"年度卓越生物医药企业"是从技术创新、研发实力、成果转化等多方面综合评估，旨在表彰在生物医药领域具有自主核心技术、持续创新并能高效将科研成 果转化为临床或商业应用的领军企业。本次评选通过定量数据分析和专家评审团等方式得出最终结果。 格隆汇以"全球视野，下注中国"为初衷，本次评选旨在打造出投资圈中最具参考价值的上市公司及独角兽公司排行榜。此次"金格奖"上市公司评选覆盖港交 所、上交所、深交所、纽交所、美国证券交易所、纳斯达克证券交易所挂牌上市的全部上市公司及独角兽公司。 12月22日，格隆汇在线上举办"科技赋能·资本破局"分享会。本次分享会，备受瞩目的卓越公司评选榜单将隆重揭晓，其中格隆汇"金格奖"年度卓越公司评选 中，百利天恒(688506.SH)、东阳光药(06887.HK)、东曜药业-B(01875.HK)、和铂医药-B(02142.HK)、华领医药-B(02552.HK)、先声药业(02096.HK)、亚盛 医药(06855.HK/AAPG.US)、真实生物8家企业荣获"年度卓越生物医药企业"奖项。（排名不分先后，按公司首部字母顺序排列） ...

百利天恒12月18日大宗交易平台出现一笔成交，成交量0.84万股，成交金额292.42万元，大宗交易成交 价为348.12元。该笔交易的买方营业部为华泰证券股份有限公司马鞍山湖东中路证券营业部，卖方营业 部为中国国际金融股份有限公司北京建国门外大街证券营业部。 12月18日百利天恒大宗交易一览 | 成交量 | 成交金 | 成交价 | 相对当日收盘 | | | | --- | --- | --- | --- | --- | --- | | （万 | 额（万 | 格 | 折溢价（%） | 买方营业部 | 卖方营业部 | | 股） | 元） | （元） | | | | | 0.84 | 292.42 | 348.12 | 0.00 | 华泰证券股份有限公司马 鞍山湖东中路证券营业部 | 中国国际金融股份有限公司 北京建国门外大街证券营业 | | | | | | | 部 | （文章来源：证券时报网） 进一步统计，近3个月内该股累计发生3笔大宗交易，合计成交金额为3773.82万元。 证券时报·数据宝统计显示，百利天恒今日收盘价为348.12元，下跌0.98%，日换手率为0.56%，成交额 为2.03亿元，全天主力资金 ...

第1笔成交价格为348.12元，成交0.84万股，成交金额292.42万元，溢价率为0.00%，买方营业部为华泰 证券股份有限公司马鞍山湖东中路证券营业部，卖方营业部为中国国际金融股份有限公司北京建国门外 大街证券营业部。 炒股就看金麒麟分析师研报，权威，专业，及时，全面，助您挖掘潜力主题机会！ 责任编辑：小浪快报 12月18日，百利天恒收跌0.98%，收盘价为348.12元，发生1笔大宗交易，合计成交量8400股，成交金额 292.42万元。 进一步统计，近3个月内该股累计发生3笔大宗交易，合计成交金额为3773.82万元。该股近5个交易日累 计下跌3.85%，主力资金合计净流出2703.13万元。 ...

Group 1 - A number of A-share listed chemical companies, including Guoen Co., Linglong Tire, Proya, and Baili Tianheng, have accelerated their plans for listing in Hong Kong, aiming to create an "A+H" dual capital platform to broaden their development paths and inject new momentum into their growth [1] - The surge in Hong Kong listings is driven by both policy support and market demand, with international expansion and enhanced global competitiveness becoming key motivations for chemical companies [1][2] - Guoen Co. announced that the Hong Kong Stock Exchange's listing committee held a hearing on its application for H-share issuance on December 11, marking a critical stage in its listing process [1] Group 2 - The listing trend is supported by ongoing reforms in Hong Kong's capital market and policies from mainland China, which have made the Hong Kong Stock Exchange more attractive for innovative companies since the introduction of new listing rules in 2018 [2] - Recent measures from the Ministry of Finance and the China Securities Regulatory Commission have expanded the list of qualified institutions for H-share auditing, enhancing the quality of auditing services available to mainland companies seeking to list in Hong Kong [2] - The move to list in Hong Kong represents a proactive choice for companies to broaden financing channels and advance international development, reflecting the dual opening of China's capital market [3]

