Core Viewpoint - The article discusses a significant advancement in the development of disease-modifying osteoarthritis drugs (DMOADs) through a novel drug delivery system that effectively targets diseased chondrocytes, addressing major challenges in osteoarthritis treatment [1][2]. Group 1 - A multifunctional peptide (CMP) mimicking viral glycoproteins was developed to enhance drug delivery to osteoarthritic chondrocytes, overcoming issues related to cartilage penetration, retention, and selective uptake by diseased cells [2][5]. - The research team synthesized CMP, which includes a type II collagen adhesion sequence and a cell-penetrating peptide activated by matrix metalloproteinase-13, allowing the drug-loaded micelles to adhere to cartilage and selectively target diseased chondrocytes [5]. - In mouse models of osteoarthritis, the developed micelles demonstrated longer joint retention times and higher uptake rates in diseased chondrocytes compared to unmodified micelles, indicating improved efficacy [5]. Group 2 - The drug delivery system maintained cartilage metabolic homeostasis, alleviated pathological changes associated with osteoarthritis, and improved symptoms without causing additional toxicity [2][5]. - Overall, the findings suggest that the developed nanomedicine represents a promising candidate for DMOADs and provides an efficient delivery strategy for targeting other therapeutic agents to diseased chondrocytes [2][5].

Group 1: Job Positions - The recruitment includes faculty positions and postdoctoral positions in various research fields such as cancer, tropical pathogens and immunobiology, cardiovascular and metabolic diseases, neuroscience, stem cells and regenerative medicine, and basic medicine [4] - Applicants for faculty positions must hold a PhD or MD/PhD, have completed several years of postdoctoral training or possess relevant industrial research experience, and demonstrate strong independent research capabilities [6][7] - Senior researchers will receive independent lab space, graduate student supervision opportunities, and dedicated funding for research assistants and technical staff [7] Group 2: Compensation and Benefits - Senior researchers will earn an annual salary ranging from 1 million to 1.5 million RMB (pre-tax), while junior researchers will earn between 500,000 and 800,000 RMB (pre-tax) [9] - Research start-up funds are provided, with senior researchers receiving between 6 million and 8 million RMB, and junior researchers receiving 1 million RMB [9] - All faculty members will have access to advanced research facilities, including high-throughput sequencing platforms, confocal microscopy systems, and flow cytometry facilities [9] Group 3: Postdoctoral Researcher Requirements - Candidates for postdoctoral positions should have a solid foundation in their research field, strong scientific literacy, excellent communication skills, and demonstrated innovative potential [11] - Postdoctoral researchers must commit full-time to the position and are not allowed to hold concurrent jobs during their tenure [12] - Preference will be given to candidates with interdisciplinary research experience and a background in tropical medicine or related fields [14] Group 4: Application Materials - Applicants must submit a CV, a 3 to 5-page research plan, and two letters of recommendation [13] - Additional required documents include a copy of the PhD certificate (or official proof of impending graduation) and representative publications [19]

Core Viewpoint - Westlake University has announced the full-time appointment of Haibin Ling, an Empire Innovation Professor from Stony Brook University, to lead the establishment of the Intelligent Computing and Applications Laboratory, focusing on artificial intelligence and interdisciplinary research [2]. Group 1: Appointment and Research Focus - Haibin Ling will serve as a chair professor at Westlake University, leading research in areas such as computer vision, multimodal AI, augmented reality, AI for Science, and quantum information [2]. - The newly established laboratory aims to advance research and applications in artificial intelligence [2]. Group 2: Academic Background and Career - Haibin Ling, born in 1974 in Anshun, Guizhou, holds a Bachelor's and Master's degree from Peking University and a Ph.D. from the University of Maryland [4][5]. - His career includes positions at Microsoft Research Asia, UCLA, Siemens Research, and Temple University, before joining Stony Brook University in 2019 [5]. - Ling's research has significantly impacted the field of computer vision, particularly in dynamic object tracking, which is crucial for various applications including security monitoring and medical imaging [5]. Group 3: Achievements and Contributions - Ling has received multiple awards, including the ACM UIST Best Student Paper Award (2003), the NSF CAREER Award (2014), and the IEEE VR Best Journal Paper Award (2021) [6]. - He has served on editorial boards for several prestigious journals and has been involved in leading roles at top AI conferences [6].

