馮宇霞 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 對 因 本 公 告 全部或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責 任。 JOINN LABORATORIES (CHINA) CO., LTD. 北京昭衍新藥研究中心股份有限公司 （於 中 華 人 民 共 和 國 註 冊 成 立 的 股 份 有 限 公 司） （股 份 代 號：6127） 海外監管公告 本公告乃北京昭衍新藥研究中心股份有限公司（「本公司」）根據香港聯合交易 所有限公司證券上市規則第13.10B條 而 作 出。 茲 載 列 本 公 司 於 上 海 證 券 交 易 所 網 站 刊 登 公 告 如 下，僅 供 參 閱。 承董事會命 北京昭衍新藥研究中心股份有限公司 董事長 中 國 北 京，2024年12月2日 於 本 公 告 日 期，本 公 司 董 事 會 包 括 主 席 兼 執 行 董 事 馮 宇 霞 女 士、執 行 董 事 左 從 林 先 生、高 大 鵬 先 生 及 孫 雲 霞 女 士 及 獨 立 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 對 因 本 公 告 全部或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責 任。 JOINN LABORATORIES (CHINA) CO., LTD. 北京昭衍新藥研究中心股份有限公司 （於 中 華 人 民 共 和 國 註 冊 成 立 的 股 份 有 限 公 司） （股 份 代 號：6127） 海外監管公告 本公告乃北京昭衍新藥研究中心股份有限公司（「本公司」）根據香港聯合交易 所有限公司證券上市規則第13.10B條 而 作 出。 茲 載 列 本 公 司 於 上 海 證 券 交 易 所 網 站 刊 登 公 告 如 下，僅 供 參 閱。 承董事會命 北京昭衍新藥研究中心股份有限公司 馮宇霞 董事長 中 國 北 京，2024年11月26日 於 本 公 告 日 期，本 公 司 董 事 會 包 括 主 席 兼 執 行 董 事 馮 宇 霞 女 士、執 行 董 事 左 從 林 先 生、高 大 鵬 先 生 及 孫 雲 霞 女 士 及 獨 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 對 因 本 公 告 全部或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責 任。 JOINN LABORATORIES (CHINA) CO., LTD. 北京昭衍新藥研究中心股份有限公司 （於 中 華 人 民 共 和 國 註 冊 成 立 的 股 份 有 限 公 司） （股 份 代 號：6127） 海外監管公告 本公告乃北京昭衍新藥研究中心股份有限公司（「本公司」）根據香港聯合交易 所有限公司證券上市規則第13.10B條 而 作 出。 茲 載 列 本 公 司 於 上 海 證 券 交 易 所 網 站 刊 登 公 告 如 下，僅 供 參 閱。 承董事會命 北京昭衍新藥研究中心股份有限公司 馮宇霞 董事長 中 國 北 京，2024年11月1日 於 本 公 告 日 期，本 公 司 董 事 會 包 括 主 席 兼 執 行 董 事 馮 宇 霞 女 士、執 行 董 事 左 從 林 先 生、高 大 鵬 先 生 及 孫 雲 霞 女 士 及 獨 立 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 對 因 本 公 告 全部或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責 任。 JOINN LABORATORIES (CHINA) CO., LTD. 北京昭衍新藥研究中心股份有限公司 （於 中 華 人 民 共 和 國 註 冊 成 立 的 股 份 有 限 公 司） （股 份 代 號：6127） 海外監管公告 本公告乃根據香港聯合交易所有限公司證券上市規則第13.10B條的規定而發 表。附 件 為 北 京 昭 衍 新 藥 研 究 中 心 股 份 有 限 公 司 於 上 海 證 券 交 易 所 刊 發 之 北京昭衍新藥研究中心股份有限公司 (1)關 於 變 更 公 司 註 冊 資 本 並 修 訂 公 司 章 程 的 公 告； (2)第 四 屆 董 事 會 第 十 次 會 議 決 議 公 告； (3)關 於 與 專 業 投 資 機 構 合 作 參 與 投 資 設 立 產 業 基 金 的 公 告；及 (4)關於董事辭任及補選非獨立董 ...

