Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the "14th Five-Year Plan" period, discussing innovative technologies and products that can sustain the industry's vitality [1]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. Group 3: Highlights of the Conference - The conference will feature forums and closed-door activities to gain insights into the development trends of biomanufacturing during the "14th Five-Year Plan" [4]. - There will be over 100 financing project roadshows to discover new cooperation opportunities [4]. - Key industry leaders, top universities, and capital from various sectors will gather to discuss and share insights [4]. Group 4: Agenda and Special Activities - The first day will include a closed-door seminar focusing on the development trends and growth points of biomanufacturing, inviting 30 industry leaders and experts [7]. - The second and third days will feature a macro forum on biomanufacturing, discussing the overall trends and progress in the industry [10]. Group 5: Specialized Forums - Specialized forums will cover topics such as green chemicals and new materials, AI in biomanufacturing, future food and agriculture, and beauty raw materials [11]. - The forums will address various key topics, including the development of bio-based chemicals, green manufacturing technologies, and the application of AI in biomanufacturing processes [11]. Group 6: Technology and Innovation - The conference will showcase technological achievements and innovations in the field of biomanufacturing, inviting participation from research institutions and enterprises [10]. - There will be a focus on discovering potential teams and technologies in biomanufacturing, with over 30 presentations planned to facilitate efficient communication and collaboration [10].

近年来，生物制造已作为多数国家提升经济竞争力的着力点，也是我国继绿色制造、智能制造后，推进制造强国建设的又一重要抓手。同时，各地政府 地区通过结合自身优势力争实现合成生物"研发－转化－产业—集群"协同发展，发挥新质生产力 作用。 8月20-22日 将于 浙江·宁波 举 办 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2 025 ) 。大会 聚焦" 1+4 " ： AI+生 物智造 这一大热门赛道； 绿色化工与新材料、 未来食品、未来农业和美妆原料四大应用领域 ，邀请国 际领先企业、代表性产业化专家、政府、园 区、资本、协会和联盟等各方共探 "十五五"生物制造产业发展趋势 ； 哪些革新技术和产品将给生物制造产业带来持续的生命力 ； 并致力于 促进科技 成果转移转化 、 产品 规模 化与人才挖掘 。 一、组织机构 主办单位： 宁波德泰中研信息科技有限公司（ DT 新材料） 协办 单位： 宁波酶赛生物工程有限公司 二、大会亮点 三、大会日程 亮点一 ： 大会论坛、闭门活动洞察"十五五"生物制造发展趋势！探索新产品、新技术、新落地、 新合作！ 亮点二： 青年创新技术与价值分享、人才对接与合作！ 亮 ...

Core Insights - Wanhua Chemical is actively recruiting top experts globally in ten key areas, including packaging materials, PVC, ePTFE membrane materials, biomanufacturing membrane products, high-end optical films, polyolefin films, synthetic biology, electrolyzers and electrodes, anode and cathode products, and battery materials [1] Group 1: Biodegradable Packaging Materials - Wanhua Chemical is focusing on biodegradable packaging solutions, expanding beyond traditional polyolefin films to include a full range of biodegradable options [2] - The PBAT product series covers various applications such as heat shrink films, cushioning bubble films, cushioning air cushion films, and cushioning air column films [2] Group 2: Biomanufacturing Membrane Materials - Separation and purification are the most costly and challenging aspects of biomanufacturing, accounting for 50%-80% of costs [3] - Wanhua is developing a range of high-efficiency membranes, including microfiltration, nanofiltration, ultrafiltration, reverse osmosis membranes, and hollow fiber ultrafiltration membranes, to address these cost challenges [3] Group 3: Synthetic Biology Innovations - The synthetic biology platform integrates gene engineering, metabolic engineering, enzyme engineering, computational science, and automation, serving as a powerful tool for developing biobased chemicals and materials [4] - Wanhua has achieved significant milestones, including the global launch of 100% naturally sourced biobased 1,3-butanediol produced via microbial fermentation from non-grain sugar raw materials [4] - The company is also developing single-cell protein (SCP) production through fermentation technology, with future capacity planned to reach several hundred thousand tons, representing a new protein source and potential biobased material precursor or additive [4]

