Core Viewpoint - The article discusses the development of a spatially decoupled electro-biosystem for efficient CO2 conversion into valuable chemicals, highlighting the integration of electrochemical and microbial fermentation processes to enhance product yield and selectivity [4][13]. Summary by Sections CO2 Reduction Technology - CO2 electroreduction (CO2 RR) technology utilizes clean electricity to convert CO2 into high-value chemicals, addressing resource scarcity [3]. - Current advancements allow for efficient conversion of CO2 into C1-C2 products like carbon monoxide, methane, and ethanol, but challenges remain in synthesizing high-energy-density long-chain hydrocarbons [3]. Innovative System Design - The research team from Beijing University of Chemical Technology has developed a modular design integrating CO2 electro-catalytic reduction with microbial fermentation, published in Advanced Energy Materials [4][13]. - The electro-catalytic system employs tannic acid-based metal-polyphenol complex nanoparticles to synthesize a covalent organic polymer catalyst, achieving high selectivity and current density for ethanol production [7][12]. Performance Evaluation - The MPN@deCOP@Ag-Cu2O catalyst demonstrated a Faradaic efficiency (FE) for ethanol of approximately 44.5% at a current density of 400 mA cm², outperforming traditional copper catalysts [12]. - The system maintained ethanol selectivity around 25% over a prolonged operation of 5.8 hours, with a product purity of 86.6% [12][13]. Microbial Conversion - Engineered E. coli strains were developed to convert ethanol into industrially valuable products such as itaconic acid, isopropanol, and polyhydroxybutyrate (PHB) [16]. - The study achieved significant yields of 482.6 mg/L for itaconic acid, 109.3 mg/L for isopropanol, and 295.1 mg/L for PHB, demonstrating the feasibility of using CO2-derived ethanol as a sustainable carbon source [16]. Future Implications - The findings suggest that the developed electro-catalysts and reactor designs have significant potential for scaling up CO2 conversion processes, addressing key challenges in CO2 RR technology applications [13].

Core Viewpoint - The article emphasizes the development of the biomanufacturing industry through the integration of artificial intelligence, as highlighted in the government's work report for 2025, which aims to foster future industries like biomanufacturing [2]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22, 2025, in Ningbo, Zhejiang, focusing on AI-enabled innovation in biomanufacturing and related fields [11][12]. - The conference will include various activities such as a youth forum, high-level discussions, and a closed-door seminar for the "2025 Artificial Intelligence Empowering Biomanufacturing Industry Innovation Development Blue Book" [11][18]. Group 2: Research and Development Focus - The "2025 Artificial Intelligence Empowering Biomanufacturing Industry Innovation Development Blue Book" will be developed through extensive field research in cities like Beijing, Shanghai, and Shenzhen, focusing on the integration of AI in biomanufacturing [2][9]. - The conference will feature discussions on the current applications of AI in biomanufacturing, showcasing typical case studies from the Ministry of Industry and Information Technology [4][34]. Group 3: Conference Agenda Highlights - The agenda includes specialized forums on topics such as green chemistry, new materials, future food, and agriculture, with a focus on the trends and growth points in biomanufacturing during the 14th Five-Year Plan [11][12][18]. - Notable sessions will cover data-driven programmable protein engineering, industrial bioprocess intelligent manufacturing technologies, and high-throughput screening solutions in synthetic biology [34][40]. Group 4: Industry Collaboration - The event is supported by various institutions, including the Ningbo Detaizhong Research Information Technology Co., Ltd., Peking University Ningbo Institute of Ocean Medicine, and several industry alliances [12][13]. - The conference aims to facilitate technology transfer, product scaling, and talent acquisition within the biomanufacturing sector [11][12]. Group 5: Future Directions - The conference will also announce the "China Synthetic Biology Industry Distribution Map (2025 Edition)," which includes a list of over 500 representative enterprises in the biomanufacturing sector [43][44]. - The focus on AI integration is expected to drive innovation and sustainability in biomanufacturing, positioning the industry for future growth [2][11].