Financial Performance - Revenue for the third quarter was RMB 485,799,506.29, a decrease of 15.51% compared to the same period last year[4] - Net profit attributable to shareholders was RMB 99,435,565.54, down 58.04% year-on-year[4] - Net profit attributable to shareholders after deducting non-recurring gains and losses was RMB 84,926,745.33, a decline of 63.74% compared to the previous year[4] - The net cash flow from operating activities was RMB 192,325,709.34, a decrease of 57.11% year-on-year[4] - Basic earnings per share were RMB 0.13, down 59.38% compared to the same period last year[4] - Net profit attributable to shareholders decreased by 121.46% year-to-date due to intensified competition, declining sales revenue, and a decrease in the fair value of biological assets[11] - Net profit attributable to shareholders after deducting non-recurring gains and losses decreased by 136.47% year-to-date, primarily due to similar factors as above[11] - Cash flow from operating activities decreased by 57.11% year-to-date, mainly due to reduced sales collections while employee compensation remained stable compared to the previous year[11] - Basic earnings per share decreased by 120.45% year-to-date, reflecting the impact of increased competition and declining sales revenue and gross margin[11] - Diluted earnings per share decreased by 120.45% year-to-date, consistent with the basic earnings per share decline[11] - Net profit attributable to shareholders for the current reporting period decreased by 58.04% due to intensified competition and declining sales revenue[11] - Net profit attributable to shareholders after deducting non-recurring gains and losses for the current reporting period decreased by 63.74%[11] - Basic earnings per share for the current reporting period decreased by 59.38% due to similar competitive pressures[11] - Diluted earnings per share for the current reporting period decreased by 59.38%, reflecting the same trends[11] Assets and Liabilities - Total assets at the end of the reporting period were RMB 9,525,184,807.98, a decrease of 5.01% from the end of the previous year[4] - Equity attributable to shareholders was RMB 8,002,435,682.20, down 3.34% compared to the end of the previous year[4] - As of September 30, 2024, the company's total current assets amounted to RMB 5.33 billion, a decrease from RMB 7.12 billion on December 31, 2023[18] - The total non-current assets as of September 30, 2024, were CNY 4,191,072,779.02, significantly higher than CNY 2,905,192,290.36 as of December 31, 2023, marking an increase of about 44.2%[21] - Total liabilities as of September 30, 2024, were CNY 1,534,350,209.75, down from CNY 1,746,119,215.39 at the end of 2023, a decrease of approximately 12.1%[20] - The total assets as of September 30, 2024, were CNY 9,525,184,807.98, compared to CNY 10,027,159,630.47 at the end of 2023, indicating a decline of about 5.0%[21] - The total equity attributable to shareholders as of September 30, 2024, was CNY 8,002,435,682.20, down from CNY 8,279,315,724.35 at the end of 2023, a decrease of about 3.4%[21] Cash Flow and Investments - The company's cash and cash equivalents decreased from RMB 2.86 billion at the end of 2023 to RMB 1.84 billion as of September 30, 2024[18] - The company's trading financial assets increased significantly from RMB 373.35 million to RMB 1.38 billion during the same period[18] - The company reported a net interest income of CNY 82,526,990.66 for the first three quarters of 2024, compared to CNY 108,316,598.07 in the same period of 2023, reflecting a decrease of approximately 23.9%[22] - Cash inflow from operating activities for the first three quarters of 2024 is 1,367,691,390.73, down from 1,874,131,001.01 in 2023, showing a decrease in cash generation[27] - The cash inflow from investment activities totaled 2,508,098,115.21, significantly increasing from 528,639,464.14 in the first three quarters of 2023[28] - The net cash flow from investment activities was -950,050,766.71, worsening from -137,147,755.87 in the same period