Group 1 - The core point of the news is that Shouyao Holdings experienced a decline of 5.01% in its stock price, reaching 42.81 CNY per share, with a total market capitalization of 6.367 billion CNY [1] - Shouyao Holdings, established on April 19, 2016, and listed on March 23, 2022, specializes in the research and development of small molecule anti-tumor drugs, with 100% of its revenue coming from technology development and services [1] Group 2 - From the perspective of fund holdings, Shouyao Holdings is a top ten holding for the Tongtai Health Theme Mixed A Fund (011002), which held 28,100 shares, accounting for 4.52% of the fund's net value [2] - The Tongtai Health Theme Mixed A Fund has a current scale of 6.1823 million CNY and has achieved a year-to-date return of 29.88%, ranking 3611 out of 8166 in its category [2] - The fund has experienced a floating loss of approximately 63,600 CNY today [2] Group 3 - The fund managers of Tongtai Health Theme Mixed A Fund are Ma Yi and Mai Jianpei, with Ma Yi having a tenure of 11 years and 208 days, managing assets totaling 6.063 billion CNY, and achieving a best fund return of 43.57% during his tenure [3] - Mai Jianpei has a tenure of 152 days, managing assets of 161 million CNY, with a best fund return of 32.24% during his short tenure [3]

Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" and the rating has been maintained [1] Core Insights - The pharmaceutical and biotechnology industry index experienced a decline of 2.72%, ranking 23rd among 31 primary industries, underperforming the CSI 300 index which declined by 2.62% [4][16] - The industry valuation as of September 30, 2025, is a PE (TTM overall method, excluding negative values) of 31.23x, down from 31.79x in the previous period, indicating a downward trend and below the average [21] - The top three sub-industries in terms of PE (TTM overall method, excluding negative values) are vaccines (55.74x), medical devices (41.29x), and hospitals (39.51x), with the median at 33.19x, while pharmaceutical circulation has the lowest valuation at 14.34x [21] Industry Review - The report highlights that during the reporting period, 51 listed companies in the pharmaceutical and biotechnology sector had a net reduction in shareholders amounting to 2.435 billion yuan, with 14 companies increasing their holdings by 681 million yuan and 37 companies reducing their holdings by 3.116 billion yuan [4] - The report emphasizes the importance of upcoming clinical data and the strong fundamentals of companies ahead of the ESMO 2025 conference, which is expected to showcase significant clinical research results from various domestic pharmaceutical companies [7][8] Important Industry News - AstraZeneca plans to list on the New York Stock Exchange [6] - The report mentions the approval of a new oral SERD drug by Eli Lilly, marking it as the second such drug approved globally [8][45] - The approval of the first domestic quadrivalent HPV vaccine in China is expected to expand the coverage population and potentially be priced lower than imported versions [8][50][52]

Core Viewpoint - Shouyao Holdings (688197.SH) reported a significant decline in revenue and continued net losses for the first half of 2025, indicating ongoing financial challenges for the company [1]. Financial Performance - The company achieved a revenue of 2 million yuan in the first half of 2025, representing a year-on-year decrease of 47.37% from 3.8 million yuan in the same period last year [3]. - The net profit attributable to shareholders was -104.37 million yuan, slightly worsening from -102.85 million yuan in the previous year [3]. - The net profit attributable to shareholders after deducting non-recurring gains and losses was -114.25 million yuan, compared to -109.89 million yuan in the same period last year [3]. - The net cash flow from operating activities was -113.62 million yuan, compared to -97.14 million yuan in the same period last year [3]. Company Background - Shouyao Holdings was listed on the Shanghai Stock Exchange's Sci-Tech Innovation Board on March 23, 2022, with an initial offering price of 39.90 yuan per share [4]. - The total amount raised during the IPO was 1.483 billion yuan, with a net amount of 1.374 billion yuan after deducting issuance costs [4]. - The company intended to use the raised funds for innovative drug research and development projects, establishing a new drug R&D and industrialization base, and supplementing working capital [4].

