Core Insights - The Chinese biomanufacturing industry is projected to reach a scale of 1.01 trillion yuan in 2024, with a year-on-year growth of 15.4%. By 2030, the industry is expected to exceed 2.5 trillion yuan, with a compound annual growth rate of 16.8% [1]. Group 1: Industry Overview - The DT New Materials Research Institute has been actively monitoring and supporting the progress and innovation in the synthetic biology sector since the release of the "China Synthetic Biology Industry Map (2023)" which includes over 300 listed companies [1]. - The upcoming "4th Synthetic Biology and Green Biomanufacturing Conference (SynbioCon 2025)" will take place from August 20-22 in Ningbo, Zhejiang, where the "China Synthetic Biology Industry Distribution Map (2025 Edition)" will be announced, featuring over 500 representative biomanufacturing companies and their product information [1][9]. Group 2: Event Details - The conference will focus on five key areas: AI + Biomanufacturing, Green Chemistry and New Materials, Future Food, Future Agriculture, and Beauty Raw Materials, inviting industry leaders, experts, and various stakeholders to explore trends in biomanufacturing development during the 14th Five-Year Plan [9]. - Participants at the conference can receive a free copy of the industry map valued at 499 yuan, and eligible biomanufacturing companies can register to be included in the map [6][10].

Core Viewpoint - The SynBioCon 2025 conference will focus on the integration of AI with biomanufacturing, green chemicals and new materials, future food, and future agriculture, aiming to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period [1]. Group 1: Conference Overview - The conference will take place from August 20-22, 2025, in Ningbo, Zhejiang [1]. - It aims to promote the transfer and transformation of scientific and technological achievements, product scaling, and talent acquisition in the biomanufacturing sector [1]. Group 2: Organizers and Support Units - Organized by Ningbo Detaizhongyan Information Technology Co., Ltd. (DT New Materials) and co-organized by several academic and research institutions [2]. - Supported by various associations and alliances, including the Chinese Society of Biotechnology and the Zhejiang Synthetic Biology Industry Technology Alliance [2]. Group 3: Expert Guests - Notable experts include Zhang Xian'en, Dean of the School of Synthetic Biology at Shenzhen University of Technology, and other prominent figures from various universities and research institutes [4][5][6][7][10][12][14][18][20][22][30][32]. - These experts will share insights on topics such as the construction of efficient cell factories and the development of biobased materials [8][11][23][27][31]. Group 4: Conference Agenda - The agenda includes a series of forums and discussions on topics like green chemicals, AI in biomanufacturing, and future food and agriculture [36][37]. - Activities will feature high-level discussions, youth forums, and technology showcases [36][37].

Core Viewpoint - The SynBioCon 2025 conference will focus on the integration of AI with biomanufacturing, green chemicals and new materials, future food, and future agriculture, aiming to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period [1]. Organizers and Support Units - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. and supported by various institutions including Peking University Ningbo Institute of Ocean Medicine and the China Society of Biotechnology [2]. Expert Guests - Notable experts such as Zhang Xian'en, a prominent figure in synthetic biology, will participate as advisory experts for the conference [4][5]. Conference Agenda - The event will feature a series of forums and discussions, including a high-level roundtable on biomanufacturing, thematic forums on green chemicals and new materials, and AI-enabled biomanufacturing innovations [36][37]. Key Topics of Discussion - The conference will cover topics such as the construction of efficient cell factories for producing aromatic compounds, biomanufacturing of polyamide materials, and the development of non-grain bulk alcohols and organic acids [8][11][12][30].

Core Insights - The article highlights the rapid development and innovation in China's synthetic biology sector, particularly focusing on Shanghai as a leading hub for synthetic biology initiatives and projects [2][3][4]. Group 1: Industry Development - Shanghai is recognized as the primary force in China's synthetic biology development, with significant milestones such as the establishment of the Chinese Academy of Sciences' synthetic biology laboratory in 2008 [2]. - In 2023, Shanghai released an action plan to accelerate synthetic biology innovation and build a high-end biomanufacturing industry cluster from 2023 to 2025 [2]. - The Shanghai Municipal Science and Technology Commission has initiated key projects in synthetic biology and computational biology to support rapid industry growth [2]. Group 2: Funding and Support - Shanghai has allocated substantial funding for synthetic biology projects, including 42 million yuan for 18 projects and 37 million yuan for 16 projects [3]. - The city has established industrial clusters in areas like Zhangjiang Science City and Lingang New Area, providing comprehensive support from research and development to pilot testing [3]. Group 3: Notable Companies - A total of 66 representative companies from Shanghai have been listed in the "China Biomanufacturing 500+ Representative Enterprises List" based on their team, core products, and competitive potential [4]. - Key companies in the synthetic biology sector include Kasei Biotech, Enkasei Pharmaceutical, and Changjin Biotech, all of which are located in the aforementioned industrial parks [3][4]. Group 4: Upcoming Events - The Fourth Synthetic Biology and Green Biomanufacturing Conference will be held from August 20-22, 2025, in Ningbo, Zhejiang, focusing on AI and biomanufacturing, green chemicals, new materials, future food, and agriculture [19][21]. - The conference aims to gather international enterprises, industry experts, and government representatives to explore trends and innovations in the biomanufacturing sector [19].

