香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準 確性或完整性亦不發表任何聲明，並明確表示概不會就因本公告全部或任何部份內容而產 生或因倚賴該等內容而引致之任何損失承擔任何責任。 （於開曼群島註冊成立之有限公司） （股份代號：2005） 截至二零二五年九月三十日止九個月 未經審核經營業績 本公告乃石四藥集團有限公司（「本公司」）根據證券及期貨條例（香港法例第571章）第 XIVA部之內幕消息條文（定義見香港聯合交易所有限公司證券上市規則（「上市規則」）） 及上市規則第13.09(2)條而作出。 本公司董事局（「董事局」）根據本公司及其附屬公司（統稱「本集團」）未經本公司核數師 審核或審閱之管理賬目，欣然公告以下本集團截至二零二五年九月三十日止九個月之未 經審核經營業績。 本集團銷售主要在中國進行並以人民幣計值，截至二零二五年九月三十日止九個月，人民幣 兌港元（「港元」）較去年同期貶值約0.9%。以港元而言，本集團截至二零二五年九月三十 日止九個月之未經審核營業額約31.02億港元，同比減少31.6%（本集團截至二零二五年六月 三十日止六個月（「二零二五年上半年」）之收益: 同比減 ...

Core Viewpoint - The company is facing challenges due to policies such as volume-based procurement and medical insurance cost control, leading to a decrease in revenue and net profit in the first three quarters of 2025 compared to the previous year [3]. Financial Performance - In the first three quarters of 2025, the company achieved a total operating revenue of 25.894 billion yuan, a year-on-year decrease of 3.42% [3]. - The net profit attributable to shareholders was 455 million yuan, down 4.64% year-on-year [3]. Corporate Actions - The company acquired 100% equity of Beijing Jinsui Technology Development Co., Ltd., resulting in retrospective adjustments to previous financial data as per accounting standards [5]. - The company has decided to waive its preferential right to acquire a 5% limited partnership interest in a health industry fund, which corresponds to a subscribed capital contribution of 100 million yuan [8]. Regulatory Developments - A subsidiary, Hubei Keyi Pharmaceutical Co., Ltd., received a drug registration certificate for Fusidic Acid Cream, which is used for skin infections caused by certain bacteria [43]. - The drug has been approved for registration after meeting the relevant requirements of the Drug Administration Law [44]. Market Context - The domestic market for Fusidic Acid Cream had total sales of approximately 500 million yuan in 2023 and is projected to reach 524 million yuan in 2024 [47]. - The company has multiple topical semi-solid formulations already on the market, and the new product will enhance its product pipeline and provide valuable experience for future generic drug development [49].

Investment Rating - The report gives an initial investment rating of "Buy" for the company 康哲药业 (00867.HK) [4][8]. Core Views - The company is positioned as a leading innovative platform in the pharmaceutical industry, with a focus on commercializing its innovative pipeline and expanding its market presence [4][7]. - The planned spin-off of 德镁医药 is expected to unlock additional value in the skin health segment, which has a comprehensive pipeline covering all indications in this area [7][8]. - The company has shown signs of a performance turnaround, with a 10.83% year-on-year increase in revenue for the first half of 2025, indicating a potential inflection point in its financial performance [7][17]. Summary by Sections Financial Performance - The company reported a total revenue of 8,013 million RMB in 2023, with a projected revenue of 8,166 million RMB in 2025, reflecting a growth rate of 9.3% [6][8]. - The net profit attributable to shareholders is expected to increase from 1,620 million RMB in 2024 to 1,681 million RMB in 2025, with a growth rate of 3.8% [6][8]. - The company’s earnings per share (EPS) is projected to be 0.69 RMB in 2025, with a return on equity (ROE) of 9.3% [6][8]. Business Strategy - 康哲药业 has undergone multiple transformations over its 30-year history, evolving from a sales agent to a company that controls product rights and now focuses on innovative product development [13][14]. - The company has diversified its business into three main segments: cardiovascular/digestive, skin health, and ophthalmology, aiming to create specialized teams for each area [21][24]. - The internationalization strategy has been accelerated with the recent listing on the Singapore Exchange, marking a significant milestone in its global expansion efforts [24][25]. Innovation and Pipeline - The company has five innovative drugs that have been commercialized in China, with several others in the NDA stage, indicating a robust pipeline for future growth [7][8]. - Key innovative products include 德昔度司他片 for chronic kidney disease anemia and ABP-671 for gout, both of which are expected to contribute significantly to future revenues [43][45]. - The company is leveraging a dual approach of collaboration and self-research to drive innovation, aiming to meet unmet clinical needs and enhance its product offerings [40][41].

