Group 1 - Heng Rui Medicine signed a licensing agreement with Glenmark Specialty S.A. for the drug Rykon Trastuzumab, receiving an upfront payment of $18 million and potential milestone payments up to $1.093 billion based on sales performance [1] - The drug Rykon Trastuzumab targets HER2 and is approved for treating HER2-mutated non-small cell lung cancer, enhancing Heng Rui's overseas market presence and innovative brand image [1] Group 2 - Tian Shi Li's subsidiary received approval for clinical trials of TSL2109 capsules, a novel dual-target small molecule inhibitor for advanced solid tumors, marking a first in the global market [2] - The company is actively transforming into innovative pharmaceuticals, with TSL2109 representing a significant step in its product development strategy [2] Group 3 - Kang Tai Bio's application for a trivalent influenza virus split vaccine has been accepted by the National Medical Products Administration, aimed at preventing influenza in individuals aged three and above [3] - The competitive vaccine market necessitates ongoing research and innovation for companies to maintain long-term core competitiveness, and successful approval of this vaccine would enhance Kang Tai's product portfolio [3]

Group 1 - President Xi Jinping announced China's new round of Nationally Determined Contributions at the UN Climate Change Summit, aiming for a 7%-10% reduction in greenhouse gas emissions by 2035, with non-fossil energy consumption exceeding 30% of total energy consumption [3] - The total installed capacity of wind and solar power is targeted to reach over 360 million kilowatts, six times that of 2020, and forest stock is expected to exceed 24 billion cubic meters [3] - The national carbon emissions trading market will cover major high-emission industries, and a climate-adaptive society is to be fundamentally established [3] Group 2 - Premier Li Qiang emphasized China's commitment to maintaining an open trade and investment market during a meeting with the President of the European Commission, urging fair competition and adherence to WTO rules [5] - The Chinese government will not seek new special and differential treatment in current and future WTO negotiations, reinforcing its role as a responsible developing country [5] - The People's Bank of China announced a 600 billion yuan MLF operation on September 25, marking a net injection of 300 billion yuan for the month, continuing a trend of high liquidity [5][6] Group 3 - Alibaba announced a collaboration with NVIDIA on Physical AI, with plans to invest 380 billion yuan in AI infrastructure and the launch of seven large model products, including Qwen3-Max, the largest and most capable model to date [4] - The Chinese Ministry of Commerce introduced 14 measures to promote digital consumption, including trials for smart connected vehicles and drone delivery services [6] Group 4 - The A-share market saw significant gains, with the Shanghai Composite Index rising 0.83% to 3853.64 points, and the ChiNext Index increasing by 2.28% [8] - The Hong Kong Hang Seng Index rose 1.37%, with notable gains in tech stocks like Alibaba and SMIC, while medical stocks faced declines [8] - Chery Automobile announced its H-share final offering price at 30.75 HKD per share, set to officially list on September 25 [8] Group 5 - The State Administration for Market Regulation is seeking public opinion on new standards for food delivery platforms, addressing issues like competition and delivery personnel rights [11] - The National Press and Publication Administration approved 145 domestic games and 11 imported games in September, indicating a positive trend in the gaming industry [12] Group 6 - The global crude steel production in August was 145.3 million tons, a year-on-year increase of 0.3%, while the cumulative production from January to August saw a decline of 1.7% [23] - The UK government faced challenges in issuing new bonds, with the latest five-year bond auction seeing the lowest oversubscription rate in nearly two years [20]

Core Viewpoint - Tianjin Tasly Pharmaceutical Group Co., Ltd. announced that its wholly-owned subsidiary, Jiangsu Tasly Diyi Pharmaceutical Co., Ltd., has received approval from the National Medical Products Administration for the clinical trial of TSL2109 capsules for advanced solid tumors [1] Group 1 - The approval notification for TSL2109 capsules marks a significant step in the company's research and development efforts in oncology [1] - This development indicates the company's commitment to expanding its product pipeline in the cancer treatment sector [1]

Group 1 - Shanghai Zhiyuan Hengyue plans to acquire 37% of the shares of Shangwei New Materials at a price of 7.78 yuan per share, requiring a maximum total funding of 1.16 billion yuan [1] - The acquisition period is set for 30 calendar days, from September 29, 2025, to October 28, 2025 [1] - Zhiyuan Hengyue and Zhiyuan Xinchuan intend to acquire at least 63.62% and up to 66.99% of Shangwei New Materials' shares [2] Group 2 - Heng Rui Pharmaceutical has signed a licensing agreement for the innovative drug SHRA1811, receiving an upfront payment of 18 million dollars and is eligible for up to 1.093 billion dollars in milestone payments [3] - The agreement aims to expand the overseas market for SHRA1811 and enhance the company's innovative brand and overseas performance [3] Group 3 - Tian Shili's subsidiary has received approval for clinical trials of TSL2109 capsules, a dual-target small molecule inhibitor for advanced solid tumors, with no similar drugs currently in clinical trials [4] - The cumulative R&D investment in TSL2109 capsules by Jiangsu Diyi has reached 24.6251 million yuan [4] Group 4 - Wanhui High-tech expects a net profit of 340 million to 420 million yuan for the first three quarters, representing a year-on-year growth of 69.81% to 109.77% [5]