Core Insights - The Chinese biomanufacturing industry is projected to reach a scale of 1.01 trillion yuan in 2024, with a year-on-year growth of 15.4%. By 2030, the industry is expected to exceed 2.5 trillion yuan, with a compound annual growth rate of 16.8% [1]. Group 1: Industry Development - The DT New Materials Research Institute has been actively monitoring and supporting the progress and innovation in the synthetic biology sector since the release of the "China Synthetic Biology Industry Map (2023)" which includes over 300 listed companies [1]. - The upcoming "4th Synthetic Biology and Green Biomanufacturing Conference (SynbioCon 2025)" will take place from August 20-22 in Ningbo, Zhejiang, where the "China Synthetic Biology Industry Distribution Map (2025 Edition)" will be announced, featuring over 500 representative biomanufacturing companies and their product information [1][9]. Group 2: Conference Details - The SynbioCon 2025 conference will focus on five key areas: AI + Biomanufacturing, Green Chemistry and New Materials, Future Food, Future Agriculture, and Beauty Raw Materials, inviting industry leaders, experts, and various stakeholders to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan [9]. - Participants at the conference will have the opportunity to receive a free copy of the industry map, valued at 499 yuan, and companies that qualify can apply to be listed on the global bio-based and biomanufacturing industry service platform [6][10].

Core Insights - The third-generation biorefining technology aims to utilize one-carbon molecules and renewable energy for "negative carbon" production of fuels and chemicals, addressing climate change and food shortages [1] - Acetic acid, derived from syngas fermentation, is increasingly recognized as a viable non-food carbon source in the biosynthesis of bulk chemicals [1] - 3-Hydroxypropionic acid (3-HP) is a renewable bulk chemical with a projected market size exceeding 3.6 million tons per year and a value surpassing $10 billion annually [1] Summary by Sections - **Engineering Achievements**: A research team from East China University of Science and Technology successfully constructed an engineered E. coli strain (ZWR18(MDA)) that synthesizes 3-HP from acetic acid via the propanoyl-CoA pathway, achieving a yield of 5.53 g/L and a conversion rate of 0.732 g/g, which is 97.60% of the theoretical yield [2][6] - **Cell-Catalyzed Production**: Under whole-cell catalysis conditions, the engineered strain can produce 23.89 g/L of 3-HP with a yield of 0.734 g/g, reaching 97.87% of the theoretical yield. When using acetic acid sourced from syngas, the strain still achieves 18.87 g/L of 3-HP with a yield of 0.58 g/g [2][6] - **Metabolic Pathway Insights**: The study outlines the metabolic pathway for converting acetic acid to 3-HP, highlighting the competition between fatty acid synthesis and 3-HP synthesis for propanoyl-CoA. The transcription factor FadR plays a crucial role in fatty acid metabolism, and the use of the antifungal antibiotic can further direct carbon flow towards 3-HP production [5][6] - **Publication Reference**: The research findings were published in "ACS Synthetic Biology" under the title "High-Yield Biosynthesis of 3‑Hydroxypropionic Acid from Acetate in Metabolically Engineered Escherichia coli" [3]

Core Viewpoint - The article discusses the "Qingdao Synthetic Biology Innovation Development Action Plan (2025-2027)", aiming to enhance the synthetic biology industry in Qingdao through innovation, technology breakthroughs, and the establishment of key projects and platforms [1]. Overall Requirements - The plan emphasizes innovation-driven development, focusing on key technologies and products to empower various industries such as healthcare, environmental protection, agriculture, and energy [2]. - By 2027, the goals include achieving at least 30 key technology breakthroughs, 5 internationally advanced innovation results, and the establishment of over 10 landmark industrial projects [2]. Key Tasks Bottom-Level Technology Innovation - The plan outlines actions for advancing foundational technologies in synthetic biology, including artificial life design, gene editing, and microbial genome databases [3]. - A target is set to establish a global marine metagenomic microbial database with over 100,000 entries by 2027 [3]. Platform-Level Tool Innovation - The initiative aims to develop high-throughput and high-precision synthesis platforms using automation and machine learning, with a goal of creating a microbial strain repository of over 40,000 strains by 2027 [4]. Empowering Biopharmaceutical Industry - Focus on mRNA vaccines, gene therapy, and the development of new drug clinical approvals, with a target of obtaining over 5 new drug clinical approvals by 2027 [5]. Empowering Food and Health Industry - The plan includes the development of marine functional sugars and high-value natural products, aiming to establish a library of over 800 marine carbohydrate compounds by 2027 [6]. Empowering Materials and Energy Industry - The initiative targets breakthroughs in biodegradable materials and biofuels, with a goal of developing over 5 landmark synthetic biology products by 2027 [7]. Empowering Agriculture and Environmental Protection - The plan emphasizes precision molecular breeding and the development of new pesticides, aiming to create a special microbial resource library for organic waste degradation by 2027 [8]. Policy Measures Support for Technological Innovation - The plan includes funding support for key technology research and development projects in synthetic biology [10]. Support for Industrial Innovation Platforms - Encouragement for the establishment of key laboratories and innovation centers, with funding for those evaluated as excellent [11]. Accelerating Local Innovation Results - The establishment of a market for technology transfer and the training of specialized technology brokers to facilitate the commercialization of synthetic biology innovations [12]. Financial Empowerment for Industry Development - A financial support system is proposed to cover the entire synthetic biology industry chain, including government-led industry funds [13]. Promotion of Innovative Product Applications - Support for the application of innovative products and the establishment of market application laboratories [14]. Development of Specialized Industrial Parks - The plan includes the construction of specialized synthetic biology parks to incubate projects and support infrastructure development [15]. Guarantee Measures - The article outlines measures for coordination, funding assurance, and industry services to support the implementation of the action plan [18].

