Financial Data and Key Metrics Changes - Group sales increased by 6% for the quarter, core operating profit rose by 12%, and core earnings per share grew by 15% to 46.5p [3][4] - Cash generation remained strong with £3.7 billion generated in the first half, supporting further investments and shareholder returns [4][55] - The dividend for the quarter was 16p, and over £800 million of the share buyback program has been completed [4][55] Business Line Data and Key Metrics Changes - Specialty medicines sales grew by 15%, while vaccine sales increased by 9% in the quarter [3][33] - The oncology portfolio saw a significant increase of 42%, with Gempelli for endometrial cancer up 91% and Adjara sales up 69% [36] - The HIV portfolio grew by 12%, driven by strong demand for long-acting injectables and Dovato, with Cabanuva and Aptitude showing robust growth [40][41] Market Data and Key Metrics Changes - Sales for vaccines in Q2 were £2.1 billion, up 9%, primarily driven by strong demand for Shingrix and meningitis vaccines [46] - Shingrix sales grew by 6% globally, with 72% of sales coming from outside the US [46] - The general medicines segment declined by 6% due to tough comparisons and continued generic competition [50] Company Strategy and Development Direction - The company is focused on investing for growth, particularly in specialty medicines and vaccines, with a commitment to R&D and business development [5][8] - GSK aims to drive a step change in performance following the demerger of Halion, with expectations to reach over £40 billion in sales by 2031 [11][12] - The company is prioritizing capital allocation towards high-potential assets and expanding its pipeline in areas of high unmet need [8][30] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in achieving the top end of financial guidance for 2025, citing strong performance and pipeline prospects [4][62] - The company remains optimistic about its long-term outlook, with a focus on delivering transformational specialty medicines and vaccines [13][32] - Management highlighted the importance of maintaining momentum in R&D and the potential for significant growth in various therapeutic areas [30][32] Other Important Information - The FDA has extended the review period for BLENREP, with a new target action date of October 23, 2025 [7][22] - The company is expanding its voluntary license agreement with the Medicines Patent Pool to include long-acting cabotegravir for HIV treatment and prevention [4][5] - GSK's overall planned investment in the USA is expected to be in the tens of billions of dollars over the next five years [10] Q&A Session Summary Question: Clarification on Camlopixant and Blendrep - Management confirmed that the updated PDUFA date for Blendrep is in October and expressed confidence in the ramp-up of Glenrep, with no change to expectations for 2028 and 2031 outlooks [65][67] Question: Confidence in Blendrep Approval and Impact on Margins - Management reiterated high confidence in Blendrep's approval and its importance for maintaining margins, emphasizing ongoing constructive dialogue with the FDA [73][78] Question: Supply Chain Costs and Gross Margin Expectations - Management indicated that while supply chain optimization charges are impacting gross margin, specialty growth is expected to drive improvement overall [87][88]

葛兰素史克公司CFO：预计下半年将出现一些关税，这将略微降低毛利率。 ...

Q2 2025 Performance Highlights - Q2 2025 sales reached £7,986 million, a 6% increase[9] - Core EPS increased by 15% to 465 pence[9] - Core operating profit increased by 12% to £2,631 million[10] - Cash generated from operations year-to-date is £37 billion[10] Specialty Medicines Growth - Specialty Medicines sales increased by 15%[9] - Specialty medicines largest business: 40% sales[14] - HIV sales increased by 12% to £1,880 million[56] - Vaccines sales increased by 22%[71] Financial Outlook and Guidance - Expect to deliver towards the top end of 2025 guidance range[9] - Sales growth is projected at 3-5%[24] - Core OP growth is projected at 6-8%[24] - Expect sales of >£40 billion in 2031[18]

(Translation of registrant's name into English) 79 New Oxford Street, London, WC1A 1DG UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of July 2025 Commission File Number 001-15170 GSK plc (Address of principal executive office) Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F. Form 20- ...

