Core Viewpoint - The AI Fund Zhaoshang Frontier Healthcare Stock A (011373) reported a profit of 41.645 million yuan for Q2 2025, with a fund net value growth rate of 7.89% and a total fund size of 570 million yuan as of the end of Q2 2025 [2][12]. Fund Performance - The fund's weighted average profit per share for the reporting period was 0.0404 yuan [2]. - As of July 17, the unit net value was 0.625 yuan [2]. - The fund's performance over various time frames includes a 32.00% growth rate over the last three months, 43.06% over the last six months, and 42.96% over the last year, ranking 22/54 and 21/53 among comparable funds respectively [2]. Fund Management - The fund is managed by Li Jiasun, who oversees four funds, all of which have shown positive returns over the past year [2]. - The fund focuses on sectors with a comparative advantage in certain growth, particularly in innovative drugs, R&D outsourcing, medical devices, and AI healthcare [2]. Risk Metrics - The fund's three-year Sharpe ratio stands at -0.1027, ranking 28/46 among comparable funds [7]. - The maximum drawdown over the last three years was 48.11%, with the largest single-quarter drawdown occurring in Q3 2022 at 26.38% [8]. Investment Strategy - The fund maintains a high stock position, averaging 90.79% over the last three years, with a peak of 94.27% at the end of Q3 2024 [11]. - The fund has a high concentration in its top ten holdings, which have consistently exceeded 60% over the past two years [15].

Group 1 - The core viewpoint of the news is the performance and holdings of the China Europe Medical Health Mixed Fund C, which has shown positive growth in recent months and has a significant allocation in leading healthcare companies [1][3]. - As of July 15, 2025, the latest net value of the fund is 1.7462 yuan, reflecting a growth of 1.28%. The fund's one-month return is 2.18%, six-month return is 18.43%, and year-to-date return is 14.30% [1]. - The fund's top ten stock holdings account for a total of 55.30%, with significant investments in companies such as Heng Rui Pharmaceutical (10.60%), WuXi AppTec (9.95%), and Mindray Medical (5.21%) [1]. Group 2 - The China Europe Medical Health Mixed Fund C was established on September 29, 2016, and as of March 31, 2025, it has a total scale of 15.566 billion yuan. The fund is managed by Guo Lan and Zhao Lei [1]. - Guo Lan, the fund manager, has a background in biomedical engineering and has held various positions in research and fund management since joining China Europe Fund Management in 2014 [2]. - Zhao Lei, also a fund manager, has experience in the pharmaceutical and biotechnology sectors, having worked as a researcher and analyst before joining China Europe Fund Management in 2021 [2].

Group 1 - The CRO (Contract Research Organization) sector is experiencing a surge in stock prices, with notable increases in companies such as Boteng Co., Ltd. (20% increase), Kailaiying (10% increase), and WuXi AppTec (9.99% increase) [1][2][3] - The Hong Kong CXO concept stocks also saw significant gains, with Kailaiying and WuXi AppTec both rising over 10% [3][4] - WuXi AppTec is projected to achieve approximately RMB 20.8 billion in revenue for the first half of 2025, representing a year-on-year growth of about 20.64%, and an adjusted net profit of approximately RMB 6.315 billion, reflecting a year-on-year increase of about 44.43% [4][5] Group 2 - The growth in performance for WuXi AppTec is attributed to its focus on meeting customer demands, expanding capabilities, and optimizing production processes [5] - The CXO sector is expected to benefit significantly from the current high demand for innovative drugs, with a new upturn in the life sciences and CXO sectors anticipated [5][6] - Analysts predict that the CXO sector will see a recovery in domestic front-end business due to supportive industrial policies and improved investment conditions [6] Group 3 - The current wave of innovation in the pharmaceutical sector is seen as a significant turning point, with a shift from following trends to creating original products, indicating a fundamental change in the industry [7][8] - Large multinational pharmaceutical companies are increasingly purchasing innovative drug patents from China, driven by pressures to lower drug prices and the expiration of patents [8]

