Core Viewpoint - The article highlights the significance of bio-based 1,4-butanediol (BDO) as a sustainable alternative to petrochemical-derived BDO, emphasizing its potential to transform the chemical industry and reduce carbon footprints [1][4]. Group 1: Investment and Production - Qore, a joint venture between Cargill and Germany's HELM AG, has officially launched the world's largest bio-based BDO production facility with a total investment of $300 million, aiming for an annual production capacity of 66,000 tons [3][4]. - The facility will utilize locally grown dent corn within a 100-mile radius, marking a significant step in sustainable raw material sourcing [3]. Group 2: Applications and Partnerships - BDO is a crucial organic chemical used across various industries, including textiles, pharmaceuticals, and biodegradable plastics, due to its ability to produce high-value derivatives [4]. - LYCRA plans to use QIRA, the brand name for bio-based BDO, to enhance the sustainability of its fibers, potentially reducing its carbon footprint by up to 44% [5]. - BASF has entered a long-term supply agreement with Qore to incorporate QIRA into its product portfolio, aiming for sustainable chemical production [6]. Group 3: Technological Advancements - Traditional BDO production methods in China rely heavily on acetaldehyde and propylene glycol, which are energy-intensive and environmentally harmful [7][8]. - The bio-based BDO production process developed by Genomatica utilizes a one-step fermentation method, which is more efficient and environmentally friendly compared to conventional methods [10]. Group 4: Global Developments - Several companies are investing in bio-based BDO production, including: - Korea's SKC Group, which plans a $1 billion facility in Vietnam with an initial capacity of 50,000 tons per year [11]. - Jinfa Technology's bio-based BDO project in Liaoning, set to produce 10,000 tons by October 2024 [11]. - Other companies like Yuanli Chemical and Shandong Lande Biotech are also making strides in bio-based BDO production [11]. Group 5: Future Outlook - Despite the current higher costs of bio-based BDO compared to petrochemical alternatives, its competitive edge is expected to grow as oil prices remain high and production technologies improve [14]. - The article suggests that bio-based BDO could become a mainstream choice in the long term, especially with advancements in production processes and potential carbon trading policies [14].

Core Viewpoint - All-trans retinoic acid (ATRA) is a key active derivative of vitamin A with extensive clinical application value, but mainstream manufacturers like BASF and DSM still rely on traditional chemical synthesis methods, which pose environmental challenges and do not meet green chemistry requirements [1][3]. Group 1: Research Breakthroughs - The team from the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, achieved a breakthrough by engineering Saccharomyces cerevisiae to produce ATRA at a fermentation yield of 1.84 g/L, providing a green solution for constructing a self-controlled vitamin industry chain [3][8]. - The research utilized a multi-faceted metabolic engineering strategy, optimizing chassis construction, module selection, cellular factory upgrades, and fermentation processes to achieve this yield [8]. Group 2: Metabolic Engineering Strategy - The initial focus was on creating a high-yield chassis for β-carotene, the precursor for ATRA, by screening genes from Xanthophyllomyces dendrorhous, leading to the construction of the Car09 strain with a β-carotene yield of 129.4 mg/L [5][6]. - The best combination for ATRA synthesis was identified as a β-carotene dioxygenase from marine bacteria and mouse retinaldehyde dehydrogenase, achieving 98.1 mg/L ATRA, although significant residual β-carotene indicated limitations in synthesis [6][7]. Group 3: Industrial Adaptation and Optimization - Four-dimensional collaborative modifications were implemented to address efficiency bottlenecks, including overexpressing transcription factors to enhance endoplasmic reticulum activity, balancing NADPH/NAD⁺ levels, and improving substrate supply, resulting in a 49.2% increase in ATRA yield [7][8]. - The development of a two-phase extraction fermentation process, combining glucose growth with ethanol and galactose induction, led to the successful production of ATRA at 1.84 g/L in a 5L fermenter [8]. Group 4: Industry Conference - The SynBioCon 2025 conference, scheduled for August 20-22 in Ningbo, will focus on the intersection of AI and biological manufacturing, exploring trends in green chemistry, new materials, future food, agriculture, and cosmetic ingredients [10][12].

Core Insights - The Chinese biomanufacturing industry is projected to reach a scale of 1.01 trillion yuan in 2024, with a year-on-year growth of 15.4%. By 2030, the industry is expected to exceed 2.5 trillion yuan, with a compound annual growth rate (CAGR) of 16.8% [1]. Industry Developments - The DT New Materials Research Institute has been actively monitoring and supporting the progress and innovation in the synthetic biology sector since the release of the "China Synthetic Biology Industry Map (2023)" which includes over 300 listed companies [1]. - The upcoming "Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025)" will take place from August 20-22 in Ningbo, Zhejiang, where the "China Synthetic Biology Industry Distribution Map (2025 Edition)" will be announced, featuring over 500 representative biomanufacturing companies and their product information [1]. Event Details - The SynBioCon 2025 conference will focus on five key areas: AI + Biomanufacturing, Green Chemistry and New Materials, Future Food, Future Agriculture, and Beauty Raw Materials. It aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan and discuss innovative technologies and products that will sustain the industry's vitality [1][10].

