本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 证券代码：000739 证券简称：普洛药业 公告编号：2025-23 普洛药业股份有限公司 2024 年年度股东大会决议公告 特别提示： 1、本次股东大会未有否决议案。 2、本次股东大会未涉及变更以往股东大会已通过的决议。 3、根据国家有关法律、法规等相关规定，上市公司回购专用证券账户所持 股份不享有股东大会的表决权，公司现有总股本1,169,323,576股，截至本次股 东大会股权登记日，公司回购专用证券账户持有公司股份10,880,000股，故公司 本次股东大会有表决权股份总数为1,158,443,576股。 1、召集人：公司第九届董事会 2、主持人：公司董事长 祝方猛先生 3、会议召开方式：现场投票与网络投票相结合 4、会议召开时间： （1）现场会议召开时间：2025 年 4 月 17 日下午 14:30 （2）网络投票时间：2025 年 4 月 17 日 一、会议召开和出席情况 其中，通过深圳证券交易所交易系统进行网络投票的具体时间为：2025 年 4 月 17 日：9:15—9:25，9:30—11:3 ...

Investment Rating - The report does not explicitly state an investment rating for the synthetic biology industry Core Insights - The synthetic biology sector is experiencing a global technological revolution, providing innovative solutions to major challenges such as health, climate change, and food security, as highlighted by the National Development and Reform Commission's "14th Five-Year Plan for Bioeconomic Development" [4] - The Huazhong Securities synthetic biology index, which includes 58 companies across various sectors, has seen a decline of 9.66% recently, underperforming compared to the Shanghai Composite Index [5][17] Industry Market Dynamics - The synthetic biology sector's stocks have performed poorly recently, with a 9.66% drop, ranking 32nd among sectors [17] - The top five gainers in the synthetic biology sector include: - Novozymes (+27%) - Shandong Heda (+10%) - Yaxiang Co. (+10%) - Pro Pharma (+3%) - Huafeng Chemical (+2%) [18] - The top five losers include: - Xinri Hengli (-18%) - Kasei Biotech (-12%) - Yabao Chemical (-9%) - Berry Genomics (-7%) - Weilan Bio (-6%) [22] Company Business Developments - Anhui Pucan has launched the world's largest CO₂-based polycarbonate production facility, with an annual capacity of 50,000 tons, expected to generate sales of 1.5 billion yuan [23] - Huafeng Chemical plans to acquire two subsidiaries to integrate its polyurethane supply chain, with projected revenues exceeding 6.4 billion yuan in 2024 [23] - Tianchen Company signed a contract for a 100,000 tons/year bioethanol project in Egypt, marking its first venture into the North African market [24] - Kosemet announced a partnership with Shanghai Xinhai Biotechnology to develop bio-synthesized retinol for skincare products [25] Industry Financing Tracking - The synthetic biology sector has seen accelerated financing, with nearly 100 companies completing new funding rounds since the beginning of 2025 [28] - Zhongsheng Suyuan Biotechnology completed a B round financing of 235 million yuan, focusing on iPSC-derived cell therapies [28] - Korean company INTAKE raised approximately 9.2 million USD in a C round financing to develop precision fermentation proteins [29] Company R&D Directions - Jinbo Biotech received approval for its recombinant type III human collagen injection product, marking a breakthrough in high-end medical aesthetics [31] - CellX's mushroom protein received FDA GRAS certification, allowing it to enter the U.S. market [31] - MycoTechnology's truffle sweet protein product received FEMA GRAS certification, showcasing advancements in natural flavoring solutions [32] - Nourish Ingredients and Cabio Biotech successfully commercialized a precision fermentation fat product, enhancing the flavor of plant-based products [34]

Investment Rating - The report does not explicitly state an investment rating for the synthetic biology industry Core Insights - The synthetic biology sector is experiencing a global revolution, integrating into economic and social development to address major challenges such as health, climate change, and food security. The National Development and Reform Commission has issued the "14th Five-Year Plan for Bioeconomic Development," indicating a trillion-yuan market potential in the bioeconomy [4] Industry Market Dynamics - The synthetic biology index decreased by 9.66% to 1437.31 during the week of April 5-11, 2025, underperforming compared to the Shanghai Composite Index, which fell by 1.62%, and the ChiNext Index, which dropped by 4.21% [5][17] - The top five performing companies in the synthetic biology sector during this period were: - Novozymes (+27%) - Shandong Heda (+10%) - Yaxing Co. (+10%) - Pro Pharma (+3%) - Huafeng Chemical (+2%) [18] - The bottom five performing companies were: - Xinri Hengli (-18%) - Kasei Biotech (-12%) - Yaborn Chemical (-9%) - Berry Genomics (-7%) - Blue Biological (-6%) [22] Company Business Developments - Anhui Pucan launched the world's largest CO₂-based polycarbonate production facility, with an annual capacity of 50,000 tons, expected to generate sales of 1.5 billion yuan [23] - Huafeng Chemical plans to acquire two subsidiaries to integrate the polyurethane supply chain, with projected combined revenue exceeding 6.4 billion yuan in 2024 [23] - Tianchen Company signed a contract for a 100,000 tons/year bioethanol project in Egypt, marking its first venture into the North African market [24] Industry Financing Tracking - Synthetic biology companies are accelerating financing, with nearly 100 firms completing new rounds of funding since the beginning of 2025. Zhongsheng Suyuan Biotechnology raised 235 million yuan in its B round, focusing on iPSC-derived cell therapies [28][29] Company R&D Directions - Jinbo Biotech received approval for its recombinant type III human collagen injection product, marking a breakthrough in high-end medical aesthetics [31] - CellX's mushroom mycelium protein received FDA GRAS certification, allowing entry into the U.S. market [31] - MycoTechnology's truffle sweet protein ClearHT received FEMA GRAS certification, showcasing advancements in natural flavoring and health foods [32]

