证券代码：002422 证券简称：科伦药业 公告编号：2025-065 四川科伦药业股份有限公司 关于签订募集资金监管协议的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚假记载、误 导性陈述或重大遗漏。 一、募集资金基本情况 经中国证券监督管理委员会《关于核准四川科伦药业股份有限公司公开发行 可转换公司债券的批复》（证监许可[2022]255 号）核准，四川科伦药业股份有 限公司（以下简称"公司"）于 2022 年 3 月 18 日公开发行 3,000.00 万张可转换 公司债券，发行价格为每张 100 元，募集资金总额为人民币 300,000.00 万元，扣 除承销保荐费及其他发行费用人民币 1,994.60 万元（不含税）后，募集资金净额 为人民币 298,005.40 万元。以上募集资金到位情况已经毕马威华振会计师事务所 （特殊普通合伙）进行验资，并出具了"毕马威华振验字第 2200707 号"《募集 资金验证报告》。 二、本次募集资金专户的开立及监管协议的签订情况 公司于 2024 年 8 月 27 日召开第八届董事会第二次会议、第八届监事会第二 次会议，于 2024 年 9 ...

Group 1 - The core viewpoint of the article highlights that Kelun Pharmaceutical (002422) recognizes the scientific evidence supporting the antioxidant properties and safety of ergotamine, which is acknowledged by various international authorities [1] - Ergotamine is described as a star molecule in the field of antioxidants, indicating its significant role and potential in multiple applications [1]

Investment Rating - The investment rating for the company is "Buy" (maintained) [5] Core Views - Short-term performance is under pressure, but international expansion of innovative products opens up long-term growth opportunities [5] - The company reported a significant decline in revenue and net profit in the first half of 2025, primarily due to reduced demand in its large infusion and intermediate products business [7] - The company has a leading global ADC (Antibody-Drug Conjugate) R&D platform, with substantial potential in overseas markets [7] - The company has successfully transitioned from generic to innovative drug development, with significant R&D investments expected to yield returns [7] Financial Performance Summary - In the first half of 2025, the company achieved revenue of 9.08 billion (RMB), a year-on-year decrease of 23.2%, and a net profit of 1.0 billion (RMB), down 44.4% [7] - The revenue forecast for 2025 is 19.376 billion (RMB), with a year-on-year growth rate of -11.17% [6] - The projected net profit for 2025 is 2.417 billion (RMB), with a year-on-year decline of 17.67% [6] - The company’s gross margin for the first half of 2025 was 49.76%, a decrease of 4.07 percentage points year-on-year [7] - The company’s R&D expenses as a percentage of revenue increased to 11.54%, up 2.42 percentage points year-on-year [7] Business Segment Performance - Revenue from large infusion products in the first half of 2025 was 3.75 billion (RMB), a decline of 19.65% year-on-year [7] - Revenue from non-infusion pharmaceuticals was 1.955 billion (RMB), down 3.18% year-on-year [7] - Revenue from antibiotic intermediates and raw materials was 2.282 billion (RMB), a decrease of 30.29% year-on-year [7] - Overseas revenue was 1.13 billion (RMB), down 39.69% year-on-year, mainly due to a decline in overseas licensing income [7] Future Outlook - The company is expected to see a recovery in revenue from its two main business segments in 2026 [7] - The projected net profit for 2026 is 2.943 billion (RMB), with a year-on-year growth rate of 21.74% [6] - The company is positioned to become a leading global pharmaceutical enterprise, with significant growth potential in innovative drugs [7]

Group 1 - The stock price of Kelun Pharmaceutical reached a historical high, with an increase of 1.27% to 40.62 yuan, and a trading volume of 3.2887 million shares, amounting to 132 million yuan in transaction value, resulting in a turnover rate of 0.25% [2] - The latest total market capitalization of the stock is 64.913 billion yuan, with a circulating market capitalization of 53.045 billion yuan [2] - In the pharmaceutical and biotechnology industry, the overall decline is 0.02%, with 128 stocks rising, including Changchun High-tech, First Pharmaceutical, and Maiwei Biological, which increased by 9.99%, 9.73%, and 7.62% respectively [2] Group 2 - The latest margin trading data shows that as of September 1, the margin balance for the stock is 804 million yuan, with a financing balance of 798 million yuan, reflecting a decrease of 11.2271 million yuan over the past 10 days, a decline of 1.39% [2] - The company's semi-annual report indicates that it achieved an operating income of 9.083 billion yuan in the first half of the year, a year-on-year decrease of 23.20%, and a net profit of 1.001 billion yuan, down 44.41% year-on-year, with basic earnings per share of 0.6300 yuan and a weighted average return on equity of 4.35% [2]