Core Viewpoint - The article discusses the rapid development and potential of the biomanufacturing industry, highlighting its role in the Fourth Industrial Revolution and the significant growth opportunities it presents in various sectors, particularly in China [3][4]. Industry Overview - Biomanufacturing is defined as an advanced production method centered on industrial biotechnology, utilizing biological resources and processes to produce target products at scale [5]. - The global biomanufacturing industry is projected to reach approximately $12,190 billion in 2024, with a year-on-year growth of 7.4%, and is expected to exceed $20 trillion by 2030, with a compound annual growth rate (CAGR) of 8.4% [9]. Market Dynamics - In China, the biomanufacturing industry is anticipated to reach a scale of 1.01 trillion yuan in 2024, growing by 15.4%, and is expected to surpass 2.5 trillion yuan by 2030, with a CAGR of 16.8% [9][10]. - The top three segments in China's biomanufacturing industry in 2024 will be biopharmaceuticals, biological food, and bio-chemical products, with biopharmaceuticals remaining the largest segment [10]. Technological Advancements - The industry is experiencing a shift from traditional resource reliance to technology-driven approaches, with significant improvements in biomass resource utilization and equipment efficiency [8]. - Innovations in biopharmaceuticals, such as the development of bispecific antibodies and ADC drugs, have seen an annual growth of 65% in product pipelines [8][12]. Application and Impact - In the medical field, biomanufacturing technologies like 3D printing are enabling personalized implants, achieving gross margins of 75% [9]. - In agriculture, microbial fertilizers have improved corn yields by 12% while reducing chemical fertilizer usage by 30% [9]. Future Trends - The article outlines several key trends, including the restructuring of industrial ecosystems, regional layout changes, deepening technological revolutions, product innovation iterations, and capital factor restructuring [17][18][19]. - The integration of AI and biotechnology is expected to enhance production efficiency and product quality, with significant implications for the industry [18]. Strategic Recommendations - Companies are encouraged to build a three-dimensional competitive system focusing on technology research and development, scene innovation, and ecosystem construction [20]. - Local governments should create a supportive industrial service matrix to foster the growth of the biomanufacturing sector [20].

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan, discussing innovative technologies and products that will sustain the industry's vitality [1]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and supported by various academic and industry institutions, including Peking University and the China Society of Biotechnology [2]. Group 3: Highlights of the Conference - Key highlights include forums and closed-door discussions on biomanufacturing trends, youth innovation technology sharing, and over 100 financing project roadshows to discover new cooperation opportunities [5]. - The event will gather leading enterprises, top universities, investment institutions, and industry stakeholders to foster collaboration [5]. Group 4: Agenda and Activities - The first day features a closed-door seminar focusing on the development trends and growth points of biomanufacturing, inviting 30 industry leaders and experts for in-depth discussions [9]. - The second and third days will include a macro forum on biomanufacturing, specialized sessions on green chemicals, AI in biomanufacturing, future food and agriculture, and beauty raw materials [13][15][18]. Group 5: Specialized Topics - Specialized discussions will cover topics such as the development of bio-based chemicals, AI applications in biomanufacturing, and the use of non-grain carbon sources for bioconversion [16][17]. - The conference will also address the synthesis of high-value food ingredients and the role of biotechnology in health and beauty products [20].

Core Viewpoint - Sieman Technology is an innovative company focused on providing high-quality biological culture solutions for the life sciences sector, aiming to enhance research efficiency and accelerate product market entry [10]. Company Overview - Sieman Technology specializes in high-quality biological culture solutions for research institutions, biopharmaceuticals, and biotechnology companies [10]. - The company emphasizes the importance of biological culture and aims to provide stable and reliable biological culture instruments [10]. Product Introduction - **Biological Culture Shaker EM-10**: A monitoring device for biological culture processes, addressing common issues such as unstable results and high failure rates in continuous operation [11]. - **AS-1000 High-Temperature Online Optical Dissolved Oxygen Sensor**: Features self-diagnosis, avoids electrolyte changes affecting measurement accuracy, and allows for quick response in dissolved oxygen measurement [12]. - **AP-100 Biological Process Biochemical Analyzer**: Automatically calculates feeding rates and controls feeding volume or mass, enabling "unmanned" biological culture processes [14]. - **AMF-101 Integrated Online Bioreactor**: Incorporates sterile automatic sampling and online biochemical detection, utilizing new optical technology for dynamic adjustments in feeding strategies [16]. Industry Event - Sieman Technology will participate in the SynBioCon 2025, scheduled for August 20-22, 2025, in Ningbo, Zhejiang, focusing on synthetic biology and green manufacturing [17]. - The conference will explore five key areas: AI + biological manufacturing, green chemistry and new materials, future food, future agriculture, and beauty raw materials, aiming to discuss trends and innovations in the biomanufacturing industry [17].