Group 1 - On September 25, Shouyao Holdings experienced a decline of 1.22% with a transaction volume of 98.81 million yuan [1] - The financing data indicates that on the same day, Shouyao Holdings had a financing purchase amount of 6.27 million yuan and a financing repayment of 14.44 million yuan, resulting in a net financing outflow of 8.17 million yuan [1] - As of September 25, the total balance of margin trading for Shouyao Holdings was 292 million yuan, accounting for 9.57% of its circulating market value, which is above the 90th percentile level over the past year [1] Group 2 - As of June 30, the number of shareholders of Shouyao Holdings increased by 5.33% to 4,526, while the average circulating shares per person decreased by 5.06% to 14,141 shares [2] - For the first half of 2025, Shouyao Holdings reported an operating income of 2 million yuan, a year-on-year decrease of 47.37%, and a net profit attributable to shareholders of -104 million yuan, a decrease of 1.48% year-on-year [2] - Among institutional holdings, as of June 30, 2025, Penghua Medical Technology Stock A was the largest circulating shareholder with 5.41 million shares, unchanged from the previous period, while China Europe Medical Health Mixed A entered as the tenth largest shareholder with 1.17 million shares [2]

证券之星消息，9月24日化学制药板块较上一交易日上涨0.13%，向日葵领涨。当日上证指数报收于 3853.64，上涨0.83%。深证成指报收于13356.14，上涨1.8%。化学制药板块个股涨跌见下表： | 代码 | 名称 | 收盘价 | 涨跌幅 | 成交量(手) | 成交额(元) | | | --- | --- | --- | --- | --- | --- | --- | | 300111 | 向日葵 | 8.57 | 20.03% | 300.34万 | | 24.00亿 | | 002020 | 京新药业 | 21.63 | 10.02% | 27.78万 | | 5.81亿 | | 002294 | 信立泰 | 60.24 | 10.01% | 14.80万 | | 8.69% | | 300584 | 海辰药业 | 61.56 | 7.98% | 15.43万 | | 9.31亿 | | 688197 | 首药控股 | 48.28 | 6.93% | 3.02万 | | 1.41亿 | | 688302 | 海创药业 | 55.69 | 6.62% | 4.06万 | | 2.26亿 | | 00 ...

Core Points - On September 23, a total of 6 listed companies had their restricted shares unlocked, with a total market value of approximately 6.569 billion yuan [1] Group 1: Company Specifics - Shanghai Airport (Stock Code: 600009) had 128 million shares unlocked, categorized as newly issued A-shares for original shareholders [1] - Hualu Hengsheng (Stock Code: 600426) had 280,000 shares unlocked, classified under equity incentive restricted circulation [1] - Electric Science Digital (Stock Code: 600850) had 81.107 million shares unlocked, categorized as newly issued A-shares for institutional placement [1] - Top Point Software (Stock Code: 603383) had 162,000 shares unlocked, classified under equity incentive restricted circulation [1] - Fengshang Culture (Stock Code: 300860) had 19,900 shares unlocked, categorized under equity incentive restricted circulation [1] - Shouyao Holdings (Stock Code: 688197) had 6.4916 million shares unlocked, with no specific category mentioned [1]

Meeting Overview - The first extraordinary general meeting of shareholders for 2025 was convened by the board of directors and chaired by Chairman Li Wenjun, utilizing a combination of on-site and online voting methods [2][4] - The meeting complied with the provisions of the Company Law of the People's Republic of China and relevant regulations [2][4] Attendance - All 7 current directors and 3 current supervisors attended the meeting in person [5] Resolutions Passed - The following resolutions were approved: 1. Appointment of the auditing firm for the 2025 financial statements and internal control [4] 2. Change of registered address, cancellation of the supervisory board, and amendments to the Articles of Association [4] 3. Amendments to the rules of procedure for shareholder meetings [6] 4. Amendments to the rules of procedure for board meetings [6] 5. Amendments to the management measures for related party transactions [6] 6. Amendments to the management measures for external investments [6] 7. Amendments to the management measures for external guarantees [6] 8. Amendments to the management measures for the use of raised funds [6] 9. Amendments to the implementation details of cumulative voting [6] 10. Amendments to the independent director work system [7] Voting Results - Resolution 2 was a special resolution requiring a two-thirds majority, which was achieved [7] - All other resolutions were ordinary resolutions passed by a simple majority [7] Legal Verification - The meeting was witnessed by Beijing Jingtian Gongcheng Law Firm, confirming that the meeting's procedures and voting results were in compliance with Chinese laws and regulations [7]