Core Points - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI with bio-manufacturing, green chemicals, new materials, future food, and future agriculture [2][3] - The conference aims to explore the development trends of the bio-manufacturing industry during the 14th Five-Year Plan, innovations driven by AI, and the technologies and products that will sustain the vitality of the bio-manufacturing sector [2][3] - Various activities will take place during the conference, including a Youth Forum on Bio-Manufacturing, a high-level roundtable discussion, and a closed-door seminar on the "2025 AI Empowering Bio-Manufacturing Industry Innovation Development Blue Book" [2][3][20] Organizational Structure - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by several institutions, including Peking University Ningbo Institute of Ocean Medicine and Ningbo Meisai Bioengineering Co., Ltd. [3] - Supporting organizations include the Chinese Society of Biotechnology's Bio-based Materials Committee and various regional bio-manufacturing alliances [3] Conference Agenda - The agenda includes registration, high-level discussions, and thematic forums on topics such as green chemicals and new materials, AI-driven innovations in bio-manufacturing, and future food and agriculture [6][7][21] - Specific sessions will cover topics like enzyme molecular engineering, bio-based carboxylic acid conversion, and the design of humanized "4D" collagen proteins [11][12][17][25] Special Acknowledgments - Several companies and institutions have been acknowledged for their support, including Ningbo Meisai Bioengineering Co., Ltd., Peking University Ningbo Institute of Ocean Medicine, and various technology firms [4] Industry Insights - The conference will also feature the release of the "China Synthetic Biology Industry Distribution Map (2025 Edition)" and a list of over 500 representative bio-manufacturing enterprises in China [50][51] - The event aims to facilitate technology transfer, product scaling, and talent acquisition within the bio-manufacturing sector [2][3]

Core Viewpoint - The article discusses the construction project of a collagen production line by Shandong Furida Biotechnology Co., Ltd., highlighting its investment, production capacity, and timeline for completion [2]. Summary by Sections Project Progress - Shandong Furida Biotechnology Co., Ltd. is expanding its collagen production line, located in Linyi City, Shandong Province, with a total investment of 12 million yuan, including 500,000 yuan for environmental protection [2]. - The project will utilize existing facilities and is expected to produce 200 kg of collagen annually upon completion in June 2025 [2]. Existing Project Status - The company has several ongoing projects, including: - Sodium hyaluronate project with an annual output of 50 tons [4]. - Various fermentation projects with different production capacities, including: - Recombinant Type II collagen: 115.2 kg/a - Recombinant Type XVII collagen: 64 kg/a - Recombinant Type III transmembrane collagen: 20.8 kg/a - The total annual production capacity for collagen will reach 200 kg [3][4]. Industry Events - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22, 2025, in Ningbo, Zhejiang Province, focusing on AI and bio-manufacturing, green chemicals, new materials, future food, and agriculture [8][9].

扫码参会报名 SynBioCon 2 025 8月20-22日，浙江·宁波 01 组织机构 SynBioCon 2025 第四届合成生物与绿色生物制造大会 8月20-22日 浙 江 ·宁波东港喜来登酒店 8月20-22日 将于 浙江·宁波 举办 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 。本届大会聚焦 "1+3"：AI+生物制造、绿色化工 与新材料、未来食品、未来农业四大方向 ，邀请行业领先企业、代表性产业化专家、政府、园区、资本、协会和联盟等各方共探"十五五"生物制造产业发 展趋势；AI赋能生物制造产业创新；哪些革新技术和产品将给生物制造产业带来持续的生命力；并致力于促进科技成果转移转化、产品规模化与人才挖掘。 大会将同期举办 生物制造青年论坛 、 生物制造产业高层座谈会（第三期） 、 《2025人工智能赋能生物制造产业创新发展蓝皮书》闭门研讨会 、 合成 生物科技成果展示与对接 等活动 。 主办单位 宁波德泰中研信息科技有限公司（DT新材料） 协办单位 北京大学宁波海洋药物研究院 宁波酶赛生物工程有限公司 支持单位 中国生物工程学会生物基材料专业委员会 浙江省合成生物产 ...