Core Viewpoint - The innovative drug concept continues to show strong performance, with significant stock price increases for companies such as Boteng Co. and Changshan Pharmaceutical, which rose over 15% [1] Group 1: Stock Performance - Boteng Co. and Changshan Pharmaceutical saw stock increases of over 15% [1] - WuXi AppTec experienced a nearly 9% rise [1] - Other companies like Kylin Pharmaceutical, Guangsheng Pharmaceutical, and Yifang Bio also saw stock increases of over 5% [1] Group 2: Policy Announcement - On July 10, the National Healthcare Security Administration announced the adjustment plan for the 2025 National Basic Medical Insurance, Maternity Insurance, and Work Injury Insurance Drug Catalogs, as well as the Commercial Health Insurance Innovative Drug Catalog [1] - The plan specifies that the adjustments to the basic medical insurance drug catalog and the establishment of the commercial health insurance innovative drug catalog will occur simultaneously in 2025 [1]

Group 1 - The Hang Seng Index initially expanded its gains to 1%, while the Hang Seng Tech Index rose by 1.06% [1] - The biopharmaceutical, innovative drug, and pharmaceutical outsourcing sectors showed strong performance [1] - Chip stocks have been rising for several consecutive days, and Chinese brokerage stocks continued their upward trend [1] Group 2 - Guotai Junan International (01788.HK) increased by over 7%, while Kelaiying (06821.HK) surged by over 16% [1] - Yesterday's popular stock, Puxing Energy (00090.HK), rose by over 22% [1]

Summary of the Conference Call Records Industry Overview: CRO and CDMO Key Points on CRO Industry - The CRO (Contract Research Organization) industry is facing challenges due to intensified competition and weakened profitability after rapid capacity expansion [1][4] - Orders for CRO companies have decreased due to obstacles in innovative drug financing and changes in pharmaceutical policies, leading to a difficult destocking phase [1][4] - In 2024, the number of drug clinical trials in China is expected to grow by 16%, with Phase III trials increasing by 31%, indicating a push in innovative drug development [1][5] - The proportion of BE (Bioequivalence) trials is close to 50%, while Phase I trials have decreased, suggesting a slowdown in early clinical trials [1][5] - Major CRO companies like Zhaoyan New Drug and Tigermed are still expanding their workforce despite the pressure on profitability, indicating market share growth [1][6] Key Points on CDMO Industry - The CDMO (Contract Development and Manufacturing Organization) industry is significantly driven by large orders, particularly from COVID-19 drug commercialization [2][7] - From 2021 to 2023, major companies like WuXi AppTec, Kelun, and Boteng collectively generated $4.2 billion in revenue from large orders, with profits reaching $1.7 billion [2][7] - The development of the peptide industry is crucial for CDMO companies, with products like Semaglutide driving growth for companies like Nuotai and WuXi AppTec [3][8] - The ADC (Antibody-Drug Conjugate) industry is expected to maintain a compound annual growth rate of over 35% until 2030, reflecting strong demand for outsourcing services [3][8] Future Trends and Opportunities - The CRO industry is undergoing a transformation as companies adjust structures and optimize resource allocation to survive [4][6] - The introduction of new listing standards for unprofitable companies may alleviate financing issues for innovative drug firms, potentially boosting CRO demand [4][6] - The potential of alphablenton, a small molecule drug for chronic disease treatment, is highlighted, with a projected sales figure exceeding $29 billion by 2035 [3][11] - The market for chronic disease treatments is expected to grow significantly, with the global adult obesity population projected to rise from 760 million in 2020 to over 1 billion by 2030 [11][12] Additional Insights - The CRO industry is currently experiencing a downturn, with many small companies facing survival challenges, while leading firms are expanding their market share [4][6] - The complex synthesis routes of products like alphablenton contribute significantly to CDMO value, indicating a shift towards more specialized and high-value offerings [10][11] - The pain management market is projected to exceed $120 billion by 2027, with new drug developments addressing unmet clinical needs [13][14] This summary encapsulates the critical insights from the conference call, focusing on the current state and future outlook of the CRO and CDMO industries, along with emerging opportunities and challenges.

