Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan and identify innovative technologies and products that will sustain the industry's vitality [1]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. Group 3: Highlights of the Conference - The conference will feature forums and closed-door activities to gain insights into the development trends of biomanufacturing during the 14th Five-Year Plan, exploring new products, technologies, and collaborations [4]. - There will be over 100 financing project roadshows to discover new cooperation opportunities [4]. - Key industry leaders, top universities, and capital from industrial parks will gather to discuss advancements in the biomanufacturing sector [4]. Group 4: Agenda and Special Activities - The first day will include a closed-door seminar focusing on the development trends and growth points of biomanufacturing, inviting 30 industry leaders and experts for in-depth discussions [7]. - The second and third days will feature a macro forum on biomanufacturing, covering the development trends and progress of policies related to the industry [10]. Group 5: Specialized Forums - The conference will host specialized forums on various topics, including green chemicals and new materials, AI in biomanufacturing, future food and agriculture, and beauty raw materials [11]. - Each forum will address specific themes such as the development of bio-based chemicals, green manufacturing technologies, and the application of AI in biomanufacturing processes [11].

Core Viewpoint - The article highlights the recent developments of Inner Mongolia Ruifen Biotechnology Co., Ltd., including the establishment of a new production base for functional sugar alcohols, which signifies a technological breakthrough in the field of functional sweeteners [1][2]. Company Overview - Ruifen Biotechnology, founded in 2007, is a national high-tech enterprise focused on the research and production of natural health food ingredients. The company aims to provide innovative and convenient solutions for the food, beverage, and nutritional supplement industries, emphasizing health, natural ingredients, and high technology [5]. Project Details - The new project involves an investment of 300 million yuan to build a production base with an annual capacity of 30,000 tons of functional sugar alcohols. The project includes the construction of various facilities such as a comprehensive building, R&D center, warehouses, workshops, and energy supply systems [2]. - A cooperation agreement was signed on April 26 between Hohhot Economic and Technological Development Zone and Ruifen Biotechnology for a project with a total investment of approximately 400 million yuan, which will be developed in two phases. The first phase will cover 120 acres and is scheduled to start construction in June 2023, with completion expected by November 2025 and production commencing in March 2026 [4]. Technological Advancements - Ruifen Biotechnology has become the third company in China to obtain approval for D-allohexose-3-epimerase, marking a significant technological advancement in the legal production of allohexose. The company has achieved self-controlled enzyme catalysis technology, which is a critical aspect of its production process [2].

Core Viewpoint - Shougang Longze Technology Co., Ltd. has delayed its global offering and listing plan, returning application funds, originally scheduled for July 9 on the Hong Kong Stock Exchange [1][2]. Company Overview - Shougang Longze focuses on the carbon capture, utilization, and storage (CCUS) industry, producing low-carbon products such as ethanol and microbial protein, and providing comprehensive low-carbon solutions [4]. - The company’s ethanol can be used as fuel and as a raw material for various products, while its microbial protein is the first novel feed protein raw material in China [4]. Financial Performance - In the previous year, Shougang Longze reported revenue of 560 million RMB, a year-on-year decline of 4.9%, with a net loss attributable to shareholders of 140 million RMB, an increase of 1.1 times [6]. - Financial projections indicate a revenue increase to 592.6 million RMB in 2023, followed by a slight decrease to 563.6 million RMB in 2024 [7]. Fund Utilization Plan - The company plans to allocate approximately 37.9% of the net proceeds for the construction and development of SAF production facilities in Baotou, Inner Mongolia, 21.2% for the second phase facility in Hebei, and 11.4% for research and development of strains, production equipment, and smart production management systems [8].

