尽管 苯乙酮及其衍生物的生物学功能已被充分报道 ， 但其 生物合成途径 仍 有待阐明 。 虽 有研究指出 苯乙酮可能通过 β-氧化途径 生成 ， 也有研究 通过同位素标记证实 苯丙氨酸代谢产生的 肉桂酸 是苯乙酮 的合成 前体 ， 然而该 合成途径中 的 具体酶 促反应步骤 和涉及的酶尚不明确 。 【SynBioCon】 获 悉， 2025年 9 月 5 日， 西北农林科技大学 徐凌飞 教授带领的梨研究团队 在 Nature Plants 在 线 发 表 了 题 为 " Naturally impaired side-chain shortening of aromatic 3- ketoacyl-CoAs reveals the biosynthetic pathway of plant acetophenones "的研究论文 （ 梨领域 首篇 ） 。该研究 以梨为材料，揭示了苯乙酮类化合物的 完整 生物合成途 SynBio团队 | 西北农林科大徐凌飞教授、苯乙酮 苯乙酮及其衍生物 在 植物 界 和微生物 界中分布 广泛 ， 具有多样的生物学功能。 在植物界， 苯乙酮 （acet ophenone ） 是 ...

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从产业生态搭建来看， 微康益生菌拥有亚洲最大的益生菌菌种研发智能制造基地 ，产品更是获评拜耳制药全球最佳供应商；还成功孵化 益一科技、康科 生物、修喵修勾科技、玖明医疗等企业 ，覆盖医疗健康、膳食营养、宠物健康等细分领域，有效补全鼓楼合成生物产业链条。 SynBio团队 | 黄和院士 【SynBioCon】 获 悉， 近 日，鼓楼区政府与南京师范大学共建的 智能生物制造创新中心 启动仪 式在南京幕府智谷成功举办。 中心以合成生物学底层技术为核心，打造"1+1+N"创新模式，既依托南师大科研平台攻克核心技术，又联动企业推动成果落地，真正破解 "实验室突破 难转化为产业产品"的痛点 。 值得关注的是， 中国工程院院士、 南京师 范大学副校长黄和将担任智能生物制造创新中心管委会主任 。他将带领团队聚焦生物制造前沿领域，依托新 科学与新技术，推动创新中心打造成为合成生物学科研高地，为生命健康产业集群发展提供有力支撑。 仪式现场，黄和院士还为 微康益生菌 、纽邦生物、迪必尔生物工程、北极光等 企业负责人颁发智能生物制造创新中心产业顾问聘书。 此次活动签约的海尔生物、德悦普惠医疗、量准科技等项目，进一步覆盖 细胞库建设 ...

Core Viewpoint - The article emphasizes the development of non-grain biomass resources for energy and bio-based materials, highlighting the upcoming NFUCon 2025 forum aimed at discussing commercialization paths and technological advancements in this sector [2]. Group 1: Forum Overview - The NFUCon 2025 forum will take place from November 27 to 29, 2025, in Hangzhou, Zhejiang, organized by DT New Materials and the National Key Laboratory of Bio-based Transportation Fuels [2][3]. - The forum will gather industry representatives and experts to explore key areas such as green pretreatment of biomass, non-grain sugars, bio-based chemicals and materials, and biomass energy [2][4]. Group 2: Forum Agenda - The forum will feature a series of specialized sessions, including topics on biomass green pretreatment technologies, non-grain sugars, bio-based chemicals, and non-grain biomass materials [6][9]. - A special focus will be on sustainable aviation fuel (SAF) and the conversion of agricultural residues into valuable energy sources [10]. Group 3: Supporting Institutions - The forum is supported by various academic and research institutions, including Zhejiang University and its associated laboratories, which focus on polymer science, bio-systems engineering, and biomass utilization [4][14]. - The event will also involve participation from enterprises engaged in biomass energy and chemical development, as well as government and association organizations [14]. Group 4: Special Activities - A special activity will be held for showcasing and connecting innovative projects in the biomass utilization field, with a goal of promoting commercialization and industry collaboration [9][10].