Core Viewpoint - The recent $5 billion upfront payment by GSK for the overseas rights of HRS-9821 and 11 innovative projects from Heng Rui Pharmaceutical highlights the growing interest and potential in the COPD treatment market, which has seen little innovation for over a decade [1][2]. Group 1: Market Dynamics - The global COPD market is projected to exceed $20 billion by 2024, with HRS-9821 being a significant new entrant after a long period without new mechanisms [1][5]. - The approval of Ensifentrine, a PDE3/4 inhibitor, has revitalized interest in COPD treatments, demonstrating a 36%-43% reduction in acute exacerbation rates [5][6]. - The transaction indicates a shift in focus for Chinese pharmaceutical companies towards common and chronic diseases, revealing untapped value in the respiratory drug market [2][3]. Group 2: Competitive Landscape - Major players in the COPD treatment market include AstraZeneca, GSK, and Boehringer Ingelheim, which have historically dominated with LABA, LAMA, and ICS therapies [3][5]. - The success of PDE3/4 inhibitors is expected to prompt other pharmaceutical companies to explore similar pathways, with companies like Zhengda Tianqing and Haisco making significant progress in their own PDE3/4 inhibitor developments [9][10]. - The market is witnessing a potential consolidation of opportunities, with Chinese companies likely to dominate the remaining PDE3/4 development space [7][9]. Group 3: Future Opportunities - The complexity of COPD's pathophysiology suggests that while PDE3/4 inhibitors are promising, they will not be the only future players, as biologics targeting different mechanisms are also emerging [10][11]. - New therapeutic approaches, including cell therapies and biologics targeting TSLP, are being explored, indicating a diversification in treatment options for COPD [12][14]. - The anticipated market for COPD treatments may evolve into a tiered selection model, where traditional therapies provide foundational care while innovative products address more challenging cases [14].

Core Viewpoint - GlaxoSmithKline (GSK) reported better-than-expected profit performance and raised revenue forecasts for its key vaccine and pharmaceutical divisions [1] Financial Performance - The company’s adjusted earnings per share for Q2 rose to 46.5 pence, exceeding analyst expectations of 42.4 pence [1] - GSK anticipates that this year’s profits and sales will reach the upper end of the company’s forecast range [1] Key Products Driving Performance - The strong performance was driven by sales of the shingles vaccine Shingrix and specialty drugs for asthma, HIV, and cancer [1] - The vaccine division is expected to maintain sales at last year's levels, an improvement from previous expectations of a decline [1] Future Developments - GSK plans to initiate late-stage clinical trials for four drugs in the second half of the year, including two cancer drugs, a treatment for fatty liver, and an ultra-long-acting HIV therapy [1] Market Context - The company’s performance has accounted for the impact of tariffs, including the recent trade agreement between the US and Europe [1] - The vaccine business has faced uncertainty under the leadership of US Health Secretary Robert F. Kennedy, who is skeptical about immunizations [1]

葛兰素史克第二季度调整后每股收益为46.5便士，预期为42.4便士。 ...

Summary of Key Points from the Conference Call Industry Overview - The conference call discusses the **U.S. pharmaceutical industry**, particularly focusing on the dynamics between multinational pharmaceutical companies and U.S. biotech firms in the context of innovative drug transactions [1][2]. Core Insights and Arguments - **Payment Differences**: There is a significant difference in upfront payment amounts between multinational pharmaceutical giants and U.S. biotech companies. The former tend to have higher upfront payments due to their cash reserves, while the latter rely on financing, resulting in larger total milestone amounts [1][2]. - **Funding Sources for Biotech**: U.S. biotech companies primarily depend on financing for their operations. Their cash inflow mainly comes from fundraising activities, both pre- and post-IPO, which are often supported by large pharmaceutical companies [4][5]. - **Role of Venture Capital**: The U.S. venture capital (VC) industry is highly active in the pharmaceutical sector, with 33% of first-round financing projects in 2024 being in the medical field. The average funding amount per project in pharmaceuticals is significantly higher than in other sectors [5]. - **Corporate Venture Capital (CVC)**: CVC plays a crucial role in the U.S. VC market, accounting for 20% of the number of transactions but 55% of the total amount. This indicates that while CVC transactions are fewer, they involve larger sums, reflecting the dominance of industrial capital in the VC space [6][7]. - **Acquisition Strategies**: Multinational pharmaceutical companies invest heavily in acquiring innovative assets to enhance their product lines and ensure future sales. For instance, AbbVie and Pfizer have disclosed substantial investments in externally acquired blockbuster drugs [8][9]. - **Cash Flow Management**: These companies manage their finances through operational, financing, and investment cash flows. For example, Merck reported nearly $20 billion in operational cash inflow over the past three years [9][10]. Additional Important Insights - **U.S. Healthcare Market**: The U.S. healthcare market is a vital revenue source for multinational pharmaceutical companies, with the top five companies holding a 43% market share in the prescription drug market [11][12]. - **Federal Budget and Healthcare Spending**: The U.S. federal budget has expanded significantly, with healthcare spending constituting 25% of the budget. This reliance on federal funding underscores the importance of government support in the healthcare ecosystem [13][14]. - **Impact of Foreign Investors**: Foreign investors are the primary holders of U.S. government debt, indicating global support for the U.S. federal budget and healthcare market development [15]. - **Economic Indicators**: The call discusses how economic indicators like interest rate inversions can signal potential economic issues, affecting policy decisions and market transactions [22]. - **Future of the Biotech Ecosystem**: The future of the U.S. innovative drug ecosystem will depend on the expansion of U.S. government debt and the prevailing interest rate environment, which will influence both multinational companies and biotech firms [25]. Conclusion - The conference call highlights the intricate relationships and financial dynamics within the U.S. pharmaceutical industry, emphasizing the critical roles of funding sources, market strategies, and economic conditions in shaping the future of innovative drug development and commercialization.

