Core Viewpoint - Kolun Pharmaceutical's subsidiary, Hunan Kolun Pharmaceutical Co., Ltd., has received drug registration approval from the National Medical Products Administration for its chemical drug "Paliperidone Palmitate Injection," which is used for the treatment of acute and maintenance phases of schizophrenia [1] Group 1 - The approved drug is specifically indicated for the treatment of schizophrenia, addressing both acute and maintenance phases [1] - The approval marks a significant milestone for Kolun Pharmaceutical, enhancing its product portfolio in the psychiatric treatment segment [1]

Core Viewpoint - Kolun Pharmaceutical's subsidiary, Hunan Kolun Pharmaceutical Co., Ltd., has received drug registration approval from the National Medical Products Administration for its chemical drug "Paliperidone Palmitate Injection" [1] Group 1: Product Approval - The "Paliperidone Palmitate Injection" was developed by Janssen Pharmaceuticals and was first approved in the United States in 2009 [1] - The drug was imported into China in 2011 and utilizes long-acting microcrystal technology, allowing for administration once a month [1] Group 2: Indications - The injection is indicated for the treatment of acute and maintenance phases of schizophrenia [1]

证券代码：002422 证券简称：科伦药业 公告编号：2025-082 四川科伦药业股份有限公司 关于公司棕榈酸帕利哌酮注射液获得药品注册批准的公告 本公司及董事会全体成员保证公告内容的真实、准确和完整，对公告的虚假记载、误 导性陈述或者重大遗漏负连带责任。 四川科伦药业股份有限公司（以下简称"公司"或"科伦药业"）子公司湖 南科伦制药有限公司的化学药品"棕榈酸帕利哌酮注射液"于近日获得国家药 品监督管理局的药品注册批准，现将相关情况公告如下： 药品批准文号：国药准字 H20255927、国药准字 H20255926、国药准字 H20255925 上市许可持有人：湖南科伦制药有限公司 审批结论：根据《中华人民共和国药品管理法》及有关规定，经审查，本品 符合药品注册的有关要求，批准注册，发给药品注册证书。 2. 药品的其他相关情况 棕榈酸帕利哌酮注射液由杨森制药研发，2009 年美国首获批，2011 年中国 批准进口，采用长效微晶技术实现每月给药一次，用于精神分裂症急性期和维持 期的治疗。 一、药品基本情况 1. 药品名称：棕榈酸帕利哌酮注射液 剂型：注射剂 规格：按 C23H27FN4O3计（1）0.75ml ...

Core Viewpoint - The Medical Health Index (980016) closed at 6572.66 points, down 0.65%, with a trading volume of 23.397 billion yuan and a turnover rate of 0.87% on November 14 [1] Group 1: Index Performance - Among the index constituents, 16 stocks rose while 33 stocks fell, with Ganli Pharmaceutical leading the gainers at a 2.0% increase and Yirui Technology leading the decliners at a 3.74% decrease [1] - The top ten constituents of the Medical Health Index include major companies such as WuXi AppTec, Hengrui Medicine, and Mindray Medical, with respective weights of 13.66%, 11.00%, and 7.57% [1] Group 2: Market Capitalization and Stock Prices - The total market capitalization of the top ten constituents ranges from 553.09 billion yuan for Kelun Pharmaceutical to 4603.55 billion yuan for Rihai Shenzhou, with stock prices varying from 12.25 yuan to 298.80 yuan [1] - The performance of the top ten stocks shows a mix of slight declines, with WuXi AppTec down 1.49% and Hengrui Medicine down 1.04% [1] Group 3: Capital Flow - The Medical Health Index constituents experienced a net outflow of 472 million yuan from major funds, while retail investors saw a net inflow of 388 million yuan [1] - Detailed capital flow data indicates that Ganli Pharmaceutical had a net inflow of 62.98 million yuan from major funds, despite a net outflow from retail investors [2]

Core Insights - The healthcare innovation sector is showing positive momentum, with the China Securities Medicine and Medical Device Innovation Index (931484) rising by 0.31% as of November 14, 2025, and several key stocks, including Sanofi and Ganli Pharmaceutical, experiencing significant gains [1] Group 1: Market Performance - The China Securities Medicine and Medical Device Innovation Index has seen a 0.31% increase, with notable stock performances: Sanofi up 4.64%, Ganli Pharmaceutical up 3.28%, and Jiutian Pharmaceutical up 1.83% [1] - The Medical Innovation ETF (516820) has also risen by 0.26%, marking its third consecutive increase [1] Group 2: Clinical Developments - AstraZeneca announced successful Phase III clinical trials for Baxdrostat, which significantly reduced 24-hour average systolic blood pressure in patients with resistant hypertension over 12 weeks, indicating a new treatment pathway for hypertension [1] Group 3: Industry Trends - According to Dongfang Caifu Securities, the pharmaceutical industry showed improvement in Q3 2025, with the medical device sector experiencing a turning point, achieving positive year-on-year revenue growth and a notable narrowing of net profit declines [1] - The CXO sector performed exceptionally well in the first three quarters of 2025, with medical R&D outsourcing revenue increasing by 12.2% and net profit rising by 56.8%, particularly in ADC CDMO and peptide CDMO fields [2] - The index reflects the performance of 30 profitable and growth-oriented companies in the pharmaceutical and medical device sectors, with the top ten stocks accounting for 64.12% of the index [2]