Investment Rating - The report maintains a "Market Weight" rating for the pharmaceutical and biotechnology industry [2][24]. Core Viewpoints - The SW pharmaceutical and biotechnology industry underperformed the Shanghai and Shenzhen 300 index, declining by 0.23% from September 26, 2025, to October 9, 2025, lagging behind the index by approximately 2.76 percentage points [9][24]. - Most sub-sectors within the industry recorded negative returns during the same period, with the medical research outsourcing and in vitro diagnostics sectors showing gains of 1.99% and 0.55%, respectively, while the raw materials and chemical preparations sectors fell by 2.23% and 1.73% [10][24]. - Approximately 54% of stocks in the industry achieved positive returns, with the top performer, Zhendemedical, increasing by 21.43%, while the largest decline was seen in Guangshentang, which fell by 21.86% [11][14]. - The overall price-to-earnings (PE) ratio for the SW pharmaceutical and biotechnology industry was approximately 55.04 times as of October 9, 2025, indicating a decrease in industry valuation [15][24]. Summary by Sections 1. Market Review - The SW pharmaceutical and biotechnology industry underperformed the Shanghai and Shenzhen 300 index, with a decline of 0.23% from September 26, 2025, to October 9, 2025 [9]. - Most sub-sectors recorded negative returns, with medical research outsourcing and in vitro diagnostics performing better than others [10]. - About 54% of stocks in the industry recorded positive returns, with significant variations in individual stock performance [11]. 2. Industry News - The 11th batch of national procurement will begin accepting applications on October 21, 2025, with 55 major varieties included [22]. - The National Medical Products Administration issued guidelines for the quality management of medical device online sales [20][21]. 3. Company Announcements - Zhejiang Haizheng Pharmaceutical announced that its product achieved Self-GRAS certification in the U.S., allowing it to enter the U.S. market [23]. 4. Weekly Industry Perspective - The report suggests focusing on investment opportunities in innovative drugs and sectors with expected business development catalysts, including medical devices and pharmaceutical commerce [24][26].

Core Viewpoint - Duorui Pharmaceutical is facing significant challenges, including a potential change in control, declining revenue from its core product, and increasing financial burdens due to acquisitions. The company is exploring new growth avenues while grappling with a deteriorating financial situation [1][2][3][4][5][6][7]. Group 1: Control Change - Duorui Pharmaceutical's controlling shareholder, Tibet Jiakang Times Technology Development Co., Ltd., is planning a change in control, which may lead to a shift in the company's actual controller [2][7]. - The stock was suspended from trading on September 29, 2025, with an expected suspension period of no more than three trading days [2][1]. - As of now, no formal agreements have been signed regarding the control change, and the outcome remains uncertain [2][7]. Group 2: Financial Performance - Duorui Pharmaceutical's revenue has significantly declined since its listing in 2021, with a projected revenue drop of nearly 50% by 2024 compared to its peak [3][4]. - The company reported a revenue of 1.07 billion yuan in the first half of 2025, a year-on-year decrease of 29.13%, and a net loss of 42.5 million yuan, which is a 1197.26% increase in losses compared to the previous year [4]. - The core product, sodium acetate Ringer's injection, has seen a drastic revenue decline, with sales dropping from 465 million yuan in 2021 to an estimated 12 million yuan in 2024 [3][4]. Group 3: Product Challenges - The sodium acetate Ringer's injection, which accounts for nearly 50% of the company's main business revenue in 2024, has faced declining sales due to policy changes such as medical insurance cost control and centralized procurement [3][4]. - The company has acknowledged the risk of having a single product structure, which has contributed to its financial struggles [3]. Group 4: Acquisition Strategy - To counteract declining revenues, Duorui Pharmaceutical has pursued acquisitions, including Hubei Xinchengda Chemical Co., Ltd. and Sichuan Duorui Pharmaceutical Co., Ltd., to diversify its revenue streams [5][6]. - In the first half of 2025, Hubei Xinchengda contributed 33.18 million yuan to the company's revenue, accounting for 31% of total revenue [5]. - The acquisition of Sichuan Duorui involved a significant financial commitment, leading to increased management, financial, and research expenses [6]. Group 5: Financial Burden - The company's financial obligations have increased, with total liabilities reaching 754 million yuan and an asset-liability ratio of 52.01% as of June 2025, up from 23.37% at the end of 2023 [6]. - To finance acquisitions, Duorui Pharmaceutical's subsidiary applied for a merger loan of up to 300 million yuan, with the company providing a guarantee [6].