Investment Rating - The report maintains an "Outperform" rating for several companies in the innovative drug and medical device industry, including Jiangsu Heng Rui Medicine, Hansoh Pharmaceutical Group, 3SBio, Sichuan Kelun Pharmaceutical, and Jiangsu Nhwa Pharmaceutical [5][6][25]. Core Insights - The report emphasizes the high prosperity in innovative drugs and continues to recommend companies with innovative pipelines that are entering a volume increase phase, maintaining "Outperform" ratings for various Biopharma/Biotech companies [5][25]. - The National Healthcare Security Administration announced the 2025 insurance drug list, which added 114 drugs, including 50 innovative drugs, further validating insurance support for innovation and indicating promising domestic demand [26][27]. Summary by Sections 1. Continuous Recommendation of Innovative Drugs and Industry Chain - The report highlights the ongoing recommendation of innovative drugs and the industry chain, with a focus on companies expected to see a revaluation due to their innovative pipelines [5][25]. - Specific companies mentioned include WuXi AppTec, WuXi XDC Cayman, Hangzhou Tigermed Consulting, and leading medical equipment companies like Beijing Chunlizhengda Medical Instruments and Lepu Medical, all rated "Outperform" [5][25]. 2. Performance of A-Shares Pharmaceutical Sector - In the second week of December 2025, the A-Shares pharmaceutical sector underperformed the market, with the SW Pharma and Biotech index falling by 1.0% compared to a 0.3% decline in the SHCOMP [8][27]. - The report notes that the premium level of the pharmaceutical sector relative to all A-Shares is at a normal level, with a current relative premium rate of 69.8% [16][27]. 3. Performance of Hong Kong and U.S. Pharmaceutical Sectors - The Hong Kong stock pharmaceutical sector underperformed the market, with the Hang Seng Healthcare index falling by 2.3%, while the U.S. stock pharmaceutical sector outperformed, with the S&P 500 Healthcare Select Sector Index rising by 0.4% [28][27].

Group 1 - The report highlights the recent performance of various industries, with notable gains in sectors such as non-ferrous metals, electronics, and power equipment, while retail and real estate sectors faced declines [1][1][1] - The central economic work conference emphasized the importance of technological breakthroughs and supply-demand optimization, indicating a shift towards quality improvement in economic growth [11][12][19] - The commercial aerospace sector is experiencing significant growth, with the establishment of a dedicated regulatory body and a notable increase in the commercial aerospace index, which has risen by 46.52% since April 7 [47][48] Group 2 - The report indicates a seasonal recovery in social financing, with November seeing an increase of 24,885 billion yuan, driven primarily by government bond issuance [4][7] - The credit environment is showing signs of marginal improvement, particularly in corporate loans, which increased by 6,100 billion yuan in November, reflecting a recovery in demand [5][6] - The report notes that the retail sector is undergoing a transformation, with a focus on quality, as highlighted by the Ministry of Commerce's emphasis on retail quality upgrades [1][1][1] Group 3 - The report discusses the rising interest in inquiry transfers, which have seen a significant increase in both project numbers and transfer scale, indicating a growing trend in the market [51][52] - The technology sector is expected to remain a key focus, with upcoming events such as the Volcano Engine FORCE conference anticipated to showcase advancements in AI and cloud services [56]

Investment Rating - The report maintains an "Overweight" rating for the innovative pharmaceutical and medical device industry chain [3][5][6]. Core Insights - The report emphasizes the continuous recommendation of innovative drugs and medical devices, highlighting the high growth potential in the innovative pharmaceutical sector. It maintains "Overweight" ratings for companies such as Heng Rui Medicine, Hansoh Pharmaceutical, and others, indicating a potential for value re-evaluation [3][5]. - The report notes that the National Medical Insurance Administration has officially announced the 2025 medical insurance drug catalog, which includes 114 new drugs, 50 of which are first-class innovative drugs. This adjustment is seen as a validation of the support for innovation in the healthcare sector [3][5]. - The A-share pharmaceutical sector underperformed the broader market in the second week of December 2025, with the SW Pharmaceutical Biotechnology index declining by 1.0% compared to a 0.3% drop in the Shanghai Composite Index [7][18]. Summary by Sections Section 1: Continuous Recommendation of Innovative Drugs and Medical Devices - The report highlights the sustained recommendation of innovative drugs and medical devices, with a focus on companies that are expected to see performance growth and value re-evaluation [5][6]. Section 2: A-share Pharmaceutical Sector Performance - In the second week of December 2025, the A-share pharmaceutical sector's performance was weaker than the overall market, ranking 16th among the primary industries [7][18]. Section 3: Hong Kong and US Market Performance - The report indicates that the Hong Kong pharmaceutical sector also underperformed, while the US pharmaceutical sector showed stronger performance compared to the broader market [18].

