Core Insights - BrightGene Pharmaceutical Co., Ltd. presented promising Phase II clinical trial data for its dual-target agonist BGM0504 at the 85th American Diabetes Association (ADA) Scientific Sessions, indicating potential advantages over Semaglutide in treating type 2 diabetes and obesity [1][4] - The company also shared preclinical results for a new Amylin, BGM1812, which shows enhanced receptor activation and potential for effective weight management [1][5] Group 1: BGM0504 Clinical Data - BGM0504 demonstrated significant reductions in HbA1c, fasting blood glucose, postprandial blood glucose, weight, and blood pressure in adult patients with type 2 diabetes during Phase II trials [3][4] - The majority of adverse events were mild to moderate and resolved without intervention, with no observed cases of hypoglycemia or unexpected adverse events, indicating a favorable risk-benefit profile [3][4] - The drug is currently undergoing Phase III clinical trials in China for weight management and type 2 diabetes, with over 1,000 patients treated, showing excellent efficacy and safety [4] Group 2: BGM1812 Development - BGM1812 is a novel Amylin designed using AI/ML optimization, characterized by strong and prolonged effects, with potential for development into a weekly oral formulation [5] - The company aims to leverage its expertise in peptide development to accelerate innovative therapies for unmet clinical needs in metabolic diseases [4]

Core Insights - 博瑞医药 announced the results of two Phase II clinical studies for its dual-target agonist BGM0504 and preclinical results for the new Amylin BGM1812 at the 85th Scientific Sessions of the American Diabetes Association [2] - BGM0504 is a GLP-1/GIP receptor dual agonist that shows potential for treating metabolic diseases, including blood sugar control, weight loss, and non-alcoholic fatty liver disease (NASH) [2] - The drug is currently undergoing Phase III clinical trials in China for weight management and type 2 diabetes, with over 1,000 patients treated, demonstrating excellent efficacy and safety [2] Clinical Study Results - The completed Phase II trial CTR202232464 in China showed that BGM0504 demonstrated comprehensive potential in glycemic control and other related benefits in type 2 diabetes patients, with preliminary efficacy appearing superior to semaglutide [3] - Adverse events during treatment were mostly mild (grade 1-2), with common gastrointestinal reactions being transient diarrhea, nausea, and bloating, and no occurrences of hypoglycemia or other unexpected adverse reactions [3] - Another Phase II trial CTR20233198 in overweight or obese non-type 2 diabetes subjects indicated significant weight management potential and comprehensive metabolic risk benefits for BGM0504 [3] Expert Commentary - Professor Ji Linong from Peking University People's Hospital stated that BGM0504 shows significant preliminary efficacy and good tolerability, making it a strong candidate for further development in type 2 diabetes treatment [4] - BGM1812, designed using AI/ML, exhibits strong and ultra-long-lasting effects, with potential for weekly oral administration [4] - Initial data from the DIO model suggests that the combination of BGM1812 and BGM0504 outperforms combinations of semaglutide with Cagrilintide or Amycretin in terms of weight loss sustainability and efficacy [4] - The chairman of 博瑞医药, 袁建栋, emphasized the international first-tier potential of BGM0504 for treating type 2 diabetes and obesity, along with the development value of BGM1812 [4]

证券代码：688166 证券简称：博瑞医药 公告编号：2025-041 博瑞生物医药（苏州）股份有限公司 本公司董事会、全体董事及相关股东保证本公告内容不存在任何虚假记载、误导性 陈述或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： ? 股东持有的基本情况 一、减持主体的基本情况 | 股东名称 先进制造产业投资基金（有限合伙） | | | | | --- | --- | --- | --- | | 控股股东、实控人及一致行动人 □是 √否 | | | | | 直接持股 5%以上股东 □是 | | | √否 | | 股东身份 | | | | | 董事、监事和高级管理人员 | √否 | | □是 | | 其他：5%以下股东 | | | | | 持股数量 18,612,863股 | | | | | 持股比例 4.40% | | | | | 当前持股股份来源 IPO 前取得：18,612,863股 | | | | | 上述减持主体无一致行动人。 | | | | | 股东上市以来未减持股份。 | | | | | 二、减持计划的主要内容 | | | | | 股东名称 先进制造产业投资基金 ...