Core Viewpoint - The SynBioCon 2025 conference aims to facilitate the transformation of scientific achievements into industrial applications, focusing on synthetic biology and green manufacturing [2][17]. Group 1: Conference Overview - The fourth Synthetic Biology and Green Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang [2][17]. - The event is organized by DT New Materials and supported by various academic and industrial organizations, emphasizing the development of industry ecosystems and technology transfer [2][17]. - The conference will feature over 100 innovative synthetic biology manufacturing achievements, promoting efficient technology transfer within the industry [2]. Group 2: Featured Projects - A project from Chongqing University focuses on a bio-manufacturing platform for bio-based materials, addressing the shortage of key monomers like hexamethylenediamine, succinic acid, and butanediol in China [7][8]. - The project utilizes advanced metabolic engineering to create a bacterial cell factory capable of producing 1,4-succinic acid with a yield of approximately 145.9 g/L and a sugar-to-acid conversion rate of 0.97 g/g, showcasing world-leading production efficiency [8][9]. Group 3: Technical Advantages - The 1,4-succinic acid production process benefits from optimized bacterial strains, shorter reaction times, lower temperatures, and cost-effective technical routes, leading to higher yields and lower costs [9]. - The 1,4-butanediol production process leverages Pichia pastoris, which is genetically stable and efficient in expressing foreign proteins, with a cost-effective acidic fermentation process [10]. Group 4: Intellectual Property and Collaboration - The project holds patents for the recombinant plasmids and engineered strains used in the production of succinic acid and hexamethylenediamine, indicating a strong intellectual property position [11]. - Collaboration with companies such as Yantai Wanhua Chemical and Guangdong Kingfa Technology is established, inviting further partnerships for technology transfer [13].

Core Viewpoint - The article highlights the approval of the "Regulations on Promoting the Development of Synthetic Biology Manufacturing Industry in Changde City," marking a significant step in the local government's efforts to foster the synthetic biology sector and establish a national-level industrial cluster [2]. Group 1: Legislative Developments - The Changde City government has prioritized the development of the synthetic biology manufacturing industry, creating a multi-faceted industrial landscape across various regions such as Jinshi City, Anxiang County, and Changde Economic Development Zone [2]. - The "Regulations" represent the first local legislation in the synthetic biology manufacturing field in China, consisting of 19 articles covering objectives, scope, government responsibilities, innovation platform construction, and more [2]. Group 2: Upcoming Events - The 4th Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22, 2025, in Ningbo, Zhejiang, focusing on the intersection of AI and bio-manufacturing, as well as advancements in green chemicals, new materials, future food, and agriculture [4][5]. - The conference will feature various activities, including a youth forum, high-level discussions, and a closed-door seminar on the "2025 Blue Book for AI-Enabled Bio-Manufacturing Industry Innovation Development" [5].

Core Viewpoint - The article highlights the advancements in synthetic biology for the production of functional lipids, showcasing the innovative research led by Professor Huang He from Nanjing Normal University and the Jiangsu Provincial Synthetic Biology Research Center [2][10][14]. Group 1: Importance of Synthetic Biology - Synthetic biology is described as a field that reprograms life, utilizing engineering methods and gene editing to transform microorganisms into efficient production "factories" for useful compounds [11][12]. - The integration of synthetic biology with clean technology offers innovative solutions to global challenges, especially with the advent of CRISPR and other gene editing tools [12]. Group 2: Role of Artificial Intelligence - Artificial intelligence (AI) is crucial in the development of synthetic biology, enabling systematic programming of biological components and significantly reducing the development time of microbial "factories" from years to months [13]. - The combination of machine learning and CRISPR technology optimizes microbial metabolic pathways, revolutionizing industrial biotechnology [13]. Group 3: Focus on Functional Lipids - The shift in dietary patterns, with a decrease in carbohydrate consumption and an increase in fat intake, underscores the importance of lipid metabolism in health and disease, prompting a focus on functional lipids, particularly unsaturated fatty acids [11]. - Traditional extraction methods for functional lipids from fish are limited by high costs and lengthy supply chains, leading to research on engineered lipid production for cost reduction and sustainable practices [11]. Group 4: Achievements and Innovations - The research team has successfully constructed a cell factory using synthetic biology methods, achieving over a twofold increase in fatty acid yield and reducing research and development time significantly [11]. - A high-throughput screening platform was developed, increasing efficiency by over ten times, reducing extraction time from three days to three hours, and cutting costs by 80% [11]. Group 5: Future Plans - Future research will explore the synthesis of functional lipids from purified components, aiming to combine various beneficial ingredients for health management [11]. - The goal includes designing formulations that integrate functional components, such as carotenoids for vision enhancement and other ingredients for brain health [11]. Group 6: Unique Advantages of the Research Center - The Jiangsu Provincial Synthetic Biology Research Center, established in 2023, focuses on industrial biological manufacturing, bridging basic science and applied research [12][14]. - The center promotes interdisciplinary exploration and engineering solutions, providing early-career researchers with autonomy and reducing administrative barriers to collaboration [12]. Group 7: Collaboration and Impact - The center collaborates with major enterprises like the National Development Investment Corporation to connect market demands with scientific breakthroughs and result transformations [14]. - The recent feature in the prestigious journal Nature highlights Professor Huang He's international academic influence in the field [14].