Core Viewpoint - The article discusses a novel RNA splicing system called SOS splicing, which actively repairs genetic information by excising DNA transposons from mRNA, thereby protecting gene function when traditional silencing mechanisms fail [2][15]. Group 1: Introduction to Transposable Elements - Transposable elements (TEs), also known as "jumping genes," are DNA sequences that can move or copy themselves within the genome, constituting a significant portion of various organisms' genomes (3%-80%) [1]. - The presence of TEs poses a threat to gene function, prompting the evolution of epigenetic systems to silence their expression and replication [1]. Group 2: Discovery of SOS Splicing - The research led by Dr. Zhao Longwen at Harvard Medical School identifies a new RNA splicing system, SOS splicing, which operates independently of the classical spliceosome [2][15]. - SOS splicing serves as an emergency response mechanism, recognizing and removing transposon sequences from host mRNA, thus attempting to restore protein expression and protect gene function [2]. Group 3: Mechanism of SOS Splicing - The SOS splicing system is triggered by a characteristic feature of DNA transposons, the inverted terminal repeat (ITR) sequence, which forms a "hairpin" structure in mRNA [11]. - Key components of this system include AKAP17A (the "scout" that recognizes mRNA with transposons), RTCB (the "repairer" that reconnects mRNA fragments), and CAAP1 (the "connector" that recruits RTCB) [12]. Group 4: Implications and Future Directions - The study reveals that SOS splicing provides a last line of defense for gene function when epigenetic silencing systems are compromised, highlighting the complexity of gene regulation [15]. - Although SOS splicing is efficient, it is not precise, often resulting in small mutations in repaired mRNA, yet it still allows for the production of functional proteins, offering survival advantages [18]. - The potential for medical applications exists, as understanding SOS splicing could lead to new gene therapy strategies to repair harmful mutations in human disease genes [18].

撰文丨王聪 编辑丨王多鱼 排版丨水成文 慢性皮肤伤口 ，例如糖尿病溃疡，因其复杂的微环境 （包括细菌感染、过度炎症和血液循环障碍） ， 难以治疗且常常会感染，导致患者长期受苦以及医疗成本 增加，从 而成为重大医疗难题。 传统 伤口敷料 往往无法解决这些多方面的问题，而先进的 水凝胶敷料 尽管具有优势，但受限于易滋生细菌、依赖不稳定的治疗成分以及长期生物相容性方面的 担忧。 近日，加拿大麦吉尔大学 陈国军 教授团队与中国科学院深圳先进技术研究院 陈支通 研究员团队合作，在 Cell 子刊 Med 上 发表了题为： Sprayed low- temperature plasma-infused hydrogel dressing for skin-wound management 的研究论文。 该研究开发了一种新型 可喷雾水凝胶 —— Ox@F127 ， 既能杀灭细菌又能促进伤口愈合 。这种水凝胶含有从低温等离子体中提取的有益物质，可轻松喷洒于伤 口处，形成一层保护性的愈合层，在多个动物模型 （包括与人类慢性伤口极为相似的 患有感染性皮肤伤口的糖尿病猪模型 ） 中均能有效对抗感染并加速组织修 复。 在这项研究中， ...

Group 1 - Nankai University is a key comprehensive university in Tianjin, China, recognized as part of the "985 Project" and "211 Project," and included in the national "Double First Class" initiative [3] - The university has implemented a talent strategy and internationalization strategy to build world-class disciplines and institutions, supported by policies from the Tianjin government [3] - High-level scholars at Nankai University will receive competitive salaries, research funding, international exchange opportunities, and support for children's education [3] Group 2 - The Nankai University High-level Talent Support Program offers annual salaries ranging from 750,000 to 1,250,000 RMB (pre-tax, including insurance), with research funding exceeding 1,500,000 RMB for natural sciences and engineering, and 500,000 RMB for humanities and social sciences [4] - The program also provides housing subsidies and relocation fees between 120,000 to 200,000 RMB, along with additional support such as allowances and laboratory space [4] Group 3 - The Nankai University Young Academic Leader Program has been cultivating high-level leading talents since 2013, focusing on candidates with strong research foundations and innovative capabilities [6] - Applicants for associate and full professor positions in natural sciences and engineering must be under 35 and 40 years old, respectively, while those in humanities and social sciences must be under 38 and 45 years old [6] - Successful applicants will receive annual salaries between 450,000 to 800,000 RMB (pre-tax, including insurance), with research funding ranging from 500,000 to 1,500,000 RMB for natural sciences and engineering, and 200,000 to 500,000 RMB for humanities and social sciences [6] Group 4 - Other positions available include professors, associate professors, lecturers, and postdoctoral researchers, with application details provided on the university's website [7] - Interested applicants are encouraged to send their resumes to the Human Resources Office at Nankai University [7]