of 2023[28] - The cash outflow from financing activities was 248,828,091.97, down from 333,289,197.75 in the first three quarters of 2023[29] - The net increase in cash and cash equivalents was -1,013,522,516.10, compared to -8,194,783.60 in the same period of 2023[29] - The ending balance of cash and cash equivalents was 1,840,124,511.87, a decrease from 2,891,274,796.93 at the end of the same period in 2023[29] - The cash inflow from recovering investments was 2,307,885,508.22, a substantial increase from 501,496,756.80 in the first three quarters of 2023[28] - The cash outflow for purchasing fixed assets and intangible assets was 188,019,727.66, up from 149,651,195.84 in the same period of 2023[28] - The cash paid for long-term assets was 3,270,129,154.26, significantly higher than 426,076,500.00 in the first three quarters of 2023[28] Operational Performance - The company signed new contracts worth approximately RMB 1.4 billion in the first three quarters, with a total order backlog of about RMB 2.65 billion as of the end of the reporting period[16] - The company reported a foreign exchange loss of -190,401,449.68 in the first three quarters of 2024, compared to -108,513,934.09 in 2023, indicating increased volatility in currency exchange[23] - The company experienced a credit impairment loss of -11,477,062.92 in the first three quarters of 2024, compared to -3,187,147.18 in 2023, reflecting worsening credit conditions[23] - The operating profit for the first three quarters of 2024 is -69,661,013.72, down from 392,084,940.00 in 2023, indicating a substantial decrease in operational performance[23] - The total comprehensive income for the first three quarters of 2024 is -79,103,195.69, a stark contrast to 336,381,200.67 in the previous year[25] - Basic and diluted earnings per share for the first three quarters of 2024 are both reported at -0.09, compared to 0.44 in 2023, indicating a loss per share[25] Shareholder Information - Total number of ordinary shareholders at the end of the reporting period was 72,246, with the top ten shareholders holding significant stakes[12] - There were no changes in the top 10 shareholders due to securities lending or borrowing activities[15] Strategic Outlook - The company has not disclosed any new product or technology developments in the recent reporting period[16] - The company has not indicated any market expansion or acquisition strategies in the latest report[16] - The company has advised investors to be cautious due to various factors affecting order execution[16]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 對 因 本 公 告 全部或任何部份內容而產生或因倚賴該等內容而引致的任何損失承擔任何責 任。 JOINN LABORATORIES (CHINA) CO., LTD. 北京昭衍新藥研究中心股份有限公司（「本公司」）董 事（「董 事」）會（「董事會」）謹 此 宣 佈，於 第 四 屆 董 事 會 第 十 次 會 議 中，董 事 會 決 議 及 批 准（其 中 包 括）：(i)建 議 變 更 本 公 司 註 冊 股 本；及(ii)建議修訂本公司組織章程細則（「組織章程細則」）。 建議變更本公司註冊股本 由於包括(i)儲 備 資 本 化；(ii)根 據2019年A股限制性股票激勵計劃及2021年A股 限 制性股票激勵計劃購回及註銷A股 限 制 性 股 票；及(iii)終 止2021年A股限制性股 票 激 勵 計 劃，並 購 回 及 註 銷 其 項 下 已 授 出 但 尚 未 解 除 限 售 的A股限制性股票等 因 素，本 公 司 的 註 冊 股 本 ...

北京昭衍新藥研究中心股份有限公司 （於 中 華 人 民 共 和 國 註 冊 成 立 的 股 份 有 限 公 司） JOINN LABORATORIES (CHINA) CO., LTD. | | 董事委員會 | | 薪酬與考核 | | | | --- | --- | --- | --- | --- | --- | | 董事 | | 戰略委員會 | 委員會 | 審計委員會 | 提名委員會 | | 執行董事 | | | | | | | 馮宇霞女士 | （主 席） | C | | | M | | 左從林先生 | | M | M | | | | 高大鵬先生 | | | | | | | 孫雲霞女士 | | M | | | | | 獨立非執行董事 | | | | | | | 孫明成先生 | | | M | C | | | 翟永功博士 | | | | M | C | | 歐小傑先生 | | M | C | | M | | 張帆先生 | | | | M | | 附 註： C 相關董事委員會的主席 M 相關董事委員會的成員 中 國，北 京，2024年10月30日 （股 份 代 號：6127） 董事名單以及其角色及職能 北京昭衍 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示 概 不 就 因 本 公 告 全 部或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責任。 JOINN LABORATORIES (CHINA) CO., LTD. 北京昭衍新藥研究中心股份有限公司 （於 中 華 人 民 共 和 國 註 冊 成 立 的 股 份 有 限 公 司） （股 份 代 號：6127） (1)執行董事辭任 及 (2)建議委任執行董事 執行董事辭任 北京昭衍新藥研究中心股份有限公司（「本公司」）董 事（「董 事」，各 自 為 一 名「董 事」）會（「董事會」）於近日收到姚大林博士（「姚博士」）的 辭 職 函。據 此，姚 博 士 因 工 作 安 排 辭 去 本 公 司 執 行 董 事 及 本 公 司 副 總 經 理 職 務。姚 博 士 已 確 認，彼 與 董 事 會 並 無 意 見 分 歧，亦 無 其 他 因 辭 任 而 需 知 會 股 東 的 事 宜。姚 博 士 辭 去 上 述 職 務 後，將 繼 續 在 公 司 其 ...