资本事件 | 格瑞农生物 【SynBioCon】 获 悉，近日， 武汉格瑞农生物科技有限公司 （以下简称：格瑞农生物）宣布完成 数千万元Pre-A+轮融资 。 本轮融资主要用于 深化噬菌体多应用场景技术布局，加速公司产品创新、 管线进展、证书申报、市场推广等工作 。 2024年12月，格瑞农生物宣布完成数千万元Pre-A轮融资。 2024年1月，格瑞农生物接连完成天使轮及天使+轮融资，累计募集资金近亿元。 格瑞农生物成立于2019年7月，是一家专注于噬菌体制剂研发与产业化的高新技术企业。 作为全球领先的噬菌体生物制造平台，通过"科研-生产-应用"全产业链布局， 深度赋能智慧养殖、生 态种植、绿色食品、生物医疗四大领域 ，现已成功构建了国际领先的噬菌体库及宿主菌库，为行业提 供了重要的科研支撑和资源平台。 格瑞农生物业务广泛覆盖动物保健（畜禽、水产）、植物保护、食品安全、消费医疗领域，已成功构建 起丰富的产品矩阵：动保领域开发了针对大肠杆菌、沙门氏菌、产气荚膜梭菌、鸭疫里氏杆菌、巴氏杆 菌、波氏杆菌及弧菌等多项噬菌体解决方案，显著降低畜禽细菌性疾病风险；植保领域则推出了推出青 枯病、溃疡病等作物重点病害的速效生 ...

Core Viewpoint - Evonik announced plans to optimize the global production layout of MetAMINO® (DL-methionine) in the third and fourth quarters of 2025, including temporary shutdowns of production facilities in Singapore and Antwerp to enhance energy efficiency and reduce CO2 emissions [1][4]. Group 1: Production Capacity and Market Dynamics - The global methionine production capacity is projected to reach 2.35 million tons per year by 2024, with Evonik, Adisseo, and Sinochem accounting for 71% of this capacity [4]. - China's methionine production capacity is expected to reach 840,000 tons per year by the end of 2024, representing 36% of the global total, with further expansion anticipated to exceed 1.2 million tons by 2029 [5][6]. - China has transitioned from a net importer to a net exporter of methionine, with a projected consumption of 430,000 tons in 2024, including 160,000 tons imported and 410,000 tons exported, resulting in a net export of 250,000 tons [6]. Group 2: Production Methods and Innovations - Biotechnological methods for producing methionine offer advantages over chemical methods, including higher efficiency and reduced safety risks associated with toxic substances [7]. - The industrialization of biological methionine production has been slow due to low yield during fermentation processes, with only one company, HJ, successfully achieving bulk production [9]. - In China, significant advancements in L-methionine biosynthesis have been made by academic teams, leading to the development of microbial cell factories for efficient precursor synthesis [11][12].