证券代码：688166 证券简称：博瑞医药 公告编号：2025-041 博瑞生物医药（苏州）股份有限公司 股东减持股份计划公告 本公司董事会、全体董事及相关股东保证本公告内容不存在任何虚假记载、误导性 陈述或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： 股东持有的基本情况 截至本公告披露日，先进制造产业投资基金（有限合伙）（以下简称"先进 制造基金"）持有博瑞生物医药（苏州）股份有限公司（以下简称"公司"）股票 18,612,863 股，占公司总股本的 4.40%。上述股份来源于公司首次公开发行前持 有的股份，且已于 2020 年 11 月 9 日上市流通。 减持计划的主要内容 先进制造基金计划自本公告披露之日起3个交易日后的3个月内通过集中竞 价、大宗交易方式择机减持公司股份，减持数量合计不超过公司总股本的 3%， 即不超过 12,683,046 股。其中，拟通过集中竞价交易方式减持公司股份的数量不 超过公司总股本的 1%，即不超过 4,227,682 股；通过大宗交易方式减持公司股份 的数量不超过公司总股本的 2%，即不超过 8,455,364 股。若减持计划期间公司有 ...

Investment Rating - The investment rating for the biopharmaceutical industry is "Positive" (maintained) [2] Core Insights - The GLP-1RA class of drugs, represented by Semaglutide and Tirzepatide, is rapidly expanding, creating a multi-billion dollar market opportunity. By 2031, global sales of GLP-1RA drugs are expected to exceed $150 billion, with significant growth anticipated in the weight loss market post-2025 [6][23] - Major multinational corporations (MNCs) are accelerating their entry into the weight loss and diabetes management market, with frequent high-value business development (BD) transactions. Notable acquisitions include Roche's $3.1 billion purchase of Carmot Therapeutics and Merck's acquisition of Hanmi Pharmaceutical's oral GLP-1 small molecule [25][28] - The development of oral and ultra-long-acting products is expected to enhance patient compliance, with ongoing research into both small molecule and peptide oral drugs. Companies like Eli Lilly and Novo Nordisk are leading in this area, with several domestic firms also showing strong potential for international expansion [30] Summary by Sections 1. MNC Accelerating Layout in Weight Loss and Diabetes Management - GLP-1RA drugs are experiencing rapid growth, with Semaglutide and Tirzepatide leading the market. In 2024, Semaglutide's global sales are projected to be approximately $29.2 billion, a year-on-year increase of about 38%, while Tirzepatide's sales are expected to reach $16.5 billion, growing by approximately 208% [16][17] - The market is currently dominated by Novo Nordisk and Eli Lilly, which together hold nearly 97% market share, indicating a duopoly in the sector [23][24] 2. Enhancing Patient Compliance through Oral and Ultra-Long-Acting Products - The development of oral GLP-1RA drugs is seen as a promising avenue to improve patient adherence, with ongoing research into both small molecule and peptide formulations. Companies like Eli Lilly and Novo Nordisk are at the forefront of this innovation [30] - Ultra-long-acting formulations are also being developed, significantly extending dosing intervals and simplifying treatment regimens, which is expected to further enhance patient compliance [7][30] 3. Multi-Target Drug Development and Combination Therapies - Multi-target weight loss drugs are being developed to overcome the limitations of single-target therapies, aiming to activate or inhibit multiple metabolic receptors for improved efficacy. Key targets include GIPR, GCGR, and AMYR [8][29] - Combination therapies that integrate special targets are anticipated to set new standards in weight loss treatment, focusing on fat reduction while preserving lean body mass [8][29] 4. Investment Recommendations - The report recommends several companies as potential investment opportunities, including Innovent Biologics, East China Pharmaceutical, and Boehringer Ingelheim, which are well-positioned in the weight loss and diabetes management sectors. Beneficiary companies include Heng Rui Medicine, Shijiazhuang Pharmaceutical Group, and others [9]