Core Viewpoint - The article emphasizes the importance of industrial biotechnology in supporting China's sustainable development and innovation in the bio-economy, focusing on key technologies and research areas that can replace fossil resources with renewable carbon resources and enhance industrial processes through modern biotechnology [5][20]. Group 1: Research Focus - The research institute focuses on three strategic themes: replacing fossil resources with renewable carbon resources, using clean biological processing instead of traditional chemical methods, and enhancing industrial levels through modern biotechnology [5]. - Key research areas include industrial protein science and biocatalysis engineering, synthetic biology and microbial manufacturing engineering, and biological systems and bioprocess engineering [5]. Group 2: Team Introduction - Zhang Yiheng, a prominent researcher and doctoral supervisor, leads the Low Carbon Synthesis Engineering Biology National Key Laboratory and has made significant contributions to the field, including the establishment of the in vitro BioTransformation (ivBT) engineering technology system [6]. - Zhang Yuzhen, another researcher, has developed microfluidic technologies for quantitative studies of microbial populations and is working on high-throughput identification techniques for important industrial enzymes [7][8]. Group 3: Recruitment Information - The institute is seeking to hire 2-3 postdoctoral research assistants and 1-2 assistant researchers, with a focus on candidates holding doctoral degrees in microbiology, molecular biology, or enzyme engineering [9][10]. - Competitive salaries and benefits are offered, including social insurance, housing funds, and opportunities for professional development and overseas visits [11][12]. Group 4: Career Development - Postdoctoral researchers can apply for permanent positions with competitive salaries and development opportunities, including potential advancement to senior technical roles based on their research achievements [13][14]. Group 5: Upcoming Events - The article mentions an upcoming forum on non-grain biomass high-value utilization, scheduled for January 27-29, 2025, in Hangzhou, focusing on clean pretreatment of biomass and commercialization of bio-based materials and fuels [20].

Core Insights - The article highlights the recent launch of a thousand-ton synthetic biology flexible production line by Siping Technology in Rugao, Jiangsu, marking a significant step in the company's full-chain layout in synthetic biology [2] - Siping Technology aims to become an innovative leader in synthetic biological manufacturing platforms, focusing on high-performance bio-based materials and carbon-negative intelligent manufacturing [2] - The company has partnered with the Tianjin Institute of Industrial Biotechnology to develop bulk bio-based material monomer products using methanol, aiming to reduce reliance on food carbon sources and promote "one-carbon bio-manufacturing" [4] Group 1 - Siping Technology's new production line is a key component in scaling up biological manufacturing technology and aims to lead the industry towards intelligent, non-food, and sustainable development [2] - The product matrix includes carbon-negative new materials, polymer monomers, and high-value-added compounds, with a focus on efficient conversion from laboratory technology to industrial application [2] - The collaboration with the Tianjin Institute is based on shared strategic goals, leveraging the institute's expertise in low-carbon synthetic biology and Siping's advancements in bio-based products [4] Group 2 - The national strategy emphasizes the innovation and development of non-food bio-based materials, utilizing resources like crop straw and bamboo [7] - A forum on high-value utilization of non-food biomass is scheduled for November 2025 in Hangzhou, focusing on clean pretreatment, non-food sugars, chemicals, and biofuels [7]

Core Viewpoint - The article discusses the recent legislative measures taken by Shenzhen to promote the synthetic biology industry, which is considered a new "golden track" in the context of the third biotechnology revolution. The new regulations aim to support innovation and development in this emerging sector, establishing a comprehensive service support system for synthetic biology enterprises [2][3]. Summary by Sections Legislative Framework - Shenzhen has passed the "Regulations on Promoting the Innovative Development of the Synthetic Biology Industry," which will take effect on October 1. This legislation is a pioneering effort in the field of industrial promotion and aims to address development bottlenecks in the synthetic biology sector [2][3]. Industry Support and Ecosystem - The regulations outline a full-chain service support system for synthetic biology, emphasizing the importance of source innovation for technology transfer. Approximately 40% of new synthetic biology enterprises in China have been established in Shenzhen over the past three years [4]. Product Market Entry - The regulations include measures to shorten the product market entry cycle for synthetic biology products, addressing the challenges of lengthy approval processes. This includes exploring new models for evaluation and technical institutions, as well as promoting the market demand for synthetic biology products through curated lists and procurement facilitation [6][7]. Financial and Spatial Support - The regulations reinforce the need for spatial and financial support for the synthetic biology industry. They prioritize land supply for enterprises and encourage financial institutions to lower financing costs for startups in this sector. Additionally, there are efforts to streamline approval processes and enhance the regulatory environment for synthetic biology enterprises [7].