中信建投证券股份有限公司 关于首药控股（北京）股份有限公司 2025 年半年度持续督导跟踪报告 | 保荐人名称：中信建投证券股份有限 | 上市公司名称：首药控股（北京）股份 | | --- | --- | | 公司 | 有限公司 | | 保荐代表人姓名：杨慧泽 | 联系方式：010-56160130 联系地址：北京市朝阳区景辉街 16 号院 | | | 号楼泰康集团大厦 层 1 10 | | 保荐代表人姓名：李彦芝 | 联系方式：010-56051825 联系地址：北京市朝阳区景辉街 号院 16 | | | 号楼泰康集团大厦 层 1 10 | 经中国证券监督管理委员会（简称"中国证监会"）"证监许可〔2022〕258 号文"批准，首药控股（北京）股份有限公司（简称"公司"或"首药控股"） 获准向社会公开发行人民币普通股（A 股）37,180,000 股，并于 2022 年 3 月 23 日在上海证券交易所科创板挂牌上市。本次公司发行新股的发行价为 39.90 元/ 股，募集资金总额为 148,348.20 万元，扣除发行费用 10,972.80 万元后（不含增 值税，含发行前已计入损益金额 508.49 万元 ...

中国北京市朝阳区建国路 77 号华贸中心 3 号写字楼 34 层 邮政编码 100025 电话: (86-10) 5809-1000 传真: (86-10) 5809-1100 北京市竞天公诚律师事务所 关于首药控股（北京）股份有限公司 2025 年第一次临时股东大会的法律意见书 致：首药控股（北京）股份有限公司 一、本次股东大会的召开程序 北京市竞天公诚律师事务所（以下称"本所"）接受首药控股（北京）股份 有限公司（以下称"公司"）的委托，指派本所律师列席了公司于 2025 年 9 月 15 日在北京市海淀区闵庄路 3 号玉泉慧谷科技园 15 号楼公司会议室召开的公司 2025 年第一次临时股东大会（以下称"本次股东大会"），并依据《中华人民 共和国公司法》《中华人民共和国证券法》等中国现行法律、法规和其他规范性 文件（以下称"中国法律法规"）及《首药控股（北京）股份有限公司章程》（以 下称"《公司章程》"）的规定，就本次股东大会的召集和召开程序、出席会议 人员资格、召集人资格、会议表决程序和表决结果等事宜（以下称"程序事宜"） 出具本法律意见书。 为出具本法律意见书，本所律师审查了公司提供的有关本次股东大 ...

证券代码：688197 证券简称：首药控股 公告编号：2025-026 首药控股（北京）股份有限公司 2025年第一次临时股东大会决议公告 本公司董事会及全体董事保证公告内容不存在任何虚假记载、误导性陈述或者重大遗 漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： 本次会议是否有被否决议案：无 一、 会议召开和出席情况 1 （五） 公司董事、监事和董事会秘书的出席情况 1、 公司在任董事7人，现场出席7人； 2、 公司在任监事3人，现场出席3人； （一） 股东大会召开的时间：2025 年 9 月 15 日 （二） 股东大会召开的地点：北京市海淀区闵庄路 3 号玉泉慧谷科技园 15 号楼 公司会议室 （三） 出席会议的普通股股东、特别表决权股东、恢复表决权的优先股股东及 其持有表决权数量的情况： | 1、出席会议的股东和代理人人数 | 68 | | --- | --- | | 普通股股东人数 | 68 | | 2、出席会议的股东所持有的表决权数量 | 96,014,724 | | 普通股股东所持有表决权数量 | 96,014,724 | | 3、出席会议的股东所持有表决权数量占公司表决权 ...