在 "十四五" 规划收官与 "十五五" 规划谋篇布局的历史节点，我国在生物制造领域的战略布局已然彰显出清晰且鲜明的阶段性演进特质。 那么， "十五五" 规划之下，释放哪些生物制造产业新信号？ 【SynBioCon】 获 悉，近日，赛迪研究院消费品工业研究所在2025赛迪论坛上发布 《"十五五"时期我国生物制造产业发展思路》报告 ，该 报告由赛迪研究院消费品工业研究所所长李博洋分享。 报 告指出，"十五五"是我国生物制造全面崛起的关键时期。其 重要目标 是 先进生物制造产业及相关服务业增加值超4万亿元，生物制造渗透 率达到8% 以上，产业迈向中高端发展 。 "十五五"时期要构建创新+产业+管理服务等三大体系，加快发展 "7+1"生物制造产业体系 ，包括 生物医药、生物基化学品和材料、生物能 源、生物发酵、生物工程食品、生物饲料、生物技术装备和生物服务 。 以下是报告部分内容： 请扫码填写 信息，可下载全部报告 | ▌ 参考信息： 文报告 来 | 本 | 自赛迪研究院 。由 | 作 | 者重新 | 编写，系作者个人观 | | --- | --- | --- | --- | --- | --- | | 点，本平台发 ...

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan and identify innovative technologies and products that will sustain the industry's vitality [1]. Group 2: Organizers and Highlights - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. - Key highlights include forums on biomanufacturing trends, youth innovation sharing, project roadshows, and participation from leading enterprises, top universities, and investment institutions [4]. Group 3: Agenda and Special Activities - The first day features a closed-door high-level seminar focusing on the development trends and growth points of biomanufacturing, with 30 industry leaders and experts invited [7]. - The second and third days will include a macro forum on biomanufacturing, specialized sub-forums on green chemicals, AI in biomanufacturing, future food and agriculture, and beauty raw materials [11]. Group 4: Focus Areas in Sub-forums - Sub-forum topics include the development of bio-based chemicals, green manufacturing technologies for fine chemicals, and the use of non-food raw materials for high-value product development [11]. - AI applications in biomanufacturing will also be discussed, including enzyme discovery and industrial fermentation process control [11].

Core Viewpoint - The article discusses the advancements in green bio-manufacturing, particularly focusing on the synthesis of aliphatic short-chain diamines and diols from renewable resources, highlighting the importance of reducing reliance on fossil resources and addressing environmental concerns [3][4][5]. Group 1: Importance of Green Bio-Manufacturing - The chemical industry is a significant part of the national economy, with over 100,000 types of fine chemical products globally. Traditional production methods heavily rely on fossil resources, leading to resource depletion and CO2 emissions [4]. - Transitioning to renewable resources for bio-manufacturing is crucial for achieving a clean, low-carbon, and sustainable environment. China has set goals to replace traditional chemical raw materials with bio-based materials [4][5]. Group 2: Advances in Bio-Synthesis - Significant progress has been made in the bio-synthesis of 1,3-propanediamine, 1,4-butanediamine, and their corresponding diols, with commercial applications already realized by companies like DuPont and Genomatica, achieving cost reductions of 37% and energy savings of 30% compared to petrochemical processes [5][6]. - Companies such as Ningxia Yipin Biotechnology and Shanghai Kaisi Bio-Industry have successfully scaled up the production of 1,5-pentanediamine using whole-cell catalysis, claiming a 30% cost reduction compared to traditional methods [5][6]. Group 3: Challenges in Bio-Synthesis - Despite advancements, challenges remain in the bio-synthesis of most diamines and diols, including high production costs and the lack of natural biosynthetic pathways for certain compounds [6][7]. - Research is focused on developing bio-synthesis routes using non-food biomass and one-carbon feedstocks to reduce fossil resource dependence and CO2 emissions [6][7]. Group 4: Metabolic Pathways and Carbon Cycling - The article outlines the carbon cycling and metabolic pathways involved in utilizing renewable resources for bio-manufacturing, emphasizing the role of biomass derived from agriculture, forestry, and waste [8][9]. - Various metabolic pathways for sugars derived from lignocellulosic biomass have been identified, which can be utilized for synthesizing short-chain diamines and diols [11][13]. Group 5: Synthesis Routes for Specific Compounds - Detailed synthesis routes for 1,3-propanediamine and 1,3-propanediol are discussed, highlighting the use of key amino acid precursors and various microbial pathways [20][21]. - The synthesis of 1,4-butanediamine and 1,4-butanediol involves multiple pathways, including those utilizing ornithine and arginine, with significant advancements in microbial engineering to enhance yields [23][24]. - The article also covers the synthesis routes for 1,5-pentanediamine and 1,5-pentanediol, focusing on the use of lysine as a precursor and the challenges in achieving high yields [25][26].