Core Viewpoint - The article highlights the launch of the Zhejiang Zhenyuan Biological Industrialization Base, emphasizing its significance in the synthetic biology sector and its role in promoting high-quality economic development in Shaoxing [3][5]. Company Progress - Zhejiang Zhenyuan officially inaugurated its biological industrialization base on August 30, marking a key milestone in the development of synthetic biology and the production of high-end amino acids [3][5]. - The base is the first in China to feature a thousand-ton-level industrialization facility for the biosynthesis of histidine, showcasing advanced synthetic biology and fermentation engineering technologies [5][6]. - The project has received recognition as a major industrial project in Zhejiang and is part of the national green low-carbon advanced technology demonstration projects [5][6]. Financial Performance - In the first half of 2025, Zhejiang Zhenyuan reported a revenue of 1.283 billion yuan, a decrease of 34.49% year-on-year, while net profit attributable to shareholders increased by 29.27% to 56.26 million yuan [6][7]. - The company’s net profit, excluding non-recurring gains and losses, was 30.12 million yuan, down 20.32% compared to the previous year [6][7]. - The company’s total assets decreased by 13.55% to approximately 2.955 billion yuan, while net assets attributable to shareholders increased by 2.62% [7]. Industry Context - The synthetic biology sector is recognized as a core component of the "third biological technology revolution," with significant support from local government policies and funding exceeding 10 billion yuan [5][6]. - The base aims to replace traditional high-pollution and high-energy consumption processes with green technologies, contributing to the development of a sustainable industrial ecosystem [6][8]. - The project aligns with national strategies for the innovation and development of non-grain biomass materials, focusing on clean energy and material systems [10].

Core Viewpoint - The article discusses recent advancements in starch modification through the research conducted by the Tianjin Institute of Industrial Biotechnology, focusing on the enzyme Amylomaltase (AM) and its potential applications in addressing food security and carbon neutrality [5][6]. Group 1: Research Findings - The research team utilized large-scale molecular simulations and quantum mechanics/molecular mechanics (QM/MM) calculations to reveal the complete catalytic cycle of AM, identifying the rate-limiting steps in cycloamyloses (CA) synthesis [6][7]. - The study demonstrated that by strategically adjusting the polysaccharide chain transfer steps, several active mutant variants were obtained, enhancing enzyme performance primarily through reduced substrate transfer affinity [6][7]. - Mass spectrometry confirmed the generation of cycloamyloses with degrees of polymerization ranging from 22 to 61, validating theoretical predictions [6][7]. Group 2: Industrial Implications - The research provides a systematic molecular-level understanding of the biosynthesis process of CA, offering a clear engineering blueprint for the AM family, which could lead to more efficient and specific glycosyltransferases [6][7]. - The findings are significant for the industrial application of starch modification, contributing to the development of biobased materials and energy systems utilizing non-grain resources [9][11]. Group 3: Support and Collaboration - The research was supported by the Chinese Academy of Sciences' strategic pilot technology projects and the Tianjin Synthetic Biology Technology Innovation Capability Enhancement Action [7]. - Collaborations included contributions from various institutions, highlighting the interdisciplinary nature of the research [7].

/生物制造产业社群/ 让上下游聚在一起, 未来食农、绿色化工、大健康、美妆个护 等产业同行❤️↓ 美丽健康 | 自然堂、极地酵母喜默因® 原料是化妆品行业的"美丽之芯"，是产品竞争力的根本。 【SynBioCon】 获 悉， 8月27日， 自然堂集团 举办 自然堂第三极生物发酵原料工厂 （以下简称"自然堂发酵工厂"）启用仪式，这座全面应用 第五 代智能生物发酵技术 的"硬核"工厂 正式宣告投产，标志着自然堂在自主研发核心功效原料的征程上迈出关键一步。 年产1000吨，第五代发酵科技超级工厂投产 据悉，区别于前四代技术，自然堂的第五代发酵技术，融合了 微生物学、合成生物学、数据科学与AI，推动菌种构造、验证及工业化效率升级 ，尤其 在研发端和生产端深度融合人工智能、计算信息学与生物信息学等交叉学科，通过 高通量实验筛选最优菌株与工艺组合 ，不仅将原料品质的稳定性与 纯度提升至新高度，更实现了功效成分的精准富集。 工厂拥有两条平行生产线， 单批次即可实现20吨的高效产能，年产能达到1000吨 。相比传统代加工的3-5吨/批，该技术支撑下的发酵原料批产量跃 升至 10-15吨/批 ，实现了约 5倍 的大幅提升。 并 ...