Summary of Conference Call Company Overview - The conference call was hosted by a pharmaceutical company, 普利奥运 (Puliouyun), discussing its operational performance for 2024 and future outlooks [1] Key Financial Metrics - Revenue for 2024 reached 12.022 billion, a year-on-year increase of 4.77% [2] - Gross profit was 1.031 billion, a decrease of 2.29% year-on-year [2] - Revenue from the fuel segment was 8.651 billion, up 8.32% year-on-year, but gross margin decreased by 7.68% [2] - The CDMO segment reported revenue of 1.884 billion, down 6.05% year-on-year [2] R&D and Investment - R&D investment for the year was 611 million, a 2.66% increase year-on-year, with expectations for continued growth in R&D spending [3] - The company has 355 commercialized projects, a 25% increase year-on-year, with 262 in usable drugs and 48 in social drugs [4] - The company has signed confidentiality agreements with 572 innovative drug companies, increasing by over 100 projects from the previous year [4] CDMO Business Insights - The CDMO business is seen as a major growth driver, with ongoing collaborations with both domestic and international companies [10] - The company aims to increase its API projects significantly, projecting 10 to 15 new DMFs annually over the next three years [5] - The CDMO team is expected to grow from 600 to around 1,000 personnel in the next two years [14] Market Challenges and Strategies - The pharmaceutical industry is experiencing intense competition, particularly in the antibiotic sector, leading to price pressures [15] - The company anticipates continued challenges in 2025 due to domestic market competition and geopolitical uncertainties [8] - Strategies include enhancing operational efficiency and adjusting production methods to mitigate price declines [15] Future Outlook - The company expects moderate growth in the CDMO segment, with a target of 3,000 operational projects in two years [18] - Gross margin is projected to increase slightly, with expectations of a 1-2% growth from the previous year's 41% [22] - The company emphasizes the importance of long-term investment strategies and technological innovation for sustainable growth [40] Additional Insights - The company is focusing on the medical beauty segment, which is expected to grow significantly, although its current contribution is limited [27] - The impact of price reductions due to competitive bidding is anticipated to be manageable, with a predicted effect of no more than 10% on overall performance [37] - The company is committed to maintaining a stable growth rate of around 20% over the coming years through strategic investments and operational improvements [31]

智通财经4月11日电，普洛药业在互动平台表示，公司2024年度直接出口美国的产品收入大约为5000万 美元，约占公司总出口收入的7%左右。目前，公司对美国的业务主要是CDMO和API业务，药品（制 剂）业务尚处于拓展期，销售很少，因此美国对药品加征关税，目前对公司影响较小。 普洛药业：对美出口收入约占公司总出口收入7% 美对药品加征关税影响较小 ...

Core Viewpoint - Prolo Pharmaceutical Co., Ltd. is currently engaged in a share repurchase plan aimed at implementing employee stock ownership and incentive programs, with a maximum repurchase price set at 22 RMB per share and a total repurchase fund between 75 million and 150 million RMB [2][4]. Trading Information Summary - As of April 2, 2025, Prolo Pharmaceutical's stock closed at 15.29 RMB, down 0.91%, with a turnover rate of 0.75%, a trading volume of 88,000 shares, and a transaction amount of 135 million RMB [1]. - On the same day, the main funds experienced a net outflow of 18.1 million RMB, accounting for 13.4% of the total transaction amount [2][4]. - Retail investors saw a net inflow of 19.1 million RMB, representing 14.11% of the total transaction amount [2]. Company Announcement Summary - The company announced on February 19, 2025, that it would use its own funds to repurchase shares through centralized bidding, with the repurchase period set for 12 months from the board's approval date [2]. - As of March 31, 2025, Prolo Pharmaceutical had not yet executed any share repurchases through the designated securities account [2][4].