撰文丨王聪 编辑丨王多鱼 排版丨水成文 心血管代谢疾病 （CMD） 给全球医疗保健系统带来了沉重负担，其中最常见的是 心血管疾病 （CVD） 和 2 型糖尿病 （T2D） ，它们与过去几十年来高热量、 高风险加工食品消费量的增加有关。 不良饮食习惯 和人类 肠道微生物组 （gut microbiome） 都与心血管代谢疾病 （CMD） 有关。饮食模式的变化会改变微生物组的物种水平组成，从而对宿主健 康产生连锁反应。然而，个体对饮食干预的反应各不相同，精准营养旨在识别调节饮食与宿主健康之间相互作用的宿主特异性因素，但目前尚无法区分饮食通过 微生物组改善心血管代谢健康的效应。此外，肠道微生物组的组成因不同的人口统计学特征、种族、性别和年龄而表现出高度的个体差异和变化，因此， 定义或 识别健康肠道微生物组的通用生物标志物，一直很困难 。 2025 年 12 月 10 日，意大利 特伦托大学的研究人员在国际顶尖学术期刊 Nature 上发表了题为： Gut micro-organisms associated with health, nutrition and dietary interventions 的研究论文 ...

Core Viewpoint - The study identifies RNA-binding proteins (RBPs) as key regulators of immune evasion in high-grade serous ovarian cancer (C5-HGSC), suggesting that inhibiting IGF2BP1 can enhance the efficacy of PD-1 blockade therapy [2][4][6]. Group 1: Research Findings - The research integrates single-cell RNA sequencing with bulk RNA sequencing data, marking the first discovery that RBPs are critical for immune evasion in C5-HGSC [4]. - IGF2BP1 is confirmed as a core mediator of immune evasion in both in vitro and in vivo models, functioning by accelerating the degradation of IRF1 protein to block gamma-interferon signaling and inhibit MHC-I antigen presentation [4]. - The study reveals that IGF2BP1 dissociates the relationship between PD-L1 expression and IRF1-dependent transcription, thereby limiting immune cell infiltration and T cell activation [4]. Group 2: Therapeutic Implications - The small molecule compound BTYNB effectively inhibits IGF2BP1 and can work synergistically with PD-1 blockade to reverse immune evasion in vivo [4]. - The findings are validated using multispectral imaging technology in human HGSC tissue samples, highlighting the role of cancer embryonic RBPs as molecular drivers of the C5-HGSC subtype [4][6].

Core Findings - The study confirms that VHL protein is a true regulator of mitochondrial metabolism under hypoxic conditions, rather than merely serving as a "backup adapter" for hypoxia-inducible factors (HIF) in low oxygen environments [5]. Group 1: Research Insights - Under chronic hypoxia, most cytoplasmic VHL protein degrades, while the remaining VHL protein primarily relocates to mitochondria [2] - Mitochondrial VHL binds and inhibits a key component of the leucine metabolism pathway, MCCC2, leading to leucine accumulation and activation of glutamate dehydrogenase, which promotes glutamine hydrolysis to generate sufficient lipids and nucleotides for hypoxic cell growth [2] - SRC-mediated phosphorylation of VHL and PRMT5-mediated methylation of MCCC2 can synergistically regulate the VHL-MCCC2 interaction and its accompanying metabolic reprogramming [2] Group 2: Mechanisms and Implications - The study demonstrates that low oxygen-dependent post-translational modifications regulate the interaction between VHL and MCCC2 [6] - Mitochondrial VHL plays a crucial role in the body's adaptive response to pathological hypoxia [6]

Core Insights - The article discusses the anticipated hot research areas for the National Natural Science Foundation of China (NSFC) funding in 2026, emphasizing the importance of understanding these trends for project design [4][5]. Group 1: Core Mechanisms - Key focus areas include immune regulation (macrophage polarization, neutrophil function, T-cell exhaustion), mitochondrial function and homeostasis, novel cell death mechanisms (ferroptosis, pyroptosis), metabolic reprogramming (glycolysis, lactylation), and post-translational modifications of proteins (ubiquitination, SUMOylation) [4]. Group 2: Frontier Interdisciplinary Areas - Emerging fields highlighted are epitranscriptomics (RNA modifications like m6A, m7G), intercellular communication (exosomes), host-microbiome interactions (gut microbiota), and stem cells with regenerative medicine [5]. Group 3: Key Technologies - Important technological advancements include single-cell and spatial multi-omics, organoids and disease models, and AI/machine learning-driven target discovery and data analysis [5]. Group 4: Research Case Studies - The article presents several research cases that exemplify how researchers are engaging with these hot topics, including: - Neutrophils and their role in thrombosis, published in the European Heart Journal [12]. - Immune evasion mechanisms in tumors, published in Cell [13]. - Gut microbiota's role in Crohn's disease, published in Gut [14]. - Glycolysis and its implications in cancer, published in Signal Transduction and Targeted Therapy [14]. - Development of organoids for bone repair, published in Advanced Materials [14].