Core Viewpoint - The article discusses the development of an intelligent feedback control system for bioethanol fermentation, which integrates online Raman spectroscopy and deep learning to enhance the precision and real-time control of carbon source concentration during fermentation, addressing the limitations of traditional methods [1][7]. Group 1: System Innovation - The research team developed a spectral-time concatenation convolutional neural network (STC-CNN) model that utilizes non-destructive data streams from high-frequency online Raman spectroscopy to overcome issues such as prediction lag and lack of labeled data [3]. - Key innovations of the system include the introduction of a time series concatenation mechanism to capture dynamic changes in fermentation, a pseudo-label data augmentation strategy that expands the training sample size by 100 times, and the integration of a Kalman filter to enhance robustness under complex conditions [3][4]. Group 2: Performance Metrics - In practical applications, the system demonstrated significant advantages, achieving over 95% correlation between model predictions and offline HPLC measurements, with the maximum prediction deviation reduced from 8.3 g/L to 2.63 g/L [4]. - When controlling glucose concentration at 30 g/L, ethanol yield increased to 140.68 g/L, an 11.9% improvement over traditional batch fermentation, while glycerol concentration decreased to 6.72 g/L, resulting in a 64.6% increase in the ethanol/glycerol ratio [4][6]. Group 3: Broader Implications - The system not only addresses the precision control challenges in bioethanol production but also provides critical support for the intelligent transformation of the fermentation industry, reducing reliance on manual experience and enhancing process stability and production efficiency [7]. - The STC-CNN architecture and Raman feedback control system have been validated across various fermentation scenarios, indicating broad applicability in food, biopharmaceuticals, and green energy sectors [7].

Core Viewpoint - The company, Jupeng Bio, is the only global entity with an integrated technology chain for producing bioethanol and green methane from biomass gasification and gas fermentation, along with single-cell protein products [1][2]. Group 1: Technology Overview - Biomass Gasification: Converts carbon-containing biomass waste into synthesis gas, which can produce various green fuels and chemicals [3]. - Gas Fermentation: Includes CO/CO2 fermentation technologies for ethanol production and CO2 coupling green hydrogen fermentation for green methane, serving as effective pathways for CO2 direct reduction and efficient green hydrogen application [3]. - Single-Cell Protein: A high-nutrition and high-value biological product that can be used as aquaculture feed or developed into high-end downstream products such as peptides and culture media [4]. Group 2: Project Developments - In 2013, the first integrated demonstration plant for biomass gasification and gas fermentation to produce fuel ethanol was established in Florida, processing 250,000 tons of biomass annually and producing 24,000 tons of bioethanol, along with 6 MW of electricity [9]. - Jupeng Bio partnered with Shanxi Lu'an Chemical Group to construct an industrial waste gas fermentation plant in Changzhi, Shanxi, which began operations in October 2021 and has been validated for large-scale commercialization [9]. - A large-scale commercial facility with a capacity of 100,000 tons/year of ethanol and 20,000 tons/year of single-cell protein is set to begin construction in Ordos, Inner Mongolia, in November 2024 [9]. Group 3: Recognition and Certifications - In 2024, Jupeng Bio was recognized as a national high-tech enterprise and a "specialized, refined, and innovative" small and medium-sized enterprise in Beijing; the Shanxi plant was also recognized as one of the first high-tech enterprises in Shanxi Province [10].

Group 1: Core Insights - The article introduces the "Global Bio-based Industry Monthly Report," providing insights into the latest trends and opportunities in the bio-based sector [1][2][3] - The report is available for free to industry peers, highlighting the importance of collaboration and information sharing within the bio-based industry [1][3] Group 2: Policy Releases - Three domestic bio-based related policies were recorded in May 2025, focusing on carbon reduction projects, including biodegradable polyester rubber and sustainable aviation fuel [7][8] - Key projects include a 110,000-ton biodegradable polyester rubber demonstration project and a 1 million-ton sustainable aviation fuel project [8] Group 3: Industry Dynamics - The report includes updates on domestic bio-based chemical companies, such as the establishment of a lactate production line with an investment of 120 million yuan [9][10] - New companies in the bio-based sector are emerging, such as Yantai Wanhua Chemical, which has launched a new subsidiary focused on food additives [10] Group 4: Capital Events - Several financing events in the bio-based sector were reported, including a B round financing of several million yuan for Senqi New Materials and angel round financing for Zhongke Kexin [11][22] - Notable investments include over 100 million yuan for a recombinant collagen company and nearly 100 million yuan for a bioactive ingredient company [22] Group 5: Scientific Research Progress - Significant breakthroughs in bio-based materials research were highlighted, including the development of a new type of conductive "E-skin" for health sensing applications [12][23] - Research on bioremediation using engineered bacteria to address complex organic pollutants was also reported, showcasing advancements in environmental applications of synthetic biology [23] Group 6: Upcoming Events - The Fourth Synthetic Biology and Green Bio-manufacturing Conference is scheduled for August 20-22, 2025, in Jinan, Shandong, focusing on the future of bio-manufacturing and technology transfer [25][26]