Healthcare Policy - National Healthcare Security Administration held a series of discussions on the adjustment of the disease-based payment grouping scheme 3.0, involving over 70 representatives from medical institutions and industry associations [1] Drug and Medical Device Approvals - Shijiazhuang Pharmaceutical Group's application for the listing of Pertuzumab injection has been accepted by the National Medical Products Administration, targeting HER2-positive breast cancer [1] - Huason Pharmaceutical received a registration certificate for its special medical purpose formula food, Ganyimei®, designed for patients over 10 years old with strict fat restrictions and digestive absorption disorders [2] - United Imaging Healthcare's subsidiary obtained a medical device registration certificate for its color Doppler ultrasound diagnostic system, enhancing its product range across various market segments [3] - Yiling Pharmaceutical's application for the listing of Memantine Hydrochloride, a drug for treating moderate to severe Alzheimer's disease, has been approved [4] - Zhifei Biological's clinical trial application for a freeze-dried varicella inactivated vaccine has been accepted by the National Medical Products Administration [10] - Changchun High-tech's subsidiary received approval for a clinical trial of an acellular pertussis-diphtheria-tetanus combined vaccine for adolescents and adults [11] Capital Market Activities - Peking University Pharmaceutical announced the release of 34,615,386 shares from pledge, representing 51.52% of the pledged shares and 5.81% of the total share capital [5] - Kelun Pharmaceutical received approval for a registration of 4 billion yuan in ultra-short-term financing bonds, with a validity period of 2 years [6][7] - Baili Tianheng decided to delay its global offering and listing of H-shares due to current market conditions [8] - Aipeng Medical announced a plan for a shareholder to reduce holdings by up to 1% of total shares, citing personal funding needs [12] - Hendi Pharmaceutical's shareholders plan to collectively reduce their holdings by up to 2.33% of total shares for personal financial planning [13] Financial Adjustments - Baihua Pharmaceutical plans to use 1.91 billion yuan from its capital reserve to cover losses, primarily due to goodwill impairment from a previous major asset restructuring [14]

Core Points - Sichuan Kelun Pharmaceutical Co., Ltd. has approved the issuance of non-financial corporate debt financing instruments at the board meeting on April 22, 2025, and this was further approved at the annual general meeting on May 19, 2025 [1][2] - The company received a registration acceptance notice from the National Association of Financial Market Institutional Investors on November 11, 2025, allowing the registration of its ultra-short-term financing bonds [1] - The company plans to issue the bonds in phases based on funding needs and market conditions, and will fulfill its information disclosure obligations in a timely manner [1]

Core Points - The Shanghai Composite Index is at 4008.92 points, above the annual line, with a change of 0.22% [1] - A total trading volume of A-shares reached 894.89 billion yuan today [1] - 39 A-shares have surpassed the annual line, with notable stocks including Hangxin Technology, Liwang Co., and Chuanfa Longmang, showing significant deviation rates [1] Summary by Category Market Performance - The Shanghai Composite Index is currently at 4008.92 points, reflecting a 0.22% increase [1] - The total trading volume for A-shares today is 894.89 billion yuan [1] Stocks Surpassing Annual Line - 39 A-shares have crossed the annual line, with the highest deviation rates recorded for: - Hangxin Technology: 4.59% - Liwang Co.: 3.56% - Chuanfa Longmang: 3.27% [1] - Other stocks with smaller deviation rates include: - Jiuzhou Group - Dali Kaipu - Tiens Wind Power [1] Detailed Stock Data - Notable stocks and their performance: - Hangxin Technology: +4.52%, turnover rate 5.95%, latest price 17.34 yuan, deviation rate 4.59% [1] - Liwang Co.: +5.42%, turnover rate 5.46%, latest price 28.02 yuan, deviation rate 3.56% [1] - Chuanfa Longmang: +3.57%, turnover rate 3.12%, latest price 13.07 yuan, deviation rate 3.27% [1]

Core Points - The company, Kelun Pharmaceutical, announced the receipt of a registration notice from the China Interbank Market Dealers Association, which accepted the registration of its ultra-short-term financing bonds [2] Group 1 - The registration notice was issued on November 11, 2025, and received by the company on November 12, 2025 [2]

Core Viewpoint - The Medical Health R Index (480016) closed at 7616.59 points, up 0.5%, with a trading volume of 25.943 billion yuan and a turnover rate of 0.88% on November 12. The index saw 27 stocks rise, led by BeiGene with a 5.62% increase, while 21 stocks fell, with Tigermed leading the decline at 1.68% [1]. Group 1: Index Performance - The Medical Health R Index reported a net inflow of 537 million yuan from main funds, while retail and speculative funds experienced net outflows of 264 million yuan and 273 million yuan, respectively [1]. - The top ten constituent stocks of the index include WuXi AppTec, Hengrui Medicine, and Mindray Medical, with respective weights of 13.66%, 11.00%, and 7.57% [1]. Group 2: Stock Details - BeiGene (688235) had the highest increase at 5.62%, closing at 293.62 yuan with a market capitalization of 452.37 billion yuan [1]. - Hengrui Medicine (600276) saw a 1.70% increase, closing at 62.10 yuan with a market capitalization of 412.17 billion yuan [1]. - WuXi AppTec (603259) experienced a slight decrease of 0.16%, closing at 92.35 yuan with a market capitalization of 275.55 billion yuan [1]. Group 3: Fund Flow Analysis - Hengrui Medicine had a main fund net inflow of 2.74 million yuan, while speculative funds saw a net outflow of 60.98 million yuan [2]. - BeiGene also experienced a main fund net inflow of 1.81 million yuan, with speculative funds facing a net outflow of 172 million yuan [2]. - The overall fund flow indicates a mixed sentiment among investors, with main funds showing some interest while retail and speculative funds are withdrawing [2].