Core Insights - The total margin balance in the market has reached 1828.65 billion yuan, marking an increase for three consecutive trading days, with a total increase of 11.95 billion yuan during this period [1] - Among the 31 industries categorized by Shenwan, 28 have seen an increase in financing balance, with the pharmaceutical and biotechnology sector experiencing the largest increase of 2.01 billion yuan [1][2] - The highest percentage increase in financing balance was observed in the comprehensive industry at 4.25%, followed by the oil and petrochemical and beauty care sectors at 2.52% and 2.12%, respectively [1][2] Industry Summary - **Pharmaceutical and Biotechnology**: Latest financing balance is 130.77 billion yuan, with an increase of 2.01 billion yuan (1.56%) [2] - **Computer**: Latest financing balance is 136.81 billion yuan, with an increase of 1.38 billion yuan (1.02%) [2] - **Electronics**: Latest financing balance is 208.98 billion yuan, with an increase of 0.84 billion yuan (0.40%) [2] - **Oil and Petrochemical**: Latest financing balance is 25.70 billion yuan, with an increase of 0.63 billion yuan (2.52%) [2] - **Beauty Care**: Latest financing balance is 5.91 billion yuan, with an increase of 0.12 billion yuan (2.12%) [2] Individual Stock Performance - 11 stocks have seen their financing balance increase by over 50%, with Weida Optoelectronics showing the highest increase of 85.51% [4][5] - The stock with the second highest increase is Beifang Changlong, with an increase of 82.13% [4][5] - The average price increase for stocks with significant financing balance growth was 8.76%, with Beifang Changlong leading at a 27.21% increase [4] Significant Financing Increases - Guizhou Moutai had the highest absolute increase in financing balance, adding 0.872 billion yuan (5.44%) [6][7] - China Ping An and Borui Pharmaceutical followed with increases of 0.617 billion yuan (2.87%) and 0.260 billion yuan (18.86%), respectively [6][7]

Market Overview - The main funds in the Shanghai and Shenzhen markets experienced a net outflow of 47.673 billion yuan, with the Sci-Tech Innovation Board seeing a net outflow of 1.553 billion yuan [1] - A total of 213 stocks saw net inflows, while 374 stocks faced net outflows [1] Sci-Tech Innovation Board Performance - On the Sci-Tech Innovation Board, 111 stocks rose, with one stock, Jin Chengzi, hitting the daily limit, while 474 stocks declined [1] - C Ying Stone, listed for five days, had a notable increase of 0.92% [1] Fund Flow Analysis - Among the stocks with net inflows, Hengxuan Technology led with a net inflow of 678 million yuan, followed by Shengyi Electronics and Borui Pharmaceutical with net inflows of 105 million yuan and 89.213 million yuan, respectively [1][2] - The stock with the highest net outflow was Chip Origin Technology, which fell by 4.22% with a net outflow of 134 million yuan [1][2] Continuous Fund Flow - There are 40 stocks that have seen continuous net inflows for more than three trading days, with the longest being Baichu Electronics and Youlide, both at seven days [2] - Conversely, 155 stocks have experienced continuous net outflows, with Bohui Technology leading at 16 consecutive days [2] Top Stocks by Fund Flow - The top stocks by net inflow include: - Hengxuan Technology: 67.752 million yuan, 19.85% inflow rate, 2.90% increase [2] - Shengyi Electronics: 10.531 million yuan, 10.19% inflow rate, 4.55% increase [2] - Borui Pharmaceutical: 8.921 million yuan, 7.88% inflow rate, 2.50% decrease [2] Stocks with Significant Outflows - The stocks with the most significant outflows include: - Chip Origin Technology: -134 million yuan, -4.22% decrease [1][2] - Haoyuan Pharmaceutical: -102 million yuan, -2.50% decrease [1][2] - Kingsoft Office: -102 million yuan, -2.50% decrease [1][2]