Group 1 - The core point of the news is the performance and holdings of the China Europe Medical Health Mixed Fund C, which has shown a recent net value increase of 0.94% but a one-month return of -0.94% [1] - The fund's three-month return is 16.34%, ranking 306 out of 1238 similar funds, while its year-to-date return is 10.10%, ranking 434 out of 1218 [1] - The top ten stock holdings of the fund account for a total of 55.30%, with significant positions in companies such as Heng Rui Pharmaceutical (10.60%) and WuXi AppTec (9.95%) [1] Group 2 - The China Europe Medical Health Mixed Fund C was established on September 29, 2016, and as of March 31, 2025, it has a total scale of 15.566 billion yuan [1] - The fund is managed by two key managers: Ms. Ge Lan, who has been managing it since its inception, and Ms. Zhao Lei, who took over management on July 4, 2025 [2]

公司名稱: 凱萊英醫藥集團（天津）股份有限公司 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年6月30日 狀態: 新提交 致：香港交易及結算所有限公司 呈交日期: 2025年7月4日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 06821 | 說明 | H股 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 27,553,260 | RMB | | | 1 RMB | | 27,553,260 | | 增加 / 減少 (-) | | | 0 | | | | RMB | | 0 | | 本月底結存 | | | 27,553,260 | RMB | | | 1 RMB | | 27,553,260 | | 2. 股份分類 ...

Summary of Key Points Core Viewpoint The company, Kailaiying Pharmaceutical Group (Tianjin) Co., Ltd., is undergoing changes in the use of raised funds, including new investment projects, adjustments in investment amounts, and delays in project timelines, to enhance operational efficiency and align with market opportunities. Group 1: Fundraising Overview - The company raised a total of RMB 2,277,875,164.30 from a non-public stock issuance, with a net amount of RMB 2,274,960,656.06 after deducting issuance costs [1][2] - The funds are stored in a dedicated account, regulated by a tripartite agreement among the company, the sponsor, and the bank [2] Group 2: Fund Usage Status - As of June 30, 2025, the company has allocated funds to various projects, including the expansion of its life sciences platform and the construction of a biopharmaceutical R&D base [3][4] - The total investment for the projects is RMB 228,070.62 million, with cumulative investments of RMB 163,909.18 million [4] Group 3: Changes in Fund Usage - The company has proposed to change the use of funds for the "Taixing Project" and redirect remaining funds to new projects, including a chemical macromolecule project and a high-end formulation project [5][6] - The investment amount for the Taixing Project will be reduced by RMB 400 million, with the remaining funds allocated to new projects [6][11] Group 4: New Investment Projects - A new project, the "Chemical Macromolecule Integration Project," will receive RMB 47,367.72 million from the remaining funds, with a total investment of RMB 50,800.00 million [11][12] - The project aims to enhance the company's capacity in the CDMO field and is expected to take 48 months to complete [12][14] Group 5: Financial Performance - The company's total assets as of December 31, 2024, were RMB 3,073,514,644.17, with total liabilities of RMB 2,080,120,300.01 and net assets of RMB 993,394,344.16 [13] - The company reported a revenue of RMB 1,597,172,881.12 and a net profit of RMB 52,163,151.56 for the same period [13] Group 6: Strategic Implications - The changes in fund usage are aligned with the company's long-term strategic planning and are expected to improve operational efficiency and competitiveness [19][20] - The company aims to leverage market trends and enhance its capabilities in innovative drug development, particularly in the chemical macromolecule sector [15][16]

一、董事会会议召开情况 证券代码：002821 证券简称：凯莱英 公告编号：2025-038 凯莱英医药集团（天津）股份有限公司 第四届董事会第六十四次会议决议的公告 本公司及全体董事会成员保证公告内容真实、准确和完整，不存 在虚假记载、误导性陈述或重大遗漏。 凯莱英医药集团（天津）股份有限公司（以下简称"公司"）第四届董事会 第六十四次会议通知于 2025 年 6 月 27 日以电子邮件及书面等形式发送给各位 董事、监事及高级管理人员，会议于 2025 年 7 月 4 日以通讯表决方式召开。公 司应到董事 9 名，实到董事 9 名，公司监事及高级管理人员列席了本次会议。会 议由公司董事长 HAO HONG 先生召集和主持，会议的召集和召开符合《公司法》 及相关法律、法规以及《公司章程》的有关规定。 二、董事会议案审议情况 会议采用通讯方式进行表决，经全体董事审议，通过了如下决议： 1、审议通过了《关于变更部分募集资金用途暨新增募集资金投资项目、调 整部分项目投资金额及延期的议案》 为了进一步提高募集资金使用效率，综合考虑市场情况、行业环境及公司实 际经营需要，公司拟变更募投项目"凯莱英药业（江苏）有限公司生 ...