撰文丨王聪 编辑丨王多鱼 排版丨水成文 异种移植 （Xenotransplantation） 是指将一个物种的器官移植到另一个物种体内，最近几年，该领域取 得了一系列令人瞩目的突破。2021 年 10 月，纽约大学朗格尼医学中心首次将基因编辑的 猪肾脏 移植给 了一位脑死亡女性。2022 年 1 月，马里兰大学医学院进行了首例活人移植基因编辑 猪心脏 的手术，患者 在移植后存活了约 2 个月时间。 2025 年 3 月，空军军医大学西京医院 窦科峰 院士团队等在 Nature 期刊发表论文 【1】 。首次将 基因编 辑的猪肝脏 移植给一名脑死亡患者， 该器官在脑死亡患者体内成功存活并正常工作 10 天。 这些突破在全世界范围内引发了广泛关注，让我们燃起了使用基因编辑猪作为供体进行异种移植来缓解人 类器官移植短缺的希望。然而， 肺移植 因其解剖学和生理学复杂性，面临着不同于其他实体器官移植的挑 战。基因编辑的猪肺尚未被移植到人体内，因此，在异种肺移植的背景下，人体免疫反应以及发生超急性 排斥反应的可能性等关键问题仍未得到解答。 在这项最新研究中，研究团队报告了一例猪到人的肺异种移植案例，将一只经过六基因编辑的猪 ...

撰文丨王聪 编辑丨王多鱼 排版丨水成文 最近几年， 异种移植 的基础与临床研究取得里程碑式突破。 2021 年 10 月，纽约大学朗格尼医学中心首次将基因编辑的 猪肾脏 移植给了一位脑死亡女性。 2022 年 1 月，马里兰大学医学院进行了世界首例活人移植基因编辑 猪心脏 的手术，患者在移植后存活了约 2 个月时间。 2025 年 3 月， 空军军医大学西京医院 窦科峰 院士、 王琳 教授、 董海龙 教授、 陶开山 教授 及中科奥格生物科技有限公司 潘登科 教授等在国际顶尖学术期 刊 Nature 上发表论文 【1】 。介绍了世界首例将基因编辑改造的 猪肝脏 移植到脑死亡的人类受体的案例 （移植手术于 2024 年 3 月 进行） ，结果显示，基因 编辑改造的猪肝脏能够在人体内存活并发挥功能，有望成为等待人类供体的肝衰竭患者的过渡疗法。 基因工程猪的最新进展推动了猪到人类的异种器官移植研究，尤其是 心脏 、 肾脏 和 肝脏 的 异种移植 研究。 在这项最新研究中，研究团队对一名接受猪肝脏异种移植的人类患者在去世时其外周血和移植肝脏中的免疫细胞群进行了表征，该患者在 异种移植 后接受了为期 10 天的监测，监测 ...

Core Insights - The Second Lake District Life and Health Scientist Conference was held in Kunshan, Jiangsu, attracting over 200 top scientists, clinical experts, entrepreneurs, and investors to explore future solutions for human health [1][2] Industry Overview - The biopharmaceutical sector is identified as the primary industry in Suzhou, with Kunshan accelerating the construction of an innovative industrial cluster [1] - As of May 2023, Kunshan has over 230 biopharmaceutical-related enterprises [1] Strategic Development - The town of Dushan Lake is leveraging its strategic location within the Yangtze River Delta integration plan, being only 30 minutes from Hongqiao Hub, and its ecological resources with a 14-kilometer golden lakeshore [1] - Dushan Lake is focusing on cutting-edge life sciences technologies to establish a new framework for scientific innovation in the region [1] Conference Highlights - The conference featured presentations from leading experts on topics such as the relationship between inflammatory microenvironments and tissue regeneration, brain-computer interfaces, and the disruptive applications of artificial intelligence in drug screening and antibody drug development [2] - Discussions also included ethical norms and clinical pathways related to xenotransplantation [2] Research and Innovation - Since the establishment of the Extraordinary Life Science Industry Innovation Center in 2022, over 30 projects have been attracted to Dushan Lake, showcasing the "Lake District Effect" in the life and health industry [3] - The Kunshan LingSi Life Health Innovation Research Institute has formed an innovative team of over 50 young scientists, creating a mentorship model of "academicians leading, youth following" [3] Collaborative Efforts - Dushan Lake is collaborating with the Shanghai Modern Service Industry Association's Medical Service Committee and scientific teams to drive the industrialization of medical research achievements [3] - The unveiling of the "Fudan University Experimental Animal Center Kunshan Branch" marks another achievement in the collaborative development between Shanghai and Kunshan [4] Resource Utilization - The Kunshan branch will utilize Fudan University's leading international animal experiment resources and innovation standards to enhance the support for high-precision fields such as pharmacology, cell biology, and molecular biology [4] - The Extraordinary Life Science Industry Innovation Center aims to gather over 1,000 R&D talents within the next decade, with more than 100 biopharmaceutical scientists already in residence [4]

