Core Insights - The company has achieved a historic profitability milestone, crossing the breakeven point with total revenue of $5.343 billion in 2025, a 40% increase year-over-year, and a net profit of $286.933 million, reversing a loss of $645 million in 2024 [1][3]. Financial Performance - Total revenue for Q4 2025 reached $1.498 billion, up 33% from $1.128 billion in Q4 2024 [2] - GAAP operating profit for 2025 was $447.136 million, compared to a loss of $79.425 million in 2024, marking a 333% improvement [2] - Non-GAAP operating profit soared to $1.1 billion, a more than 23-fold increase from $45.36 million in 2024 [3] - Free cash flow turned positive at $942 million, a significant turnaround from a negative $633 million in 2024 [3] Product Performance - The flagship product, Bruton Tyrosine Kinase (BTK) inhibitor, generated $3.9 billion in global sales for 2025, a 49% increase, with Q4 sales exceeding $1.1 billion, up 38% [2][4] - The second core product, 百泽安, achieved global sales of $182 million in Q4, an 18% increase, and $737 million for the year, a 19% increase [5] Pipeline Developments - The BCL2 inhibitor, Sotoclar, received global approval in China and is expected to be a key growth driver with an FDA decision anticipated in H1 2026 [6] - Multiple early-stage products have commenced human trials, with a CDK4 inhibitor expected to start a Phase 3 trial in H1 2026 [6] Profitability and Cost Management - GAAP gross margins improved to 87.3% for 2025, up from 84.3% in 2024, reflecting enhanced production efficiency [7] - Operating expenses grew by 12% to $4.227 billion, significantly lower than the 40% revenue growth, indicating effective cost management [7] Cash Flow and Balance Sheet - Cash and cash equivalents increased to $4.61 billion, a 75% rise from $2.64 billion at the end of 2024 [8] - The company reported a net cash inflow from operating activities of $1.128 billion, a stark contrast to a net outflow of $141 million in 2024 [8] 2026 Guidance - The company projects total revenue between $6.2 billion and $6.4 billion for 2026, representing an approximate 20% year-over-year growth [3][9] - Expected GAAP operating profit is forecasted to be between $700 million and $800 million, with non-GAAP operating profit anticipated to reach $1.4 billion to $1.5 billion [9]

內幕消息 百濟神州有限公司 截至2025年12月31日止三個月未經審核業績 及截至2025年12月31日止全年經審核業績以及 業務進展 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 BeOne Medicines Ltd. 百濟神州有限公司 （根據瑞士法律註冊成立的公司） （股份代號：06160） 本公告乃根據香港聯合交易所有限公司證券上市規則（「上市規則」）第13.09條及 根據證券及期貨條例（香港法例第571章）第XIVA部而刊發。 百濟神州有限公司（「本公司」或「百濟神州」）欣然公佈其截至2025年12月31日 止第四季度的未經審核綜合財務業績及截至2025年12月31日止全年的經審核綜 合財務業績以及業務進展。 本公司欣然公佈本公司及其附屬公司截至2025年12月31日第四季度未經審核綜合 財務業績（「季度業績」）及截至2025年12月31日止全年經審核綜合財務業績（「全 年業績」）以及關鍵業務亮點和2026年財務指引（「業務進展」）。季度業 ...

目录 美国 证券交易委员会 Washington, D.C. 20549 表格 10-K （选择一项） ☒ 根据 1934 年证券交易法第 13 条或第 15 条(d)节的年度报告 截至 2025 年 12 月 31 日的财政年度 或 ☐ 根据 1934 年证券交易法第 13 条或第 15 条(d)节的过渡报告 过渡期从 至 交易委员会递交编号：001-37686 BEONE MEDICINES LTD. 百济神州有限公司 （注册人章程载明的确切名称） | 各类别名称 | 交易代码 | 各证券交易所名称 | | --- | --- | --- | | 每股美国存托股份相当于 13 股普通股，每股面值 0.0001 美元 | ONC | 纳斯达克全球精选市场 | | 普通股，每股面值 0.0001 美元* | 06160 | 香港联合交易所有限公司 | （注册成立或组建的州或其他司法管辖区） （美国国家税务局雇主身份识别号码） 瑞士 98-1209416 c/o BeOne Medicines I GmbH 94 Aeschengraben 27 Basel 4051 瑞士 （主要行政办事处地址，包括邮政编码） ...

Core Viewpoint - BeiGene reported a significant increase in revenue and profitability for the fiscal year 2025, driven by product sales growth and improved operational efficiency [1] Financial Performance - The company achieved a revenue of 38.205 billion yuan, representing a year-on-year growth of 40.4% [1] - The net profit attributable to shareholders was approximately 1.422 billion yuan, marking a turnaround from previous losses [1] Growth Drivers - The revenue increase was primarily attributed to the sales growth of Baiyueze, licensed products from Amgen, and Baizean [1] - Profitability improvements were supported by revenue growth and enhanced operational efficiency through effective cost management [1]

茲載列本公司於上海證券交易所網站刊發的《百濟神州有限公司自願披露關於 2026年度經營業績預測的公告》，僅供參閱。 承董事會命 百濟神州有限公司 主席 歐雷強先生 香港，2026年2月26日 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 BeOne Medicines Ltd. 百濟神州有限公司 （根據瑞士法律註冊成立的公司） （股份代號：06160） 海外監管公告 本公告乃百濟神州有限公司（BeOne Medicines Ltd., 「本公司」）根據香港聯合交易 所有限公司證券上市規則第13.10B條作出。 於本公告日期，本公司董事會包括主席兼執行董事歐雷強先生、非執 行董事王曉東博士，以及獨立非執行董事 Olivier Brandicourt 博士、 Margaret Han Dugan博士、Michael Goller先生、Anthony C. Hooper先生、 Ranjeev Krishana先生、Alessandro Riva博士、Cor ...