Financial Performance - Revenue for Q3 2024 was RMB 485,799,506.29, a decrease of 15.51% compared to the same period last year[2] - Net profit attributable to shareholders for Q3 2024 was RMB 99,435,565.54, down 58.04% year-on-year[2] - Net profit attributable to shareholders after deducting non-recurring gains and losses for Q3 2024 was RMB 84,926,745.33, a decline of 63.74% compared to the previous year[2] - Year-to-date net profit attributable to shareholders was RMB -70,307,075.11, a decrease of 121.46% compared to the same period last year[2] - Year-to-date revenue was RMB 1,335,156,050.40, down 15.87% year-on-year[2] - Basic earnings per share for Q3 2024 was RMB 0.13, a decrease of 59.38% compared to the same period last year[3] - The net profit for Q3 2024 was -74,244,009.94 RMB, a significant decrease compared to the net profit of 326,197,002.65 RMB in Q3 2023, representing a decline of approximately 122.7%[22] - Operating profit for Q3 2024 was -69,661,013.72 RMB, compared to an operating profit of 392,084,940.00 RMB in the same period last year, indicating a substantial drop[22] - Total operating revenue for the first three quarters of 2024 was CNY 1,335,156,050.40, a decrease of 15.8% compared to CNY 1,587,079,779.38 in the same period of 2023[20] - The total comprehensive income for Q3 2024 was -79,103,195.69 RMB, compared to 336,381,200.67 RMB in Q3 2023, indicating a decline of approximately 123.5%[23] Assets and Liabilities - Total assets at the end of the reporting period were RMB 9,525,184,807.98, a decrease of 5.01% from the end of the previous year[3] - Total assets amounted to CNY 9,525,184,807.98, down from CNY 10,027,159,630.47, a decrease of 5.0%[19] - Total liabilities decreased to CNY 1,534,350,209.75 from CNY 1,746,119,215.39, a reduction of 12.1%[19] - The company's total equity decreased to CNY 7,990,834,598.23 from CNY 8,281,040,415.08, a decline of 3.5%[19] - Inventory decreased to CNY 1,631,793,427.45 from CNY 1,863,081,944.56, a decrease of 12.4%[18] Cash Flow - The net cash flow from operating activities year-to-date was RMB 192,325,709.34, down 57.11% year-on-year[2] - The cash flow from operating activities for the first three quarters of 2024 was 192,325,709.34 RMB, a decrease from 448,440,218.42 RMB in the same period of 2023, showing a decline of approximately 57.1%[24] - The total cash inflow from investment activities for the first three quarters of 2024 was 2,508,098,115.21 RMB, a significant increase from 528,639,464.14 RMB in the same period of 2023[24] - The net cash flow from investing activities was -950,050,766.71, compared to -137,147,755.87 in the previous period, indicating a significant increase in cash outflow for investments[25] - The total cash outflow from financing activities was 248,828,091.97, down from 333,289,197.75 in the previous period, reflecting a reduction in financing costs[25] - The net increase in cash and cash equivalents was -1,013,522,516.10, compared to -8,194,783.60 in the previous period, showing a substantial decline in liquidity[25] - The ending balance of cash and cash equivalents was 1,840,124,511.87, down from 2,891,274,796.93 in the previous period, indicating a decrease in available cash[25] Shareholder Information - The total number of common shareholders at the end of the reporting period was 72,246, with no preferred shareholders having voting rights[9] - The largest shareholder, Feng Yuxia, holds 167,160,633 shares, representing 22.30% of the total shares[10] - The second largest shareholder, HKSCC Nominees Limited, holds 118,974,786 shares, accounting for 15.87%[10] - The company has not reported any changes in the top 10 shareholders due to margin trading or stock lending activities during the reporting period[14] - The top 10 shareholders include several institutional investors, with the largest being a medical index fund[12] Business Operations - The contribution of laboratory service business to net profit year-to-date was RMB -1,705,100, a decline of 100.55% compared to the previous year[4] - The fair value change of biological assets resulted in a net loss of RMB 17,698,420.00 year-to-date[4] - The total new signed orders for the first three quarters amounted to approximately RMB 1.4 billion, with the total outstanding orders at approximately RMB 2.65 billion as of the report date[15] - The outstanding orders execution is influenced by various factors, and investors are advised to pay attention to investment risks[15] - The company has not disclosed any new product developments or market expansion strategies in the current report[11] - The company is focusing on expanding its market presence and enhancing its product development capabilities, although specific new products or technologies were not detailed in the report[20] Research and Development - Research and development expenses for Q3 2024 were 71,085,657.06 RMB, down from 77,639,680.27 RMB in Q3 2023, reflecting a decrease of about 8.1%[22] Accounting and Standards - The company’s financial statements are unaudited as of September 30, 2024[16] - The company has adopted new accounting standards starting in 2024, which may impact future financial reporting[26]