Policy Developments - The National Health Commission of China is taking measures to ensure blood supply in key areas and important time periods due to a noticeable decline in voluntary blood donations, influenced by factors such as aging population and lifestyle changes [2] - In 2024, the total blood supply in China is expected to decrease year-on-year, with a cumulative blood allocation of 3.613 million units, including 583,000 units allocated between provinces, representing a 35.1% increase [2] Drug and Medical Device Approvals - Kelun Pharmaceutical announced that its subsidiary has received drug registration approval for "Cefazolin Sodium/ Sodium Chloride Injection," which is packaged in a dual-chamber bag and is suitable for emergency treatment [4] - *ST Sailong's subsidiary has obtained a drug registration certificate for Famotidine Injection, classified as a Category A drug under the national medical insurance list, primarily used for treating upper gastrointestinal bleeding [5] Capital Market Activities - Borui Pharmaceutical plans to invest 20 million yuan to subscribe to the increased registered capital of Geek Gene Technology, acquiring a 4.1667% stake in the company [7] Industry Developments - Eli Lilly announced the launch of the multi-dose prefilled pen for Tirzepatide Injection in China, aimed at addressing the needs of the growing number of diabetes and obesity patients [9] - The adult overweight rate in China is 34.3%, with an obesity rate of 16.4%, highlighting the increasing demand for weight management treatments [9] - In the first quarter of this year, Tirzepatide contributed $6.15 billion in revenue to Eli Lilly, accounting for approximately 48% of the company's total revenue [10] - Hanyu Pharmaceutical has completed the enrollment of all subjects for the Phase III clinical trial of Semaglutide Injection for weight management, currently in the follow-up phase [11] Shareholder Actions - Nine Strong Bio's major shareholder completed a share reduction plan, reducing their holdings from 30,969,636 shares to 30,769,636 shares, a decrease from 5.30% to 5.26% of voting shares [13] - Yifeng Pharmacy's controlling shareholder plans to reduce their stake by up to 2%, amounting to no more than 24,248,336 shares [14]

证券代码：688166 证券简称：博瑞医药 公告编号：2025-035 转债代码：118004 转债简称：博瑞转债 | 证券代码 | 证券简称 | 停复牌类型 | 停牌起始日 | 停牌期间 | 停牌终止日 | 复牌日 | | --- | --- | --- | --- | --- | --- | --- | | 118004 | 博瑞转债 | 可转债转股复牌 | | | 2025/6/20 | 2025/6/23 | 博瑞生物医药（苏州）股份有限公司 一、转股价格调整依据 关于 2024 年年度权益分派调整可转债转股价格的公告 公司于 2025 年 5 月 19 日召开 2024 年年度股东大会，审议通过了《2024 年年 度利润分配预案》。公司拟以实施权益分派股权登记日登记的总股本扣减公司回购 专用证券账户中股份为基数分配利润，向全体股东每 10 股派发现金红利 0.96 元（含 税）。如在公告披露之日起至实施权益分派股权登记日期间，公司总股本发生变动 调整前转股价格：34.84 元/股 调整后转股价格：34.74 元/股 转股价格调整实施日期：2025 年 6 月 23 日 本公司董事会及全体董事保证本公 ...

关于博瑞生物医药（苏州）股份有限公司 对外投资暨关联交易的核查意见 民生证券股份有限公司（以下简称"民生证券"）作为博瑞生物医药（苏州） 股份有限公司（以下简称"博瑞医药"或"公司"） 首次公开发行股票并在科 创板上市以及向不特定对象发行可转换公司债券、以简易程序向特定对象发行股 票的保荐机构，履行持续督导职责，并根据《证券发行上市保荐业务管理办法》 《上海证券交易所科创板股票上市规则》等规范性法律文件的要求，对博瑞医药 对外投资暨关联交易事宜进行了审慎核查，核查情况及意见如下： 一、对外投资暨关联交易概述 根据公司发展战略规划，公司拟对苏州极客基因科技有限公司增资。极客基 因本轮融资金额3,000万元，对应增加注册资本26.7612万元，其中公司拟以2,000 万元认购极客基因人民币17.8408万元的新增注册资本。增资款中，人民币17.8408 万元计入标的公司的注册资本，人民币1,982.1592万元计入标的公司的资本公积 金。本次增资后博瑞医药将取得标的公司4.1667%股权。 公司董事长袁建栋先生、苏州鸿博创业投资合伙企业（有限合伙）、苏州鸿 博二期投资合伙企业（有限合伙）为本轮增资前现有股东，且袁 ...