Investment Rating - The report maintains a "Buy" rating for the company with a target price of 44, compared to the last closing price of 36.46 [1][7] Core Insights - The company has shown a recovery in Q2 revenue, with a quarter-on-quarter growth of 6.90%, despite a year-on-year decline in revenue and net profit for the first half of 2025 [4][5] - The innovative drug pipeline is entering a harvest phase, with several products receiving approvals and expected to contribute to future revenue growth [6][7] Financial Performance Summary - For the first half of 2025, the company reported revenue of 90.83 billion, a year-on-year decrease of 23.20%, and a net profit of 10.01 billion, down 44.41% year-on-year [4][5] - The gross profit for the first half was 45.19 billion, with a gross margin of 49.76%, a decrease of 4.07 percentage points compared to the same period last year [5] - The company’s operating expenses showed a slight increase, with a sales expense ratio of 15.82%, a decrease of 0.40 percentage points year-on-year, while the management expense ratio increased by 1.60 percentage points [5] Revenue and Profit Forecast - The company is projected to achieve revenues of 202.75 billion, 221.00 billion, and 243.00 billion for the years 2025, 2026, and 2027, respectively, with year-on-year growth rates of -7.05%, +9.00%, and +9.95% [7][9] - The forecasted net profit for the same years is 28.48 billion, 30.17 billion, and 32.01 billion, with growth rates of -3.01%, +5.96%, and +6.09% [7][9] Market Position and Competitive Landscape - The report indicates that the impact of centralized procurement on the company is expected to weaken, while the continuous contribution from innovative drugs is anticipated to drive growth [7]

Group 1 - The chemical pharmaceutical sector increased by 3.54% on September 1, with Maiwei Biotech leading the gains [1] - The Shanghai Composite Index closed at 3875.53, up 0.46%, while the Shenzhen Component Index closed at 12828.95, up 1.05% [1] - Notable gainers in the chemical pharmaceutical sector included Maiwei Biotech, which rose by 20.00% to a closing price of 57.60, and Xingqi Eye Medicine, which increased by 14.65% to 77.54 [1] Group 2 - The chemical pharmaceutical sector saw a net inflow of 1.245 billion yuan from main funds, while retail funds experienced a net outflow of 41.1167 million yuan [2] - The top stocks by main fund inflow included Heng Rui Medicine with 474 million yuan and Fuxing Medicine with 256 million yuan [3] - Conversely, stocks like Duorui Medicine and ST Suwu experienced significant declines, with Duorui Medicine down 9.36% to 41.17 [2][3]

Group 1 - The stock price of Kelun Pharmaceutical (SZ:002422) reached its daily limit, closing at 40.11 yuan, with an increase of 10.01% [1] - The total market capitalization of Kelun Pharmaceutical is 64.098 billion yuan [1]

Core Viewpoint - The company expects a stable long-term demand for antibiotics despite a short-term decline in market demand compared to the previous year [1] Antibiotic Intermediates Overview - The market demand for thiocyanate erythromycin remains stable, with a balanced supply and demand [1] - Domestic and international demand for cephalosporin intermediates has decreased year-on-year, but the absence of new large-scale production capacity has allowed the company to optimize production allocation, keeping market prices stable [1] - The demand for penicillin intermediates has declined due to changes in disease prevalence and the introduction of new production capacity, leading to a significant price drop; however, the company anticipates a gradual stabilization of prices as some outdated capacities are shut down and Indian production capacity does not meet expectations [1]

Group 1 - The core point of the article is that Kelun Pharmaceutical (002422) has successfully reduced production costs and improved efficiency through the operation of two high-speed production lines [1] - The company reported a cost reduction of approximately 20% in workshop costs compared to previous levels, indicating enhanced operational efficiency [1]

Core Viewpoint - Kelun Pharmaceutical (002422) announced on September 1 that the market and production capacity of traditional antibiotic fermentation in China remain stable, with no significant new capacity expected in the short term due to national policies against overcapacity and internal competition [1] Group 1: Domestic Market Dynamics - The market structure and production capacity of traditional antibiotics in China are overall stable [1] - Under the backdrop of national policies aimed at reducing overcapacity, significant new production capacity for the three major antibiotic intermediates is unlikely to emerge in the short term [1] Group 2: International Competition - In India, the PLI (Production-Linked Incentive) scheme has led to increased production capacity in the penicillin sector, but Chinese companies still hold a significant cost advantage and influence in the penicillin fermentation field [1] - Chinese companies are accelerating direct exports to international markets, indicating a shift towards global competition in the penicillin industry between China and India [1] - China is expected to maintain a dominant position in the global competition due to its technological and cost advantages [1]