自愿披露关于2026年度经营业绩预测的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 百济神州有限公司（以下简称"公司"）于 2026 年 2 月 26 日发布根据美 国公认会计原则及美国证券交易委员会适用规则编制的截至 2025 年 12 月 31 日 止年度经审计财务业绩并同步发布根据中国企业会计准则编制的 2025 年度未经 审计业绩快报公告。为让投资者更好地了解公司经营业绩情况和未来业绩前景， 公司将 2026 年度经营业绩预测情况公告如下： 一、2026 年度经营业绩预测 综合近年来的业务发展趋势，公司预计的中国企业会计准则下 2026 年全年 的经营业绩如下： | | 年度经营业绩预测 2026 | | | | --- | --- | --- | --- | | 营业收入 | 将介于人民币 436 450 | 亿元至 | 亿元之间 | | 毛利率% | 80%区间的高位 | | | | 研发费用、销售及管理费用合计 | 将介于人民币 333 | 亿元至 348 | 亿元之间 | A 股代码：688235 ...

北京商报讯（记者 丁宁）2月26日晚间，百济神州（688235）发布关于2026年度经营业绩预测的公告显 示，综合近年来的业务发展趋势，公司预计的中国企业会计准则下2026年营业收入将介于436亿元至450 亿元之间，毛利率将为80%区间的高位。 ...

Core Viewpoint - BeiGene reported a significant turnaround in its financial performance for the year 2025, achieving a total revenue of 38.205 billion yuan, a year-on-year increase of 40.4%, and a net profit attributable to shareholders of 1.422 billion yuan, compared to a net loss of 4.978 billion yuan in the previous year [1] Financial Performance - The total revenue for 2025 reached 38.205 billion yuan, marking a 40.4% increase compared to the previous year [1] - The net profit attributable to the parent company's shareholders was 1.422 billion yuan, a significant recovery from a net loss of 4.978 billion yuan in the prior year [1] - The increase in revenue was primarily driven by sales growth of Baiyueze®, licensed products from Amgen, and Baizean® [1] Operational Efficiency - The company achieved profitability in operating profit, total profit, net profit attributable to shareholders, net profit excluding non-recurring items, and basic earnings per share compared to the previous year [1] - The improvement in profitability was attributed to revenue growth from products and enhanced operational efficiency driven by effective cost management [1]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 BeOne Medicines Ltd. 百濟神州有限公司 （根據瑞士法律註冊成立的公司） （股份代號：06160） 海外監管公告 本公告乃百濟神州有限公司（BeOne Medicines Ltd., 「本公司」）根據香港聯合交易 所有限公司證券上市規則第13.10B條作出。 茲載列本公司於上海證券交易所網站刊發的《百濟神州有限公司2025年度業績快 報公告》，僅供參閱。 承董事會命 百濟神州有限公司 主席 歐雷強先生 香港，2026年2月26日 於本公告日期，本公司董事會包括主席兼執行董事歐雷強先生、非執 行董事王曉東博士，以及獨立非執行董事 Olivier Brandicourt 博士、 Margaret Han Dugan博士、Michael Goller先生、Anthony C. Hooper先生、 Ranjeev Krishana先生、Alessandro Riva博士、Corazon (Cor ...

Core Insights - The company reported a significant increase in product revenue and total revenue for the fiscal year 2025, with product revenue reaching 37.77 billion yuan, a year-on-year increase of 39.9%, and total revenue at 38.205 billion yuan, up 40.4% [1] Group 1: Financial Performance - The net profit attributable to the parent company was 1.422 billion yuan for the reporting period [1] - Total assets increased to 57.423 billion yuan, reflecting a growth of 34.1% compared to the beginning of the period [1] - Equity attributable to the parent company rose to 30.601 billion yuan, marking a 26.6% increase from the start of the period [1] Group 2: Product Performance - The global sales of Baiyueze reached 28.067 billion yuan, representing a year-on-year growth of 48.8%, solidifying its position as a global leader in the BTK inhibitor market [2] - Sales in the U.S. amounted to 20.206 billion yuan, up 45.5%, while European sales were 4.265 billion yuan, increasing by 66.4% [2] - In China, sales totaled 2.472 billion yuan, reflecting a growth of 33.1% [2] - Baiyueze's sales in 2025 were significantly driven by its broad regulatory approvals and strong clinical efficacy data in chronic lymphocytic leukemia (CLL) [2] Group 3: Clinical Development - Baiyueze is the only BTK inhibitor with flexible dosing options and has been involved in over 45 clinical trials across more than 30 countries, enrolling over 7,900 patients [3] - The drug has shown significant benefits in progression-free survival (PFS) in the global Phase 3 ALPINE trial, with a median follow-up of 29.6 months [3] - The company plans to conduct a mid-term analysis of the Phase 3 MANGROVE trial in the first half of 2026 [3] Group 4: Other Products - Baizean, a cornerstone product for solid tumors, has shown potential across various cancer types and has been approved in over 50 markets globally [4] - The company is expanding Baizean's market presence and has reported significant survival improvements in HER2-positive gastric cancer patients when combined with chemotherapy [4] - Regulatory submissions for new indications of Baizean are expected in the first half of 2026 in the U.S. and China [4]