Core Viewpoint - Guangdong Zhumei Biotechnology has achieved a significant breakthrough in the industrialization of natural high-intensity sweet protein by completing the first domestic pilot test of recombinant Brazzein using Pichia pastoris as the chassis cell, aiming for ton-level production capacity by 2026, which will greatly increase the yield of Brazzein [1][2]. Group 1: Characteristics of Brazzein - Brazzein is derived from the fruit of a wild plant in West Africa and is known to be 500-2000 times sweeter than sucrose, making it one of the sweetest natural substances known to humans [4]. - It maintains stability across a pH range of 2.5-8 and retains its sweetness even after being heated at 80°C for 4 hours or 98°C for 2 hours [5]. - As a protein, Brazzein is easily digested into amino acids, has no impact on blood sugar, and poses no health risks [6]. - It offers a clean taste similar to sucrose without metallic or bitter aftertastes, making it suitable for widespread application in the food industry [6]. - Research indicates that Brazzein may possess anti-inflammatory and antioxidant properties, with similarities to antimicrobial peptides, providing some antibacterial and antifungal activity [6]. Group 2: Market Potential and Challenges - The global market for Brazzein was valued at $500 million in 2023 and is projected to reach $790 million by 2029 [7]. - Traditional extraction methods yield very low extraction rates (~0.2%), making precision fermentation and genetic engineering the most promising methods for developing Brazzein [7]. - Current microbial expression systems face challenges such as low protein expression levels, incorrect protein folding leading to reduced activity, and complex, costly purification processes, which limit the widespread application of sweet proteins [9]. Group 3: Industry Developments - In May 2023, Sweegen successfully produced Brazzein using precision fermentation and became the first to receive FEMA GRAS certification [11]. - In 2024, Oobli's Brazzein production received FDA GRAS certification for general food applications, and they announced a partnership with Ingredion to advance sweet protein applications [11]. - Ginkgo Bioworks and GreenLab are collaborating to enhance Brazzein expression in corn and scale up production through precision fermentation [11]. - Waterdrop Farm also achieved FDA SELF-GRAS status in March 2025, becoming one of the few companies to commercialize Brazzein [11]. Group 4: Company Overview - Guangdong Zhumei Biotechnology is a high-tech enterprise specializing in the research, production, and sales of synthetic biology products, with a 1000 square meter intelligent research center [12]. - The company utilizes synthetic biology technology to efficiently produce various products, including recombinant human collagen, astaxanthin, beta-carotene, antimicrobial peptides, and lysozyme [12].

Core Viewpoint - The article discusses the upcoming SynBioCon 2025 conference, focusing on the research and industrial applications of poly-γ-glutamic acid (γ-PGA), a biopolymer with significant potential in various fields such as functional foods, cosmetics, biomedicine, and biomaterials [1][3]. Summary by Sections γ-PGA Characteristics and Applications - γ-PGA's physiological functions and application areas are highly dependent on the proportion of L-glutamic acid monomers and molecular weight, with low molecular weight γ-PGAs (Mw<500 kDa) suitable for drug delivery and tissue engineering, while high molecular weight γ-PGAs (Mw>1500 kDa) serve as thickeners or flocculants [2]. Industrial Biotechnology Challenges - The efficient biosynthesis of γ-PGA from scratch and the directed synthesis of γ-PGA with varying L-glutamic acid monomer ratios and molecular weights are critical industrial biotechnology challenges that need to be addressed [3]. SynBioCon 2025 Conference Details - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on the intersection of AI and biological manufacturing, as well as advancements and opportunities in green chemicals, new materials, future foods, future agriculture, and cosmetic raw materials [7][8]. - The conference will feature a special session, the "Youth Forum on Biological Manufacturing," aimed at providing insights into scientific issues, solutions, results, scalability, and future directions in the research field [7][8]. Conference Agenda - The agenda includes registration, a closed-door seminar for industry leaders, project roadshows, and various forums covering topics such as green chemicals, new materials, and future foods and agriculture [8][10].