主办单位 宁波德泰中研信息科技有限公司（DT新材料） 协办单位 SynBioCon 2025 第四届合成生物与绿色生物制造大会 8月20-22日 浙 江 ·宁波东港喜来登酒店 8月20-22日 将于 浙江·宁波 举办 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 。本届大会聚焦 "1+3"：AI+生物制造、绿色化工 与新材料、未来食品、未来农业四大方向 ，邀请行业领先企业、代表性产业化专家、政府、园区、资本、协会和联盟等各方共探"十五五"生物制造产业 发展趋势；AI赋能生物制造产业创新；哪些革新技术和产品将给生物制造产业带来持续的生命力；并致力于促进科技成果转移转化、产品规模化与人才挖 掘。 大会将同期举办 生物制造青年论坛 、 生物制造产业高层座谈会（第三期） 、 《2025人工智能赋能生物制造产业创新发展蓝皮书》闭门研讨会 、 合成 生物科技成果展示与对接 等活动 。 扫码参会报名 SynBioCon 2 025 8月20-22日，浙江·宁波 01 组织机构 北京大学宁波海洋药物研究院 宁波酶赛生物工程有限公司 支持单位 中国生物工程学会生物基材料专业委员会 浙江省合成生物 ...

Core Insights - The article discusses the innovative use of synthetic biology to produce sandalwood essential oil sustainably, addressing the scarcity and high cost of natural sandalwood resources [2][3][15] Group 1: Research Breakthroughs - The research team developed a P450 enzyme peroxisome surface display technology, overcoming catalytic bottlenecks and achieving a record production yield of 10.4 g/L of sandalwood alcohol [3][5] - Initial attempts to synthesize sandalwood alcohol resulted in low yields, prompting the team to optimize the supply of acetyl-CoA and reducing power by targeting key enzymes to peroxisomes [5][10] - The innovative strategy of displaying P450 enzymes on the peroxisome surface significantly improved the proximity of the enzyme to the substrate, increasing sandalwood alcohol yield to 1.3 g/L and conversion rate to 36.2% [7][10] Group 2: Production Optimization - The team induced the proliferation of peroxisomes in engineered yeast, which increased the number of "factories" for storing acetyl-CoA and expanded the membrane surface area for enzyme anchoring, leading to a 42.6% increase in sandalwood alcohol yield and a conversion rate of 60.6% [10][12] - The optimized strain was scaled up in a 5L fermentation tank, achieving a record yield of 13.1 g/L of sandalwood olefin and 10.4 g/L of sandalwood alcohol, with a conversion rate of 44.2% [12][14] - The cost of producing sandalwood essential oil using this method is projected to be under $100 per kilogram, significantly lower than the market price of $2500 per kilogram [12][15] Group 3: Implications and Future Prospects - The research demonstrates the potential of peroxisome engineering in synthesizing high-value natural products, particularly those involving complex terpenes catalyzed by P450 enzymes [14][15] - The significant reduction in production costs for sandalwood essential oil could transform the traditional supply chain reliant on scarce plant resources, contributing to the conservation of endangered sandalwood species [15]