证券代码：000739 证券简称：普洛药业 公告编号：2025-22 普洛药业股份有限公司 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 普洛药业股份有限公司（以下简称"公司"）于2025年2月19日召开第九届 董事会第十次会议审议通过了《关于回购公司股份方案的议案》，同意公司使用 自有资金以集中竞价交易方式回购公司部分股份，用于实施公司股权激励和员工 持股计划。本次回购股份价格不超过人民币22元/股（含），回购资金总额不低 于人民币7,500万元（含）且不超过人民币15,000万元（含）。具体回购股份数 量以回购期限届满或回购股份实施完毕时实际回购股份数量为准。回购期限为自 公司董事会审议通过回购股份方案之日起12个月内。具体内容详见公司分别于 2025 年 2 月 20 日 、 2025 年 2 月 21 日 在 《 证 券 时 报 》 和 巨 潮 资 讯 网 （http://www.cninfo.com.cn）上披露的《第九届董事会第十次会议决议公告》 （公告编号：2025-04）、《关于回购公司股份方案的公告》（公告编号：2025-05） 及《关于回 ...

证券代码：000739 证券简称：普洛药业 公告编号：2025-21 普洛药业股份有限公司 关于对下属公司担保的进展公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 一、担保情况概述 1、2025 年 3 月 28 日，普洛药业股份有限公司（以下简称"公司"）与招 商银行股份有限公司金华义乌支行（"招商银行"）签订《不可撤销担保书》（合 同编号：571HT250328T00018501）,同意为公司全资子公司浙江普洛家园药业有 限公司（以下简称"家园药业"）与招商银行签署的《借款合同》（合同编号： 571HT250328T000185）提供流动资金借款 2,000 万元连带责任保证，担保期限为 12 个月。 2、2025 年 3 月 28 日，公司与中国银行股份有限公司东阳支行（以下简称 "中国银行"）签订《保证合同》（合同编号：横店 2025 人保字 062 号），同 意为公司全资子公司山东普洛汉兴医药有限公司（以下简称"山东汉兴"）与中 国银行签署的《流动资金借款合同》（合同编号：横店 2025 人借字 062 号）中 的流动资金贷款 2,000 万元 ...

Investment Rating - The report maintains a "Buy" rating for the company, indicating an expected relative price increase of over 20% against the market benchmark within the next six months [7][20]. Core Views - The company experienced short-term fluctuations in its performance for 2024, with a revenue of 12.022 billion yuan, a year-on-year growth of 4.8%, and a net profit of 1.031 billion yuan, down 2.3% year-on-year. The operating cash flow showed strong performance, reaching 1.21 billion yuan, an increase of 17.2% [3][5][4]. - The CDMO (Contract Development and Manufacturing Organization) business is expected to see significant growth, with a project count increasing by 77% year-on-year, indicating a robust pipeline for future revenue [6][7]. - The antibiotic API and formulation sales are under short-term pressure, but the raw material and formulation business is projected to have a "front low and back high" trend in 2025, with improved profitability expected as the product matrix expands [6][7]. Financial Performance Summary - In 2024, the company achieved a revenue of 12.022 billion yuan, with a breakdown showing raw material drug revenue at 8.65 billion yuan (+8.3%), formulation revenue at 1.26 billion yuan (+0.5%), and CDMO revenue at 1.88 billion yuan (-6.1%). The overall gross margin for formulations improved to 60.8% (+7.7 percentage points) [5][6]. - The net profit forecast for 2025-2027 is adjusted to 1.15 billion yuan, 1.33 billion yuan, and 1.56 billion yuan, with growth rates of 12%, 15%, and 17% respectively [7][8]. - The company’s financial ratios indicate a stable outlook, with a projected P/E ratio decreasing from 17.4 in 2024 to 11.5 in 2027, reflecting anticipated growth in earnings [8][14].

Transaction Overview - The company is optimizing its asset structure through a transaction where its wholly-owned subsidiary, Zhejiang Puluo Debang Pharmaceutical Co., Ltd., transfers 100% equity and a debt of 6.9 million yuan in Sichuan Xinquan Dong Health Technology Co., Ltd. to Sichuan Jingxin Electric Co., Ltd. [1] - The transfer price is based on the net asset value of 26.4683 million yuan as of June 30, 2024, assessed by Shanghai Shenwei Asset Appraisal Co., Ltd. [1] Transaction Details - The transaction does not require approval from the board of directors or shareholders and does not constitute a related party transaction or a major asset restructuring as per relevant regulations [2] - The buyer, Sichuan Jingxin Electric Co., Ltd., has total assets of 42.9828 million yuan and net assets of 9.5720 million yuan for the year 2024 [2] Target Company Information - The target company, Sichuan Xinquan Dong Health Technology Co., Ltd., has total assets of 5.6510 million yuan and a net asset deficit of 1.2635 million yuan for the year 2024 [3] - The target company reported no operating income for the first two months of 2025 and a net loss of 19.40 million yuan [3] Agreement Highlights - The transfer includes 100% equity and a debt of 6.9 million yuan [4] - The total transfer price for the equity is set at 30.18 million yuan, with a total of 35.08 million yuan to be deposited in a fund supervision account [4] Purpose and Impact of the Transaction - The transaction aims to further optimize the company's asset structure and aligns with its development strategy [5] - Post-transaction, the target company will no longer be included in the company's consolidated financial statements, and it is expected to increase the company's profit by approximately 27.60 million yuan for the year 2025 [5]