Core Viewpoint - The article highlights the upcoming "Youth Forum on Biomanufacturing" scheduled for August 20 in Ningbo, Zhejiang, as part of the SynBioCon 2025 event, aimed at promoting innovation and collaboration in the field of synthetic biology and biomanufacturing [2][3]. Group 1: Event Details - The "Youth Forum on Biomanufacturing" will focus on addressing scientific issues, solutions, achievements, scalability, and future directions in the research field [3]. - The event will take place on August 20, 2025, with limited seating available (only 30 seats) [6]. - Participants can choose to register for either the Youth Forum or the Technology Achievement Showcase [6]. Group 2: Participation and Contributions - The event encourages universities and research institutions to apply for sharing their innovative achievements [4]. - SynBioCon 2025 will also feature a "Technology Achievement Showcase" to publicly collect 100 innovative achievements and projects in the field of synthetic biology and biomanufacturing for on-site display and networking [6]. Group 3: Organizers and Previous Events - The event is organized by Ningbo Detaizhongyan Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [11]. - Previous editions of the SynBioCon were successfully held in 2022, 2023, and 2024 in Ningbo, showcasing the growing interest and development in the field [13].

Core Viewpoint - The article emphasizes the growing interest in the development of new carbon sources and biotechnological conversion, particularly in the context of industrial carbon-rich gas fermentation for fuel ethanol production. Group 1: Industrial Carbon-Rich Gas Fermentation Technology - The anaerobic microorganisms utilize the Wood-Ljungdahl pathway to absorb and fix CO and CO2 from industrial carbon-rich gases, synthesizing products like acetic acid and ethanol. The main advantages of this technology include low energy consumption, high safety, strong substrate specificity of enzymes, and high adaptability to raw material gas composition [3][4]. - The overall efficient conversion process is identified as a core challenge for scaling up industrial applications, closely related to stable gas supply, efficient strain development, fermentation process optimization, and market prospects [3][4]. Group 2: Progress of Industrial Carbon-Rich Gas Biomanufacturing Enterprises - Companies like LanzaTech and Jupeng Bio have established multiple industrial fermentation facilities. LanzaTech, a leader in gas fermentation, has formed a joint venture with Shougang Group, operating four production bases in China with an annual capacity of 210,000 tons of fuel ethanol and 23,200 tons of microbial protein by 2025 [4][6]. - Jupeng Bio is noted for its unique full-chain technology from biomass gasification to gas fermentation, with a demonstration plant completed in 2021 and a large-scale commercial facility under construction in Inner Mongolia [6][8]. - Other companies such as Synata Bio and Jitai Laibo Bio are rapidly developing in this field, with Synata Bio's 10-ton gas fermentation facility already completed [7][8]. Group 3: Challenges in Industrialization - The technology faces four main challenges: 1. **Gas Source Stability**: Variability in gas composition and quantity from upstream industries can affect the growth and metabolism of acetic acid-producing bacteria, potentially leading to fermentation system failure [9]. 2. **Process Control Precision**: There is a need for precise control technologies for gas inflow and product composition, as current methods for monitoring CO levels are inadequate [10][11]. 3. **Reactor Design**: Existing reactors often have low capacity and high production costs, necessitating the development of larger reactors while considering efficiency and operational costs [16][17]. 4. **Separation and Purification**: The low concentration of ethanol in fermentation necessitates the development of new separation technologies to reduce energy consumption during purification [20][22]. Group 4: Upcoming Industry Events - The Fourth Synthetic Biology and Green Bio-Manufacturing Conference will be held from August 20-22, 2025, in Ningbo, Zhejiang, focusing on new carbon source exploration and bioconversion opportunities [23][28].