Core Viewpoint - Zhenghai Biological (300653) has reported that it is actively participating in volume-based procurement for its meninges products across multiple provinces, indicating a strategic response to market changes and regulatory developments [1] Group 1: Company Developments - As of now, six provincial and two inter-provincial alliances have initiated volume-based procurement for meninges products, covering a total of 24 provinces (autonomous regions and corps) [1] - The company has successfully won bids for its meninges series in all provinces where centralized procurement has been implemented, leading to a stable market share despite price reductions [1] Group 2: Market Impact - The centralized procurement has resulted in a decrease in the selling price of the company's meninges products, which has correspondingly increased sales volume [1] - The company is preparing for upcoming volume-based procurement projects, particularly in response to a notification from Tianjin regarding the maintenance of medical consumables information for hard brain (spinal) membrane patches [1]

Investment Rating - The report maintains a "Buy" rating for the company [5] Core Views - The company experienced short-term pressure on domestic performance due to policy disruptions, but expects a recovery in both volume and price in Q3 2025, leading to a potential inflection point in performance [2][3] - The overseas market continues to show strong growth, with local operations deepening, which is expected to result in a dual boost in revenue and profit [2][3] - The company has made significant progress in the installation of mid-to-high-end instruments, establishing a solid foundation for reagent sales [3] Summary by Sections Financial Performance - In H1 2025, the company achieved revenue of 2.185 billion yuan, a year-on-year decline of 1.18%, and a net profit of 771 million yuan, down 14.62% year-on-year [1] - Q2 2025 saw revenue of 1.060 billion yuan, a decrease of 10.88% year-on-year, and a net profit of 334 million yuan, down 30.06% year-on-year [1] - The gross margin in Q2 2025 was 68.89%, a decrease of 2.68 percentage points year-on-year, primarily due to a decline in the gross margin of instrument products [2] Domestic Market Insights - Domestic revenue in H1 2025 was 1.229 billion yuan, down 12.81% year-on-year, with reagent revenue declining by 18.96% while instrument revenue increased by 18.18% [2] - The report anticipates a recovery in domestic reagent revenue in Q3 2025 as the market adjusts to previous policy changes [2] Overseas Market Insights - The company achieved overseas revenue of 952 million yuan in H1 2025, an increase of 19.57% year-on-year, with overseas reagent business revenue growing by 36.86% [2] - The company has established 14 overseas branches and its products are sold in 161 countries and regions, indicating a strong international presence [2] Instrument Installation Progress - In H1 2025, the company installed 774 chemiluminescence instruments in the domestic market, with large machines accounting for 74.81% of installations [3] - The overseas market saw 1,971 installations, with large and medium-sized high-end models making up 77.02% of the total [3] Profit Forecast and Investment Recommendations - Revenue projections for 2025-2027 are 4.811 billion, 5.625 billion, and 6.624 billion yuan, with year-on-year growth rates of 6.1%, 16.9%, and 17.8% respectively [3] - Net profit forecasts for the same period are 1.887 billion, 2.243 billion, and 2.645 billion yuan, with year-on-year growth rates of 3.2%, 18.9%, and 17.9% respectively [3]

