University, which significantly accelerates in vivo protein evolution and addresses limitations of traditional directed evolution methods [1][2]. Group 1: Technology Overview - The OTM system integrates three broadly host-compatible bacteriophage RNA polymerases and two deaminases, creating an efficient and modular protein evolution platform [2]. - The core principle involves RNA polymerase unwinding DNA to form single-stranded regions, allowing deaminases to edit exposed single-stranded DNA, achieving base mutations with a mutation efficiency increased by 1.5 million times compared to spontaneous mutations [2][3]. Group 2: Experimental Results - The research team successfully inserted bacteriophage promoters upstream and downstream of target genes, ensuring uniform distribution of mutations across target genes, overcoming previous biases in mutation distribution [3]. - The orthogonality experiments demonstrated that the OTM components could specifically recognize their respective promoters, avoiding cross-interference and enabling modular design [3]. Group 3: Applications and Future Prospects - The OTM system has shown great potential in applications, such as generating engineered strains with various colors by mutating fluorescent and pigment proteins, and creating unique shapes of engineered strains by targeting cytoskeletal and division-related proteins [3]. - In industrial applications, the system successfully evolved the σ70 global transcription regulator RpoD and lysine efflux protein LysE, enhancing L-arginine tolerance and transport capabilities [3][5]. - The technology has broad expansion potential, with possibilities to integrate other types of deaminases to enrich mutation diversity and explore compatibility in other non-model organisms [5].

Core Viewpoint - The establishment of Huaxi Tang'an Bio-Tech in Guangming Science City marks a significant strategic deployment for Huaxi Bio, expanding its diversification beyond hyaluronic acid and establishing a global non-animal heparin full industry chain platform in the Guangdong-Hong Kong-Macao Greater Bay Area [1][3]. Group 1: Company Development - Huaxi Bio focuses on synthetic biology, emphasizing glycomics and cell biology, and has developed four major business segments: bioactive raw materials, pharmaceuticals and medical devices, skin science innovation, and nutritional science innovation [1]. - Huaxi Tang'an has achieved multi-dimensional technological breakthroughs in the field of enzyme-synthesized heparin, with applications in cosmetics, pharmaceuticals, and medical devices, particularly in preventing and treating thromboembolic diseases and cardiovascular surgeries [1][3]. Group 2: Industry Collaboration and Ecosystem - The signing ceremony involved partnerships with Guangming District, the National Bio-Manufacturing Industry Innovation Center, and private equity funds, leveraging policy and resource advantages to accelerate project development [3]. - Guangming District has attracted over 130 companies in the synthetic biology sector, with an estimated industry valuation of nearly 40 billion, establishing a comprehensive innovation ecosystem covering research, technology development, and talent support [3][4]. Group 3: Future Prospects - The establishment of Huaxi Tang'an is expected to attract more upstream and downstream enterprises in the medical beauty and cosmetics sectors, contributing to the creation of a distinctive industrial cluster in Guangming [4].

Core Insights - The article discusses the ongoing development and innovation in the synthetic biology sector in China, highlighting the upcoming release of the "Top 500 Representative Enterprises in Biological Manufacturing" list by DT New Materials Research Institute in August 2025 [1][12]. Industry Overview - The synthetic biology industry has seen significant growth, with over 300 companies listed in the "China Synthetic Biology Industry Map (2023)" and more than 5,000 copies distributed within the industry [1]. - The global market for biopharmaceuticals is projected to reach $1.5 trillion by 2025, indicating a robust growth trajectory for the biopharmaceutical sector, particularly in Zhejiang Province, which is identified as a leading industry hub [4]. Regional Development Plans - In 2019, Zhejiang Province initiated the "Zhejiang Province Biological Economy Development Action Plan (2019-2022)," aiming to establish the biological economy as a new growth point by 2022 [3]. - The Hangzhou City government released the "Three-Year Action Plan for High-Quality Development of the Synthetic Biology Industry (2024-2026)" in November 2024, followed by the "Implementation Plan for Accelerating the Innovation and Development of the Synthetic Biology Industry in Zhejiang Province" in January 2025, targeting an industry scale exceeding 100 billion [5]. Company Listings and Achievements - Hangzhou has over 260 synthetic biology-related enterprises, achieving a production value of over 25 billion in 2023 [6]. - The "Top 500 Representative Enterprises in Biological Manufacturing" list for Zhejiang includes 65 companies, evaluated based on team strength, core products, and competitive potential [7]. Upcoming Events - The Fourth Synthetic Biology and Green Biological Manufacturing Conference will be held in Ningbo from August 20-22, 2025, focusing on AI and biological manufacturing, green chemicals, future food, agriculture, and beauty raw materials [12][13].

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan, discussing innovative technologies and products that can sustain the industry's vitality [1]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Bioengineering Co., Ltd. [2]. - Supporting organizations include the Chinese Society of Biotechnology's Biobased Materials Committee and various local industry alliances [2]. Group 3: Highlights of the Conference - The conference will feature forums and closed-door activities to gain insights into the development trends of biomanufacturing and explore new products, technologies, and collaborations [5]. - There will be over 100 financing project roadshows to discover new cooperation opportunities [5]. - Key players from leading enterprises, top universities, investment institutions, and industry stakeholders will gather to discuss advancements in the field [5]. Group 4: Agenda and Activities - The first day will include a closed-door seminar focusing on the development trends and growth points of biomanufacturing [10]. - The second and third days will feature a macro forum on biomanufacturing, specialized sub-forums on green chemicals, AI in biomanufacturing, future food and agriculture, and beauty raw materials [14]. - The conference will also host a technology achievement showcase to promote innovative results and projects in the biomanufacturing sector [15].