Financial Performance - JOINN Laboratories reported a revenue of RMB 1.2 billion for the first half of 2024, representing a year-on-year increase of 25%[6]. - The company achieved a net profit of RMB 300 million, up 30% compared to the same period last year[6]. - Revenue for the first half of 2024 was RMB 849,357,000, a decrease of 16.1% compared to RMB 1,012,077,000 in the same period of 2023[12]. - Gross profit for the first half of 2024 was RMB 211,301,000, down 52.8% from RMB 447,799,000 in the first half of 2023[12]. - The company reported a net loss attributable to equity shareholders of RMB 169,742,000 for the first half of 2024, a decline of 287.3% compared to a profit of RMB 90,627,000 in the same period of 2023[12]. - The gross margin decreased to 24.9% in the first half of 2024 from 44.2% in the same period of 2023, a reduction of 19.3 percentage points[12]. - The company reported a net loss of RMB 172.2 million for the six months ended June 30, 2024, compared to a profit of RMB 89.5 million for the same period in 2023, resulting in a net profit margin of -20.3%[30]. - The company reported a total comprehensive loss for the six months ended June 30, 2024, was RMB 169,213 thousand, compared to a total comprehensive income of RMB 102,760 thousand in 2023[91]. Market Expansion and Strategy - JOINN Laboratories plans to expand its market presence in Southeast Asia, targeting a 20% increase in market share by 2025[6]. - The company is exploring potential acquisitions to enhance its capabilities in biopharmaceuticals, with a budget of RMB 500 million allocated for this purpose[6]. - The company aims to enhance its market share and international influence in the non-clinical pharmacology and toxicology evaluation business, focusing on expanding upstream and downstream capabilities[36]. - The company plans to improve service quality by establishing new technologies and methods, optimizing internal management systems, and expanding production capacity to maintain its market share in non-clinical research services[37]. Research and Development - The company is investing RMB 200 million in R&D for new drug development, focusing on oncology and rare diseases[6]. - The company is focusing on enhancing its R&D service capabilities and quality, leveraging AI and information technology to improve operational efficiency[13]. - The company aims to expand its upstream and downstream business capabilities and build a new drug discovery platform to enhance one-stop service levels[13]. - The company is continuously updating and improving its non-clinical safety evaluation system for innovative drugs, including new types of ADC and PROTAC drugs[19]. - The company has established a high-level technical team of over 40 people and set up laboratories in Suzhou and Beijing for drug quality research and testing[23]. Operational Efficiency - JOINN Laboratories aims to enhance operational efficiency, targeting a reduction in operational costs by 10% by the end of 2024[6]. - The company plans to enhance its project management capabilities and operational efficiency to ensure the smooth launch of new experimental facilities[37]. - The company will continue to improve its performance evaluation, training, and compensation systems to boost employee productivity and support overall strategic goals[38]. Facilities and Compliance - The construction of the Suzhou Zhaoyan Phase II facility, covering 20,000 square meters, has been completed in 2023 and is expected to be operational by early 2025, enhancing business throughput and performance growth[15]. - The company has successfully passed the FDA GLP inspection for its Beijing facility for the third time, demonstrating its compliance with international GLP operational management standards[17]. - The company is actively advancing the construction of the Guangzhou Zhaoyan Anping base to support strategic planning and business needs[15]. Shareholder Information - The board does not recommend the payment of an interim dividend for the six months ending June 30, 2024[42]. - As of June 30, 2024, the company has a total of 749,888,699 issued shares, including 630,893,493 A shares and 118,995,206 H shares[44]. - Major shareholder Mr. Zhou holds 74,725,981 A shares, representing approximately 11.84% of the A shares and 9.96% of the total shares[46]. Financial Position and Assets - Total assets as of June 30, 2024, were RMB 9,661,274,000, a decrease of 3.6% from RMB 10,027,159,000 at the end of 2023[12]. - Cash and cash equivalents as of June 30, 2024, were RMB 2,158.2 million, a decrease of 24.6% from RMB 2,862.9 million as of December 31, 2023[32]. - The company reported a total of RMB 1,843,164,000 in financial assets at fair value through profit or loss as of June 30, 2024, an increase of 92.5% from RMB 961,138,000 as of December 31, 2023[132]. Employee and Talent Management - The company has a professional service team of 2,585 members as of June 30, 2024, reflecting ongoing talent development initiatives[14]. - The company is actively applying for national and regional talent policies to ensure long-term stability of its talent pool[14]. - The company will actively recruit industry experts with overseas experience to strengthen its domestic team's international business capabilities[37]. Related Party Transactions - The company has significant related party transactions with entities controlled by major shareholders, including Shutaishen (Beijing) Biopharmaceutical Co., Ltd.[163]. - Revenue from services provided to Shuyishen Group decreased to RMB 10,385,000 for the six months ended June 30, 2024, down from RMB 31,542,000 for the same period in 2023, representing a decline of approximately 67.0%[166].