Core Insights - The pharmaceutical industry is experiencing a surge in innovative products, with clear domestic demand and significant potential for international expansion [4][14][25] - Investment opportunities are concentrated in innovative drugs and their supply chains, with a notable performance from CRO/CMO and chemical pharmaceuticals [9][15][17] - The report emphasizes the importance of innovation as the primary solution to industry challenges, driven by stable demand and supportive policies [26][32][41] Industry Overview - The pharmaceutical sector has faced revenue declines, with a 0.9% year-on-year decrease in revenue for the first three quarters of 2025, and net profit down by 2.2% [15][16] - The innovative drug sector has outperformed, with CRO/CMO and chemical pharmaceuticals showing net profit growth of 31.0% and 16.6% respectively [17][18] - The overall market is characterized by low fund holdings and historical valuation bottoms, indicating high investment value [20][25] Demand and Payment Dynamics - The demand for healthcare services is steadily increasing, with a projected 5% growth in total medical visits and hospital admissions in 2024 [26][28] - The aging population is expected to drive long-term demand, with 220 million people aged 65 and above by 2050 [28][30] - The medical insurance fund's income growth has outpaced expenditure growth, leading to a significant increase in fund reserves [32][36] Financing and Market Trends - The IPO market for healthcare has rebounded, with 28 IPOs in the first three quarters of 2025, a 100% increase from the previous year [42][43] - License-out transactions have surged, with transaction numbers increasing by 41% and total amounts reaching $92 billion, indicating a robust market for innovative drug licensing [48][50] - The number of IND applications and new clinical trials for innovative drugs has been steadily increasing, with a notable rise in NDA approvals [53][57] Technological Advancements - The report highlights the emergence of new technologies such as ADC and small nucleic acids, with domestic companies leading in these areas [60] - The focus on dual antibodies and GLP-1 drugs is expected to drive significant growth, with multiple development directions emerging [9][60] - The report notes that domestic companies are increasingly recognized for their innovative capabilities, particularly in the ADC space [60]

Core Viewpoint - Rhine Biotech is undergoing a change in control, with the majority of shares being transferred to Guangzhou Defu Nutrition Investment Partnership, while simultaneously planning to acquire at least 80% of Beijing Jinkangpu Food Technology Co., Ltd. [2][4] Group 1: Control Change and Acquisition - Rhine Biotech's controlling shareholder, Qin Benjun, will transfer part of his shares to Guangzhou Defu Nutrition, which will become the new controlling shareholder [2][4] - The acquisition involves purchasing at least 80% of Beijing Jinkangpu's shares, which is expected to enhance Rhine Biotech's competitiveness in the food and health product sectors [6][7] Group 2: Financial Performance and Market Position - Rhine Biotech, known as the "King of Sugar" in China, reported a revenue of approximately 1.272 billion yuan for the first three quarters of the year, reflecting a year-on-year growth of 8.73%, but faced a net profit decline of 30.73% to about 70.4 million yuan due to intense market competition [6] - The sweetener market is showing signs of stagnation, impacting Rhine Biotech's profitability despite revenue growth [6] Group 3: Financial Challenges and Regulatory Issues - The company is under financial pressure, with a significant portion of Qin Benjun's shares pledged, amounting to approximately 1.77 billion shares, representing a pledge ratio of 65.13% [8][9] - Regulatory scrutiny has increased, with the company facing a fine of 600,000 yuan due to a production safety incident and other compliance issues [9]

Core Viewpoint - Baili Tianheng's market value has surged from billions to trillions, making its founder Zhu Yi the richest person in Sichuan, but the company faces significant performance volatility and relies heavily on licensing income from BMS [1][6]. Group 1: Company Performance - Baili Tianheng's revenue is almost entirely dependent on licensing income from BMS, leading to a sharp decline in revenue due to a lack of new large licensing confirmations [1][6]. - The company reported a net profit of 3.708 billion yuan in 2024, ranking sixth in the pharmaceutical industry, but this was primarily due to a significant licensing deal with BMS for the drug iza-bren [6][7]. - Despite a recovery in the third quarter with a $250 million milestone payment, the company still recorded a loss of 494 million yuan in the first three quarters of the year [1][6]. Group 2: IPO and Market Strategy - Baili Tianheng has delayed its Hong Kong IPO, a rare move in the market, due to concerns about potential share price drops amid a sluggish sentiment in the biotech sector [2][3]. - The company has attempted to list on the Hong Kong Stock Exchange three times, with the latest attempt being postponed just days before the deadline [2][3]. - The expected pricing range for the H-shares is between 347.5 and 389 HKD, which is almost at par with A-shares, making it less attractive for international investors looking for arbitrage opportunities [2][3]. Group 3: Research and Development - The company has significantly increased its R&D investment, with R&D expenses reaching 746 million yuan in 2023, accounting for 132.81% of revenue [7]. - The anticipated drug iza-bren is crucial for the company's future, with expectations for it to be the first to market in China next year, potentially changing the company's reliance on licensing income [7]. - Baili Tianheng's traditional pharmaceutical business is facing challenges due to price reductions from centralized procurement, leading to declines in revenue and profit margins [7].