Core Viewpoint - Tianxing Medical, the largest sports medicine solution provider in China, has submitted an application for listing on the Hong Kong Stock Exchange after a failed attempt to list on the Shanghai Stock Exchange due to the withdrawal of its sponsor [1][4]. Company Overview - Tianxing Medical was established in 2017 and focuses on innovative medical devices for sports medicine, including implants, active devices, consumables, and surgical tools [1]. - As of December 31, 2024, the company had a market share of 6.5% in China's sports medicine market, with its products available in over 3,000 hospitals, including more than 1,000 tertiary hospitals [1]. Financial Performance - The company has shown explosive growth in revenue from 2022 to 2024, with revenues of approximately 147 million RMB, 239 million RMB, and 327 million RMB, respectively, representing a compound annual growth rate (CAGR) of over 40% [2][3]. - Net profits for the same period were 40.34 million RMB, 57.11 million RMB, and 95.39 million RMB, with gross margins increasing from 68.7% in 2022 to 71.7% in 2024 [2][3]. - In the first five months of 2025, the company achieved revenue of 111.41 million RMB, a year-on-year increase of 39.7%, and a profit of 32.60 million RMB, with a gross margin of 73.7% [2][3]. International Expansion - Tianxing Medical has increased its overseas presence, with overseas revenues growing significantly, reaching 2.09 million RMB in 2024 and 20.60 million RMB in the first five months of 2025, a year-on-year increase of 370.5% [3]. Shareholder Structure - The company was co-founded by three individuals, with the actual controller holding 41.47% of the shares before the IPO [4]. - There have been significant fluctuations in shareholding, with one founder reducing their stake from 55% to 4.9% through multiple transfers, raising concerns about the motivations behind these changes [4]. Valuation Concerns - The rapid increase in company valuation, from 800 million RMB in 2020 to 3.5 billion RMB before the IPO, has raised questions about the legitimacy of external investments aimed at inflating the company's valuation [4][5].

Investment Rating - The report maintains a "Buy" rating for the company with a target price of RMB 23.61 [7][8]. Core Views - The company reported a revenue of RMB 103.01 billion and a net profit attributable to shareholders of RMB 4.29 billion for 1H25, showing a year-on-year decline of 3.2% and 7.5% respectively. However, the revenue growth in 2Q25 improved compared to 1Q25, indicating a positive trend [1][2]. - The company has introduced a stock incentive and employee shareholding plan for 2025, reflecting confidence in future performance and aiming to enhance employee motivation and team stability [3]. - The overall expense ratio remained stable in 1H25, while the gross profit margin decreased by 0.74 percentage points year-on-year, primarily due to the impact of centralized procurement [4]. Summary by Sections Financial Performance - In 1H25, the industrial revenue was RMB 5.63 billion, with a net profit of RMB 0.90 billion, showing a slight increase in revenue but a decline in net profit. The wholesale revenue was RMB 80.51 billion, down 4.7% year-on-year, while retail revenue grew by 3.62% to RMB 16.43 billion [2][4]. - The company expects a gradual recovery in performance due to improved cash collection and the digestion of policy impacts [1][5]. Incentive Plans - The stock incentive plan aims for a growth rate of 6% to 12% in net profit and 20% to 30% in industrial revenue over the next two years compared to the average of 2022-2024 [3]. Valuation and Forecast - The forecast for net profit attributable to shareholders is adjusted to RMB 8.5 billion, RMB 8.9 billion, and RMB 9.2 billion for 2025, 2026, and 2027 respectively, with corresponding EPS of RMB 2.14, RMB 2.24, and RMB 2.32 [5][10]. - The company is valued at a PE ratio of 13x for industrial business, 10x for wholesale, and 11x for retail, reflecting the expected performance and market conditions [5][11].

Core Viewpoint - Weigao Group (01066) experienced a significant stock decline, with a drop of over 10% at one point, closing down 7.86% at HKD 5.98, with a trading volume of HKD 42.6254 million [1] Financial Performance - For the six months ending June 30, 2025, the company reported revenue of RMB 6.644 billion, representing a year-on-year increase of 0.13% [1] - The profit attributable to the company's owners was RMB 1.008 billion, a decrease of 8.96% year-on-year [1] - Basic earnings per share were RMB 0.22, with an interim dividend proposed at RMB 0.0969 per share [1] Margin and Cost Management - The group's gross profit margin decreased from 50.9% in the same period last year to 49.7%, although it stabilized on a quarter-on-quarter basis [1] - The company actively responded to national and regional volume-based procurement, leading to a reduction in sales prices for some products [1] - Efforts to reduce production costs partially offset the impact of price reductions on gross margin, and operational expenses were optimized to mitigate the effects of volume-based procurement on operating profit [1]