Core Viewpoint - The innovative drug sector is experiencing significant growth, highlighted by a surge in stock prices and a notable partnership between Heng Rui Pharmaceutical and GlaxoSmithKline (GSK) for the development of up to 12 innovative drugs [1] Group 1: Market Performance - The innovative drug sector saw substantial gains, with Zai Lab rising over 16%, and Tigermed and Jiuzhou Pharmaceutical increasing by more than 8% [1] - The Tianhong Innovative Drug ETF (517380) rose approximately 5%, reaching a new high in this rebound, with a year-to-date increase of over 57%, making it the top-performing industry ETF [1] Group 2: Strategic Partnerships - Heng Rui Pharmaceutical and GSK have entered a collaboration agreement, with GSK paying a $500 million upfront fee and potential milestone payments totaling around $12 billion based on successful development, registration, and sales [1] - This partnership indicates a stronger trend of high-value external licensing for domestic innovative drugs and the gradual shift of global innovative drug R&D centers to China [1] Group 3: ETF Highlights - The Tianhong Innovative Drug ETF uniquely tracks the "Innovative Drug Industry Smart Beta Index," which includes opportunities from the Hong Kong, Shanghai, and Shenzhen markets [2] - The ETF focuses on the entire innovative drug industry chain, which helps mitigate uncertainties associated with investing in individual innovative drug companies, aiming for better risk-return characteristics and long-term investment returns [2] - The ETF includes both innovative drug companies and CXO enterprises, capturing growth opportunities in the innovative drug sector [3] - The ETF's quantitative indicators have been optimized for better performance, with a net value growth rate of 54.76% over the past year, outperforming the benchmark return of 50.36% by 4.4 percentage points [3]

Core Viewpoint - Heng Rui Medicine has made a significant announcement regarding its collaboration with GlaxoSmithKline (GSK), involving the licensing of global exclusive rights for the HRS-9821 project and up to 11 additional projects, marking a record for the company's innovative drug exports [2][3][4]. Group 1: Financial Details - The initial payment from GSK to Heng Rui is $500 million, with potential milestone payments amounting to approximately $12 billion, setting a new record for Heng Rui's innovative drug exports [2][4]. - Since the beginning of 2024, Heng Rui's total contract value from innovative drug exports is expected to exceed $20 billion [6]. - In Q1 2025, Heng Rui reported a net profit of 1.874 billion yuan, representing a year-on-year increase of 36.90% [9]. Group 2: Research and Development - Heng Rui's R&D investment for 2024 is 8.228 billion yuan, accounting for 29.40% of its operating revenue, with total R&D investment over the past decade reaching 42.267 billion yuan [2][7]. - The company has a robust pipeline with over 90 innovative products in clinical development and approximately 400 clinical trials ongoing domestically and internationally [7][8]. Group 3: Market Impact - Following the announcement of the record deal, Heng Rui's stock price surged, bringing its market capitalization back to 411.77 billion yuan [10]. - In 2024, Heng Rui's innovative drug sales revenue reached 13.892 billion yuan, a year-on-year increase of 30.60% [8].