Core Insights - The Chinese biomanufacturing industry is projected to reach a scale of 1.01 trillion yuan in 2024, with a year-on-year growth of 15.4%. By 2030, the industry is expected to exceed 2.5 trillion yuan, with a compound annual growth rate of 16.8% [1]. Group 1: Industry Development - The DT New Materials Research Institute has been actively monitoring and supporting the progress and innovation in the synthetic biology industry since the release of the "China Synthetic Biology Industry Map (2023)" which includes over 300 listed companies [1]. - The upcoming "4th Synthetic Biology and Green Biomanufacturing Conference (SynbioCon 2025)" will take place from August 20-22 in Ningbo, Zhejiang, where the "China Synthetic Biology Industry Distribution Map (2025 Edition)" will be announced, featuring over 500 representative biomanufacturing companies and their product information [1][9]. Group 2: Conference Details - The conference will focus on five key areas: AI + Biomanufacturing, Green Chemistry and New Materials, Future Food, Future Agriculture, and Beauty Raw Materials, inviting industry leaders, experts, and various stakeholders to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan [9]. - Participants at the conference can receive a free copy of the industry map valued at 499 yuan, and eligible biomanufacturing companies can apply to be listed on the map [6][10].

Core Viewpoint - The SynBioCon 2025 conference will focus on the integration of AI with biomanufacturing, green chemicals and new materials, future food, and future agriculture, aiming to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period [1]. Group 1: Conference Overview - The conference will be held from August 20-22, 2025, in Ningbo, Zhejiang [1]. - It aims to promote the transfer and transformation of scientific and technological achievements, product scaling, and talent acquisition in the biomanufacturing sector [1]. Group 2: Organizers and Supporters - Organized by Ningbo Detaizhongyan Information Technology Co., Ltd. (DT New Materials) and co-organized by several academic and research institutions [2]. - Supported by various associations and alliances, including the Chinese Society of Biotechnology and the Zhejiang Synthetic Biology Industry Technology Alliance [2]. Group 3: Key Speakers and Experts - Notable experts include Zhang Xian'en, Dean of the School of Synthetic Biology at Shenzhen University, and other prominent figures from various universities and research institutes [4][5][7][8][11][15][19][21][27][30]. - The conference will feature discussions on innovative biomanufacturing technologies and applications, including the development of bio-based products and processes [9][12][24][31]. Group 4: Conference Agenda - The agenda includes a series of forums and discussions on topics such as green chemicals, AI in biomanufacturing, and future food and agriculture [36][37]. - Activities will include a high-level roundtable, youth forums, and specialized sessions focusing on various aspects of biomanufacturing [36][37].

Core Viewpoint - Isomaltulose is a new type of natural sweetener with low calories (4 kcal/g), high stability, and no adverse health effects, widely used in pharmaceuticals and food industries [1]. Market Overview - The global isomaltulose market reached $16.2 million in 2023 and is expected to grow to $48.9 million by 2030, with a compound annual growth rate (CAGR) of 17.19% from 2024 to 2030 [2]. Production Technology - The enzymatic preparation of isomaltulose has high conversion rates and meets green environmental requirements. Sucrose isomerase (SI) is an effective enzyme for catalyzing isomaltulose production. Immobilizing SI can improve its stability, reduce inactivation, and enhance recyclability in industrial applications [3]. Research and Development - Professor Liu Fufeng's team at Tianjin University of Science and Technology developed a directed immobilized enzyme that significantly improves heat resistance and reusability while maintaining high activity after multiple cycles. This work lays a solid foundation for the green manufacturing of isomaltulose and provides innovative ideas for the development of new directed immobilized enzyme technologies [4]. Conference Information - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on AI and biological manufacturing, as well as four application areas: green chemicals and new materials, future food, future agriculture, and beauty raw materials. The "Youth Forum on Biological Manufacturing" will highlight scientific issues, solutions, results, scalability, and future directions in the research field [8][11].