Group 1: ETF Market Overview - The total scale of ETFs surpassed 4 trillion yuan, reaching 4.31 trillion yuan, a year-on-year increase of 15.57% [1] - Bond ETFs experienced the largest growth, increasing by 120.71% to 383.976 billion yuan [1] - Broad-based ETFs accounted for half of the total ETF scale, with a current size of 2.23 trillion yuan, reflecting a 2% increase [1] - Eighteen ETFs saw their scale grow by over 10 billion yuan, with seven being stock ETFs, primarily in broad-based and thematic sectors [1] - 华夏基金 led the market with an increase of 93.17 billion yuan, managing a total of 751.336 billion yuan in ETFs [1] Group 2: Fund Distributions - Over a thousand funds have distributed dividends this year, totaling over 120 billion yuan, a 38% increase year-on-year [1] - The 华泰柏瑞沪深300ETF set a record with a single distribution of 8.394 billion yuan, the highest in domestic ETF history [1] Group 3: Special Bonds and Debt Issuance - The issuance of special bonds is expected to accelerate in the second half of the year, enhancing investment and growth stability [2] - The Ministry of Finance announced the issuance of 11 ultra-long special government bonds in the third quarter, with some issuance dates moved forward [2] Group 4: Industry Capacity Reduction - Various industries, including steel and photovoltaics, have initiated capacity reduction measures in response to "involution" competition [3] - The central government emphasized the need for orderly exit of backward production capacity, leading to a wave of industry adjustments [3] Group 5: Natural Gas Processing Facility - China's first full-chain deep cold processing plant for natural gas has commenced operations, capable of processing 2 billion cubic meters annually [3] Group 6: Corporate Developments - 河北资产管理股份有限公司 has submitted an application for an IPO in Hong Kong, marking a significant step for local asset management companies [5] - 立讯精密 is planning to issue H-shares and list on the Hong Kong Stock Exchange to enhance its global strategy and financing capabilities [5] - 天赐材料's subsidiary has filed a lawsuit for commercial secret infringement, with expected economic losses of 8.87 billion yuan [6] - 瑞康医药's board member has been placed under detention, but the company's operations remain unaffected [7] - 棒杰股份 reported overdue loans totaling 9.67 billion yuan in its photovoltaic segment, representing 322.51% of its audited net assets for 2024 [8]

Group 1 - The research team has developed a detailed "molecular battle map" of human immune cells responding to transplanted pig kidney tissues, marking a significant breakthrough in overcoming xenotransplantation immune rejection issues [1][2] - The study reveals that signs of antibody-mediated rejection can be detected as early as day 10 post-transplant, peaking at day 33, confirming the understanding that rejection reactions are aggressive yet progress slowly [1] - A dynamic tracking period of 61 days allowed the identification of a critical "treatment time window," and targeted therapeutic interventions have shown significant effects in suppressing immune attacks [1][2] Group 2 - By understanding specific immune interactions at the molecular level, the research enables the formulation of precise anti-rejection strategies, potentially increasing transplant survival rates [2] - The findings provide a roadmap for optimizing genetically edited pigs and developing new anti-rejection drugs, with genetically modified pig kidneys expected to enter clinical routine applications within ten years, pending regulatory approval [2] - The research identifies key intervention time windows, laying a solid foundation for developing more effective anti-rejection therapies and guiding future research directions [2]

Core Insights - The "New Silk Road" International Thoracic Surgery Exchange Salon was successfully held in Nanjing, focusing on advancements in thoracic surgery and the importance of international collaboration in the field [1][19]. Group 1: Event Overview - The event was hosted by Jiangsu Provincial People's Hospital and featured seven leading thoracic surgery experts from Germany, including Professor Thorsten Walles and Professor Martin Eichhorn [1]. - The salon included comprehensive discussions on hot topics, treatment advancements, and technological innovations in thoracic surgery [1]. Group 2: Key Presentations - Professor Chen Liang presented on "Conical Resection for Deep Early Lung Cancer," discussing surgical indications, operational key points, and postoperative complication prevention [8]. - Professor Wu Weibing addressed "Neoadjuvant Chemotherapy and Immunotherapy for Locally Advanced Central Lung Cancer," highlighting revolutionary opportunities for individualized treatment strategies [8]. - Professor Zhu Quan discussed the "Fissure-type Lung Segment Resection," detailing its technical points and clinical application value [8]. Group 3: International Collaboration - The event emphasized the importance of international collaboration in thoracic surgery, aiming to build a more open and inclusive global network [19]. - The German delegation shared insights on the "Magdeburg Model," showcasing how to establish an efficient thoracic surgery diagnosis and treatment system between hospitals [10]. - The exchange aimed to enhance cooperation in talent cultivation, technological innovation, and clinical research to address global challenges in thoracic surgery [19]. Group 4: Hands-on Learning - The event included live demonstrations of advanced surgical techniques such as three-dimensional reconstruction navigation surgery and single-port thoracoscopic lung segment resection [12]. - The German experts showed great interest in Jiangsu Provincial People's Hospital's precise lung segment and sub-segment resection surgical system [12]. Group 5: Closing Ceremony - A certificate awarding ceremony was held, recognizing the contributions of participating experts [15][17]. - The event concluded with the presentation of a book on innovative thoracic surgery techniques to the German physicians, marking a successful academic exchange [17].