Core Viewpoint - The integration of chemical and biological synthesis is essential for achieving efficient chemical bond activation, cleavage, and reorganization, emphasizing the collaborative potential of both methods [2][4]. Group 1: Chemical and Biological Synthesis - The core goal of chemical-biological synergy is to enhance efficiency and reduce costs by leveraging the strengths of both chemical and biological synthesis methods [2][4]. - Chemical synthesis will not be completely replaced by biological synthesis; instead, the focus is on how to complement each other to create lower-cost and higher-value pathways [4][5]. Group 2: Case Studies and Applications - Examples include the production of artemisinin, where biological synthesis converts sugars to artemisinic acid, while chemical methods enhance production efficiency through hydrogenation and oxidation [6]. - Collaborative efforts in various fields, such as polymer materials and drug development, have shown significant results, indicating a broad application prospect for chemical-biological synergy [6]. Group 3: Advances in Catalysis - Biomimetic catalysis is a key area where chemists learn from biologists, with future developments focusing on the diversity of catalytic systems and synergistic catalytic functions [7]. - Breakthroughs in artificial enzymes and non-natural reactions have been achieved by combining chemical catalysts with protein systems, providing new pathways for complex molecule synthesis [8]. Group 4: Innovations in Synthetic Biology - Combinatorial biosynthesis through genome recombination and editing generates non-natural products, with chemical methods playing a crucial role in precursor provision and subsequent modifications [9]. - The synthesis of nucleic acids, proteins, and carbohydrates faces challenges, but advancements are being made in functionalization and long DNA synthesis [11][12][13]. Group 5: Future Outlook and Technological Integration - AI and big data are poised to play significant roles in promoting the integration of chemical and biological synthesis, accelerating genome mining, molecular design, and synthesis pathway optimization [14]. - The deep-sea scientific program exemplifies the potential for protein and enzyme modification in extreme environments, showcasing innovative research directions [15]. Group 6: Policy and Support for Research - A call for national-level top-level design to promote interdisciplinary research in chemical-biological synergy, particularly supporting young researchers in fields like medicine, materials, energy, and carbon neutrality [16].

Core Viewpoint - Suzhou Yike Biotechnology Co., Ltd. is the world's first company to possess PCT patents for producing PHA biodegradable plastic resins, focusing on high-performance eco-friendly materials for food and medical packaging [1][3]. Group 1: Company Overview - Suzhou Yike Biotechnology Co., Ltd. held a project signing ceremony on June 12 and obtained its business license on the same day [1]. - The company aims to establish a research and development center and production base in Taihu New City, targeting an annual production capacity of 10,000 tons, with a phased construction plan [3]. Group 2: Market Potential - The global market for PHA microspheres and PHA bioplastics was valued at $18.8 million in 2023 and is projected to reach $36.7 million by 2030, with a compound annual growth rate (CAGR) of 10.1% from 2024 to 2030 [3]. - The top five global PHA manufacturers hold over 85% of the market share, indicating a concentrated industry [3]. Group 3: Industry Challenges - PHA materials have advantages in biodegradability and biocompatibility over traditional plastics, but their production costs remain higher, with raw material costs accounting for 60% of expenses [3]. - The ex-factory price of PHA products is approximately 40,000 yuan per ton, which limits industrial production and application [3]. Group 4: Future Outlook - The company plans to drive innovation in technology and aims to become a leading player in the bioplastics industry with a global presence [3]. - The industry is expected to see increased interest as more companies accelerate their efforts to develop low-cost raw materials and improve production efficiency [4].