Core Viewpoint - Tianjin Tianshili (600535.SH) announced that its wholly-owned subsidiary, Jiangsu Tianshili Diyi Pharmaceutical Co., Ltd., received approval from the National Medical Products Administration for the clinical trial of TSL2109 capsules for advanced solid tumors [1] Group 1 - TSL2109 capsules are a novel dual-target small molecule inhibitor developed in collaboration with China Pharmaceutical University [1] - The drug works by selectively inhibiting downstream signaling pathways of the dual targets, blocking the tumor cell cycle and inducing apoptosis in tumor cells [1] - TSL2109 aims to synergistically kill tumor cells through its dual-target mechanism [1]

Core Viewpoint - Tianshili (600535.SH) announced that its wholly-owned subsidiary, Jiangsu Tianshili Diyi Pharmaceutical Co., Ltd. (referred to as "Jiangsu Diyi"), has received approval from the National Medical Products Administration for the clinical trial of TSL2109 capsules for advanced solid tumors [1] Group 1 - TSL2109 capsules are a novel dual-target small molecule inhibitor developed in collaboration with China Pharmaceutical University [1] - The drug works by selectively inhibiting downstream signaling pathways of the two targets, blocking the tumor cell cycle and inducing tumor cell apoptosis [1] - TSL2109 aims to synergistically kill tumor cells through its dual-target mechanism [1]

Core Viewpoint - Tianshili's subsidiary, Jiangsu Diyi, has received approval from the National Medical Products Administration for clinical trials of TSL2109 capsules for advanced solid tumors [1] Company Summary - Tianshili's full subsidiary Jiangsu Diyi has been granted a clinical trial approval notice for TSL2109 capsules [1]

Core Viewpoint - Tianjin Tianshi Company (600535.SH) announced that its wholly-owned subsidiary, Jiangsu Tianshi Diyi Pharmaceutical Co., Ltd., received approval from the National Medical Products Administration for the clinical trial of TSL2109 capsules for advanced solid tumors [1] Group 1 - TSL2109 capsules are a novel dual-target small molecule inhibitor developed in collaboration with China Pharmaceutical University [1] - The drug works by selectively inhibiting downstream signaling pathways of the dual targets, blocking the tumor cell cycle and inducing tumor cell apoptosis [1] - TSL2109 is designed to synergistically kill tumor cells through its dual-target mechanism [1]

证券代码：600535 证券简称：天士力 编号：临 2025-065 号 天士力医药集团股份有限公司 关于获得药物临床试验批准通知书的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 近日，天士力医药集团股份有限公司（以下简称"公司"）全资子公司江苏 天士力帝益药业有限公司（以下简称"江苏帝益"）收到国家药品监督管理局核 准签发关于TSL2109胶囊用于晚期实体瘤的《药物临床试验批准通知书》，现就 相关情况公告如下： 一、药物基本情况 药品名称：TSL2109胶囊 注册分类：化学药品1类 适应症：晚期实体瘤 剂型：胶囊剂 规格：（1）100 mg（2）25 mg 申请人：江苏天士力帝益药业有限公司、中国药科大学 审批结论：根据《中华人民共和国药品管理法》及有关规定，经审查，2025 年 07 月 23 日受理的 TSL2109 胶囊临床试验申请符合药品注册的有关要求，同意 本品开展晚期实体瘤的临床试验。 二、药物研发及相关情况 TSL2109 胶囊是由江苏帝益和中国药科大学联合申报的具有全新结构的双靶 点小分子抑制剂 ...

每经AI快讯，9月24日，天士力（600535）(600535.SH)公告称，全资子公司江苏天士力帝益药业有限公 司收到国家药品监督管理局核准签发关于TSL2109胶囊用于晚期实体瘤的《药物临床试验批准通知 书》。TSL2109胶囊是由江苏帝益和中国药科大学联合申报的具有全新结构的双靶点小分子抑制剂，目 前国内外尚无同类双靶点药物进入临床试验阶段。截至公告日，江苏帝益对TSL2109胶囊的累计研发投 入为2462.51万元。根据相关法律法规，药物在获得临床试验通知书后，尚需开展临床试验，然后经国 家药监局审评、审批通过后方可上市生产。新药研发周期长、环节多，未来产品市场竞争形势也将发生 变化，公司将积极推进该项目，并及时履行信息披露义务。 ...