Group 1 - The establishment of the Agricultural Biological Manufacturing - Feed Innovation Consortium aims to enhance collaboration among leading enterprises, universities, and research institutions to drive technological and industrial innovation in the feed industry [1] - The consortium will utilize synthetic biology technology to create microbial cell factories for producing high-quality, environmentally friendly, and nutritious biological feed products, promoting a resource-efficient and ecologically safe aquaculture production system [1] - The first working meeting of the consortium was attended by ten founding units, including Beijing Dabeinong Technology Group Co., Ltd., and various universities and research institutes, to discuss key tasks and division of responsibilities [1] Group 2 - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on five key areas: AI + biological manufacturing, green chemicals and new materials, future food, future agriculture, and beauty raw materials [3] - The conference aims to explore the development trends of the biological manufacturing industry during the 14th Five-Year Plan and identify innovative technologies and products that will sustain the industry's vitality [3] - The event will facilitate the scaling of products and the transfer and transformation of scientific and technological achievements [3]

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan, discussing innovative technologies and products that will sustain the industry's vitality [1]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and supported by various academic and industry institutions, including Peking University and the China Society of Biotechnology [2]. Group 3: Highlights of the Conference - Key highlights include forums and closed-door discussions on biomanufacturing trends, youth innovation technology sharing, and over 100 financing project roadshows to discover new cooperation opportunities [5]. - The event will gather leading enterprises, top universities, and investment institutions to foster collaboration across the biomanufacturing ecosystem [5]. Group 4: Agenda and Activities - The first day features a closed-door seminar focusing on the development trends and growth points of biomanufacturing, inviting industry leaders and experts for in-depth discussions [9]. - Subsequent days will include various specialized forums covering topics such as green chemicals, AI in biomanufacturing, future food and agriculture, and beauty raw materials [13][15][18]. Group 5: Specialized Topics - Specific discussions will address the development of bio-based chemicals, new carbon source biomanufacturing, and the application of AI in enzyme discovery and industrial fermentation processes [16][17]. - The conference will also explore the biomanufacturing of high-value food ingredients and the integration of biotechnology in cosmetic applications [20].

Core Viewpoint - The article highlights the upcoming SynBioCon 2025 event, focusing on the potential of synthetic biology and biomanufacturing, showcasing innovative research teams, technologies, and products in the field [2][5][14]. Group 1: Event Overview - The SynBioCon 2025 will take place from August 20-22 in Ningbo, Zhejiang, featuring a special session called the "Biomanufacturing Youth Forum" with nearly 30 presentations [2][10]. - The event aims to facilitate the exchange of innovative research outcomes and promote collaboration between researchers and industry stakeholders [2][14]. Group 2: Forum Details - The Youth Forum will include presentations from various universities and research institutions, such as Anhui University of Technology and South China University of Technology [4][5]. - The forum is designed to help attendees understand key scientific issues, solutions, and future development directions in biomanufacturing within a 15-minute format [3][14]. Group 3: Special Activities - A closed-door high-level seminar will discuss the trends and growth points of biomanufacturing as part of the event's agenda [11]. - The event will also feature project roadshows and technology showcases, inviting participation from leading parks and investment institutions [14][20]. Group 4: Thematic Discussions - The conference will cover various topics, including green chemicals, new materials, AI in biomanufacturing, and future food and agriculture [15][17][19]. - Specific focus areas include the development of bio-based materials, non-grain carbon source utilization, and the application of AI in enhancing biomanufacturing processes [18][22].

Group 1 - The core project is the flexible production line renovation project for synthetic biology at Zhejiang Haizheng Pharmaceutical Co., Ltd., with a total investment of 171.06 million yuan, including 5.1 million yuan for environmental protection [2][4]. - The project aims to produce 72,000 tons of 60% liquid glucose, 93,816 tons of 30% liquid glucose, 1,500 tons of yeast, and various other products annually, including 2,000 tons of HS31101 sulfate and 1,000 tons of HS31101 hydrochloride [2][3]. - The project will utilize existing production lines in the Y108, Y109, Y110, Y112, and Y27 workshops at the Yantou plant [2][3]. Group 2 - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held in Ningbo, Zhejiang, from August 20 to 22, focusing on five key areas: AI + biological manufacturing, green chemicals and new materials, future food, future agriculture, and beauty raw materials [5][6]. - The conference aims to explore the development trends of the bio-manufacturing industry during the 14th Five-Year Plan and discuss innovative technologies and products that will sustain the industry [5].